Epidemiology, risk factors, and impact of bacterial infections on outcomes for pancreatic grafts.

Abstract:

:We aimed to determine the epidemiology, risk factors, and impact of bacterial infection on pancreatic function after pancreas transplantation. Data for pancreas transplant recipients were retrospectively reviewed between 2000 and 2014 for at least 1 year. We collected and analyzed post-transplant data for bacterial infection, morbidity, and mortality. During the study period, 312 pancreas transplants were performed. In total, 509 episodes of bacterial infection were diagnosed in 191 patients (61%). Multidrug-resistant (MDR) organisms were present in 173 of the 513 isolated microorganisms (33%). Risk factors independently associated with bacterial infection were acute allograft rejection (OR 1.7, 95%CI 1.1-3), the need for post-transplant hemodialysis, (OR 5.3, 95%CI 1.8-15.7) and surgical re-intervention (OR 2.8, 95%CI 1.5-5.1), which was also considered a risk factor for infections caused by MDR bacteria. Graft survival was associated with the occurrence of one or more episodes of bacterial infection (log-rank test = 0.009). Surgical re-intervention was independently associated with graft loss (OR 2.5, 95%CI 1.3-4.7). To conclude, pancreas recipients frequently experienced bacterial infections associated with the need for hemodialysis or surgical re-intervention. Infection by MDR organisms is a growing concern in these patients and was related to graft survival. Graft loss was independently associated with surgical re-intervention.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Bodro M,Ferrer J,Ricart MJ,Sanclemente G,Linares L,Cervera C,Cofan F,Ventura-Aguiar P,Lopez-Boado MÁ,Marco F,Fuster J,García-Valdecasas JC,Moreno A

doi

10.1111/ctr.13333

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

e13333

issue

8

eissn

0902-0063

issn

1399-0012

journal_volume

32

pub_type

杂志文章
  • An analysis of pancreas transplantation outcomes based on age groupings--an update of the UNOS database.

    abstract:INTRODUCTION:Previously, increasing age has been a part of the exclusion criteria used when determining eligibility for a pancreas transplant. However, the analysis of pancreas transplantation outcomes based on age groupings has largely been based on single-center reports. METHODS:A UNOS database review of all adult p...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12407

    authors: Siskind E,Maloney C,Akerman M,Alex A,Ashburn S,Barlow M,Siskind T,Bhaskaran M,Ali N,Basu A,Molmenti E,Ortiz J

    更新日期:2014-09-01 00:00:00

  • Short- and midterm results for internal jugular vein extension for short right renal vein kidney transplant.

    abstract::Renal transplantation remains the definitive treatment for end-stage renal disease (ESRD). The shorter renal vein in right donor nephrectomies is associated with higher incidence of technical failure. We present here our experience with autologous internal jugular vein (IJV) conduits to facilitate living-donor transpl...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/ctr.13312

    authors: Lu T,Yi SG,Bismuth J,Knight RJ,Gaber AO,Bechara CF

    更新日期:2018-08-01 00:00:00

  • Quadruple immunosuppression with basiliximab, tacrolimus, mycophenolate mofetil and prednisone is safe and effective for renal transplantation.

    abstract:INTRODUCTION:Recent immunosuppression with tacrolimus and mycophenolate mofetil has improved the results of renal transplantation. In this study, we analyzed the effect and safety of basiliximab as an induction therapy. MATERIAL AND METHODS:Forty-nine kidney recipients were given tacrolimus, mycophenolate mofetil and ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2005.00393.x

    authors: Miura M,Harada H,Fukuzawa N,Iwami D,Taniguchi A,Seki T,Togashi M,Ogawa Y,Satoh H,Hirano T

    更新日期:2005-01-01 00:00:00

  • Cutaneous cryptococcosis mimicking bacterial cellulitis in a liver transplant recipient: case report and review in solid organ transplant recipients.

