Post-transplant lymphoproliferative disease in lung transplantation: A nested case-control study.

Abstract:

:Post-transplant lymphoproliferative disorder (PTLD) may compromise long-term outcome of lung transplant (LTx) recipients. A case-control study was performed, comparing LTx recipients with PTLD (n=31) to matched recipients without PTLD (Controls, n=62). Risk factors for PTLD and post-transplant outcomes were assessed. PTLD prevalence was 3.9%, time to PTLD 323 (166-1132) days; and 54.8% had early-onset PTLD versus 45.2% late-onset PTLD. At LTx, more Epstein-Barr virus (EBV)-seronegative patients were present in PTLD (42%) compared to Controls (5%) (P<.0001); most of whom had undergone EBV seroconversion upon PTLD diagnosis. EBV viral load was higher in PTLD versus Controls (P<.0001). Overall, lower hemoglobin and higher C-reactive protein levels were present in PTLD versus Controls (P<.0001). EBV status at LTx (P=.0073) and EBV viral load at PTLD (P=.0002) were the most important risk determinates for later PTLD. Patients with PTLD demonstrated shorter time to onset of chronic lung allograft dysfunction (CLAD) (P=.0006) and poorer 5-year survival post-LTx (66.6% versus 91.5%), resulting in worse CLAD-free survival (HR 2.127, 95%CI 1.006-4.500; P=.0483) and overall survival (HR 3.297 95%CI 1.473-7.382; P=.0037) compared to Controls. Late-onset PTLD had worse survival compared to early-onset PTLD (P=.021). Primary EBV infection is a risk for PTLD; which is associated with worse long-term outcome post-LTx.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Leyssens A,Dierickx D,Verbeken EK,Tousseyn T,Verleden SE,Vanaudenaerde BM,Dupont LJ,Yserbyt J,Verleden GM,Van Raemdonck DE,Vos R

doi

10.1111/ctr.12983

subject

Has Abstract

pub_date

2017-07-01 00:00:00

issue

7

eissn

0902-0063

issn

1399-0012

journal_volume

31

pub_type

杂志文章
  • Outcomes after simultaneous kidney-pancreas versus pancreas after kidney transplantation in the current era.

    abstract::Simultaneous pancreas and kidney (SPK) and pancreas after kidney (PAK) transplant are both potential options for diabetic ESRD patients. Historically, PAK pancreas graft outcomes were felt to be inferior to SPK pancreas graft outcomes. Little is known about outcomes in the modern era of transplantation. We analyzed ou...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/ctr.13732

    authors: Parajuli S,Arunachalam A,Swanson KJ,Aziz F,Garg N,Redfield RR,Kaufman D,Djamali A,Odorico J,Mandelbrot DA

    更新日期:2019-12-01 00:00:00

  • Granulomatous tubulointerstitial nephritis in a renal allograft: three cases report and review of literature.

    abstract::Granulomatous interstitial nephritis (GIN) is a rare histologic diagnosis in renal allografts. We report three cases with GIN. Case 1: a 37-yr-old woman received a kidney from her mother. On follow-up 15 months later, serum creatinine was increased and a graft biopsy showed epithelioid granuloma in the center of massi...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-0012.2012.01643.x

    authors: Hotta K,Fukasawa Y,Sasaki H,Seki T,Togashi M,Harada H

    更新日期:2012-07-01 00:00:00

  • Analysis of preexisting baseline kidney lesions revealed by biopsy in living kidney donors: relationship with clinical parameters at the time of donation.

    abstract::Because the safety of living organ donors is essential, we have been performing donor kidney biopsy before donation in cases where decision-making regarding suitability is marginal. To clarify the degree to which pathological change in the kidney can be predicted on the basis of clinical data obtained non-invasively, ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2010.01276.x

    authors: Okamoto M,Koshino K,Nobori S,Ushigome H,Okajima H,Urasaki K,Yoshimura N

    更新日期:2010-07-01 00:00:00

  • Higher dose of CD34+ peripheral blood stem cells is associated with better survival after haploidentical stem cell transplantation in pediatric patients.

