Risk of adverse maternal and fetal outcomes during pregnancy in living kidney donors: A matched cohort study.


BACKGROUND:We examined the risk of adverse pregnancy outcomes in primiparous kidney donors compared to matched controls. METHODS:Fifty-nine women with a history of kidney donation prior to their first pregnancy with normal renal function and no history of kidney disease, diabetes or chronic hypertension were matched 1:4 by age (within 2 years) and race to women with two kidneys using data from an integrated healthcare delivery system. Adverse pregnancy outcomes were defined as preterm delivery (delivery <37 weeks), delivery via cesarean section, gestational hypertension, preeclampsia/eclampsia, gestational diabetes, length of stay in the hospital >3 days, infant death/transfer to acute facility and low birthweight (<2500 g). RESULTS:Living kidney donors did not have a higher risk of adverse outcomes compared to matched controls. There was a trend toward an increased risk of preeclampsia/eclampsia in kidney donors but it did not reach statistical significance (Odds ratio [OR]: 2.96, 95% CI: 0.98-8.94, P = 0.06). However, in kidney donors ≤30 years of age, there was a fourfold increased risk of preeclampsia/eclampsia (OR: 4.09, 95% CI: 1.07-15.59, P = 0.04). CONCLUSION:Overall, the risk of pregnancy-associated complications following kidney donation is small but potential female kidney donors should be counseled on the possible increased risk of preeclampsia.


Clin Transplant


Clinical transplantation


Davis S,Dylewski J,Shah PB,Holmen J,You Z,Chonchol M,Kendrick J




Has Abstract


2019-01-01 00:00:00












  • Anemia following renal transplantation: erythropoietin response and iron deficiency.

    abstract::To define the etiology of anemia post-renal transplantation, we assessed hematologic parameters and EPO levels in 38 anemic and 16 non-anemic control renal transplant recipients (RTRs) with varying degrees of allograft function at periods > 3 months post-transplantation. Significant differences between the two groups ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Miles AM,Markell MS,Daskalakis P,Sumrani NB,Hong J,Sommer BG,Friedman EA

    更新日期:1997-08-01 00:00:00

  • Transplantation of a severely lacerated liver--a case report with review of the literature.

    abstract::Using lacerated livers for liver transplantation (LTx) can add an option to the extended donor criteria. We present an LTx case using a severely lacerated liver and review of the literature for reported cases. We used a high-grade lacerated liver from a 19-yr-old brain-dead patient caused by traffic accident. The live...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审


    authors: Mehrabi A,Fonouni H,Ahmadi R,Schmied BM,Müller SA,Welsch T,Hallscheidt P,Zeier M,Weitz J,Schmidt J

    更新日期:2009-06-01 00:00:00

  • Severe late acute allograft rejection in a child after living-related auxiliary partial orthotopic liver transplantation for ornithine transcarbamylase deficiency.

    abstract::Auxiliary liver transplantation (ALT) is known to correct liver-based metabolic disorders. However, it remains unclear whether the presence of a native liver influences the long-term prognosis of ALT for metabolic diseases. We reported on a 4-yr-old girl who had undergone living-related auxiliary partial orthotopic li...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Komatsu H,Inui A,Fujisawa T,Sogo T,Miyagawa Y,Inui M,Uemoto S,Inomata Y,Tanaka K

    更新日期:1999-08-01 00:00:00


    abstract::Lymphocyte cultures grown from liver allograft biopsies were shown to exhibit alloreactivity towards donor cells as measured by primed lymphocyte testing (PLT). The PLT specificity was determined in assays using HLA typed panel cells and/or by inhibition testing with HLA specific monoclonal antibodies. Certain culture...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Markus BH,Demetris AJ,Saidman S,Fung JJ,Zeevi A,Starzl TE,Duquesnoy RJ

    更新日期:1988-01-01 00:00:00

  • Extracorporeal membrane oxygenation as a bridge vs. non-bridging for lung transplantation: A systematic review and meta-analysis.

    abstract::Whether extracorporeal membrane oxygenation (ECMO) as a bridge to lung transplantation (BTT) can achieve a similar survival to non-BTT remains controversial. We conducted this meta-analysis to compare the outcomes between ECMO BTT and non-BTT to facilitate better clinical decision-making. Seven databases were searched...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Wan X,Bian T,Ye S,Cai P,Yu Z,Zhu J,Zhang W

    更新日期:2020-11-22 00:00:00

  • Reviews on mysterious vascular endothelial cells in renal allografts.

