Abstract：
BACKGROUND:Methamphetamine (MA) has cumulative deleterious effects on multiple organ systems. A history of MA exposure in kidney donors may affect adversely graft function in recipients. METHODS:Between September 2000 and March 2004, all deceased kidney donors were identified from the local registry (97 donors). Twenty donors (21%) with any MA exposure through history or toxicology were selected. Donors that did not fulfill UNOS standard criteria were excluded. Donor characteristics and subsequent recipient characteristics were retrospectively compared with a control group without MA exposure histories. The main outcome measure was mean serum creatinine at one-yr post-transplant (Cr365). Secondary outcome measures of delayed graft function and rejection episodes were reviewed. RESULTS:Baseline serum creatinine at seven d post-transplant were equivalent between groups (Cr7 = 2.5 +/- 2.0 vs. 2.8 +/- 3.4, p = 0.75). At one yr, Cr365 was significantly elevated in recipients of MA exposed kidneys compared with controls (1.9 +/- 1.0 vs. 1.4 +/- 0.4, p = 0.028). When adjusted for confounding variables, MA exposure lost its statistical significance (p = 0.07-0.09) as an independent predictor of increased Cr365. CONCLUSION:Donor MA exposure may be associated with increased Cr365 in recipients. Transplant centers can expect to encounter donors with MA use histories at rates higher that regional use rates. Larger studies may demonstrate MA exposure as an independent predictor of impaired graft function.
journal_name
Clin Transplantjournal_title
Clinical transplantationauthors
Inouye DS,Kickertz K,Wong LLdoi
10.1111/j.1399-0012.2007.00703.xsubject
Has Abstractpub_date
2007-09-01 00:00:00pages
643-50issue
5eissn
0902-0063issn
1399-0012pii
CTR703journal_volume
21pub_type
杂志文章abstract：:Differentiating acute pyelonephritis (APN) from acute rejection (AR) in renal allograft biopsies can sometimes be difficult because of overlapping clinical and histologic features, lack of positive urine cultures,and variable response to antibiotics. We wanted to study differential gene expression between AR and APN u...
journal_title：Clinical transplantation
pub_type： 杂志文章
doi：10.1111/ctr.12795
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND:The clinical consequences of type 1 diabetes mellitus (IDDM) include diabetic triopathy: retinopathy, nephropathy, and neuropathy, as well as microangiopathy, accelerated atherosclerotic disease, and hypercoagulability. The etiology of the hypercoagulability is multifactorial, involving various clotting fact...
journal_title：Clinical transplantation
pub_type： 杂志文章
doi：10.1111/j.1399-0012.2004.00183.x
更新日期：2004-08-01 00:00:00
abstract：:In recent years, several researchers have unraveled the previously unrecognized effects of granulocyte colony-stimulating factor (G-CSF) on hematopoiesis and the immune cell functions of bone marrow in healthy donors. In human leukocyte antigen-matched or haploidentical transplant settings, available data have establi...
journal_title：Clinical transplantation
pub_type： 杂志文章,评审
doi：10.1111/j.1399-0012.2010.01298.x
更新日期：2011-01-01 00:00:00
abstract：:As many as 50% of liver transplant patients suffer gastrointestinal (GI) disturbances post-transplant. Conversion from mycophenolate mofetil (MMF) to mycophenolate sodium (EC-MPS) alleviates GI symptom burden in renal transplant recipients. We employed a validated patient and physician-reported assessment to evaluate ...
journal_title：Clinical transplantation
pub_type： 临床试验,杂志文章
doi：10.1111/j.1399-0012.2011.01444.x
更新日期：2012-01-01 00:00:00
abstract：:The amount of irreversible injury on renal allograft biopsy predicts function, but little is known about the early evolution of this damage. In a single-center cohort, we examined the relationship between donor-, recipient-, and transplantation-associated factors and change in a morphometric index of chronic damage (I...
journal_title：Clinical transplantation
pub_type： 杂志文章
doi：10.1111/ctr.12251
更新日期：2013-11-01 00:00:00
abstract：:To define the etiology of anemia post-renal transplantation, we assessed hematologic parameters and EPO levels in 38 anemic and 16 non-anemic control renal transplant recipients (RTRs) with varying degrees of allograft function at periods > 3 months post-transplantation. Significant differences between the two groups ...
journal_title：Clinical transplantation
pub_type： 杂志文章
doi：
更新日期：1997-08-01 00:00:00
abstract：BACKGROUND:Although innate immunity is crucial to host defense against pathogens, the extent to which innate immune mechanisms participate in the rejection of allogenic tissues in humans is unknown. We hypothesize that activation of innate immunity through Toll-like receptors (TLRs) critically regulates the development...
