Post-transplant lymphoproliferative disorders: clinicopathological analysis of 43 cases in a single center, 1990-2009.

Abstract:

:Post-transplant lymphoproliferative disorders (PTLDs) are a heterogeneous set of complications of organ transplantation associated with poor patient prognosis. We analyzed the clinicopathological features of PTLDs in 43 adult and pediatric recipients of solid organ or bone marrow transplantation at a large transplant service in the Republic of Korea between 1990 and 2009. Of 4545 solid organ and 747 bone marrow transplant recipients, 37 (0.81%) and 6 (0.8%), respectively, developed heterogeneous types of PTLDs. The cumulative incidences of PTLDs during this period were 1.79% (4/223) for heart transplant recipients, 0.78% (17/2192) for kidney transplant recipients, and 0.77% (16/2067) for liver transplant recipients. The patterns of disease onset, histology, and patient survival were associated with the types of organs transplanted. There is a trend for shorter overall survival (OS) in recipients with early-onset PTLDs and monomorphic PTLD histology, while kidney transplant recipients showed favorable OS. This study may be the first comprehensive analysis of the characteristics of PTLDs in Korean patients.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Yoon SO,Yu E,Cho YM,Suh C,Kim KM,Han DJ,Lee SG,Huh J

doi

10.1111/j.1399-0012.2010.01392.x

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

67-73

issue

1

eissn

0902-0063

issn

1399-0012

journal_volume

26

pub_type

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    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

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