Growth of a nation part I: impact of organ donor obesity on whole-organ pancreas transplantation.


:Obesity has reached epidemic proportions in the USA. Consequently, there are an increasing number of potential organ donors that are obese, but would otherwise be appropriate donors for pancreas transplantation (PTx). This is a retrospective study of all PTx performed at Indiana University between 2003 and 2009 (n = 308) comparing donors with body mass index (BMI) <25, 25-29.9, and ≥30 kg/m(2) . Data included recipient and donor demographics, seven and 90-d graft loss, one-yr pancreas, kidney (for simultaneous pancreas and kidney transplant only) and patient survival, causes of graft loss and death, peak amylase and lipase, length of stay, readmissions, complications, HbA1C, and c-peptide. Of the 308 donors, 84 (27%) were overweight and 43 (14%) were obese. The overweight donors were significantly older, and the obese donors had hypertension significantly more frequently than the other two groups. There were no significant differences in recipient transplant demographics. There was no significant difference in length of stay or 90-d readmissions, seven or 90-d pancreas graft loss, one-yr graft or patient survival, peak serum amylase or lipase, HbA1C, or c-peptide. The incidence of post-transplant technical, immunological, and infectious complications were similar. Although technically challenging, PTx of allografts from obese donors can be accomplished with similar results compared to normal BMI donors.


Clin Transplant


Clinical transplantation


Fridell JA,Mangus RS,Taber TE,Goble ML,Milgrom ML,Good J,Vetor R,Powelson JA




Has Abstract


2011-05-01 00:00:00












  • Living donor evaluation and exclusion: the Stanford experience.

    abstract:BACKGROUND:The proportion of prospective living donors disqualified for medical reasons is unknown. The objective of this study is to delineate and quantify specific reasons for exclusion of prospective living donors from kidney donation. METHODS:All adult prospective kidney donors who contacted our transplant program...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章


    authors: Lapasia JB,Kong SY,Busque S,Scandling JD,Chertow GM,Tan JC

    更新日期:2011-09-01 00:00:00

  • Short-term outcomes of en bloc combined heart and liver transplantation in the failing Fontan.

    abstract::Patients with failing Fontan physiology and liver cirrhosis are being considered for combined heart and liver transplantation. We performed a retrospective review of our experience with en bloc combined heart and liver transplantation in Fontan patients > 10 years old from 2006 to 18 per Institutional Review Board app...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章


    authors: Vaikunth SS,Concepcion W,Daugherty T,Fowler M,Lutchman G,Maeda K,Rosenthal DN,Teuteberg J,Woo YJ,Lui GK

    更新日期:2019-06-01 00:00:00

  • Serum globulin levels in predicting the extent of hepatic fibrosis in patients with recurrent post-transplant hepatitis C infection.

    abstract::The progression of HCV-related disease is particularly aggressive in the post-transplantation setting. Recipients with recurrent HCV infection undergo repeated liver biopsies in order to estimate disease progression. A strong association was found between serum immunoglobulins levels and hepatic fibrosis in non-transp...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Schmilovitz-Weiss H,Cohen M,Pappo O,Sulkes J,Braun M,Tur-Kaspa R,Ben-Ari Z

    更新日期:2007-05-01 00:00:00

  • Association of treatment with 15-deoxyspergualin and BK virus nephropathy in kidney allograft recipients.

    abstract:OBJECTIVE:BK virus nephropathy (BKVN) has been proposed as an important cause of allograft dysfunction and loss in kidney allograft recipient over the last decade. Intense immunosuppression and tubular injury have been shown to promote the replication of polyomavirus. 15-deoxyspergualin (DSG), an effective immunosuppre...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Shi Y,Moriyama T,Namba Y,Yamanaka M,Hanafuse T,Imamura R,Ichimaru N,Oka K,Kyo M,Tian Y,Takahara S,Ichikawa S,Okuyama A

    更新日期:2007-07-01 00:00:00

  • Candida infections in solid organ transplantation: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.

    abstract::These updated guidelines from the American Society of Transplantation Infectious Diseases Community of Practice provide recommendations for the diagnosis and management of Candida infections in solid organ transplant recipients. Candida infections manifest primarily as candidemia and invasive candidiasis and cause con...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Aslam S,Rotstein C,AST Infectious Disease Community of Practice.