journal_title：Clinical transplantation
pub_type： 杂志文章
doi：10.1111/j.1399-0012.2005.00436.x
更新日期：2006-01-01 00:00:00
abstract：:An increasing number of patients and families are utilizing online crowdfunding to support their medical expenses related to organ transplantation. The factors influencing the success of crowdfunding campaigns are poorly understood. Crowdfunding campaigns were abstracted from a popular crowdfunding web site. Campaigns...
journal_title：Clinical transplantation
pub_type： 杂志文章
doi：10.1111/ctr.13267
更新日期：2018-06-01 00:00:00
abstract：BACKGROUND/AIM:The aim of this study was to determine whether the expression of CD25, CD28 and CD38 (which reflects the degree of T-cell activation) by peripheral blood mononuclear cells constitutes a useful means of measuring the immune status of liver transplant recipients. METHODS:Fifty-two patients enrolled in a p...
journal_title：Clinical transplantation
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1399-0012.2008.00815.x
更新日期：2008-07-01 00:00:00
abstract：BACKGROUND:It is estimated that 25%-35% of heart transplant recipients develop de novo donor-specific antibodies (dnDSA). One factor that appears to play a role in clinical outcomes is DSA persistence. The objective of this study was to determine the incidence of transient and persistent dnDSA in a Canadian heart trans...
journal_title：Clinical transplantation
pub_type： 杂志文章
doi：10.1111/ctr.13416
更新日期：2018-11-01 00:00:00
abstract：INTRODUCTION:Totally implantable venous access devices (TIVADs) are the preferred devices for patients with advanced lung disease who require long-term venous access. The primary purpose of this study was to describe the natural history of TIVADs left in place at the time of transplant. METHODS:This multicenter retros...
journal_title：Clinical transplantation
pub_type： 杂志文章,多中心研究
doi：10.1111/ctr.13465
更新日期：2019-02-01 00:00:00
abstract：:Transplantation tolerance is the ultimate goal of organ transplantation. Natural regulatory T cells (Treg) have been expected to reach clinical applications for tolerance induction because their initial description. More than ten yr later, Treg have started moving from experimental animal models into clinical applicat...
journal_title：Clinical transplantation
pub_type： 杂志文章,评审
doi：10.1111/j.1399-0012.2009.01103.x
更新日期：2009-12-01 00:00:00
abstract：:The study included 110 consecutive patients with hematological malignancies receiving fludarabine-based reduced intensity conditioning (RIC) and hematopoietic stem cell transplantation (HSCT) from matched unrelated donors. The median age was 55 yr (range 11-68) and all but 15 patients received peripheral blood stem ce...
journal_title：Clinical transplantation
pub_type： 杂志文章
doi：10.1111/ctr.12131
更新日期：2013-07-01 00:00:00
abstract：:Cytokines, produced by both the recipient and the newly vascularized allograft, are central mediators in the inflammatory response to allografted tissue. This study examines the relationship between pre- and intraoperative levels of TNF, IL-1, IL-6, and IL-8 and hepatic allograft function in the early postoperative pe...
journal_title：Clinical transplantation
pub_type： 杂志文章
doi：
更新日期：1997-12-01 00:00:00
abstract：:Sezer S, Ozdemir FN, Akcay A, Arat Z, Boyacioglu S, Haberal M. Renal transplantation offers a better survival in HCV-infected ESRD patients. Clin Transplant 2004 DOI: 10.1111/j.1399-0012.2004.00252. Abstract: The presence of hepatitis C virus (HCV) infection has been found to adversely affect the morbidity and mortali...
journal_title：Clinical transplantation
pub_type： 杂志文章
doi：10.1111/j.1399-0012.2004.00252.x
更新日期：2004-10-01 00:00:00
abstract：:We report the case of a female with chronic pancreatitis who underwent multiple surgical procedures leading to total resection of the pancreas with successful islet auto-transplantation. Postoperatively, she developed heparin-induced thrombocytopenia. Heparinization prior to islet infusion is currently recommended to ...
journal_title：Clinical transplantation
pub_type： 杂志文章
doi：10.1111/j.1399-0012.2005.00457.x
更新日期：2006-03-01 00:00:00
abstract：BACKGROUND:The accurate estimation of liver volume and right/left ratio in donor candidates is critical, but there is no method using portal vein (PV) flow. METHODS:Of 125 donor candidates, right/left liver volume ratio was estimated using ultrasound (US)-PV area ratio and Doppler US-PV flow ratio, and the results wer...
journal_title：Clinical transplantation
pub_type： 杂志文章
doi：10.1111/ctr.13050
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND:In cardiac transplant recipients, long-term survival may be limited by transplant coronary artery disease (TxCAD). Hyperhomocysteinemia (Hhcy) has been associated with vascular disease and is common in transplant recipients. The objective of this study was to determine the relationship between fasting homocy...
