Perioperative outcomes of coronary artery bypass graft in renal transplant recipients in the United States: results from the Nationwide Inpatient Sample.

Abstract:

BACKGROUND:Cardiovascular disease is the leading cause of morbidity and mortality in patients with chronic kidney disease (CKD). In fact, death from cardiovascular disease is the number one cause of graft loss in kidney transplant (KTx) patients. Compared to patients on dialysis, CKD patients with KTx have increased quality and length of life. It is not known, however, whether outcomes of coronary artery bypass graft (CABG) surgery differ between CKD patients with KTx or on dialysis. METHODS:This was a retrospective cohort study comparing CKD patients with KTx or on dialysis undergoing CABG surgery included in the Nationwide Inpatient Sample from 2002 to 2011. Logistic and linear regression models were used to estimate the adjusted associations of KTx on all-cause in-hospital mortality, length of stay, cost of hospitalization, and rate of complications in CABG surgery. RESULTS:CKD patients with KTx had decreased all-cause in-hospital mortality (2.68% vs 5.86%, odds ratio (OR)=0.56, 95% confidence interval (CI)=0.32 to 0.99, P=.046), length of stay (β=-2.96, 95% CI=-3.67 to -2.46, P<.001), and total hospital charges (difference=-$38 884, 95% CI=-$48 173 to -29 596, P<.001). They also had decreased rate of a number of perioperative complications. CONCLUSIONS:CKD patient with KTx have better perioperative outcomes in CABG surgery compared to patients on dialysis.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Tooley JE,Bohl DD,Kulkarni S,Rodriguez-Davalos MI,Mangi A,Mulligan DC,Yoo PS

doi

10.1111/ctr.12816

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

1258-1263

issue

10

eissn

0902-0063

issn

1399-0012

journal_volume

30

pub_type

杂志文章
  • Early changes in scores of chronic damage on transplant kidney protocol biopsies reflect donor characteristics, but not future graft function.

    abstract::The amount of irreversible injury on renal allograft biopsy predicts function, but little is known about the early evolution of this damage. In a single-center cohort, we examined the relationship between donor-, recipient-, and transplantation-associated factors and change in a morphometric index of chronic damage (I...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12251

    authors: Caplin B,Veighey K,Mahenderan A,Manook M,Henry J,Nitsch D,Harber M,Dupont P,Wheeler DC,Jones G,Fernando B,Howie AJ,Veitch P

    更新日期:2013-11-01 00:00:00

  • A prospective 3-yr evaluation of tacrolimus-based immunosuppressive therapy in immunological high risk renal allograft recipients.

    abstract:BACKGROUND:There have been no published data on use of the the newer immunosuppressants tacrolimus and mycophenolate mofetil (MMF) in high immunological risk renal transplantation. We therefore undertook a prospective study to systematically assess outcomes using these agents as part of an aggressive immunosuppressive ...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1111/j.1399-0012.2005.00275.x

    authors: Zaltzman JS,Boucher A,Busque S,Halloran PF,Landsberg DN,McAlister VC,Russell D,Shoker A,Shapiro J,Tchervenkov JI,Ferguson R

    更新日期:2005-02-01 00:00:00

  • A calcineurin antagonist-free induction/maintenance strategy for immunosuppression in elderly recipients of renal allografts from elderly cadaver donors: long-term results from a prospective single centre trial.

    abstract:BACKGROUND:With the aim to improve the inferior outcomes in elderly recipients of kidneys from elderly cadaver donors, we applied and investigated a therapeutic regimen consisting of calcineurin inhibitor (CNI)-free, mycophenolate mofetil (MMF)-based immunosuppressive (i.s.) induction/maintenance protocol. In this arti...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1399-0012.2005.00309.x

    authors: Arbogast H,Hückelheim H,Schneeberger H,Illner WD,Tarabichi A,Fertmann J,Wimmer CD,Hillebrand GF,Mistry-Burchardi N,Thomae R,Acikgöz A,Land W