    更新日期:2019-09-01 00:00:00

  • Successful pancreas transplantation alone is associated with excellent self-identified health score and glucose control: A retrospective study from a high-volume center in the United States.

    abstract:BACKGROUND:The benefits of pancreas transplantation are often difficult to measure. Here, we sought to determine the difference in quality of life for diabetic patients with and without a functional pancreas transplant alone (PTA). METHODS:Pancreas transplant alone cases from 1993 to 2015 were considered. An IRB-appro...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Scalea JR,Pettinato L,Fiscella B,Bartosic A,Piedmonte A,Paran J,Todi N,Siskind EJ,Bartlett ST

    更新日期:2018-02-01 00:00:00

  • Marijuana use should not preclude consideration for kidney transplantation.

    abstract::Transplant eligibility for tobacco and/or marijuana using candidates varies among transplant centers. This study compared the impact of marijuana use and tobacco use on kidney transplant recipient outcomes. Kidney transplant recipients at a single center from 2001 to 2015 were reviewed for outcomes of all-cause graft ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Fabbri KR,Anderson-Haag TL,Spenningsby AM,Israni A,Nygaard RM,Stahler PA

    更新日期:2019-10-01 00:00:00

  • The role of tacrolimus in adult kidney transplantation: a review.

    abstract::The use of tacrolimus (FK506) in adult kidney-transplant recipients has been the subject of a number of single- and multi-center studies. This review article focuses on those studies in which tacrolimus was used either as rescue therapy in patients who developed refractory rejection on cyclosporine (CyA)-based regimen...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审


    authors: Laskow DA,Neylan JF 3rd,Shapiro RS,Pirsch JD,Vergne-Marini PJ,Tomlanovich SJ

    更新日期:1998-12-01 00:00:00

  • Cervical human papillomavirus infection in the early postoperative period after liver transplantation: Prevalence, risk factors, and concordance with anal infections.

    abstract::Solid organ transplant recipients are at increased risk of developing several human papillomavirus (HPV)-related malignancies, including cervical and anal cancers. The purpose of this prospective study was to assess the initial prevalence and risk factors for high-risk HPV (HR-HPV) cervical infections in liver transpl...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Grąt K,Grąt M,Wronka KM,Pietrzak B,Suchońska B,Walter de Walthoffen S,Młynarczyk G,Krawczyk M,Wielgoś M

    更新日期:2017-03-01 00:00:00

  • Initial experience using histidine-tryptophan-ketoglutarate solution in clinical pancreas transplantation.

    abstract:BACKGROUND:The colloid-based University of Wisconsin (UW) preservation solution has been used extensively in clinical pancreas transplantation. Experimental studies support the use of the crystalloid-based histidine-tryptophan-ketoglutarate (HTK) preservation solution for this purpose. AIM:We report our initial experi...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Potdar S,Malek S,Eghtesad B,Shapiro R,Basu A,Patel K,Broznick B,Fung J

    更新日期:2004-12-01 00:00:00

  • Ethnicity, medical insurance, and living kidney donation.

    abstract:BACKGROUND:Relationships between race/ethnicity, recipient medical insurance, and living donor kidney transplantation (LKT) are incompletely described. METHODS:Associations between medical insurance and LKT were assessed in 447 recipients at a southeastern US transplant center. Primary and secondary payers were includ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Reeves-Daniel AM,Farney AC,Fletcher AJ,Assimos D,Westcott C,Rogers J,Stratta RJ,Rocco MV,Freedman BI

    更新日期:2013-07-01 00:00:00

  • Ten-year protocol biopsy findings of renal allografts in the calcineurin inhibitor era.

    abstract::Ten-year protocol biopsies were performed in 16 patients treated with calcineurin inhibitor (CNI) continuously. All kidney grafts were functioning well at the time of biopsy with the mean serum creatinine level of 1.6 +/- 0.8 mg/dL. The specimen of biopsy showed various degrees of tissue injury. According to the Banff...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Okamoto M,Akioka K,Ushigome H,Higuchi A,Nobori S,Ogino S,Uryuhara K,Kaihara S,Hatta T,Urasaki K,Yoshimura N

