Post-transplant lymphoproliferative disorders after live donor renal transplantation.

Abstract:

:The development of post-transplant lymphoproliferative disorders (PTLD) is a well-recognized complication of solid organ transplantation in patients receiving immunosuppressive therapy. The literature on PTLD in live renal allograft recipients is scarce and most of the data pertains to PTLD in cadaveric transplants. As live donor grafts form the mainstay of transplantation programme in India, this study was carried out to define the profile of PTLD in live donor renal allograft recipients. On retrospective evaluation, nine cases of PTLD amongst 1700 live donor allograft recipients from January 1989 to August 2004, were detected at a tertiary care hospital in north India. The clinicopathological features of these cases were evaluated. Mean age at diagnosis of PTLD was 38 yr with median post-transplant latency period of 7 yr. All cases were from extra-renal sites, five being in ileum/jejunum, three in retroperitoneal lymph nodes and one in epididymus. All cases received cyclosporin, azathioprine and prednisolone in varying combinations as immunosuppressive therapy. One case was treated for rejection by anti-thymocyte globulin. Seven patients were seronegative for Epstein-Barr virus at the time of diagnosis. All were B-cell monomorphic PTLD, classifiable as B-cell diffuse large cell lymphomas, with five extranodal and three nodal lymphomas. Management included reduction in immunosuppression, acyclovir therapy, surgical excision and chemotherapy. On follow-up, four patients died, two presented with recurrence, two were in remission and one was lost to follow-up. This study comprising of live related/unrelated renal allograft recipients observed late onset high grade monomorphic PTLD with paucity of early onset polymorphic lesions. Long post-transplant latency period, aggressive behaviour and poor response to treatment necessitate long-term cancer surveillance to facilitate early detection and newer therapeutic strategies to improve the outcome in these patients.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Jain M,Badwal S,Pandey R,Srivastava A,Sharma RK,Gupta RK

doi

10.1111/j.1399-0012.2005.00406.x

subject

Has Abstract

pub_date

2005-10-01 00:00:00

pages

668-73

issue

5

eissn

0902-0063

issn

1399-0012

pii

CTR406

journal_volume

19

pub_type

杂志文章
  • Nitric oxide attenuates ischaemia-reperfusion (I/R) injury in the diabetic liver.

    abstract:BACKGROUND:Liver ischaemia-reperfusion (I/R) occurs during resuscitation from haemorrhagic shock, hepatic transplantation and anatomic resection of the liver. This injury is associated with hepatocellular enzyme release and hepatocyte necrosis. The impact of chronic illnesses such as diabetes mellitus (DM) on hepatic I...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2004.00210

    authors: Rogers H 3rd,Zibari GB,Roberts J,Turnage R,Lefer DJ

    更新日期:2004-01-01 00:00:00

  • Hypoglycaemia after pancreas transplantation: usefulness of a continuous glucose monitoring system.

    abstract:BACKGROUND:After pancreas transplantation (PTx) some patients report occasional symptoms of hypoglycaemia and at times, serious hypoglycaemia. Continuous blood glucose monitoring (CBGM) allows determination of the daily glucose profile and detection of unrecognized hypoglycaemia. The aims of our study were to determine...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1046/j.1399-0012.2003.00101.x

    authors: Esmatjes E,Flores L,Vidal M,Rodriguez L,Cortés A,Almirall L,Ricart MJ,Gomis R

    更新日期:2003-12-01 00:00:00

  • Heparin-induced thrombocytopenia following pancreatectomy and islet auto-transplantation.

    abstract::We report the case of a female with chronic pancreatitis who underwent multiple surgical procedures leading to total resection of the pancreas with successful islet auto-transplantation. Postoperatively, she developed heparin-induced thrombocytopenia. Heparinization prior to islet infusion is currently recommended to ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2005.00457.x

    authors: Rastellini C,Brown ML,Cicalese L

    更新日期:2006-03-01 00:00:00

  • Effect of dexmedetomidine on hepatic ischemia-reperfusion injury in the setting of adult living donor liver transplantation.