    更新日期:2005-06-01 00:00:00

  • Massive gastrointestinal hemorrhage due to rupture of a donor pancreatic artery pseudoaneurysm in a pancreas transplant patient.

    abstract::Enteric drainage of secretions by anastomosing the donor duodenum to the recipient's small bowel has become common in pancreatic transplantation. While it eliminates many problems, endoscopic access to the transplanted duodenum and pancreas is made difficult. After a pancreas kidney transplant, the patient presented w...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2004.00111.x

    authors: Green BT,Tuttle-Newhall J,Suhocki P,Smith SR,O'Connor JB

    更新日期:2004-02-01 00:00:00

  • Differential gene expression in non-adherent heart transplant survivors: Implications for regulatory T-cell expression.

    abstract::Survival despite prolonged non-adherence with immunosuppression is rare but has been reported in kidney, lung, and liver transplantation. Its occurrence in heart transplantation is quite rare. Our study was prompted by an index patient who survived despite prolonged medication non-adherence. Prospective consent and bl...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13834

    authors: Baran DA,Rao P,Deo D,Zucker MJ

    更新日期:2020-05-01 00:00:00

  • Effectiveness and safety of the conversion to MeltDose® extended-release tacrolimus from other formulations of tacrolimus in stable kidney transplant patients: A retrospective study.

    abstract::Tacrolimus is the cornerstone of immunosuppressive therapy after kidney transplantation. Its narrow therapeutic window mandates serum level strict monitoring and dose adjustments to ensure the optimal risk-benefit balance. This observational retrospective study analyzed the effectiveness and safety of conversion from ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13767

    authors: Sánchez Fructuoso A,Ruiz JC,Franco A,Diekmann F,Redondo D,Calviño J,Serra N,Aladrén MJ,Cigarrán S,Manonelles A,Ramos A,Gómez G,González Posada JM,Andrés A,Beneyto I,Muñiz AL,Perelló M,Lauzurica R

    更新日期:2020-01-01 00:00:00

  • Molecular assessment of antibody-mediated rejection in human pancreas allograft biopsies.

    abstract::Pancreas transplant longevity is limited by immune rejection, which is diagnosed by graft biopsy using the Banff Classification. The histological criteria for antibody-mediated rejection (AMR) are poorly reproducible and inconsistently associated with outcome. We hypothesized that a 34-gene set associated with antibod...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.14065

    authors: Roufosse C,Drachenberg C,Renaudin K,Willicombe M,Toulza F,Dominy K,McLean A,Simmonds N,de Kort H,Cantarovitch D,Scalea J,Mengel M,Adam B

    更新日期:2020-11-01 00:00:00

  • Psychosocial outcome of living donors after living donor liver transplantation: a pilot study.

    abstract::In view of the scarcity of organ resources available for transplantation, living donor liver transplantation (LDLT) is gaining growing importance in the treatment of chronically terminal liver diseases. In the period between December 1999 and October 2000, 47 potential living liver donors were evaluated and 24 right h...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2002.02002.x

    authors: Walter M,Bronner E,Pascher A,Steinmüller T,Neuhaus P,Klapp BF,Danzer G

    更新日期:2002-10-01 00:00:00

  • Risk factors for acute rejection in renal transplant recipients experiencing delayed graft function.

    abstract::Acute rejection (AR) superimposed upon delayed graft function (DGF) following renal transplantation worsens graft outcomes. However, risk factors for AR in patients displaying DGF remain unclear. In this study, 71 patients displaying DGF >/= 5 d were investigated. All received cyclosporine, adjunctive azathioprine or ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2008.00837.x

    authors: Moore J,Tan K,Cockwell P,Krishnan H,McPake D,Ready A,Mellor S,Hamsho A,Ball S,Lipkin G,Borrows R

    更新日期:2008-09-01 00:00:00

  • Randomized trial of early corticosteroid reduction vs. regular-dose corticosteroid maintenance in combination with tacrolimus and mycophenolate mofetil in living donor kidney transplant recipients: the Brazilian CORRETA trial.

