Malignancies after heart transplantation: presence of Epstein-Barr virus and cytomegalovirus.

Abstract:

:The presence of Epstein-Barr virus (EBV), human papilloma virus (HPV), and cytomegalovirus (CMV) was studied in 20 patients who developed malignancies after heart transplantation in the Helsinki University Central Hospital. The tumors were analyzed for the presence of HPV by polymerase chain reaction and for EBV by in situ hybridization. Clinical CMV infection was verified by immunochemical quantitation of CMV antigen in peripheral blood cells. HPV was detected in one of the eight epithelial malignant tumors studied. Three of the six lymphomas were positive for EBV. Two (67%) of 3 patients with EBV-positive lymphomas and one (33%) of the other three lymphomas but only 2 (14%) of 14 patients who developed other malignancies had a history of a manifest post-transplantation CMV infection prior to the development of malignancy. These results confirm the presence of EBV in lymphomas of heart transplant recipients and suggest that CMV might have a contributory role in the development of EBV-associated lymphomas.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Mattila PS,Aalto SM,Heikkilä L,Mattila S,Nieminen M,Auvinen E,Hedman K,Tarkkanen J

doi

10.1034/j.1399-0012.2001.150506.x

subject

Has Abstract

pub_date

2001-10-01 00:00:00

pages

337-42

issue

5

eissn

0902-0063

issn

1399-0012

pii

150506

journal_volume

15

pub_type

杂志文章
  • Retrograde arterial flush of the liver graft in living donor liver transplantation may ameliorate post-transplantational cholestasis--prospective randomized study.

    abstract::Retrograde arterial flush (RGAF) of liver grafts, which prevents arterial intima injuries in living donor liver transplantation (LDLT), seemed to reduce post-transplantational cholestasis by our preliminary study. The aim of this study was to further confirm this effect of RGAF of grafts in LDLT by a prospective rando...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-0012.2011.01493.x

    authors: Liu C,Loong CC,Hsia CY,Wang SC,Yeh YC,Lin NC,Tsai HL,Tsou MY

    更新日期:2012-03-01 00:00:00

  • Perioperative outcomes of coronary artery bypass graft in renal transplant recipients in the United States: results from the Nationwide Inpatient Sample.

    abstract:BACKGROUND:Cardiovascular disease is the leading cause of morbidity and mortality in patients with chronic kidney disease (CKD). In fact, death from cardiovascular disease is the number one cause of graft loss in kidney transplant (KTx) patients. Compared to patients on dialysis, CKD patients with KTx have increased qu...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12816

    authors: Tooley JE,Bohl DD,Kulkarni S,Rodriguez-Davalos MI,Mangi A,Mulligan DC,Yoo PS

    更新日期:2016-10-01 00:00:00

  • Living donor evaluation and exclusion: the Stanford experience.

    abstract:BACKGROUND:The proportion of prospective living donors disqualified for medical reasons is unknown. The objective of this study is to delineate and quantify specific reasons for exclusion of prospective living donors from kidney donation. METHODS:All adult prospective kidney donors who contacted our transplant program...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1399-0012.2010.01336.x

    authors: Lapasia JB,Kong SY,Busque S,Scandling JD,Chertow GM,Tan JC

    更新日期:2011-09-01 00:00:00

  • Multicultural issues in organ transplantation: the influence of patients' cultural perspectives on compliance with treatment.

    abstract::The potential influence of racially or ethnically diverse cultural perspectives on patient compliance with post-transplant treatments is discussed. Domains of competency regarding culturally sensitive clinical practice are outlined to assist providers in better understanding the perspectives that may influence the vie...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Prieto LR,Miller DS,Gayowski T,Marino IR

    更新日期:1997-12-01 00:00:00

  • A randomized, crossover pharmacokinetic study comparing generic tacrolimus vs. the reference formulation in subpopulations of kidney transplant patients.

    abstract::An exploratory, post hoc analysis was performed using data from a prospective, multicenter, open-label, randomized, two-period (14 d per period), two-sequence, crossover, steady-state pharmacokinetic study comparing generic tacrolimus (Sandoz) vs. reference tacrolimus in stable renal transplant patients receiving thei...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/ctr.12256

    authors: Bloom RD,Trofe-Clark J,Wiland A,Alloway RR

    更新日期:2013-11-01 00:00:00

  • Flow cytometry crossmatching and primary cadaver kidney graft outcome: relevance of T and B cell targets, historic sera and autologous controls.

    abstract::There is limited information regarding the role of flow cytometry crossmatching (FCXM) in primary cadaver kidney allografting and even less about B cell reactivity and graft survival (GS). Furthermore, there is little or no published data concerning reaction strength (cutoff value), the effect of historic sera reactio...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: LeFor WM,Ackermann JR,Alveranga DY,Bowers VD,Heinrichs DF,Kahana L,Shires DL Jr,Weinstein SS,Wright CE