journal_title：Clinical transplantation
pub_type： 杂志文章
doi：10.1034/j.1399-0012.2001.150407.x
更新日期：2001-08-01 00:00:00
abstract：:Diabetic transplant recipients are at a high risk for foot pathology leading to amputation. This retrospective study from 1/85 to 2/95 examines the risk of foot complications in a population (n = 340) of diabetic renal and combined renal/pancreas transplant recipients. All groups suffered high lower extremity amputati...
journal_title：Clinical transplantation
pub_type： 杂志文章
doi：
更新日期：1996-12-01 00:00:00
abstract：:In Norway living kidney donors account for approximately 40% of all renal transplants. There is a shortage of information about how living kidney donors experience the donation process during the initial recovery from surgery. The aim of this study was to explore physical and psychosocial issues related to the experie...
journal_title：Clinical transplantation
pub_type： 杂志文章
doi：10.1111/j.1399-0012.2004.00304.x
更新日期：2005-02-01 00:00:00
abstract：OBJECTIVE:To determine whether depressive symptoms predicted survival before and after lung transplantation. We hypothesized that depressive symptoms might predict survival of wait-listed patients, but would not predict survival post-transplant. METHODS:This was a prospective, longitudinal study. Participants complete...
journal_title：Clinical transplantation
pub_type： 杂志文章
doi：10.1111/j.1399-0012.2010.01236.x
更新日期：2010-09-01 00:00:00
abstract：:Patients with severe liver disease and accompanying malnutrition may exhibit electrolyte disturbances including the magnesium balance. In 18 patients plasma magnesium (p-Mg) was determined at the start of the liver transplantation and during the anhepatic and reperfusion phases of the operation. The blood loss was 6.9...
journal_title：Clinical transplantation
pub_type： 杂志文章
doi：
更新日期：1996-04-01 00:00:00
abstract：INTRODUCTION:Abdominal wall vascularized composite allotransplantation (AW-VCA) is a rarely utilized technique for large composite abdominal wall defects. The goal of this article is to systematically review the literature and current concepts of AW-VCA, outline the challenges ahead, and provide an outlook for the futu...
journal_title：Clinical transplantation
pub_type： 杂志文章,评审
doi：10.1111/ctr.12243
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND:The shortage of grafts for kidney transplantation (Tx) has resulted in an expansion of criteria for pediatric donors. However, the limitations of pediatric donors for kidney Tx are not yet clearly established. We investigated the outcomes of recipients with pediatric kidney grafts from Colorado to elucidate ...
journal_title：Clinical transplantation
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：:This study was undertaken to examine the presentation and outcomes relative to solid organ donation in patients with fatal cerebral gunshot wounds at a level I trauma center over a 7-year period. A retrospective chart review of patients with such wounds over the years 1993-99 was completed. Eighty (80) patients were c...
journal_title：Clinical transplantation
pub_type： 杂志文章
doi：10.1034/j.1399-0012.2001.00002.x
更新日期：2001-01-01 00:00:00
abstract：:Subclinical rejection (SCR) is quite common early following renal transplantation and decreases progressively with time. The immunological profile of the recipient, the immunosuppressive regimen used, and the occurrence of prior episodes of clinical acute rejection (AR) are all risk factors for SCR. SCR, in turn, is a...
journal_title：Clinical transplantation
pub_type： 杂志文章,评审
doi：10.1111/j.1399-0012.2008.00888.x
更新日期：2009-03-01 00:00:00
abstract：BACKGROUND:Although liver transplantation may potentially cure hepatocellular carcinoma (HCC), the risk of HCC recurrence is 8%-20% at five years post-transplant. Pre-transplant alpha-fetoprotein (AFP) is a predictor of HCC recurrence, but it is unknown if pre-transplant AFP also predicts survival in patients with recu...
journal_title：Clinical transplantation
pub_type： 杂志文章
doi：10.1111/ctr.13634
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND:Post-transplant gastrointestinal (GI) side effects can impair a patient's quality of life (QoL). This study investigates the improvement in GI side effects and related QoL changes in recipients of liver transplantation (OLT) after converting patients from mycophenolate mofetil (MMF) to enteric-coated mycophe...
journal_title：Clinical transplantation
pub_type： 临床试验,杂志文章
doi：10.1111/j.1399-0012.2009.01019.x
更新日期：2009-11-01 00:00:00
abstract：:There is currently an imbalance between the need for cadaveric kidneys for transplantation and the supply. The medical criteria for accepting cadaveric donors are changing and organs that were originally thought to be unacceptable have functioned well. Previous reports have discussed the problems with transplanting ...
journal_title：Clinical transplantation
pub_type： 杂志文章
doi：
更新日期：1992-12-01 00:00:00
abstract：:Endothelin-1 is a vasoconstrictor peptide released by the vascular endothelium by various chemical and mechanical factors. Cellular rejection is one of the most common complications following orthotopic liver transplantation, endotheliitis being its most specific and consistent histological feature. To assess the role...
journal_title：Clinical transplantation
pub_type： 杂志文章
doi：
更新日期：1997-02-01 00:00:00
