Rescue therapy with mycophenolate mofetil. The Mycophenolate Mofetil Renal Refractory Rejection Study Group.

Abstract:

:Research with human transplant recipients has shown that mycophenolate mofetil (MMF) is a powerful and selective immunosuppressant for maintenance therapy following renal transplantation. An additional body of work suggests that it might also be a valuable tool for arresting ongoing rejection episodes. One randomized, open-label, multicenter study has compared the efficacy and safety of MMF administered with cyclosporine and maintenance corticosteroids versus high-dose intravenous corticosteroids (i.v. steroids) and conventional triple therapy, over a 6-month postenrollment period, for the treatment of refractory acute cellular renal allograft rejection. Treatment with MMF resulted in a 45% reduction in graft loss and death by 6 months postenrollment. (The number of deaths were the same in both treatment groups during the 6-month postenrollment period.) Treatment with MMF also significantly reduced the risk of experiencing a subsequent biopsy-proven rejection episode or treatment failure by almost 50%. The number of patients receiving one or more full courses of antilymphocyte therapy for a rejection episode subsequent to enrollment was more than twofold greater in the i.v. steroid group compared with the MMF group. Overall, and in most of the body systems, more adverse events were reported for patients in the MMF group, but the overall benefit-risk ratio for MMF supports its use with cyclosporine and maintenance corticosteroids for the treatment of refractory acute cellular renal allograft rejection.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

subject

Has Abstract

pub_date

1996-02-01 00:00:00

pages

131-5

issue

1 Pt 2

eissn

0902-0063

issn

1399-0012

journal_volume

10

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
  • Multidetector CT angiography in living donor renal transplantation: accuracy and discrepancies in right venous anatomy.

    abstract::Multidetector computed tomography (MDCT) angiography is a reliable technique for assessing pre-operative renal anatomy in living kidney donors. The method has largely evolved into protocols that eliminate dedicated venous phase and instead utilize a combined arterial/venous phase to delineate arterial and venous anato...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2009.01193.x

    authors: Kulkarni S,Emre S,Arvelakis A,Asch W,Bia M,Formica R,Israel G

    更新日期:2011-01-01 00:00:00

  • Technique of bile duct reconstruction and management of biliary complications in right lobe living donor liver transplantation.

    abstract::From December 1999 to January 2002, 50 right lobe living donor liver transplantations were performed. The donor operations included an intraoperative cholangiography to elicit variations in bile duct anatomy. The biliary reconstruction was done whenever possible as an end-to-end microanastomosis of the donor right hep...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2003.02058.x

    authors: Settmacher U,Steinmüller TH,Schmidt SC,Heise M,Pascher A,Theruvath T,Hintze R,Neuhaus P

    更新日期:2003-02-01 00:00:00

  • Itraconazole for the treatment of pulmonary aspergillosis in heart transplant recipients.

    abstract::The objective of this study was to evaluate the effects of itraconazole as a first choice drug in the treatment of pulmonary aspergillosis in heart transplant recipients. Heart transplant recipients suffering from invasive pulmonary aspergillosis were included in this study. Group 1 included 4 patients treated with i....

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Nanas JN,Saroglou G,Anastasiou-Nana MI,Kostis EB,Petrochilou-Paschou VP,Kontoyannis DA,Stamatelopoulos SF,Moulopoulos SD

    更新日期:1998-02-01 00:00:00

  • Heparin-induced thrombocytopenia following pancreatectomy and islet auto-transplantation.

    abstract::We report the case of a female with chronic pancreatitis who underwent multiple surgical procedures leading to total resection of the pancreas with successful islet auto-transplantation. Postoperatively, she developed heparin-induced thrombocytopenia. Heparinization prior to islet infusion is currently recommended to ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2005.00457.x

    authors: Rastellini C,Brown ML,Cicalese L

    更新日期:2006-03-01 00:00:00

  • Clostridioides difficile colonization and infection in patients admitted for a first autologous transplantation: Incidence, risk factors, and patient outcomes.

    abstract:BACKGROUND:More data are needed regarding the incidence, risk factors, and outcomes for Clostridioides difficile infection (CDI) and colonization in patients undergoing an autologous hematopoietic stem cell transplantation (AHSCT). METHODS:We studied 472 consecutive patients admitted for a first AHSCT and conducted a ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13712

    authors: Ford CD,Lopansri BK,Coombs J,Webb BJ,Nguyen A,Asch J,Hoda D

    更新日期:2019-11-01 00:00:00

  • Histological factors of 1-h biopsy influencing the delayed renal function and outcome in cadaveric renal allografts.