    更新日期:1996-12-01 00:00:00

  • Interstitial alterations in renal cortex in acute tubular necrosis (ATN) post-renal transplantation and in patients with ATN not related to renal transplant.

    abstract:BACKGROUND:Abnormalities of renal function with long-term implications can persist after acute tubular necrosis (ATN), probably because of permanent loss of nephrons. Residual areas of fibrosis are also observed in the renal cortex post-ATN. In this study, we investigate the interstitial alterations post-ATN using hist...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1046/j.1399-0012.2003.00140.x

    authors: Moyses Neto M,Costa RS,Volpini RA,Garcia TM,Rodrigues FF,Coimbra TM

    更新日期:2004-04-01 00:00:00

  • Epidemiology, risk factors, and impact of bacterial infections on outcomes for pancreatic grafts.

    abstract::We aimed to determine the epidemiology, risk factors, and impact of bacterial infection on pancreatic function after pancreas transplantation. Data for pancreas transplant recipients were retrospectively reviewed between 2000 and 2014 for at least 1 year. We collected and analyzed post-transplant data for bacterial in...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13333

    authors: Bodro M,Ferrer J,Ricart MJ,Sanclemente G,Linares L,Cervera C,Cofan F,Ventura-Aguiar P,Lopez-Boado MÁ,Marco F,Fuster J,García-Valdecasas JC,Moreno A

    更新日期:2018-08-01 00:00:00

  • Low birthweight and risk of albuminuria in living kidney donors.

    abstract::Low birthweight is linked to hypertension, chronic kidney disease and even end-stage renal disease. We hypothesized that living kidney donors born with lower birthweight may be at increased risk of hypertension, albuminuria, or reduced GFR beyond what is typical following uninephrectomy. Two hundred fifty-seven living...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12321

    authors: Berglund D,MacDonald D,Jackson S,Spong R,Issa N,Kukla A,Reule S,Weber M,Matas AJ,Ibrahim HN

    更新日期:2014-03-01 00:00:00

  • Association of treatment with 15-deoxyspergualin and BK virus nephropathy in kidney allograft recipients.

    abstract:OBJECTIVE:BK virus nephropathy (BKVN) has been proposed as an important cause of allograft dysfunction and loss in kidney allograft recipient over the last decade. Intense immunosuppression and tubular injury have been shown to promote the replication of polyomavirus. 15-deoxyspergualin (DSG), an effective immunosuppre...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2007.00677.x

    authors: Shi Y,Moriyama T,Namba Y,Yamanaka M,Hanafuse T,Imamura R,Ichimaru N,Oka K,Kyo M,Tian Y,Takahara S,Ichikawa S,Okuyama A

    更新日期:2007-07-01 00:00:00

  • Analysis of preexisting baseline kidney lesions revealed by biopsy in living kidney donors: relationship with clinical parameters at the time of donation.

    abstract::Because the safety of living organ donors is essential, we have been performing donor kidney biopsy before donation in cases where decision-making regarding suitability is marginal. To clarify the degree to which pathological change in the kidney can be predicted on the basis of clinical data obtained non-invasively, ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2010.01276.x

    authors: Okamoto M,Koshino K,Nobori S,Ushigome H,Okajima H,Urasaki K,Yoshimura N

    更新日期:2010-07-01 00:00:00

  • Changing the paradigm of organ utilization from PHS increased-risk donors: an opportunity whose time has come?

    abstract::Approximately 8-11% of all organ donors are classified by Public Health Service (PHS) as increased-risk. The proportion of PHS increased-risk donors is on the rise. At the University of Washington Medical Center, in 2014, the proportion of transplants from PHS increased-risk donors was 28% of liver transplants and 23%...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12582

    authors: Sibulesky L,Javed I,Reyes JD,Limaye AP

    更新日期:2015-09-01 00:00:00

  • Sequential biological immunosuppression. Induction therapy with rabbit antithymocyte globulin.

    abstract::This paper describes 108 consecutively treated patients receiving 109 cadaveric (CD) and living donor (LD) renal allografts using a protocol of quadruple sequential immunosuppression with a rabbit anti-human thymocyte IgG (Thymoglobuline), azathioprine, tapering corticosteroids, and delayed introduction of cyclosporin...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Guttmann RD,Flemming C

    更新日期:1997-06-01 00:00:00

  • Use of immune globulin to prevent symptomatic cytomegalovirus disease in transplant recipients--a meta-analysis.