    abstract:OBJECTIVE:The aim of this study was to investigate the hypothesis that intraoperative infusion of dexmedetomidine can exert a protective effect against hepatic ischemia-reperfusion injury (IRI) in adult living donor liver transplantation (LDLiver transplantation). PATIENTS AND METHODS:Forty recipients were allocated i...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/ctr.12713

    authors: Fayed NA,Sayed EI,Saleh SM,Ehsan NA,Elfert AY

    更新日期:2016-04-01 00:00:00

  • Effectiveness and safety of the conversion to MeltDose® extended-release tacrolimus from other formulations of tacrolimus in stable kidney transplant patients: A retrospective study.

    abstract::Tacrolimus is the cornerstone of immunosuppressive therapy after kidney transplantation. Its narrow therapeutic window mandates serum level strict monitoring and dose adjustments to ensure the optimal risk-benefit balance. This observational retrospective study analyzed the effectiveness and safety of conversion from ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13767

    authors: Sánchez Fructuoso A,Ruiz JC,Franco A,Diekmann F,Redondo D,Calviño J,Serra N,Aladrén MJ,Cigarrán S,Manonelles A,Ramos A,Gómez G,González Posada JM,Andrés A,Beneyto I,Muñiz AL,Perelló M,Lauzurica R

    更新日期:2020-01-01 00:00:00

  • Successful treatment for graft-versus-host disease after pancreas transplantation.

    abstract::Graft-versus-host disease (GVHD) after pancreas transplantation is a rare but serious complication: All previously reported cases were fatal. We herein report three cases of GVHD after pancreas transplantation with favorable outcomes. Patients with a history of kidney (and pancreas) transplantation subsequently receiv...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12300

    authors: Chang Jw,Sageshima J,Ciancio G,Mattiazzi A,Chen L,Tsai HL,Ruiz P,Burke GW 3rd

    更新日期:2014-02-01 00:00:00

  • Impact of venous drainage on regeneration of the anterior segment of right living-related liver grafts.

    abstract::The effect of additional venous reconstruction on morphologic and functional regeneration of the anterior segment of right-lobe liver grafts was compared among three groups according to graft type: right liver graft without the middle hepatic vein (MHV) or MHV tributaries (n=7), with MHV tributaries (n=25) and with th...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2006.00515.x

    authors: Mizuno S,Iida T,Yagi S,Usui M,Sakurai H,Isaji S,Uemoto S

    更新日期:2006-07-01 00:00:00

  • Role of 99mTc-labeled DISIDA scan in the assessment of marginal liver grafts after orthotopic transplantation.

    abstract::Accurate prognostic indicators are lacking for livers with early marginal graft function, making the decision to re-transplant a difficult one. Therefore, we studied 99mTc-labeled DISIDA scanning as a predictor of recovery of marginal grafts. Records of 28 liver transplant recipients with prolonged periods of marginal...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Karademir S,Csete ME,Jurim O,Finstad T,Hawkins R,Bussuttil RW,Shaked A

    更新日期:1994-02-01 00:00:00

  • Liver cell transplantation in children.

    abstract::With increasing shortage of donor organs and changes in organ allocation systems, there is a considerable need for alternative or supportive techniques in the field of liver transplantation. Liver cell transplantation (LCT) is such an innovative technique that is especially promising for use in children, because it is...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-0012.2009.01113.x

    authors: Meyburg J,Schmidt J,Hoffmann GF

    更新日期:2009-12-01 00:00:00

  • Factors related to attitudes toward organ donation after death in the immigrant population in Spain.

    abstract::Considering the relevance of the migratory processes in Western societies, the attitudes toward organ donation after death are analyzed by means of a survey applied to a representative random sample of the resident immigrant population in Spain, comprising 1202 subjects (estimated margin of error of ± 2.88%, p = q, p ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-0012.2011.01586.x

    authors: López JS,Valentín MO,Scandroglio B,Coll E,Martín MJ,Sagredo E,Martínez JM,Serna E,Matesanz R

