Liver transplantation in patients aged 65 and over: a case-control study.

Abstract:

INTRODUCTION:The average age of patients undergoing liver transplantation (LT) is consistently increasing. The aim of this case-control study is to evaluate survival and outcome of patients ≥65 yr compared to younger patients undergoing LT. MATERIALS AND METHODS:From 10/00 to 4/08 we performed 330 primary LT, 31 (9.4%) of these were in patients aged 65-70. Following a case-control approach, we compared these patients with 31 patients aged between 41 and 64 yr and matched according to sex, LT indication, viral status, cadaveric/living donor, LT timing, and Model for End-Stage Liver Disease (MELD) score. RESULTS:There were no statistically significant differences in demographic and surgical donor characteristics. The mean MELD score was under 18 in both groups. Post-LT complications occurred with a similar incidence in the two groups. one-, three-, and five-yr survival was 83.9%, 80.6%, and 80.6%, respectively, for the elderly group, and 80.6%, 73.8%, and 73.8%, respectively, for the young group (p = 0.61). DISCUSSION:Patients aged between 65 and 70 with low MELD score who undergo LT have the same short- and middle-term survival expectancy, morbidity, and outcome quality as younger patients with the same indication and same pre-LT pathology severity, whatever they might be. Thus, chronological age alone should not deter LT workup in patients >65 and <70.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Montalti R,Rompianesi G,Di Benedetto F,Ballarin R,Gerring RC,Busani S,De Pietri L,De Ruvo N,Iemmolo RM,Guerrini GP,Smerieri N,Gerunda GE

doi

10.1111/j.1399-0012.2010.01230.x

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

E188-93

issue

5

eissn

0902-0063

issn

1399-0012

pii

CTR1230

journal_volume

24

pub_type

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