Uncontrolled donation after circulatory death improves access to kidney transplantation: A decision analysis.

Abstract:

AIM:Uncontrolled donation after cardiac death (uDCD) remains an underutilized source of kidney allografts in the United States. The objective of this study was to estimate the impact of the implementation of a uDCD program on transplantation rates and long-term survival for patients with end-stage renal disease (ESRD) in the United States. METHODS:A decision-analytic Markov state transition model was created using medical decision-making software (DATA 3.5; TreeAge Software, Inc) to estimate the impact of an uDCD program on transplantation rates and patient survival. Additionally, sensitivity analysis of uDCD donor pool increase was modeled. All model statistic parameters were extracted from the literature. RESULTS:A uDCD program increased the rate of transplant at 10 years (37.8%, Accept uDCD group, vs 35.9%, Reject uDCD group). At 10 years, overall survival for Accept uDCD was 55.6% compared to 54.8% in the Reject uDCD. CONCLUSIONS:Uncontrolled DCD improves access to transplant for ESRD patients on the kidney transplant waitlist, thereby improving long-term survival.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Choudhury RA,Prins K,Dor Y,Moore HB,Yaffe H,Nydam TL

doi

10.1111/ctr.13868

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

e13868

issue

7

eissn

0902-0063

issn

1399-0012

journal_volume

34

pub_type

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