    更新日期:2012-05-01 00:00:00

  • Retrograde arterial flush of the liver graft in living donor liver transplantation may ameliorate post-transplantational cholestasis--prospective randomized study.

    abstract::Retrograde arterial flush (RGAF) of liver grafts, which prevents arterial intima injuries in living donor liver transplantation (LDLT), seemed to reduce post-transplantational cholestasis by our preliminary study. The aim of this study was to further confirm this effect of RGAF of grafts in LDLT by a prospective rando...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-0012.2011.01493.x

    authors: Liu C,Loong CC,Hsia CY,Wang SC,Yeh YC,Lin NC,Tsai HL,Tsou MY

    更新日期:2012-03-01 00:00:00

  • Changing the paradigm of organ utilization from PHS increased-risk donors: an opportunity whose time has come?

    abstract::Approximately 8-11% of all organ donors are classified by Public Health Service (PHS) as increased-risk. The proportion of PHS increased-risk donors is on the rise. At the University of Washington Medical Center, in 2014, the proportion of transplants from PHS increased-risk donors was 28% of liver transplants and 23%...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12582

    authors: Sibulesky L,Javed I,Reyes JD,Limaye AP

    更新日期:2015-09-01 00:00:00

  • A new approach to kidney wait-list management in the kidney allocation system era: Pilot implementation and evaluation.

    abstract::Kidney transplant wait-list management is becoming increasingly complex. We introduced a novel wait-list management strategy at our center, the Transplant Readiness Assessment Clinic (TRAC), whereby patients whose Kidney Allocation Scores surpass a threshold are actively managed. From January 1, 2016 through June 30, ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13406

    authors: Cheng XS,Busque S,Lee J,Discipulo K,Hartley C,Tulu Z,Scandling JD,Tan JC

    更新日期:2018-11-01 00:00:00

  • Diffuse large B-cell lymphoma in a renal allograft associated with Epstein-Barr virus in the recipient: a case report and a review of lymphomas presenting in a transplanted kidney.

    abstract::The purpose of this review was to evaluate the case reports with lymphoproliferative disorders exclusively localized in the allograft transplanted kidney. We also report a rare case of diffuse large B-cell lymphoma originated from the lymphocytes of the recipient with exclusive localization in the kidney allograft. We...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2008.00804.x

    authors: Cobo F,García C,Talavera P,Ruiz-Cabello F,Bravo J,Concha A

    更新日期:2008-07-01 00:00:00

  • Calcineurin inhibitor withdrawal and conversion to mycophenolate mofetil and steroids in cardiac transplant recipients with chronic renal failure: a word of caution.

    abstract:BACKGROUND:Chronic renal failure (CRF) is a common complication of calcineurin inhibitor (CNI)-based immunosuppression following cardiac transplantation (HTx). The aim of this prospective study was to evaluate the impact of an immunosuppressive conversion from CNIs to mycophenolate mofetil (MMF) and steroids in cardiac...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2008.00828.x

    authors: Groetzner J,Kaczmarek I,Schirmer J,Uberfuhr P,Gulbins H,Daebritz S,Meiser B,Reichart B

    更新日期:2008-09-01 00:00:00

  • Conversion from sirolimus to everolimus in kidney transplant recipients receiving a calcineurin-free regimen.

    abstract:BACKGROUND:Everolimus (EVL) and sirolimus (SRL) were introduced into immunosuppressive regimens, in an attempt to replace or reduce the dose of the nephrotoxic calcineurin inhibitors (CNI). In our institution, due to an administrative decision, conversion from SRL to EVL, was carried out, providing us the opportunity t...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2011.01446.x

    authors: Carvalho C,Coentrão L,Bustorff M,Patrício E,Sampaio S,Santos J,Oliveira G,Pestana M