    abstract::Endothelial cells (ECs) are involved in allograft rejection and are prime targets, but also key players. HLA antigens are the most prominent targets of alloantibodies in transplantation. Alloantibodies against other antigens such as ABO blood group antigens and non-HLA antigens could also be demonstrated. Alloantibodi...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审


    authors: Yamaguchi Y

    更新日期:2012-07-01 00:00:00

  • Impact of gastrointestinal-related side effects on mycophenolate mofetil dosing and potential therapeutic strategies.

    abstract::In renal transplant patients receiving mycophenolate mofetil (MMF), maintaining an adequate dosing regimen has been shown to maximize short- and long-term outcomes. Gastrointestinal (GI) adverse events associated with MMF are frequent, and lead to MMF dose reduction or withdrawal in 40-50% of cases. Among MMF-treated ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审


    authors: Bunnapradist S,Ambühl PM

    更新日期:2008-11-01 00:00:00

  • Impact of the ratio of graft kidney volume to recipient body surface area on graft function after live donor kidney transplantation.

    abstract::Functioning nephron mass is a determinant of the graft function of kidney transplant recipients. The graft kidney volume and its weight have been reported to be surrogates of the nephron mass. To investigate the impact of the ratios of the surrogates to recipient body surface area (BSA) and body weight on the graft fu...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Lee JH,Won JH,Oh CK

    更新日期:2011-11-01 00:00:00

  • Human parvovirus B19 infection in organ transplant recipients.

    abstract::We report a 61-yr-old kidney transplant recipient with human Parvovirus B19 (HPV B19) infection presenting as a severe pancytopenia 1 month after transplantation. Bone marrow aspiration revealed severe erythroid hypoplasia with giant and dystrophic proerythroblasts. Bone marrow cells were positive for HPV B19 DNA dete...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审


    authors: Marchand S,Tchernia G,Hiesse C,Tertian G,Cartron J,Kriaa F,Boubenider S,Goupy C,Lecointe D,Charpentier B

    更新日期:1999-02-01 00:00:00

  • Low infectious complications in segmental living related small bowel transplantation in adults.

    abstract::Clinical small bowel transplantation (SBTx) has been associated with a high rate of infectious complications. Laparotomy, preservation injury, abnormal motility, lymphatic disruption, aberrant systemic venous drainage, rejection and antibiotic therapy could all be implicated in the etiology of these complications. In ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Cicalese L,Sileri P,Asolati M,Rastellini C,Abcarian H,Benedetti E

    更新日期:2000-12-01 00:00:00

  • Low molecular weight heparin dosing and monitoring in solid organ transplant recipients.

    abstract::Anti-Xa monitoring for low molecular weight heparin (LMWH) is currently recommended in obese, renally impaired, and pregnant patients. Substantial evidence indicates that solid organ transplant (SOT) patients are at an increased risk of renal impairment, thus representing a population at risk of LMWH accumulation. The...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Moten MA,Gaber AO,Putney D,Patel SJ

    更新日期:2013-11-01 00:00:00

  • Engraftment of heavily transfused patients with severe aplastic anemia with a fludarabine-based regimen.

    abstract::We have developed a practical conditioning regimen without anti-thymocyte globulin (ATG), irradiation, or other myeloablative alkylating agent for low-income countries in which patients with severe aplastic anemia (SAA), who usually have heavily transfused and a prolonged disease history. The application of ATG, Busul...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章


    authors: Wang SB,Li L,Pan XH,Hu DM,Peng LH,Liu L,Xie ZJ,Yin B,Sun XJ,Yu J,Liang Y

    更新日期:2013-03-01 00:00:00

  • Early- and long-term outcomes of liver transplantation with rescue allocation grafts.

    abstract::In France, liver grafts which have been refused by at least five centers are proposed as rescue allocation (RA). The aim of this study is to clarify the feasibility and safety of RA grafts in liver transplantation (LT). Short- and long-term outcomes of patients who received RA grafts (RA group) were compared with thos...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Kitano Y,Allard MA,Nakada S,Beghdadi N,Karam V,Vibert E,Sa Cunha A,Castaing D,Cherqui D,Baba H,Adam R

    更新日期:2020-07-19 00:00:00

  • Combination of pancreas volume and HbA1c level predicts islet yield in patients undergoing total pancreatectomy and islet autotransplantation.

    abstract::Islet yield is an important predictor of acceptable glucose control after total pancreatectomy with islet autotransplantation (TP-IAT). We assessed if pancreas volume calculated with preoperative MRI could assess islet yield and postoperative outcomes. We reviewed dynamic MRI studies from 154 adult TP-IAT patients (20...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Nanno Y,Wilhelm JJ,Heller D,Schat R,Freeman ML,Trikudanathan G,Kirchner VA,Pruett TL,Beilman GJ,Hering BJ,Bellin MD

    更新日期:2020-08-01 00:00:00

  • Lamivudine monoprophylaxis for liver transplant recipients with non-replicating hepatitis B virus infection.