    abstract::Cutaneous cryptococcosis is an uncommon manifestation of disseminated cryptococcal disease. We report a liver transplant recipient presenting with onset over 3 days of progressive pain and swelling of the lower extremity and foot with erythema and heat. Cryptococcal cellulitis was documented, but in retrospect the cli...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:

    authors: Singh N,Rihs JD,Gayowski T,Yu VL

    更新日期:1994-08-01 00:00:00

  • Methamphetamine use in deceased kidney donors impairs one-yr graft function.

    abstract:BACKGROUND:Methamphetamine (MA) has cumulative deleterious effects on multiple organ systems. A history of MA exposure in kidney donors may affect adversely graft function in recipients. METHODS:Between September 2000 and March 2004, all deceased kidney donors were identified from the local registry (97 donors). Twent...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2007.00703.x

    authors: Inouye DS,Kickertz K,Wong LL

    更新日期:2007-09-01 00:00:00

  • Conundrums with FlowPRA beads.

    abstract::In 1969, a study by Patel and Terasaki persuaded the renal transplant community that a pre-transplant cross-match should always be performed between donor and recipient to detect HLA antibodies and prevent hyperacute allograft rejection. Although the role of the cross-match among nonsensitized patients is controversia...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.16.s7.3.x

    authors: Gebel HM,Harris SB,Zibari G,Bray RA

    更新日期:2002-01-01 00:00:00

  • Measurement of liver volumes by portal vein flow by Doppler ultrasound in living donor liver transplantation.

    abstract:BACKGROUND:The accurate estimation of liver volume and right/left ratio in donor candidates is critical, but there is no method using portal vein (PV) flow. METHODS:Of 125 donor candidates, right/left liver volume ratio was estimated using ultrasound (US)-PV area ratio and Doppler US-PV flow ratio, and the results wer...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13050

    authors: Choi SH,Kwon JH,Kim KW,Jang HY,Kim JH,Kwon HJ,Lee J,Song GW,Lee SG

    更新日期:2017-09-01 00:00:00

  • CD25, CD28 and CD38 expression in peripheral blood lymphocytes as a tool to predict acute rejection after liver transplantation.

    abstract:BACKGROUND/AIM:The aim of this study was to determine whether the expression of CD25, CD28 and CD38 (which reflects the degree of T-cell activation) by peripheral blood mononuclear cells constitutes a useful means of measuring the immune status of liver transplant recipients. METHODS:Fifty-two patients enrolled in a p...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-0012.2008.00815.x

    authors: Boleslawski E,BenOthman S,Grabar S,Correia L,Podevin P,Chouzenoux S,Soubrane O,Calmus Y,Conti F

    更新日期:2008-07-01 00:00:00

  • Current concepts and systematic review of vascularized composite allotransplantation of the abdominal wall.

    abstract:INTRODUCTION:Abdominal wall vascularized composite allotransplantation (AW-VCA) is a rarely utilized technique for large composite abdominal wall defects. The goal of this article is to systematically review the literature and current concepts of AW-VCA, outline the challenges ahead, and provide an outlook for the futu...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/ctr.12243

    authors: Berli JU,Broyles JM,Lough D,Shridharani SM,Rochlin D,Cooney DS,Lee WP,Brandacher G,Sacks JM

    更新日期:2013-11-01 00:00:00

  • Comparison of histopathological characteristics of allograft biopsy between responder and non-responder to antiproteinuric effect of angiotensin-converting enzyme inhibitor (ACEI).

    abstract::Angiotensin-converting enzyme inhibitor (ACEI) has become recognized as agents that have renoprotective effects in the treatment of progressive renal diseases including post-transplant kidneys. Previously we demonstrated the safety and effectiveness of ACEI treatment on the hypertensive proteinuric post-transplant pat...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2004.00244.x

    authors: Namba Y,Moriyama T,Kyo M,Oka K,Kokado Y,Shi Y,Imamura R,Ichimaru N,Okuyama A,Takahara S