    abstract::This multicenter, randomized trial aimed to compare the safety and efficacy of an early reduction in corticosteroid dose vs. long-term maintenance in Brazilian patients on an immunosuppressive regimen based on tacrolimus and mycophenolate mofetil (MMF). In the control arm, prednisone was progressively reduced from day...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1399-0012.2009.01185.x

    authors: Garcia VD,Carvalho DB,Gonçalves RT,Cavalcanti RL,Campos HH,Abbud-Filho M,Lobao-Neto AA

    更新日期:2010-07-01 00:00:00

  • Heart transplantation in the early phase of the COVID-19 pandemic: A single-center case series.

    abstract::The infectious disease coronavirus disease 2019 (COVID-19) was declared a pandemic by the World Health Organization in March 2020. The impact of COVID-19 on solid organ transplantations, including heart transplantation, is currently unclear. Many transplant programs have been forced to swiftly re-evaluate and adapt th...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.14042

    authors: Hsu JJ,Al-Saffar F,Ardehali R,Baas AS,Carlson M,Cruz D,Deng M,Fan A,Fraschilla S,Gaynor P,Kamath M,Kubak BM,Schaenman J,Stimpson E,Vucicevic D,Ardehali A,Nsair A

    更新日期:2020-09-01 00:00:00

  • A prospective randomized study comparing cyclosporine versus tacrolimus combined with daclizumab, mycophenolate mofetil, and steroids in heart transplantation.

    abstract:BACKGROUND:Cyclosporine (CsA) and tacrolimus (Tac) in heart transplantation (HTx) have been compared but with certain drawbacks. We compared both drugs in a prospective analysis with medium-term follow-up. METHODS:Hundred and six patients were randomized to receive CsA or Tac (53 per group). Target levels of CsA were ...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-0012.2010.01309.x

    authors: Sánchez-Lázaro IJ,Almenar L,Martínez-Dolz L,Buendía-Fuentes F,Agüero J,Navarro-Manchón J,Vicente JL,Salvador A

    更新日期:2011-07-01 00:00:00

  • A call to action: Feasible strategies to reduce the discard of transplantable kidneys in the United States.

    abstract::Changes to the United States kidney allocation system targeted at reducing organ discard have failed to improve organ utilization. High Kidney Donor Profile Index kidneys continue to be discarded at high rates as a result of the regulatory and financial barriers to widespread utilization of these organs. However, ther...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13990

    authors: Stewart ZA,Shah SA,Formica RN,Kandaswamy R,Paramesh AS,Friedman J,Squires R,Cooper M,Axelrod DA

    更新日期:2020-09-01 00:00:00

  • Low infectious complications in segmental living related small bowel transplantation in adults.

    abstract::Clinical small bowel transplantation (SBTx) has been associated with a high rate of infectious complications. Laparotomy, preservation injury, abnormal motility, lymphatic disruption, aberrant systemic venous drainage, rejection and antibiotic therapy could all be implicated in the etiology of these complications. In ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2000.140609.x

    authors: Cicalese L,Sileri P,Asolati M,Rastellini C,Abcarian H,Benedetti E

    更新日期:2000-12-01 00:00:00

  • Risk of adverse maternal and fetal outcomes during pregnancy in living kidney donors: A matched cohort study.

    abstract:BACKGROUND:We examined the risk of adverse pregnancy outcomes in primiparous kidney donors compared to matched controls. METHODS:Fifty-nine women with a history of kidney donation prior to their first pregnancy with normal renal function and no history of kidney disease, diabetes or chronic hypertension were matched 1...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13453

    authors: Davis S,Dylewski J,Shah PB,Holmen J,You Z,Chonchol M,Kendrick J

    更新日期:2019-01-01 00:00:00

  • Clostridioides difficile colonization and infection in patients admitted for a first autologous transplantation: Incidence, risk factors, and patient outcomes.

