Risk factors for native kidney dysfunction in patients with abdominal multivisceral/small bowel transplantation.

Abstract:

:Kidney dysfunction is a recognized complication after non-renal solid organ transplantation, particularly after intestinal transplant. In our study, we reviewed data on 33 multivisceral transplant (MVT)- and 15 isolated small bowel (ISB)-transplant patients to determine risk factors for kidney dysfunction. Kidney function was estimated by modified diet in renal disease (MDRD) and Schwartz formula for adults and children, respectively. Acute kidney injury (AKI) was defined as an increase in the serum Cr (sCr) greater than twofold. Kidney function declined significantly at one yr after transplantation with 46% of subjects showing an estimated GFR (eGFR) <60 mL/min. Patients with an episode of AKI were more likely to have reduced eGFR than those without AKI (p < 0.025). In linear regression analyses, age, pre-transplant sCr, eGFR at postoperative day (POD) 30, 90, 180, 270, and tacrolimus level at POD 7 showed significant correlation with one yr post-transplant eGFR (p < 0.05). Pediatric patients and patients with MVT had lesser decline in kidney function compared with adults or patients with ISB. In conclusion, risk factors for post-transplant kidney dysfunction in intestinal transplantation included age, pre-transplant sCr, AKI episode, eGFR at POD 30, 90, 180, 270, and tacrolimus level at POD 7.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Suzuki M,Mujtaba MA,Sharfuddin AA,Yaqub MS,Mishler DP,Faiz S,Vianna RM,Mangus RS,Tector JA,Taber TE

doi

10.1111/j.1399-0012.2012.01672.x

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

E351-8

issue

4

eissn

0902-0063

issn

1399-0012

journal_volume

26

pub_type

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