Influence of anti-rejection therapy on the timing of cytomegalovirus disease and other infections in renal transplant recipients.

Abstract:

:Infections are an important cause of mortality and morbidity in renal transplant recipients. To study the impact of anti-rejection therapy on the timing of infections, the records of 599 consecutive renal transplants, performed prior to 31 December 1996 at the Royal Melbourne Hospital, were reviewed. Patients were grouped according to acute rejection (AR) episode and treatment during the first 6 months after transplantation. Group 1 [n = 168 (35%)] patients did not experience any episode of AR. Group 2 [n = 169 (35%)] patients had one or more episodes of AR and received high doses of steroids. Group 3 [n = 141 (30%)] patients had more than one episode of AR and received anti-lymphocyte antibodies in addition to high doses of steroids. Infections were more common in Groups 2 and 3 but only cytomegalovirus (CMV) disease occurred earlier in patients treated with lympholytics. Given the high incidence and early onset of CMV disease in patients receiving lympholytics and considering that an effective prophylactic protocol remains undetermined, pre-emptive treatment with ganciclovir in this high risk group appears justified.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Jamil B,Nicholls KM,Becker GJ,Walker RG

doi

10.1034/j.1399-0012.2000.140104.x

subject

Has Abstract

pub_date

2000-02-01 00:00:00

pages

14-8

issue

1

eissn

0902-0063

issn

1399-0012

journal_volume

14

pub_type

杂志文章
  • Microemulsion technology in the reformulation of cyclosporine: the reason behind the pharmacokinetic properties of Neoral.

    abstract::Management of transplant patients receiving cyclosporine therapy is complicated by interpatient and intrapatient variability in pharmacokinetic parameters caused by the drug's unpredictable bioavailability. Cyclosporine, a highly lipophilic cyclic polypeptide, has recently been reformulated using a microemulsion deliv...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:

    authors: Ritschel WA

    更新日期:1996-08-01 00:00:00

  • Neutrophil gelatinase-associated lipocalin associated with irreversibility of pre-liver transplant kidney dysfunction.

    abstract::Kidney outcomes in early post-liver transplantation (LT) are crucial for long-term prognosis, but difficult to predict. Among 203 adult LT patients, we studied the value of plasma neutrophil gelatinase-associated lipocalin (NGAL) measured pre-LT for predicting acute kidney injury (AKI), kidney-replacement therapy with...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12394

    authors: Aberg F,Lempinen M,Hollmén M,Nordin A,Mäkisalo H,Isoniemi H

    更新日期:2014-08-01 00:00:00

  • Steroid withdrawal in kidney transplant recipients: is it a safe option?

    abstract::The long-term side effects of lifelong steroid immunosuppression are well documented, therefore, steroid withdrawal (SW) if safe would clearly be of benefit. From 1987-1996, 470 kidney transplants were performed at our institution. During this time period, steroid withdrawal was offered to a select group of patients (...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Sanfey H,Haussman G,Isaacs I,Ishitani M,Lobo P,McCullough C,Pruett T

    更新日期:1997-10-01 00:00:00

  • Ethnicity, medical insurance, and living kidney donation.

    abstract:BACKGROUND:Relationships between race/ethnicity, recipient medical insurance, and living donor kidney transplantation (LKT) are incompletely described. METHODS:Associations between medical insurance and LKT were assessed in 447 recipients at a southeastern US transplant center. Primary and secondary payers were includ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12168

    authors: Reeves-Daniel AM,Farney AC,Fletcher AJ,Assimos D,Westcott C,Rogers J,Stratta RJ,Rocco MV,Freedman BI

    更新日期:2013-07-01 00:00:00

  • Religious beliefs and opinions on clinical xenotransplantation--a survey of university students from Kenya, Sweden and Texas.

    abstract::This study investigated the association between religious beliefs and opinions on xenotransplantation among students from three different countries. A lower proportion of religious students accepted xenotransplantation than did non-religious students. A higher proportion of Protestant students seemed to accept xenotra...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2001.150610.x

    authors: Hagelin J,Hau J,Schapiro SJ,Suleman MA,Carlsson HE

    更新日期:2001-12-01 00:00:00

  • Preservation of the donor pancreas for whole pancreas and islet transplantation.

    abstract::Whole pancreas and islet cell transplantation are both reliant upon the procurement and preservation of a high quality donor pancreas for a successful outcome. In the climate of a reducing donor pool it is imperative that donor optimization, meticulous surgical retrieval and evidence based methods of preservation are ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-0012.2009.01151.x

    authors: Ridgway D,Manas D,Shaw J,White S

    更新日期:2010-01-01 00:00:00

  • Low-dose basiliximab induction therapy in heart transplantation.