    abstract:BACKGROUND:More data are needed regarding the incidence, risk factors, and outcomes for Clostridioides difficile infection (CDI) and colonization in patients undergoing an autologous hematopoietic stem cell transplantation (AHSCT). METHODS:We studied 472 consecutive patients admitted for a first AHSCT and conducted a ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13712

    authors: Ford CD,Lopansri BK,Coombs J,Webb BJ,Nguyen A,Asch J,Hoda D

    更新日期:2019-11-01 00:00:00

  • Deceased organ donor factors influencing pancreatic graft transplantation and survival.

    abstract::Criteria for organ acceptance in brain-dead organ donors remain inconsistent, especially when concerning pancreatic transplants. We sought to examine donor-specific predictors of pancreatic graft use and survival to better guide the selection and management of potential donors. A prospective observational study of all...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13571

    authors: Sally MB,Ellis MK,Hutchens M,Groat T,Swanson E,Patel MS,Niemann CU,Malinoski DJ

    更新日期:2019-06-01 00:00:00

  • Conundrums with FlowPRA beads.

    abstract::In 1969, a study by Patel and Terasaki persuaded the renal transplant community that a pre-transplant cross-match should always be performed between donor and recipient to detect HLA antibodies and prevent hyperacute allograft rejection. Although the role of the cross-match among nonsensitized patients is controversia...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.16.s7.3.x

    authors: Gebel HM,Harris SB,Zibari G,Bray RA

    更新日期:2002-01-01 00:00:00

  • Steroid withdrawal in kidney transplant recipients: is it a safe option?

    abstract::The long-term side effects of lifelong steroid immunosuppression are well documented, therefore, steroid withdrawal (SW) if safe would clearly be of benefit. From 1987-1996, 470 kidney transplants were performed at our institution. During this time period, steroid withdrawal was offered to a select group of patients (...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Sanfey H,Haussman G,Isaacs I,Ishitani M,Lobo P,McCullough C,Pruett T

    更新日期:1997-10-01 00:00:00

  • Monitoring changes in cyclosporine dosage by trough level testing.

    abstract::The concept of a narrow therapeutic window has guided the management of transplant recipients on cyclosporine immunosuppression since its inception more than a decade ago. The need to maintain immunosuppression and avoid toxicity imposed the requirement of monitoring cyclosporine levels within a limited range. The use...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Takasugi M,Takasugi JK,Barba L

    更新日期:1995-04-01 00:00:00

  • An analysis of pancreas transplantation outcomes based on age groupings--an update of the UNOS database.

    abstract:INTRODUCTION:Previously, increasing age has been a part of the exclusion criteria used when determining eligibility for a pancreas transplant. However, the analysis of pancreas transplantation outcomes based on age groupings has largely been based on single-center reports. METHODS:A UNOS database review of all adult p...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12407

    authors: Siskind E,Maloney C,Akerman M,Alex A,Ashburn S,Barlow M,Siskind T,Bhaskaran M,Ali N,Basu A,Molmenti E,Ortiz J

    更新日期:2014-09-01 00:00:00

  • Impact of donor coronary angiography on kidney transplantation outcomes.

    abstract::Coronary angiography (CA) is the gold standard evaluation of coronary artery disease in potential multi-organ donors. This use of iodinated contrast media could lead to contrast-induced acute kidney injury and consequently to delayed graft function (DGF). All patients in France who received a kidney from a 45-70-year-...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13355

    authors: Lesouhaitier M,Legeai C,Savoye E,Cantrelle C,Pipien I,Macher MA,Vigneau C,Dorent R

    更新日期:2018-09-01 00:00:00

  • Perspectives on donor lung allocation from both sides of the Atlantic: The United States.

    abstract::Donor lung allocation in the United States focuses on decreasing waitlist mortality and improving recipient outcomes. The implementation of allocation policy to match deceased donor lungs to waitlisted patients occurs through a unique partnership between government and private organizations, namely the Organ Procureme...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13873

    authors: Tsuang WM,Snyder LD,Budev MM

    更新日期:2020-07-01 00:00:00

  • Prednisone-free maintenance immunosuppression in obese kidney transplant recipients.

