Successful treatment for graft-versus-host disease after pancreas transplantation.

Abstract:

:Graft-versus-host disease (GVHD) after pancreas transplantation is a rare but serious complication: All previously reported cases were fatal. We herein report three cases of GVHD after pancreas transplantation with favorable outcomes. Patients with a history of kidney (and pancreas) transplantation subsequently received a pancreas (and kidney) transplantation (i.e., pancreas retransplantation or pancreas after kidney transplantation) and developed acute GVHD. All of them responded to increased immunosuppression (e.g., steroid bolus, antithymocyte globulin) and retained normal graft function. Because the clinical manifestations are non-specific, vigilance is necessary to make an accurate diagnosis. We underscored the importance of a biopsy of involved organs and the clinicopathologic correlation in the early diagnosis of GVHD. Augmented immunosuppression to prevent progression from a self-limited disease to life-threatening pancytopenia or sepsis may be most critical to improve outcome.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Chang Jw,Sageshima J,Ciancio G,Mattiazzi A,Chen L,Tsai HL,Ruiz P,Burke GW 3rd

doi

10.1111/ctr.12300

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

217-22

issue

2

eissn

0902-0063

issn

1399-0012

journal_volume

28

pub_type

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