    abstract:BACKGROUND:The aim of this study was to evaluate the efficacy of lamivudine (LAM) monoprophylaxis for patients with non-replicating hepatitis B virus (HBV) infection at orthotopic liver transplantation (OLT). METHODS:Among 128 liver recipients with HBV infection between 1994 and 2004 transplanted at our institution, 6...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Yoshida H,Kato T,Levi DM,Regev A,Madariaga JR,Nishida S,Martinez EJ,Schiff ER,Omata M,Tzakis AG

    更新日期:2007-03-01 00:00:00

  • Efficacy of tonsillectomy for patients with recurrence of IgA nephropathy after kidney transplantation.

    abstract::From January 2007, we started to perform the tonsillectomy for every patient with recurrent IgA nephropathy (IgAN) after kidney transplantation. Up to September 2008, four recipients with primary IgAN had biopsy-proven recurrent IgAN. They had also progressive hematuria or proteinuria from on the average 14.3 months a...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Ushigome H,Suzuki T,Fujiki M,Nobori S,Sakamoto S,Okamoto M,Urasaki K,Yoshimura N

    更新日期:2009-08-01 00:00:00

  • Access to living donor transplantation for Aboriginal recipients: a study of living donor presentation and exclusion.

    abstract::Aboriginals experience high rates of end-stage renal disease (ESRD) and are less likely to receive a kidney transplant from a living donor. We hypothesized that higher rates of hypertension and diabetes in Aboriginal communities would result in fewer potential living donors coming forward and more exclusions for medic...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Dunsmore S,Karpinski M,Young A,Storsley L

    更新日期:2011-11-01 00:00:00

  • Characteristics, risks, and outcomes of post-transplant lymphoproliferative disease >3 years after pediatric heart transplant: A multicenter analysis.

    abstract::Post-transplant lymphoproliferative disorder (PTLD) is a significant complication after pediatric heart transplantation (HT), occurring in 5%-15% of patients within 3 years. Data >3 years from HT are limited. We sought to describe the prevalence, risk factors, and outcomes of PTLD occurring late (>3 years) after pedia...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,多中心研究


    authors: West SC,Friedland-Little JM,Schowengerdt KO Jr,Naftel DC,Pruitt Freeze E,Smith KS,Urschel S,Michaels MG,Kirklin JK,Feingold B

    更新日期:2019-05-01 00:00:00

  • Randomized trial of early corticosteroid reduction vs. regular-dose corticosteroid maintenance in combination with tacrolimus and mycophenolate mofetil in living donor kidney transplant recipients: the Brazilian CORRETA trial.

    abstract::This multicenter, randomized trial aimed to compare the safety and efficacy of an early reduction in corticosteroid dose vs. long-term maintenance in Brazilian patients on an immunosuppressive regimen based on tacrolimus and mycophenolate mofetil (MMF). In the control arm, prednisone was progressively reduced from day...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Garcia VD,Carvalho DB,Gonçalves RT,Cavalcanti RL,Campos HH,Abbud-Filho M,Lobao-Neto AA

    更新日期:2010-07-01 00:00:00

  • Pseudoaneurysm of the superior mesenteric artery with an arteriovenous fistula after simultaneous kidney-pancreas transplantation.

    abstract::Vascular complications remain a significant source of morbidity after pancreatic transplantation. We describe a pseudoaneurysm of the superior mesenteric artery (SMA) with an arteriovenous fistula (AVF) involving the SMA and the superior mesenteric vein (SMV) discovered and treated surgically in the second week after ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Khan TF,Ciancio G,Burke GW 3rd,Sfakianakis GN,Miller J

    更新日期:1999-06-01 00:00:00

  • Initial experience using histidine-tryptophan-ketoglutarate solution in clinical pancreas transplantation.

    abstract:BACKGROUND:The colloid-based University of Wisconsin (UW) preservation solution has been used extensively in clinical pancreas transplantation. Experimental studies support the use of the crystalloid-based histidine-tryptophan-ketoglutarate (HTK) preservation solution for this purpose. AIM:We report our initial experi...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Potdar S,Malek S,Eghtesad B,Shapiro R,Basu A,Patel K,Broznick B,Fung J

    更新日期:2004-12-01 00:00:00

  • The impact of obesity in renal transplantation: an analysis of paired cadaver kidneys.

    abstract:BACKGROUND:Previous studies indicate that obesity is a risk factor in renal transplantation. However, these analyses did not control for variable donor factors that may strongly influence outcome. To control for donor variables such as age, cause of death, procurement techniques, preservation methods, cold ischaemia ti...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Yamamoto S,Hanley E,Hahn AB,Isenberg A,Singh TP,Cohen D,Conti DJ

