Low-dose basiliximab induction therapy in heart transplantation.

Abstract:

:We prospectively studied efficacy and safety outcomes of two 10-mg doses of intravenous basiliximab on day 0 and day 4 for induction therapy in 17 consecutive de novo heart transplant recipients. By the 2-week assessment post-transplant, there were no deaths, graft failures, or acute cellular rejections (ACRs) ISHLT grade ≥ 2R. By the 1-year assessment post-transplant, there were 1 (6%) infectious death, no graft failures, 2 (12%) grade 2R ACRs, 6 (35%) asymptomatic cytomegalovirus (CMV) infections, and 4 (25%) treated infections. Our study was the first to show that low-dose basiliximab induction in heart transplant resulted in favorable efficacy and safety outcomes. Additionally, calcineurin inhibitor (CNI) initiation in a low-risk population could be safely delayed using the strategy of modified low-dose postoperative basiliximab. This strategy also appears to allow subsequent early corticosteroid wean, although with the concomitant maintenance of higher CNI levels and higher dosing of mycophenolate.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Kittipibul V,Tantrachoti P,Ongcharit P,Ariyachaipanich A,Siwamogsatham S,Sritangsirikul S,Thammanatsakul K,Puwanant S

doi

10.1111/ctr.13132

subject

Has Abstract

pub_date

2017-12-01 00:00:00

issue

12

eissn

0902-0063

issn

1399-0012

journal_volume

31

pub_type

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