    abstract::We prospectively studied efficacy and safety outcomes of two 10-mg doses of intravenous basiliximab on day 0 and day 4 for induction therapy in 17 consecutive de novo heart transplant recipients. By the 2-week assessment post-transplant, there were no deaths, graft failures, or acute cellular rejections (ACRs) ISHLT g...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13132

    authors: Kittipibul V,Tantrachoti P,Ongcharit P,Ariyachaipanich A,Siwamogsatham S,Sritangsirikul S,Thammanatsakul K,Puwanant S

    更新日期:2017-12-01 00:00:00

  • Attitudes of commercial renal transplant recipients toward renal transplantation in India.

    abstract::Renal transplantation offers patients with end-stage renal disease the best opportunity for rehabilitation and long-term survival. However, there is a critical shortage of transplantable kidneys worldwide. This plays well into the hands of transplanters and entrepreneurs involved in commercial renal transplantation, p...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Qunibi W,Abulrub D,Shaheen F,el-Din AB,Alfurayh O,Almeshari K

    更新日期:1995-08-01 00:00:00

  • New onset diabetes mellitus post-kidney transplantation.

    abstract::The study explores the prevalence of unrecognized diabetes mellitus (DM), the incidence and risk factors new onset diabetes mellitus (NODM) and determines whether patient survival differs between patients with transient (NODM that resolves) compared with those with fixed NODM. This is a single center review of solitar...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2006.00529.x

    authors: Kiberd M,Panek R,Kiberd BA

    更新日期:2006-09-01 00:00:00

  • Perspectives on donor lung allocation from both sides of the Atlantic: The United States.

    abstract::Donor lung allocation in the United States focuses on decreasing waitlist mortality and improving recipient outcomes. The implementation of allocation policy to match deceased donor lungs to waitlisted patients occurs through a unique partnership between government and private organizations, namely the Organ Procureme...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13873

    authors: Tsuang WM,Snyder LD,Budev MM

    更新日期:2020-07-01 00:00:00

  • Adverse drug reaction driven immunosuppressive drug manipulations: a single-center comparison of enteric-coated mycophenolate sodium vs. mycophenolate mofetil.

    abstract:UNLABELLED:Enteric-coated mycophenolate sodium (MPS) has been developed to help circumvent the upper gastrointestinal side-effects of mycophenolic acid by facilitating drug release in the small intestine. Many questions regarding the side-effect profile of MPS remain. Therefore, the purpose of this study is to review a...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2008.00820.x

    authors: Hardinger KL,Hebbar S,Bloomer T,Murillo D

    更新日期:2008-09-01 00:00:00

  • Quadruple immunosuppression with basiliximab, tacrolimus, mycophenolate mofetil and prednisone is safe and effective for renal transplantation.

    abstract:INTRODUCTION:Recent immunosuppression with tacrolimus and mycophenolate mofetil has improved the results of renal transplantation. In this study, we analyzed the effect and safety of basiliximab as an induction therapy. MATERIAL AND METHODS:Forty-nine kidney recipients were given tacrolimus, mycophenolate mofetil and ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2005.00393.x

    authors: Miura M,Harada H,Fukuzawa N,Iwami D,Taniguchi A,Seki T,Togashi M,Ogawa Y,Satoh H,Hirano T

    更新日期:2005-01-01 00:00:00

  • Primary endoluminal stenting of transplant renal artery stenosis from cadaver and non-heart-beating donor kidneys.

    abstract::This study evaluated the efficacy of primary endovascular stenting in cases of transplant renal artery stenosis (TRAS) from cadaver and non-heart-beating donor kidneys. Patients with TRAS (n = 13) from a single-centre transplant population (n = 476) were treated by primary percutaneous angioplasty and endovascular ste...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2006.00499.x

    authors: Ridgway D,White SA,Nixon M,Carr S,Blanchard K,Nicholson ML

    更新日期:2006-05-01 00:00:00

  • Validity of patient skin cancer report among organ transplant recipients.

    abstract::Skin cancer is a common, potentially life-threatening malignancy in organ transplant recipients (OTR), and it is important for transplant physicians to be aware of patient history of skin cancer. Patient self-report represents a quick method of obtaining past medical history of skin cancer but no study has validated t...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2012.01601.x

    authors: Dybbro E,Mihalis E,Hirose R,Arron ST

    更新日期:2012-03-01 00:00:00

  • The early diagnostic value of serum galactomannan antigen test combined with chest computed tomography for invasive pulmonary aspergillosis in pediatric patients after hematopoietic stem cell transplantation.