    更新日期:2004-01-01 00:00:00

  • De novo donor-specific HLA antibodies in heart transplantation: Do transient de novo DSA confer the same risk as persistent de novo DSA?

    abstract:BACKGROUND:It is estimated that 25%-35% of heart transplant recipients develop de novo donor-specific antibodies (dnDSA). One factor that appears to play a role in clinical outcomes is DSA persistence. The objective of this study was to determine the incidence of transient and persistent dnDSA in a Canadian heart trans...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13416

    authors: Moayedi Y,Fan CS,Tinckam KJ,Ross HJ,McCaughan JA

    更新日期:2018-11-01 00:00:00

  • Pseudoaneurysm of the superior mesenteric artery with an arteriovenous fistula after simultaneous kidney-pancreas transplantation.

    abstract::Vascular complications remain a significant source of morbidity after pancreatic transplantation. We describe a pseudoaneurysm of the superior mesenteric artery (SMA) with an arteriovenous fistula (AVF) involving the SMA and the superior mesenteric vein (SMV) discovered and treated surgically in the second week after ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.1999.130310.x

    authors: Khan TF,Ciancio G,Burke GW 3rd,Sfakianakis GN,Miller J

    更新日期:1999-06-01 00:00:00

  • Efficacy and safety of enteric-coated mycophenolate sodium in renal transplant patients with diabetes mellitus: post hoc analyses from three clinical trials.

    abstract::To examine the efficacy and safety of enteric-coated mycophenolate sodium (EC-MPS, myfortic) in renal transplant patients with diabetes mellitus, six- and 12-month data from three clinical trials with EC-MPS (Studies B301, B302, and myPROMS) were analyzed post hoc. Studies B301 (de novo patients) and B302 (maintenance...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2006.00615.x

    authors: Pietruck F,Budde K,Salvadori M,Sollinger H,Bourbigot B,Gentil MA,Oppenheimer F

    更新日期:2007-01-01 00:00:00

  • Differences in perceived health status between kidney transplant recipients and dialyzed patients are based mainly on the selection process.

    abstract::Kidney transplantation offers longer survival, less morbidity and lower costs than dialysis. It is also believed to improve quality of life. The aim of this study was to compare prospectively the perceived health status (PHS) of dialyzed patients on a waiting list with kidney transplant recipients after transplantatio...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2009.01080.x

    authors: Rosenberger J,van Dijk JP,Prihodova L,Majernikova M,Nagyova I,Geckova AM,Roland R,van den Heuvel WJ,Groothoff JW

    更新日期:2010-05-01 00:00:00

  • Risk factors and outcome of stroke in renal transplant recipients.

    abstract::Stroke incidence is high in end-stage renal disease, and risk factors differ between the dialysis and general populations. However, risk factors and outcomes following renal transplantation remain unclear. We analyzed all adult patients with a functioning renal transplant from 01/01/2007 to 12/31/2012. Data were extra...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12765

    authors: Findlay MD,Thomson PC,MacIsaac R,Jardine AG,Patel RK,Stevens KK,Rutherford E,Clancy M,Geddes CC,Dawson J,Mark PB

    更新日期:2016-08-01 00:00:00

  • Quality of life assessment in renal transplant: review and future directions.

    abstract::We performed a systematic search of the literature using the MEDLINE (through 2006) database to identify the patient-reported outcome measures of quality of life (QOL) used most often in the renal transplant literature. After applying limits and reviewing references, we identified 338 renal transplant articles with a ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-0012.2007.00784.x

    authors: Butt Z,Yount SE,Caicedo JC,Abecassis MM,Cella D

    更新日期:2008-05-01 00:00:00

  • A critical analysis of racial difference with mycophenolate mofetil (MMF) dosing, clinical outcomes and adverse effects in pediatric kidney transplant patients.