    更新日期:2011-07-01 00:00:00

  • The association of acute rejection vs recurrent glomerular disease with graft outcomes after kidney transplantation.

    abstract:BACKGROUND:It has been shown that glomerulonephritis (GN) recurrence affects graft survival more than acute rejection. Thus, we assessed allograft survival after biopsy-confirmed diagnosis of acute rejection or recurrent GN in current era of immunosuppression. METHODS:Allograft survival following a biopsy diagnosis of...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13738

    authors: Singh T,Astor BC,Zhong W,Mandelbrot DA,Maursetter L,Panzer SE

    更新日期:2019-12-01 00:00:00

  • Use of immune globulin to prevent symptomatic cytomegalovirus disease in transplant recipients--a meta-analysis.

    abstract::The objective of this meta-analysis was to review the evidence for the use of immune globulin in the prevention of symptomatic cytomegalovirus (CMV) disease in transplant recipients. A computerized search of Medline from 1980 to October 1991 was conducted using the textword "cytomegalo:" and the subheading "prevention...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,meta分析

    doi:

    authors: Glowacki LS,Smaill FM

    更新日期:1994-02-01 00:00:00

  • Prospective study of microchimerism in renal allograft recipients: association between HLA-DR matching, microchimerism and acute rejection.

    abstract::The presence of donor-derived hematopoietic cells in blood and various tissues of the organ recipients, termed allogeneic microchimerism, has been considered to play an essential role in establishment of organ acceptance. In this study, we prospectively determined the presence of peripheral blood microchimerism (PBM) ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2001.150308.x

    authors: Tajik N,Singal D,Pourmand G,Ebrahimi-Rad M,Radjabzadeh M,Tavasoli P,Khosravi F,Nikbin B

    更新日期:2001-06-01 00:00:00

  • Depletion of natural antibodies in non-human primates--a step towards successful discordant xenografting in humans.

    abstract::There is evidence to suggest that long-term survival of discordant xenografts may be possible if the organ is transplanted at a time when the host natural anti-species (xenoreactive) antibodies are temporarily absent or otherwise inhibited from reacting with the donor antigens. There is also evidence that the target ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:

    authors: Cooper DK

    更新日期:1992-06-01 00:00:00

  • Coronary artery disease in lung transplant patients.

    abstract::Coronary artery disease (CAD) is a pathology often found in patients with end-stage lung disease. Although in the past CAD might have been considered an absolute contraindication, modern revascularization techniques have helped increase the number of transplants performed in this population. However, discrepancies in ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/ctr.14078

    authors: Sinha N,Balayla G,Braghiroli J

    更新日期:2020-11-01 00:00:00

  • Interleukin 6 at reperfusion: A potent predictor of hepatic and extrahepatic early complications after liver transplantation.

    abstract:BACKGROUND AND AIMS:Ischemia-reperfusion injury impacts early liver graft function. Interleukin 6 (IL-6) as early as at reperfusion has shown to predict in-hospital complications, but its impact on vascular complications and long-term outcomes is not ascertained. METHODS:A retrospective study was conducted on all cons...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13357

    authors: Faitot F,Besch C,Lebas B,Addeo P,Ellero B,Woehl-Jaegle ML,Namer IJ,Bachellier P,Freys G

    更新日期:2018-09-01 00:00:00

  • Influence of dialysis on post-transplant events.

    abstract:INTRODUCTION:We examined the effect of haemodialysis (HD) or peritoneal dialysis (PD) on acute rejection, delayed graft function (DGF), graft and patient survival after cadaveric renal transplantation. MATERIALS AND METHODS:We carried out a retrospective analysis of 325 patients (cyclosporin [CyA]-based therapy) who h...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2002.00069.x

    authors: Joseph JT,Jindal RM

    更新日期:2002-02-01 00:00:00

  • ALLOREACTIVE T LYMPHOCYTES CULTURED FROM LIVER TRANSPLANT BIOPSIES: ASSOCIATIONS OF HLA SPECIFICITY WITH CLINICOPATHOLOGICAL FINDINGS.