    abstract::The morphological characteristics of a kidney biopsy specimen taken 1 h after reperfusion of blood into the graft (1-h biopsy) during a cadaveric transplant operation were studied. The aim of the 1-h biopsy is to evaluate the pre-transplant risk factors for the delayed graft function, assess the renal function of the ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Oda A,Morozumi K,Uchida K

    更新日期:1999-01-01 00:00:00

  • Prospective study of microchimerism in renal allograft recipients: association between HLA-DR matching, microchimerism and acute rejection.

    abstract::The presence of donor-derived hematopoietic cells in blood and various tissues of the organ recipients, termed allogeneic microchimerism, has been considered to play an essential role in establishment of organ acceptance. In this study, we prospectively determined the presence of peripheral blood microchimerism (PBM) ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2001.150308.x

    authors: Tajik N,Singal D,Pourmand G,Ebrahimi-Rad M,Radjabzadeh M,Tavasoli P,Khosravi F,Nikbin B

    更新日期:2001-06-01 00:00:00

  • Epidemiology, risk factors, and impact of bacterial infections on outcomes for pancreatic grafts.

    abstract::We aimed to determine the epidemiology, risk factors, and impact of bacterial infection on pancreatic function after pancreas transplantation. Data for pancreas transplant recipients were retrospectively reviewed between 2000 and 2014 for at least 1 year. We collected and analyzed post-transplant data for bacterial in...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13333

    authors: Bodro M,Ferrer J,Ricart MJ,Sanclemente G,Linares L,Cervera C,Cofan F,Ventura-Aguiar P,Lopez-Boado MÁ,Marco F,Fuster J,García-Valdecasas JC,Moreno A

    更新日期:2018-08-01 00:00:00

  • Steroid withdrawal in kidney transplant recipients: is it a safe option?

    abstract::The long-term side effects of lifelong steroid immunosuppression are well documented, therefore, steroid withdrawal (SW) if safe would clearly be of benefit. From 1987-1996, 470 kidney transplants were performed at our institution. During this time period, steroid withdrawal was offered to a select group of patients (...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Sanfey H,Haussman G,Isaacs I,Ishitani M,Lobo P,McCullough C,Pruett T

    更新日期:1997-10-01 00:00:00

  • Molecular assessment of antibody-mediated rejection in human pancreas allograft biopsies.

    abstract::Pancreas transplant longevity is limited by immune rejection, which is diagnosed by graft biopsy using the Banff Classification. The histological criteria for antibody-mediated rejection (AMR) are poorly reproducible and inconsistently associated with outcome. We hypothesized that a 34-gene set associated with antibod...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.14065

    authors: Roufosse C,Drachenberg C,Renaudin K,Willicombe M,Toulza F,Dominy K,McLean A,Simmonds N,de Kort H,Cantarovitch D,Scalea J,Mengel M,Adam B

    更新日期:2020-11-01 00:00:00

  • Association between increased-risk donor social behaviors and recipient outcomes after heart transplantation.

    abstract:BACKGROUND:This study aims to investigate the association between social behaviors of increased-risk donors (IRD) and recipient outcomes after heart transplantation. METHODS:The United Network for Organ Sharing (UNOS) database was queried to identify patients who received a heart transplant between 2004 and 2015. Pati...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13787

    authors: Okoh AK,Chan O,Schultheis M,Gupta M,Shah A,Gold J,Russo MJ,Lee LY,Camacho M

    更新日期:2020-03-01 00:00:00

  • Outcome of lung transplantation in non-idiopathic pulmonary fibrosis interstitial lung disease.

    abstract::Lung transplantation remains the only curative treatment option for selected patients with end-stage interstitial lung disease (ILD). Candidate selection is impeded by patient heterogeneity, particularly in the subgroup of non-idiopathic pulmonary fibrosis (non-IPF) interstitial lung diseases. We performed a descripti...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13661

    authors: Bode H,Verleden SE,Wuyts WA,Yserbyt J,Verleden GM,Vos R

    更新日期:2019-10-01 00:00:00

  • Optimal timing for living-related liver transplantation in children.

    abstract:BACKGROUND:The pediatric end stage liver disease (PELD) score has been used widely to prioritize children awaiting cadaveric liver transplantation (LTx). To establish the objective parameter for optimal timing of living-related LTx (LRLTx), we have assessed our cases using the PELD score. METHODS:From 1997 to 2002, 24...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2004.00194.x

    authors: Kimura T,Hasegawa T,Sasaki T,Shimizu Y,Mushiake S,Fukuzawa M,Okada A

    更新日期:2004-10-01 00:00:00

  • Steroid-related complications in the cyclosporine era.