    abstract::Haploidentical stem cell transplantation (SCT) is increasingly used to treat pediatric patients with malignant or nonmalignant hematological disorders. The CD34+ dose of bone marrow or peripheral blood stem cells (PBSCs) has been shown to be an important determinant of the transplant outcome in adults under various pr...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12880

    authors: Chen Y,Xu LP,Liu KY,Chen H,Chen YH,Zhang XH,Wang Y,Wang FR,Han W,Wang JZ,Yan CH,Huang XJ

    更新日期:2017-02-01 00:00:00

  • Association between opioid use and readmission following liver transplantation.

    abstract::The aim of this study was to assess the independent association between pre-transplant prescription opioid use and readmission following liver transplantation. We reviewed the medical records of all patients at a single medical center undergoing primary, single-organ, liver transplantation from 2004 to 2014. We assess...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12806

    authors: Rogal S,Mankaney G,Udawatta V,Good CB,Chinman M,Zickmund S,Bielefeldt K,Jonassaint N,Jazwinski A,Shaikh O,Hughes C,Humar A,DiMartini A,Fine MJ

    更新日期:2016-10-01 00:00:00

  • No apparent impact of increased post-operative blood glucose levels on clinical outcome in kidney transplant recipients.

    abstract:BACKGROUND:Our objective is to evaluate whether hyperglycemia in the first 48 h after renal transplantation is independently associated with rejection, post-operative infection and post-transplant diabetes mellitus (PTDM) in a retrospective cohort study. METHODS:Patients who received a renal transplant in our hospital...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2008.00910.x

    authors: van den Berg TJ,Bogers H,Vriesendorp TM,Surachno JS,DeVries JH,ten Berge IJ,Hoekstra JB

    更新日期:2009-03-01 00:00:00

  • Ezetimibe effectively lowers LDL-cholesterol in cardiac allograft recipients on stable statin therapy.

    abstract::We investigated tolerability and efficacy of ezetimibe treatment (10 mg/d) in 25 heart allograft recipients already on stable statin therapy. Total cholesterol (TC), low-density cholesterol (LDL-C), high-density cholesterol (HDL-C), triglycerides (TG), immunosuppressant drug levels, laboratory and clinical parameters ...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1399-0012.2008.00838.x

    authors: Konstandin MH,Blessing E,Doesch A,Ammon K,Koch A,Wabnitz GH,Gleissner CA,Remppis A,Katus HA,Dengler TJ

    更新日期:2008-09-01 00:00:00

  • Measurement of liver volumes by portal vein flow by Doppler ultrasound in living donor liver transplantation.

    abstract:BACKGROUND:The accurate estimation of liver volume and right/left ratio in donor candidates is critical, but there is no method using portal vein (PV) flow. METHODS:Of 125 donor candidates, right/left liver volume ratio was estimated using ultrasound (US)-PV area ratio and Doppler US-PV flow ratio, and the results wer...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13050

    authors: Choi SH,Kwon JH,Kim KW,Jang HY,Kim JH,Kwon HJ,Lee J,Song GW,Lee SG

    更新日期:2017-09-01 00:00:00

  • Atelectasis--an unusual and late complication of lung transplant.

    abstract::We report a previously unrecognized late complication of allograft lung transplantation - persistent recurrent atelectasis of the transplanted lung. The patient developed sudden, severe respiratory distress about 2 yr after a right lung transplant, because of acute atelectasis of her transplanted lung. Multiple transb...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2002.01121.x

    authors: Zhao Y,Al-Kaade S,Keller CA,deMello DE

    更新日期:2002-06-01 00:00:00

  • Feasibility of exercise stress echocardiography for cardiac risk assessment in chronic kidney disease patients prior to renal transplantation.

    abstract:BACKGROUND:Pharmacologic stress testing is utilized in preference to exercise stress echocardiography (ESE) for cardiac risk evaluation in potential renal transplant recipients due to the perceived lower feasibility of ESE for achieving adequate workload and target heart rate (THR) in this population. METHODS:Consecut...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12796

    authors: Nerlekar N,Mulley W,Rehmani H,Ramkumar S,Cheng K,Vasanthakumar SA,Rashid H,Barton T,Nasis A,Meredith IT,Moir S,Mottram PM