    abstract::There is paucity in the data examining the differences in mycophenolate mofetil (MMF) dosing and outcomes among pediatric kidney transplant recipients (PKTX) between races. The aims of this study were as follows (i) to assess whether higher doses of MMF are being utilized in African American (AA) PKTX (ii) to determin...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1399-0012.2010.01304.x

    authors: Jensen CJ,Shrivastava S,Taber DJ,Weimert NA,Shatat IF,Orak J,Chavin KD,Baliga PK

    更新日期:2011-07-01 00:00:00

  • Deceased organ donor factors influencing pancreatic graft transplantation and survival.

    abstract::Criteria for organ acceptance in brain-dead organ donors remain inconsistent, especially when concerning pancreatic transplants. We sought to examine donor-specific predictors of pancreatic graft use and survival to better guide the selection and management of potential donors. A prospective observational study of all...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13571

    authors: Sally MB,Ellis MK,Hutchens M,Groat T,Swanson E,Patel MS,Niemann CU,Malinoski DJ

    更新日期:2019-06-01 00:00:00

  • Prolonged cardiac allograft ischemic time--no impact on long-term survival but at what cost?

    abstract:INTRODUCTION:The aim of this paper was to review the outcomes of cardiac transplantation with regards to short- and long-term survival, focusing particularly on patients who receive organs with long ischemic times and the resource utilization necessary to support such patients through their postoperative period. METHO...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2007.00644.x

    authors: Marasco SF,Esmore DS,Richardson M,Bailey M,Negri J,Rowland M,Kaye D,Bergin PJ

    更新日期:2007-05-01 00:00:00

  • Describing barriers and facilitators for medication adherence and self-management among kidney transplant recipients using the information-motivation-behavioral skills model.

    abstract:BACKGROUND:We aimed to develop an adapted information-motivation-behavioral skills (IMB) model to describe barriers and facilitators for adherence and self-management among kidney transplant recipients. METHODS:We conducted a review of literature about kidney transplant recipients' knowledge, perceptions, and experien...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13862

    authors: Ranahan M,Von Visger J,Kayler LK

    更新日期:2020-06-01 00:00:00

  • Improving graft survival for patients undergoing liver transplantation.

    abstract::Liver transplant (LT) outcomes are reported to be improving in non-HCV recipients but not for those infected with HCV. Our aim was to evaluate graft survival and predictors of outcome in HCV and non-HCV patients before and after 2003. Patients with primary LT between February 1, 1998, and December 31, 2005, were inclu...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2011.01428.x

    authors: Dickson RC,Pungpapong S,Keaveny AP,Taner CB,Ghabril M,Aranda-Michel J,Satyanarayana R,Bonatti H,Kramer DJ,Nguyen JH

    更新日期:2011-05-01 00:00:00

  • Liver transplantation in patients aged 65 and over: a case-control study.

    abstract:INTRODUCTION:The average age of patients undergoing liver transplantation (LT) is consistently increasing. The aim of this case-control study is to evaluate survival and outcome of patients ≥65 yr compared to younger patients undergoing LT. MATERIALS AND METHODS:From 10/00 to 4/08 we performed 330 primary LT, 31 (9.4%...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2010.01230.x

    authors: Montalti R,Rompianesi G,Di Benedetto F,Ballarin R,Gerring RC,Busani S,De Pietri L,De Ruvo N,Iemmolo RM,Guerrini GP,Smerieri N,Gerunda GE

    更新日期:2010-09-01 00:00:00

  • New onset diabetes mellitus post-kidney transplantation.

    abstract::The study explores the prevalence of unrecognized diabetes mellitus (DM), the incidence and risk factors new onset diabetes mellitus (NODM) and determines whether patient survival differs between patients with transient (NODM that resolves) compared with those with fixed NODM. This is a single center review of solitar...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2006.00529.x

    authors: Kiberd M,Panek R,Kiberd BA

    更新日期:2006-09-01 00:00:00

  • Heparin-induced thrombocytopenia following pancreatectomy and islet auto-transplantation.