    abstract:OBJECTIVE:The purpose of our study was to evaluate the diagnostic value of serum galactomannan antigen (GM) testing combined with chest computed tomography (CT) of invasive pulmonary aspergillosis (IPA) in pediatric patients after hematopoietic stem cell transplantation. METHODS:A retrospective nested case-control stu...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13641

    authors: Qiu KY,Liao XY,Huang K,Xu HG,Li Y,Fang JP,Zhou DH

    更新日期:2019-08-01 00:00:00

  • BK polyomavirus in solid organ transplantation-Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.

    abstract::The present AST-IDCOP guidelines update information on BK polyomavirus (BKPyV) infection, replication, and disease, which impact kidney transplantation (KT), but rarely non-kidney solid organ transplantation (SOT). As pretransplant risk factors in KT donors and recipients presently do not translate into clinically val...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13528

    authors: Hirsch HH,Randhawa PS,AST Infectious Diseases Community of Practice.

    更新日期:2019-09-01 00:00:00

  • Differential contribution of graft and recipient to perioperative TNF-alpha, IL-1 beta, IL-6 and IL-8 levels and correlation with early graft function in clinical liver transplantation.

    abstract::Cytokines, produced by both the recipient and the newly vascularized allograft, are central mediators in the inflammatory response to allografted tissue. This study examines the relationship between pre- and intraoperative levels of TNF, IL-1, IL-6, and IL-8 and hepatic allograft function in the early postoperative pe...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Boros P,Suehiro T,Curtiss S,Sheiner P,Emre S,Guy S,Schwartz ME,Miller CM

    更新日期:1997-12-01 00:00:00

  • Ganciclovir exposure under a 450 mg daily dosage of valganciclovir for cytomegalovirus prevention in kidney transplantation: a prospective study.

    abstract::This prospective study aimed at determining the ganciclovir exposure observed under a daily dosage of 450 mg valganciclovir routinely applied to kidney transplant recipients with a GFR above 25 mL/min at risk for cytomegalovirus (CMV) disease. Ganciclovir levels at trough (C(trough)) and at peak (C₃(h)) were measured ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2009.01205.x

    authors: Manuel O,Pascual M,Perrottet N,Lamoth F,Venetz JP,Decosterd LA,Buclin T,Meylan PR

    更新日期:2010-11-01 00:00:00

  • Post-transplant lymphoproliferative disorders: clinicopathological analysis of 43 cases in a single center, 1990-2009.

    abstract::Post-transplant lymphoproliferative disorders (PTLDs) are a heterogeneous set of complications of organ transplantation associated with poor patient prognosis. We analyzed the clinicopathological features of PTLDs in 43 adult and pediatric recipients of solid organ or bone marrow transplantation at a large transplant ...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1399-0012.2010.01392.x

    authors: Yoon SO,Yu E,Cho YM,Suh C,Kim KM,Han DJ,Lee SG,Huh J

    更新日期:2012-01-01 00:00:00

  • Can the Timed Up & Go Test and Montreal Cognitive Assessment predict outcomes in patients waitlisted for renal transplant?

    abstract:PURPOSE:Frail patients who undergo renal transplantation (RT) have more complications; however, little is known if these patients can sustain the wait to RT. We used the Timed Up and Go Test (TUGT) and Montreal Cognitive Assessment (MoCA) to determine outcomes of RT candidates. METHODS:In this retrospective study, 526...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.14161

    authors: Bozhilov K,Vo KB,Wong LL

    更新日期:2020-11-20 00:00:00

  • Anemia following renal transplantation: erythropoietin response and iron deficiency.

    abstract::To define the etiology of anemia post-renal transplantation, we assessed hematologic parameters and EPO levels in 38 anemic and 16 non-anemic control renal transplant recipients (RTRs) with varying degrees of allograft function at periods > 3 months post-transplantation. Significant differences between the two groups ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Miles AM,Markell MS,Daskalakis P,Sumrani NB,Hong J,Sommer BG,Friedman EA

    更新日期:1997-08-01 00:00:00

  • Prolonged cardiac allograft ischemic time--no impact on long-term survival but at what cost?

    abstract:INTRODUCTION:The aim of this paper was to review the outcomes of cardiac transplantation with regards to short- and long-term survival, focusing particularly on patients who receive organs with long ischemic times and the resource utilization necessary to support such patients through their postoperative period. METHO...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2007.00644.x

    authors: Marasco SF,Esmore DS,Richardson M,Bailey M,Negri J,Rowland M,Kaye D,Bergin PJ

    更新日期:2007-05-01 00:00:00

  • Direct pressure measurement in the hepatic artery during liver transplantation: can it prevent the "steal" syndrome?