    更新日期:2016-10-01 00:00:00

  • Bone mineral density and osteoporosis in heart transplanted patients: A single-center retrospective study at Skåne University Hospital in Lund 1988-2016.

    abstract::Bone mineral density (BMD) in the lumbar spine and femoral neck, the incidence of osteoporosis, and survival up to 10 years after heart transplantation (HT) were investigated in 169 patients who underwent HT at Skåne University Hospital in Lund, Sweden, 1988-2016. Within the first year post-transplantation, mean (SD) ...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/ctr.13477

    authors: Löfdahl E,Söderlund C,Rådegran G

    更新日期:2019-03-01 00:00:00

  • Influence of CYP3A5 and ABCB1 gene polymorphisms on calcineurin inhibitor-related neurotoxicity after hematopoietic stem cell transplantation.

    abstract:BACKGROUND:One severe side effect of calcineurin inhibitors (CNIs: such as cyclosporine [CsA] and tacrolimus [FK506]) is neurotoxicity. CNIs are substrates for CYP3A5 and P-glycoprotein (P-gp), encoded by ABCB1 gene. In the present study, we hypothesized that genetic variability in CYP3A5 and ABCB1 genes may be associa...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2009.01181.x

    authors: Yanagimachi M,Naruto T,Tanoshima R,Kato H,Yokosuka T,Kajiwara R,Fujii H,Tanaka F,Goto H,Yagihashi T,Kosaki K,Yokota S

    更新日期:2010-11-01 00:00:00

  • Ten-year protocol biopsy findings of renal allografts in the calcineurin inhibitor era.

    abstract::Ten-year protocol biopsies were performed in 16 patients treated with calcineurin inhibitor (CNI) continuously. All kidney grafts were functioning well at the time of biopsy with the mean serum creatinine level of 1.6 +/- 0.8 mg/dL. The specimen of biopsy showed various degrees of tissue injury. According to the Banff...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2006.00544.x

    authors: Okamoto M,Akioka K,Ushigome H,Higuchi A,Nobori S,Ogino S,Uryuhara K,Kaihara S,Hatta T,Urasaki K,Yoshimura N

    更新日期:2006-01-01 00:00:00

  • CXCL10 levels identify individuals with rapid fibrosis at 12 months post-transplant for hepatitis C virus and predict treatment response.

    abstract:BACKGROUNDS:Recurrent hepatitis C virus (HCV) infection is universal post-transplantation. Fibrosis (F) stage ≥2 at 12 months identifies patients with rapid fibrosis progression. Antiviral therapy (AVT) remains the only option to attenuate fibrosis progression. We hypothesized that CXCL10 levels can distinguish between...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12354

    authors: Joshi D,Carey I,Foxton M,Al-Freah M,Bruce M,Heaton N,Quaglia A,O'Grady J,Aluvihare V,Agarwal K

    更新日期:2014-05-01 00:00:00

  • Peritoneal metastasis of intracranial glioblastoma via a ventriculoperitoneal shunt preventing organ retrieval: case report and review of the literature.

    abstract::The case of patient with glioblastoma metastatic to the peritoneal cavity 9 months after ventriculoperitoneal shunt surgery precluding cadaver organ procurement is presented. Even though central nervous tumors rarely metastasize spontaneously, the literature indicates that systemic metastases are related to previous s...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:

    authors: Fecteau AH,Penn I,Hanto DW

    更新日期:1998-08-01 00:00:00

  • A new approach for increasing the organ supply.

    abstract::The donation of organs and tissues for the benefit of another person is an altruistic act and one that is a guaranteed option for the next-of-kin through various national Required Request legislations. At the Washington Hospital Center we have developed an approach that permits organ recovery from non-heart beating do...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Kowalski AE,Light JA,Ritchie WO,Sasaki TM,Callender CO,Gage F

    更新日期:1996-12-01 00:00:00

  • Renal transplantation in systemic amyloidosis.