    abstract::Lymphocyte cultures grown from liver allograft biopsies were shown to exhibit alloreactivity towards donor cells as measured by primed lymphocyte testing (PLT). The PLT specificity was determined in assays using HLA typed panel cells and/or by inhibition testing with HLA specific monoclonal antibodies. Certain culture...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Markus BH,Demetris AJ,Saidman S,Fung JJ,Zeevi A,Starzl TE,Duquesnoy RJ

    更新日期:1988-01-01 00:00:00

  • Deceased organ donor factors influencing pancreatic graft transplantation and survival.

    abstract::Criteria for organ acceptance in brain-dead organ donors remain inconsistent, especially when concerning pancreatic transplants. We sought to examine donor-specific predictors of pancreatic graft use and survival to better guide the selection and management of potential donors. A prospective observational study of all...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13571

    authors: Sally MB,Ellis MK,Hutchens M,Groat T,Swanson E,Patel MS,Niemann CU,Malinoski DJ

    更新日期:2019-06-01 00:00:00

  • Multidrug-resistant Acinetobacter baumannii infections in lung transplant patients in the cardiothoracic intensive care unit.

    abstract:BACKGROUND:Multidrug-resistant (MDR) gram-negative bacteria are a growing threat to solid organ transplantation (SOT) patients in the intensive care unit (ICU). We aimed to examine the mortality rates of gram-negative MDR bacterial infection in SOT patients compared with patient population undergoing other cardiothorac...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12575

    authors: Biderman P,Bugaevsky Y,Ben-Zvi H,Bishara J,Goldberg E

    更新日期:2015-09-01 00:00:00

  • Use of enteric-coated mycophenolate sodium in liver transplant patients with intestinal intolerance caused by mycophenolate mofetil.

    abstract:BACKGROUND:Post-transplant gastrointestinal (GI) side effects can impair a patient's quality of life (QoL). This study investigates the improvement in GI side effects and related QoL changes in recipients of liver transplantation (OLT) after converting patients from mycophenolate mofetil (MMF) to enteric-coated mycophe...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1399-0012.2009.01019.x

    authors: Doria C,Ramirez CB,Frank AM,Vaccino S,Fraser N,Marino IR

    更新日期:2009-11-01 00:00:00

  • The impact of diabetes mellitus and glycemic control on clinical outcomes following liver transplant for hepatitis C.

    abstract::Hepatitis C is the leading indication for liver transplantation in the USA and recurrence is universal. The impact of preexisting diabetes, new-onset diabetes after transplant (NODAT), and glycemic control on fibrosis progression has not been studied. This retrospective longitudinal cohort study included adult liver r...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12391

    authors: Morbitzer KA,Taber DJ,Pilch NA,Meadows HB,Fleming JN,Bratton CF,McGillicuddy JW,Baliga PK,Chavin KD

    更新日期:2014-08-01 00:00:00

  • Variability in the reporting of renal function endpoints in immunosuppression trials in renal transplantation: time for consensus?

    abstract::Early measures of graft function are increasingly used to assess efficacy in clinical trials of kidney transplant immunosuppression. This study aimed to assess the variability and quality of reporting of these endpoints in contemporary trials. Data regarding renal function endpoints were extracted from 213 reports fro...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12861

    authors: Knight SR,Hussain S

    更新日期:2016-12-01 00:00:00

  • Outcomes of antiviral treatment in hepatitis C virus liver transplant patients off immunosuppression in the direct acting antivirals era: A case series.

    abstract:BACKGROUND:Clearance of hepatitis C virus (HCV) under antiviral therapy, including direct-acting antivirals (DAAs), has been associated with higher risk of rejection. Whether patients who are not on immunosuppression (IS) during DAA therapy are at higher risk of rejection is unknown. METHODS:Four transplant recipients...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13303

    authors: Campos-Varela I,Agudelo EZ,Terrault NA

    更新日期:2018-07-01 00:00:00