    abstract::Obese transplant recipients (BMI ≥ 30 kg/m2 ) have decreased posttransplant patient and graft survival compared with their nonobese counterparts. At the same time, many prednisone-related side effects (eg, new-onset diabetes) are similar to those associated with obesity. Using SRTR data, we studied outcomes associated...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13668

    authors: Matas AJ,Vock DM

    更新日期:2019-10-01 00:00:00

  • Improvement of gastrointestinal symptoms after conversion from mycophenolate mofetil to enteric-coated mycophenolate sodium in liver transplant patients.

    abstract::As many as 50% of liver transplant patients suffer gastrointestinal (GI) disturbances post-transplant. Conversion from mycophenolate mofetil (MMF) to mycophenolate sodium (EC-MPS) alleviates GI symptom burden in renal transplant recipients. We employed a validated patient and physician-reported assessment to evaluate ...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1399-0012.2011.01444.x

    authors: Toledo AH,Hendrix L,Buchholz V,Fisher E,Newton K,Smith C,Gerber DA

    更新日期:2012-01-01 00:00:00

  • Risk of early, intermediate, and late rejection following heart transplantation: Trends over the past 25 years and relation to changes in medical management. Tertiary center experience: The Sheba Heart Transplantation Registry.

    abstract:AIM:To explore the trends in the risk for rejection following heart transplantation (HT) over the past 25 years, and their relation to changes in medical management. METHODS:The study population comprised 216 HT patients. Rejection periods were defined as follows: 0-3 months (early), 3-12 months (intermediate), and 12...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13063

    authors: Katz M,Freimark D,Raichlin E,Har-Zahav Y,Arad M,Kassif Y,Peled A,Asher E,Elian D,Kogan A,Shlomo N,Ofek E,Lavee J,Goldenberg I,Peled Y

    更新日期:2017-10-01 00:00:00

  • ALLOREACTIVE T LYMPHOCYTES CULTURED FROM LIVER TRANSPLANT BIOPSIES: ASSOCIATIONS OF HLA SPECIFICITY WITH CLINICOPATHOLOGICAL FINDINGS.

    abstract::Lymphocyte cultures grown from liver allograft biopsies were shown to exhibit alloreactivity towards donor cells as measured by primed lymphocyte testing (PLT). The PLT specificity was determined in assays using HLA typed panel cells and/or by inhibition testing with HLA specific monoclonal antibodies. Certain culture...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Markus BH,Demetris AJ,Saidman S,Fung JJ,Zeevi A,Starzl TE,Duquesnoy RJ

    更新日期:1988-01-01 00:00:00

  • Thrombotic microangiopathy after liver-small bowel transplant.

    abstract::We herein report the first case of immunosuppression-associated thrombotic microangiopathy (TMA) in which an extrarenal graft was primarily affected by the characteristic microvascular lesions. Although TMA is a well-known complication of cyclosporine (CSA) or tacrolimus therapy in renal and extrarenal (liver, heart, ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Humar A,Jessurun J,Sharp HL,Gruessner RW

    更新日期:1998-12-01 00:00:00

  • Orthotopic placement of a segmental pancreas graft for transplant: a case report.

    abstract::Pancreas retransplantation has become more frequent and represents a technical challenge for surgeons. Knowledge of alternative surgical options could be useful in difficult cases. We present a case of brutal diabetes mellitus in a patient with severe vascular disease that underwent a third pancreas transplant. Diffic...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2009.01149.x

    authors: Garcia-Roca R,Humar A,Sturdevant M,Kobayashi T,Dunn T,Kandaswamy R,Sutherland D

    更新日期:2010-05-01 00:00:00

  • Contrast-enhanced ultrasound of the transplant pancreas in the post-operative setting.

    abstract:BACKGROUND/OBJECTIVES:Vascular thrombosis is the most common cause of early graft loss after transplantation. Routine grayscale and Doppler ultrasound frequently fail to adequately visualize vascular compromise. Contrast-enhanced ultrasound is a novel approach to identifying these complications. METHODS:This was a pro...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13733

    authors: Swensson J,Nagaraju S,O'Brien D,Tann M,Shah A,Mangus R,Powelson J,Fridell J

    更新日期:2019-12-01 00:00:00