    abstract::Renal transplantation was performed in a 24-yr-old woman with type AA systemic amyloidosis. Renal biopsy at 11 yr post-transplantation showed no amyloid recurrence, but the presence of mesangial proliferative glomerulonephritis and focal segmental glomerular sclerosis. Renal function was satisfactory with the exceptio...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Nishikido M,Koga S,Kanetake H,Saito Y,Harada T,Taguchi T,Matsuya F,Shindo K

    更新日期:1999-01-01 00:00:00

  • Prevention of hepatitis B virus recurrence after liver transplantation.

    abstract::Liver transplantation for hepatitis B virus (HBV)-related liver disease has changed from a contraindication to outcomes comparable with non-HBV-related liver transplantations during the last two decades. Mainly the implementation of immunoprophylaxis with hepatitis B immunoglobulin (HBIG) and the use of nucleoside ana...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-0012.2006.00609.x

    authors: Eisenbach C,Sauer P,Mehrabi A,Stremmel W,Encke J

    更新日期:2006-01-01 00:00:00

  • The feasibility of HLA matching for lung transplantation.

    abstract::The benefits of HLA matching have been clearly demonstrated in renal and cardiac transplantation. Recent studies suggest that HLA matching may be associated with improved survival rates for transplantation as well. However, the effect of HLA matching for lung transplantation has not been clearly demonstrated. Despite ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: McGee C,Fox MD,Loyd JE

    更新日期:1996-12-01 00:00:00

  • A case of living-related renal transplant from the donor with membranous nephropathy.

    abstract:INTRODUCTION:When a patient who had renal replacement therapy becomes older, an elder donor candidate may be considered as a potential donor for living-related transplantation. Elder donor candidate might have pre-existing disease including mild renal dysfunction, such as proteinuria. Marginally appropriate donors migh...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2009.00999.x

    authors: Akioka K,Okamoto M,Ushigome H,Nobori S,Suzuki T,Sakai K,Sakamoto S,Urasaki K,Yanagisawa A,Fukatsu A,Yoshimura N

    更新日期:2009-08-01 00:00:00

  • Successful treatment for graft-versus-host disease after pancreas transplantation.

    abstract::Graft-versus-host disease (GVHD) after pancreas transplantation is a rare but serious complication: All previously reported cases were fatal. We herein report three cases of GVHD after pancreas transplantation with favorable outcomes. Patients with a history of kidney (and pancreas) transplantation subsequently receiv...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12300

    authors: Chang Jw,Sageshima J,Ciancio G,Mattiazzi A,Chen L,Tsai HL,Ruiz P,Burke GW 3rd

    更新日期:2014-02-01 00:00:00

  • The effect of sirolimus on sex hormone levels of male renal transplant recipients.

    abstract:BACKGROUND:It is unclear whether sirolimus, a newer immunosuppressive agent, widely used in renal transplantation, affects male sex hormone levels or sexual function. METHODS:Sex hormone profiles in male renal transplant recipients were obtained and compared between a sirolimus-treated group and a group not on sirolim...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2005.00257.x

    authors: Lee S,Coco M,Greenstein SM,Schechner RS,Tellis VA,Glicklich DG

    更新日期:2005-04-01 00:00:00

  • Risk factors for native kidney dysfunction in patients with abdominal multivisceral/small bowel transplantation.

    abstract::Kidney dysfunction is a recognized complication after non-renal solid organ transplantation, particularly after intestinal transplant. In our study, we reviewed data on 33 multivisceral transplant (MVT)- and 15 isolated small bowel (ISB)-transplant patients to determine risk factors for kidney dysfunction. Kidney func...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2012.01672.x

    authors: Suzuki M,Mujtaba MA,Sharfuddin AA,Yaqub MS,Mishler DP,Faiz S,Vianna RM,Mangus RS,Tector JA,Taber TE

    更新日期:2012-07-01 00:00:00

  • Multidetector CT angiography in living donor renal transplantation: accuracy and discrepancies in right venous anatomy.