    abstract::Steroid withdrawal has potential risks (rejection) and benefits (fewer complications). Most data on steroid-related complications predates cyclosporine (CsA). We tabulated the incidence of posttransplant complications considered to be steroid-related in 748 adult kidney transplant recipients (with at least 1 year of f...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Fryer JP,Granger DK,Leventhal JR,Gillingham K,Najarian JS,Matas AJ

    更新日期:1994-06-01 00:00:00

  • Adverse drug reaction driven immunosuppressive drug manipulations: a single-center comparison of enteric-coated mycophenolate sodium vs. mycophenolate mofetil.

    abstract:UNLABELLED:Enteric-coated mycophenolate sodium (MPS) has been developed to help circumvent the upper gastrointestinal side-effects of mycophenolic acid by facilitating drug release in the small intestine. Many questions regarding the side-effect profile of MPS remain. Therefore, the purpose of this study is to review a...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2008.00820.x

    authors: Hardinger KL,Hebbar S,Bloomer T,Murillo D

    更新日期:2008-09-01 00:00:00

  • Prognostic role of pre-transplantation serum C-reactive protein levels in patients with acute leukemia undergoing myeloablative allogeneic stem cell transplantation.

    abstract::The aim of this study was to identify indicators of outcome prior to transplantation in allogeneic hematopoietic stem cell transplantation (HCT). Clinical data of 106 patients with acute leukemia were retrospectively analyzed. We examined the role of pre-conditioning serum C-reactive protein (CRP) and ferritin levels,...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12028

    authors: Akı ŞZ,Suyanı E,Bildacı Y,Çakar MK,Baysal NA,Sucak GT

    更新日期:2012-09-01 00:00:00

  • Plasma magnesium during human liver transplantation.

    abstract::Patients with severe liver disease and accompanying malnutrition may exhibit electrolyte disturbances including the magnesium balance. In 18 patients plasma magnesium (p-Mg) was determined at the start of the liver transplantation and during the anhepatic and reperfusion phases of the operation. The blood loss was 6.9...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Skak C,Ejlersen E,Mogensen T,Winkel P,Secher NH

    更新日期:1996-04-01 00:00:00

  • Surgical strategies for liver transplantation in the case of portal vein thrombosis--current role of cavoportal hemitransposition and renoportal anastomosis.

    abstract::Portal vein thrombosis (PVT), a common complication of end stage liver disease, is no longer considered a definite contraindication for liver transplantation (LTx). The clinical decision to perform an LTx in the case of PVT depends on the degree of PVT and the experience of the surgeon. Eversion thromboendovenectomy w...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-0012.2006.00560.x

    authors: Paskonis M,Jurgaitis J,Mehrabi A,Kashfi A,Fonouni H,Strupas K,Büchler MW,Kraus TW

    更新日期:2006-09-01 00:00:00

  • Cadaveric organ donor recruitment at Los Angeles County Hospital: improvement after formation of a structured clinical, educational and administrative service.

    abstract:BACKGROUND/AIMS:There remains a critical shortage of cadaveric organs. At a large inner city level one trauma centre, several strategies were devised and combined to (a). optimize the physiologic status of potential donors, (b). promote awareness of the donation process among health care professionals and (c). perform ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.17.s9.10.x

    authors: Roth BJ,Sher L,Murray JA,Belzberg H,Mateo R,Heeran A,Romero J,Mone T,Chan L,Selby R

    更新日期:2003-01-01 00:00:00

  • Higher dose of CD34+ peripheral blood stem cells is associated with better survival after haploidentical stem cell transplantation in pediatric patients.

    abstract::Haploidentical stem cell transplantation (SCT) is increasingly used to treat pediatric patients with malignant or nonmalignant hematological disorders. The CD34+ dose of bone marrow or peripheral blood stem cells (PBSCs) has been shown to be an important determinant of the transplant outcome in adults under various pr...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12880

    authors: Chen Y,Xu LP,Liu KY,Chen H,Chen YH,Zhang XH,Wang Y,Wang FR,Han W,Wang JZ,Yan CH,Huang XJ

    更新日期:2017-02-01 00:00:00

  • Open or laparoscopic mesh repair of incisional hernia in patients that underwent liver transplantation: A systematic review and proportional meta-analysis.

    abstract:BACKGROUND:Incisional hernias, that significantly affect the quality of life of patients, are common complications especially after major surgery, such as liver transplantation. The purpose of this meta-analysis is to outline the available evidence on the complications occurring after mesh implantation as a treatment o...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/ctr.14103

    authors: Frountzas M,Nikolaou C,Maris S,Stavrou E,Giannopoulos P,Schizas D,Stergios K,Toutouzas K

    更新日期:2020-12-01 00:00:00

  • Brain natriuretic peptide and right heart dysfunction after heart transplantation.