    abstract::We report the case of a female with chronic pancreatitis who underwent multiple surgical procedures leading to total resection of the pancreas with successful islet auto-transplantation. Postoperatively, she developed heparin-induced thrombocytopenia. Heparinization prior to islet infusion is currently recommended to ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2005.00457.x

    authors: Rastellini C,Brown ML,Cicalese L

    更新日期:2006-03-01 00:00:00

  • Variability in the reporting of renal function endpoints in immunosuppression trials in renal transplantation: time for consensus?

    abstract::Early measures of graft function are increasingly used to assess efficacy in clinical trials of kidney transplant immunosuppression. This study aimed to assess the variability and quality of reporting of these endpoints in contemporary trials. Data regarding renal function endpoints were extracted from 213 reports fro...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12861

    authors: Knight SR,Hussain S

    更新日期:2016-12-01 00:00:00

  • Can the Timed Up & Go Test and Montreal Cognitive Assessment predict outcomes in patients waitlisted for renal transplant?

    abstract:PURPOSE:Frail patients who undergo renal transplantation (RT) have more complications; however, little is known if these patients can sustain the wait to RT. We used the Timed Up and Go Test (TUGT) and Montreal Cognitive Assessment (MoCA) to determine outcomes of RT candidates. METHODS:In this retrospective study, 526...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.14161

    authors: Bozhilov K,Vo KB,Wong LL

    更新日期:2020-11-20 00:00:00

  • LabMELD-based organ allocation increases total costs of liver transplantation: a single-center experience.

    abstract:INTRODUCTION:In 2006, model for end-stage liver disease (MELD)-based allocation was implemented in the Eurotransplant (ET) region. Sick patients, who in general require more resources, are prioritized. In this analysis, the effect of MELD on costs for liver transplantation (LTx) was assessed. METHODS:Total costs for L...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1399-0012.2011.01483.x

    authors: Bruns H,Hillebrand N,Schneider T,Hinz U,Fischer L,Schmidt J,Goldschmidt AJ,Schemmer P

    更新日期:2011-09-01 00:00:00

  • Mycobacterium tuberculosis infections in solid organ transplantation: Guidelines from the infectious diseases community of practice of the American Society of Transplantation.

    abstract::These updated guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation review the diagnosis, prevention, and management of tuberculosis in the pre- and post-transplant period. The challenges of screening for both latent and active TB in the setting of transplantation are...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13513

    authors: Subramanian AK,Theodoropoulos NM,Infectious Diseases Community of Practice of the American Society of Transplantation.

    更新日期:2019-09-01 00:00:00

  • Long-term outcome in kidney transplant patients with hepatitis C (HCV) infection.

    abstract::To assess the prevalence and long-term impact of HCV on kidney transplant recipients, we assayed 716 pre-transplant sera using a first-generation ELISA. The anti-HCV positive sera were confirmed by a 6-antigen radioimmunoassay (RIA). Patients were followed up for 5 years. Graft survival, function, evidence of chemical...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Orloff SL,Stempel CA,Wright TL,Tomlanovich SJ,Amend WJ,Stock PG,Melzer JS,Vincenti F

    更新日期:1995-04-01 00:00:00

  • Influence of CYP3A5 and ABCB1 gene polymorphisms on calcineurin inhibitor-related neurotoxicity after hematopoietic stem cell transplantation.

    abstract:BACKGROUND:One severe side effect of calcineurin inhibitors (CNIs: such as cyclosporine [CsA] and tacrolimus [FK506]) is neurotoxicity. CNIs are substrates for CYP3A5 and P-glycoprotein (P-gp), encoded by ABCB1 gene. In the present study, we hypothesized that genetic variability in CYP3A5 and ABCB1 genes may be associa...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2009.01181.x

    authors: Yanagimachi M,Naruto T,Tanoshima R,Kato H,Yokosuka T,Kajiwara R,Fujii H,Tanaka F,Goto H,Yagihashi T,Kosaki K,Yokota S

    更新日期:2010-11-01 00:00:00