    abstract::Multidetector computed tomography (MDCT) angiography is a reliable technique for assessing pre-operative renal anatomy in living kidney donors. The method has largely evolved into protocols that eliminate dedicated venous phase and instead utilize a combined arterial/venous phase to delineate arterial and venous anato...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2009.01193.x

    authors: Kulkarni S,Emre S,Arvelakis A,Asch W,Bia M,Formica R,Israel G

    更新日期:2011-01-01 00:00:00

  • Outcomes, complications, and economic impact of ABO-incompatible living kidney transplantation: A single-center Japanese cohort study.

    abstract::ABO-incompatible kidney transplantation (ABO-ILKT) has been reported to have a higher rate of early complications and higher medical costs than ABO-compatible kidney transplantation (ABO-CLKT). We aimed to compare the clinical outcomes, complications, and medical costs between ABO-ILKTs and ABO-CLKTs at 2 years post-t...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/ctr.13591

    authors: Kakuta Y,Okumi M,Unagami K,Iizuka J,Takagi T,Ishida H,Tanabe K

    更新日期:2019-06-01 00:00:00

  • Ganciclovir exposure under a 450 mg daily dosage of valganciclovir for cytomegalovirus prevention in kidney transplantation: a prospective study.

    abstract::This prospective study aimed at determining the ganciclovir exposure observed under a daily dosage of 450 mg valganciclovir routinely applied to kidney transplant recipients with a GFR above 25 mL/min at risk for cytomegalovirus (CMV) disease. Ganciclovir levels at trough (C(trough)) and at peak (C₃(h)) were measured ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2009.01205.x

    authors: Manuel O,Pascual M,Perrottet N,Lamoth F,Venetz JP,Decosterd LA,Buclin T,Meylan PR

    更新日期:2010-11-01 00:00:00

  • Adverse symptoms of immunosuppressants: A survey of Canadian transplant clinicians.

    abstract::Adverse symptoms of immunosuppressants (ASI) impact quality of life (QOL) in solid organ transplant recipients; however, standardized approaches for active ASI surveillance and intervention are lacking. While management is highly clinician dependent, clinician views remain largely unexplored. We surveyed Canadian Soci...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12940

    authors: Harrison JJ,Mansell H,Blydt-Hansen T

    更新日期:2017-05-01 00:00:00

  • Rejection after conversion to a proliferation signal inhibitor in chronic heart transplantation.

    abstract::We sought to determine the incidence, risk factors, and consequences of acute rejection (AR) after conversion from a calcineurin inhibitor (CNI) to a proliferation signal inhibitor (PSI) in maintenance heart transplantation. Relevant clinical data were retrospectively obtained for 284 long-term heart transplant recipi...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,多中心研究

    doi:10.1111/ctr.12241

    authors: González-Vílchez F,Vázquez de Prada JA,Paniagua MJ,Almenar L,Mirabet S,Gómez-Bueno M,Díaz-Molina B,Arizón JM,Delgado J,Pérez-Villa F,Crespo-Leiro MG,Martínez-Dolz L,Roig E,Segovia J,Lambert JL,Lopez-Granados A,Escribano P

    更新日期:2013-11-01 00:00:00

  • Use of G-CSF-stimulated marrow in allogeneic hematopoietic stem cell transplantation settings: a comprehensive review.

    abstract::In recent years, several researchers have unraveled the previously unrecognized effects of granulocyte colony-stimulating factor (G-CSF) on hematopoiesis and the immune cell functions of bone marrow in healthy donors. In human leukocyte antigen-matched or haploidentical transplant settings, available data have establi...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-0012.2010.01298.x

    authors: Chang YJ,Huang XJ

    更新日期:2011-01-01 00:00:00

  • Complications related to totally implantable venous access devices in children and adults following lung transplantation.

    abstract:INTRODUCTION:Totally implantable venous access devices (TIVADs) are the preferred devices for patients with advanced lung disease who require long-term venous access. The primary purpose of this study was to describe the natural history of TIVADs left in place at the time of transplant. METHODS:This multicenter retros...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,多中心研究

    doi:10.1111/ctr.13465

    authors: Cho JK,Acord M,Goldfarb SB,Reddy SN,Goldberg HJ,Courtwright AM

    更新日期:2019-02-01 00:00:00