    更新日期:2002-08-01 00:00:00

  • Renal retransplants: effect of primary allograft nephrectomy on early function, acute rejection and outcome.

    abstract::Although risk factors for failure of renal retransplants have been well studied, the impact of allograft nephrectomy on subsequent renal transplantation in the cyclosporin era is not well defined. The purpose of this study is to define the effect of nephrectomy of the primary allograft on subsequent allograft survival...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Douzdjian V,Rice JC,Carson RW,Gugliuzza KK,Fish JC

    更新日期:1996-04-01 00:00:00

  • Calcineurin inhibitor withdrawal and conversion to mycophenolate mofetil and steroids in cardiac transplant recipients with chronic renal failure: a word of caution.

    abstract:BACKGROUND:Chronic renal failure (CRF) is a common complication of calcineurin inhibitor (CNI)-based immunosuppression following cardiac transplantation (HTx). The aim of this prospective study was to evaluate the impact of an immunosuppressive conversion from CNIs to mycophenolate mofetil (MMF) and steroids in cardiac...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Groetzner J,Kaczmarek I,Schirmer J,Uberfuhr P,Gulbins H,Daebritz S,Meiser B,Reichart B

    更新日期:2008-09-01 00:00:00

  • Anti-IL-2R blockers comparing with polyclonal antibodies: Higher risk of rejection without negative mid-term outcomes after ABO-incompatible kidney transplantation.

    abstract::There is no recommendation regarding the type of induction therapy to use in ABO-incompatible (ABOi) kidney transplantation. The aim of this retrospective study was to compare the outcome of ABOi living donor kidney transplant (LDKT) recipients who received either polyclonal antibodies or anti-interleukin-2 receptor (...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Del Bello A,Divard G,Belliere J,Congy-Jolivet N,Lanfranco L,Ricard R,Delas A,Colombat M,Esposito L,Hebral AL,Cointault O,Lefaucheur C,Loupy A,Kamar N

    更新日期:2019-10-01 00:00:00

  • Importance of bone marrow cell dose in bone marrow transplantation.

    abstract::The importance of the size of the infused marrow cell dose (MCD) was investigated in 274 patients undergoing allogeneic BMT between 1975 and 1990. Among those, 65 had acute myelogenous leukemia (AML), 79 acute lymphoblastic leukemia (ALL), 58 chronic myelogenous leukemia (CML) and 25 severe aplastic anemia (SAA). MC...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Paulin T

    更新日期:1992-02-01 00:00:00

  • Role of total artificial heart in the management of heart transplant rejection and retransplantation: case report and review.

    abstract::Cardiac allograft rejection and failure may require mechanical circulatory support as bridge-to-retransplantation. Prognosis in this patient group is poor and implantable ventricular assist devices have had limited success due to organ failure associated with the high dose immunosuppression required to treat ongoing r...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审


    authors: Kalya A,Jaroszewski D,Pajaro O,Scott R,Gopalan R,Kasper D,Arabia F

    更新日期:2013-07-01 00:00:00

  • Immunosuppressive standards in simultaneous kidney-pancreas transplantation.

    abstract::Simultaneous pancreas-kidney transplantation is an established procedure for patients with type I diabetes and end-stage renal disease. Continuous advances in the operation techniques with consequent reduction of perioperative morbidity and mortality and the introduction of modern immunosuppressive agents improved not...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审


    authors: Schmied BM,Müller SA,Mehrabi A,Welsch T,Büchler MW,Zeier M,Schmidt J

    更新日期:2006-01-01 00:00:00

  • Cardiac diastolic dysfunction in renal-transplant recipients is associated with increased circulating Adrenomedullin.

    abstract:BACKGROUND:Renal transplantation is an excellent therapeutic alternative for end-stage renal diseases. Nevertheless, the cardiac function is often impaired in renal-transplant patients (RTR) and importantly determines their prognosis. Adrenomedullin (ADM), a peptide involved in cardiovascular homeostasis, is believed t...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Geny B,Ellero B,Chakfé N,Kretz JG,Brandenberger G,Piquard F

    更新日期:2006-05-01 00:00:00

  • The profile of inflammatory and metabolic response in children undergoing heart transplantation.

    abstract::Inflammatory and metabolic response is an important factor to determine clinical outcomes. However, it remains unknown in children undergoing heart transplantation (HTx). We examined the perioperative changes in the inflammatory and metabolic response markers C-reactive protein (CRP) and prealbumin (PA) in 38 heart-tr...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Yu X,Larsen B,Urschel S,Cheung PY,Ross DB,Rebeyka I,West L,Li J

    更新日期:2012-03-01 00:00:00