    abstract::Splenic artery "steal" syndrome after orthotopic liver transplantation (OLT) is an important cause of graft dysfunction. Direct pressure measurement in the hepatic (HA) and radial artery (RA) may identify patients at risk allowing its prevention. This observational study compared radial and hepatic mean arterial press...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2011.01478.x

    authors: Wojcicki M,Pakosz-Golanowska M,Lubikowski J,Post M,Jarosz K,Milkiewicz P

    更新日期:2012-03-01 00:00:00

  • Interstitial expression of heat-shock protein 47 correlates with capillary deposition of complement split product C4d in chronic allograft nephropathy.

    abstract:BACKGROUND:Chronic allograft nephropathy (CAN), associated with late-allograft dysfunction is caused by alloantigen-dependent and -independent mechanisms, and eventually leads to interstitial fibrosis (ci). Activation of complement cascade is considered to be a poor prognostic marker of graft survival. This study was d...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2005.00426.x

    authors: Ohba K,Miyata Y,Koga S,Nishikido M,Kanetake H,Nazneen A,Razzaque MS,Taguchi T

    更新日期:2005-12-01 00:00:00

  • The curative treatment of familial hypercholesterolemia: Liver transplantation.

    abstract:BACKGROUND:Familial hypercholesterolemia (FH) is an autosomal dominant genetic disorder characterized by premature mortal cardiovascular complications. Liver transplantation (LT) is the only curative treatment option. In this study, the long-term clinical follow-up data of 8 patients who underwent LT with a diagnosis o...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13730

    authors: Gulsoy Kirnap N,Kirnap M,Bascil Tutuncu N,Moray G,Haberal M

    更新日期:2019-12-01 00:00:00

  • Mothers of children evaluated for transplantation: stress, coping resources, and perceptions of family functioning.

    abstract::The stress, coping resources, and family functioning of 36 mothers of children awaiting transplantation were evaluated. Using standardized assessment techniques, we found that, overall, 20% of mothers reported clinically elevated stress responses and that parenting stress was higher for mothers of children evaluated f...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Rodrigue JR,Hoffmann RG 3rd,MacNaughton K,Graham-Pole J,Andres JM,Novak DA,Fennell RS

    更新日期:1996-10-01 00:00:00

  • Accelerated atherosclerosis with apolipoprotein(a) and oxidized low-density lipoprotein deposition in acute rejection of transplanted kidney: analogous to atherosclerosis.

    abstract::Atherosclerosis is a chronic inflammatory process affecting mainly elastic and muscular arteries. Although small arteries and arterioles are usually spared, atherosclerosis can occur in these small vasculatures for a very short period. Here we report a case of atherosclerosis-like lesions that occurred in a transplant...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.16.s8.7.x

    authors: Shimoyamada H,Fan J,Watanabe T,Nagata M

    更新日期:2002-01-01 00:00:00

  • The impact of bacterial colonization on graft success after total pancreatectomy with autologous islet transplantation: considerations for early definitive surgical intervention.

    abstract:OBJECTIVE:The purpose of this study was to determine whether bacterial contamination of islets affects graft success after total pancreatectomy with islet autotransplantation (TPIAT). BACKGROUND:Factors associated with insulin independence after TPIAT are inconclusive. Although bacterial contamination does not preclud...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12842

    authors: Jolissaint JS,Langman LW,DeBolt CL,Tatum JA,Martin AN,Wang AY,Strand DS,Zaydfudim VM,Adams RB,Brayman KL

    更新日期:2016-11-01 00:00:00

  • The effect of sirolimus on sex hormone levels of male renal transplant recipients.

    abstract:BACKGROUND:It is unclear whether sirolimus, a newer immunosuppressive agent, widely used in renal transplantation, affects male sex hormone levels or sexual function. METHODS:Sex hormone profiles in male renal transplant recipients were obtained and compared between a sirolimus-treated group and a group not on sirolim...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2005.00257.x

    authors: Lee S,Coco M,Greenstein SM,Schechner RS,Tellis VA,Glicklich DG

    更新日期:2005-04-01 00:00:00

  • Hyperhomocysteinemia and transplant coronary artery disease in cardiac transplant recipients.

    abstract:BACKGROUND:In cardiac transplant recipients, long-term survival may be limited by transplant coronary artery disease (TxCAD). Hyperhomocysteinemia (Hhcy) has been associated with vascular disease and is common in transplant recipients. The objective of this study was to determine the relationship between fasting homocy...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2001.150407.x

    authors: Miner SE,Cole DE,Evrovski J,Verma A,Daly PA,Ross HJ

    更新日期:2001-08-01 00:00:00