    abstract::The objective of this meta-analysis was to review the evidence for the use of immune globulin in the prevention of symptomatic cytomegalovirus (CMV) disease in transplant recipients. A computerized search of Medline from 1980 to October 1991 was conducted using the textword "cytomegalo:" and the subheading "prevention...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,meta分析

    doi:

    authors: Glowacki LS,Smaill FM

    更新日期:1994-02-01 00:00:00

  • Pediatric transplantation in Europe during the COVID-19 pandemic: Early impact on activity and healthcare.

    abstract::The current pandemic SARS-CoV-2 has required an unusual allocation of resources that can negatively impact chronically ill patients and high-complexity procedures. Across the European Reference Network on Pediatric Transplantation (ERN TransplantChild), we conducted a survey to investigate the impact of the COVID-19 o...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,多中心研究

    doi:10.1111/ctr.14063

    authors: Doná D,Torres Canizales J,Benetti E,Cananzi M,De Corti F,Calore E,Hierro L,Ramos Boluda E,Melgosa Hijosa M,Garcia Guereta L,Pérez Martínez A,Barrios M,Costa Reis P,Teixeira A,Lopes MF,Kaliciński P,Branchereau S,Boyer O

    更新日期:2020-10-01 00:00:00

  • Use of enteric-coated mycophenolate sodium in liver transplant patients with intestinal intolerance caused by mycophenolate mofetil.

    abstract:BACKGROUND:Post-transplant gastrointestinal (GI) side effects can impair a patient's quality of life (QoL). This study investigates the improvement in GI side effects and related QoL changes in recipients of liver transplantation (OLT) after converting patients from mycophenolate mofetil (MMF) to enteric-coated mycophe...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1399-0012.2009.01019.x

    authors: Doria C,Ramirez CB,Frank AM,Vaccino S,Fraser N,Marino IR

    更新日期:2009-11-01 00:00:00

  • HMGCoA reductase inhibitors and omega-3 fatty acids as adjunctive agents in maintenance immunosuppression after solid organ transplantation.

    abstract::Omega-3 fatty acids have been shown to play a role in preventing development of both acute and chronic rejection. New evidence also suggests that HMGCoA reductase inhibitors may have an immunomodulatory effect and may decrease the incidence of rejection in both animal and human transplant models. Omega-3 fatty acids a...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Katznelson S,Wilkinson AH

    更新日期:1995-06-01 00:00:00

  • Pleural catheter placement and intrapleural fibrinolysis following lung transplantation.

    abstract:BACKGROUND:This study aimed to investigate the characteristics of lung transplant recipients requiring additional pleural drainage catheters early post-lung transplantation and to determine the safety and efficacy of intrapleural fibrinolytics in these patients. METHODS:A retrospective review of lung transplant recipi...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13592

    authors: Kao CC,Cuevas JF,Tuthill S,Parulekar AD

    更新日期:2019-06-01 00:00:00

  • A peculiar vacuolization in the kidney transplant of a child treated with tacrolimus.

    abstract::Tacrolimus (TAC) is a useful immunosuppressive agent in the prevention of rejection. However, the blood level between its therapeutic and toxic levels is narrow such that its nephrotoxicity is a problem. Moreover, its bioavailability and pharmacokinetics are highly variable. We experienced a case of acute nephrotoxici...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2000.0140s3030.x

    authors: Watanabe S,Yamaguchi Y,Hattori M,Chikamoto H,Matsumoto N,Suzuki T,Oonishi M,Horita S,Tokumoto T,Tanabe K,Shiraga H,Toma H,Ito K

    更新日期:2000-01-01 00:00:00

  • Attitudes and opinions on organ donation: an opportunity to educate in a Canadian city.

    abstract:BACKGROUND:Patients on organ transplant waiting lists continue to far exceed donor rates. We seek to understand the barriers preventing people in a Canadian city from donating organs for transplantation. METHODS:One thousand adults were surveyed assessing knowledge, personal involvement, and attitudes about organ dona...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2010.01260.x

    authors: Lee E,Midodizi W,Gourishankar S

    更新日期:2010-11-01 00:00:00

  • Role of total artificial heart in the management of heart transplant rejection and retransplantation: case report and review.

    abstract::Cardiac allograft rejection and failure may require mechanical circulatory support as bridge-to-retransplantation. Prognosis in this patient group is poor and implantable ventricular assist devices have had limited success due to organ failure associated with the high dose immunosuppression required to treat ongoing r...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/ctr.12146

    authors: Kalya A,Jaroszewski D,Pajaro O,Scott R,Gopalan R,Kasper D,Arabia F

    更新日期:2013-07-01 00:00:00

  • The Transplant Palliative Care Clinic: An early palliative care model for patients in a transplant program.

    abstract::Although patients within a transplant program are awaiting or have received disease modifying or curative treatment, they are also facing advanced illness and the possibility of death. The involvement of specialized palliative care services for these patients may improve symptom management and facilitate advance care ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12838

    authors: Wentlandt K,Dall'Osto A,Freeman N,Le LW,Kaya E,Ross H,Singer LG,Abbey S,Clarke H,Zimmermann C