    abstract::Heart transplantation (HT) should normalize cardiac endocrine function, but brain natriuretic peptide (BNP) levels remain elevated after HT, even in the absence of left ventricular hemodynamic disturbance or allograft rejection. Right ventricle (RV) abnormalities are common in HT recipients (HTx), as a result of engra...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/ctr.12969

    authors: Talha S,Charloux A,Piquard F,Geny B

    更新日期:2017-06-01 00:00:00

  • De novo malignancy post-liver transplantation: a single center, population controlled study.

    abstract:BACKGROUND:With the growing numbers of liver transplant recipients, it is increasingly important to understand the risks of de novo malignancy after liver transplantation. AIM:To characterize the incidence of de novo malignancy after liver transplantation compared with a control non-transplant population. METHODS:We ...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/ctr.12171

    authors: Chatrath H,Berman K,Vuppalanchi R,Slaven J,Kwo P,Tector AJ,Chalasani N,Ghabril M

    更新日期:2013-07-01 00:00:00

  • Prevention of de novo hepatitis B infection after liver transplantation with allografts from hepatitis B core antibody positive donors.

    abstract::The frequent scarcity of organ donors has made it necessary to consider transplantation of organs that may have the potential to transmit hepatitis B virus (HBV) to the recipient. Previous reports have documented the probability of infection of particular recipient populations with transplanted livers from hepatitis B...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Dodson SF

    更新日期:2000-01-01 00:00:00

  • The association of acute rejection vs recurrent glomerular disease with graft outcomes after kidney transplantation.

    abstract:BACKGROUND:It has been shown that glomerulonephritis (GN) recurrence affects graft survival more than acute rejection. Thus, we assessed allograft survival after biopsy-confirmed diagnosis of acute rejection or recurrent GN in current era of immunosuppression. METHODS:Allograft survival following a biopsy diagnosis of...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13738

    authors: Singh T,Astor BC,Zhong W,Mandelbrot DA,Maursetter L,Panzer SE

    更新日期:2019-12-01 00:00:00

  • Comparative effects of renal transplantation and maintenance dialysis on arterial stiffness and left ventricular mass index.

    abstract:BACKGROUND:Arterial stiffness and left ventricular hypertrophy (LVH) are major independent risk factors for cardiovascular disease in healthy and renal population. In this study, we aimed to investigate comparative long-term effects of renal transplantation (RTx) and of hemodialysis (HD) on both arterial stiffness and ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2008.00794.x

    authors: Keven K,Calayoglu R,Sengul S,Dincer I,Kutlay S,Erturk S,Erbay B,Nergizoglu G

    更新日期:2008-05-01 00:00:00

  • Limitations of pediatric donor kidneys for transplantation.

    abstract:BACKGROUND:The shortage of grafts for kidney transplantation (Tx) has resulted in an expansion of criteria for pediatric donors. However, the limitations of pediatric donors for kidney Tx are not yet clearly established. We investigated the outcomes of recipients with pediatric kidney grafts from Colorado to elucidate ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Yagisawa T,Kam I,Chan L,Springer JW,Dunn S

    更新日期:1998-12-01 00:00:00

  • Interaction between panel reactive antibodies, auto- and cold reactive antibodies, and a positive B cell cross-match in renal and cardiac allograft survival.

    abstract::We analyzed the influence on allograft survival of pretransplant panel reactive antibodies (PRA) < 10%, PRA > 10%, autoantibodies, cold antibodies and a positive B cell crossmatch in 807 renal and 237 cardiac transplant recipients. Donors and recipients were predominantly of mixed ancestry (Khoi, San, Xhosa and Caucas...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Creemers P,Brink J,Kahn D

    更新日期:1997-04-01 00:00:00

  • Organ donation in Hawaii: impact of the final rule.

    abstract:BACKGROUND:In an effort to increase organ donation, the Department of Health and Human Services issued the Final Rule in 1998. The Health Care Financing Administration (HCFA) later required hospitals to notify organ procurement organizations (OPO) of all deaths and imminent deaths in order to remain eligible for Medica...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2002.01102.x

    authors: Higashigawa KH,Carroll C,Wong LL,Wong LM

    更新日期:2002-06-01 00:00:00

  • Growth of a nation part I: impact of organ donor obesity on whole-organ pancreas transplantation.

    abstract::Obesity has reached epidemic proportions in the USA. Consequently, there are an increasing number of potential organ donors that are obese, but would otherwise be appropriate donors for pancreas transplantation (PTx). This is a retrospective study of all PTx performed at Indiana University between 2003 and 2009 (n = 3...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2011.01419.x

    authors: Fridell JA,Mangus RS,Taber TE,Goble ML,Milgrom ML,Good J,Vetor R,Powelson JA

    更新日期:2011-05-01 00:00:00