    更新日期:2016-12-01 00:00:00

  • Kidney graft survival in patients with hepatitis C: a single center experience.

    abstract::Hepatitis C virus (HCV) infection is highly prevalent in renal transplant candidates; however, its effect on the transplant outcome is still controversial. The aim of the present study was to determine the effect of HCV infection in the outcome of kidney transplantation in a single transplant center. The study populat...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2007.00679.x

    authors: Arango J,Arbelaez M,Henao J,Mejia G,Arroyave I,Carvajal J,Garcia A,Gutierrez J,Velásquez A,Garcia L,Aguirre C

    更新日期:2008-01-01 00:00:00

  • Massive gastrointestinal hemorrhage due to rupture of a donor pancreatic artery pseudoaneurysm in a pancreas transplant patient.

    abstract::Enteric drainage of secretions by anastomosing the donor duodenum to the recipient's small bowel has become common in pancreatic transplantation. While it eliminates many problems, endoscopic access to the transplanted duodenum and pancreas is made difficult. After a pancreas kidney transplant, the patient presented w...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2004.00111.x

    authors: Green BT,Tuttle-Newhall J,Suhocki P,Smith SR,O'Connor JB

    更新日期:2004-02-01 00:00:00

  • Steroid-related complications in the cyclosporine era.

    abstract::Steroid withdrawal has potential risks (rejection) and benefits (fewer complications). Most data on steroid-related complications predates cyclosporine (CsA). We tabulated the incidence of posttransplant complications considered to be steroid-related in 748 adult kidney transplant recipients (with at least 1 year of f...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Fryer JP,Granger DK,Leventhal JR,Gillingham K,Najarian JS,Matas AJ

    更新日期:1994-06-01 00:00:00

  • Ten-year protocol biopsy findings of renal allografts in the calcineurin inhibitor era.

    abstract::Ten-year protocol biopsies were performed in 16 patients treated with calcineurin inhibitor (CNI) continuously. All kidney grafts were functioning well at the time of biopsy with the mean serum creatinine level of 1.6 +/- 0.8 mg/dL. The specimen of biopsy showed various degrees of tissue injury. According to the Banff...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2006.00544.x

    authors: Okamoto M,Akioka K,Ushigome H,Higuchi A,Nobori S,Ogino S,Uryuhara K,Kaihara S,Hatta T,Urasaki K,Yoshimura N

    更新日期:2006-01-01 00:00:00

  • Low molecular weight heparin dosing and monitoring in solid organ transplant recipients.

    abstract::Anti-Xa monitoring for low molecular weight heparin (LMWH) is currently recommended in obese, renally impaired, and pregnant patients. Substantial evidence indicates that solid organ transplant (SOT) patients are at an increased risk of renal impairment, thus representing a population at risk of LMWH accumulation. The...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12240

    authors: Moten MA,Gaber AO,Putney D,Patel SJ

    更新日期:2013-11-01 00:00:00

  • Anemia following renal transplantation: erythropoietin response and iron deficiency.

    abstract::To define the etiology of anemia post-renal transplantation, we assessed hematologic parameters and EPO levels in 38 anemic and 16 non-anemic control renal transplant recipients (RTRs) with varying degrees of allograft function at periods > 3 months post-transplantation. Significant differences between the two groups ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Miles AM,Markell MS,Daskalakis P,Sumrani NB,Hong J,Sommer BG,Friedman EA

    更新日期:1997-08-01 00:00:00

  • Clinical relevance of endoscopy with histopathological assessment in children with suspected gastrointestinal graft-versus-host disease.

    abstract::Endoscopy with histopathological assessment is an established practice to confirm gastrointestinal graft-versus-host disease (GI-GVHD). However, the clinical relevance of this approach in children is incompletely evaluated. In a retrospective cohort study, we investigated the frequency of treatment changes in response...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13867

    authors: Mårtensson T,Mellgren K,Toporski J,Arvidson J,Szakos A,Casswall TH,Gustafsson B

    更新日期:2020-07-01 00:00:00

  • Urinary microbiome associated with chronic allograft dysfunction in kidney transplant recipients.

    abstract:BACKGROUND:We performed a study to identify differences in the urinary microbiome associated with chronic allograft dysfunction (CAD) and compared the urinary microbiome of male and female transplant recipients with CAD. METHODS:This case-control study enrolled 67 patients within the Deterioration of Kidney Allograft ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13436

    authors: Wu JF,Muthusamy A,Al-Ghalith GA,Knights D,Guo B,Wu B,Remmel RP,Schladt DP,Alegre ML,Oetting WS,Jacobson PA,Israni AK

    更新日期:2018-12-01 00:00:00