    更新日期:2006-01-01 00:00:00

  • Social support and immunosuppressant therapy adherence among adult renal transplant recipients.

    abstract:BACKGROUND:The purpose of the study was to assess the relationship between social support and immunosuppressant therapy adherence among adult renal transplant recipients. METHODS:A cross-sectional, survey design was employed. Mailed questionnaires were used to collect data from 81 recipients, and included the Immunosu...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Chisholm-Burns MA,Spivey CA,Wilks SE

    更新日期:2010-05-01 00:00:00

  • Efficacy and side-effects of cyclosporine dose monitoring with levels 6 h after the morning dose in heart transplant patients.

    abstract::The purpose of this study was to compare CsA dose monitoring with trough levels (T0) vs. levels obtained 6 h after the morning dose of CsA (T6), with respect to the incidence of acute rejection and renal dysfunction, and the cumulative dose, as well as the cost of CsA after heart transplantation. Twenty consecutive ad...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Cantarovich M,Besner JG,Fitchett DH,Latter DA

    更新日期:1997-10-01 00:00:00

  • Granulomatous tubulointerstitial nephritis in a renal allograft: three cases report and review of literature.

    abstract::Granulomatous interstitial nephritis (GIN) is a rare histologic diagnosis in renal allografts. We report three cases with GIN. Case 1: a 37-yr-old woman received a kidney from her mother. On follow-up 15 months later, serum creatinine was increased and a graft biopsy showed epithelioid granuloma in the center of massi...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审


    authors: Hotta K,Fukasawa Y,Sasaki H,Seki T,Togashi M,Harada H

    更新日期:2012-07-01 00:00:00

  • Technique of bile duct reconstruction and management of biliary complications in right lobe living donor liver transplantation.

    abstract::From December 1999 to January 2002, 50 right lobe living donor liver transplantations were performed. The donor operations included an intraoperative cholangiography to elicit variations in bile duct anatomy. The biliary reconstruction was done whenever possible as an end-to-end microanastomosis of the donor right hep...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Settmacher U,Steinmüller TH,Schmidt SC,Heise M,Pascher A,Theruvath T,Hintze R,Neuhaus P

    更新日期:2003-02-01 00:00:00

  • Heart transplantation in the early phase of the COVID-19 pandemic: A single-center case series.

    abstract::The infectious disease coronavirus disease 2019 (COVID-19) was declared a pandemic by the World Health Organization in March 2020. The impact of COVID-19 on solid organ transplantations, including heart transplantation, is currently unclear. Many transplant programs have been forced to swiftly re-evaluate and adapt th...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Hsu JJ,Al-Saffar F,Ardehali R,Baas AS,Carlson M,Cruz D,Deng M,Fan A,Fraschilla S,Gaynor P,Kamath M,Kubak BM,Schaenman J,Stimpson E,Vucicevic D,Ardehali A,Nsair A

    更新日期:2020-09-01 00:00:00

  • Comparison of nutritional status in hemodialysis patients with and without failed renal allografts.

    abstract:BACKGROUND:The survival of patients returning to hemodialysis (HD) following kidney transplant failure is unfavorable. However, the factors responsible for this poor outcome are largely unknown; chronic inflammation due to failed allograft and malnutrition may contribute to morbidity and mortality. We aimed to compare ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Yelken BM,Gorgulu N,Caliskan Y,Yazici H,Turkmen A,Yildiz A,Sever MS

    更新日期:2010-07-01 00:00:00

  • Depressive symptoms and mortality in lung transplant.

    abstract:OBJECTIVE:To determine whether depressive symptoms predicted survival before and after lung transplantation. We hypothesized that depressive symptoms might predict survival of wait-listed patients, but would not predict survival post-transplant. METHODS:This was a prospective, longitudinal study. Participants complete...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Evon DM,Burker EJ,Galanko JA,Dedert E,Egan TM

    更新日期:2010-09-01 00:00:00

  • Multicultural issues in organ transplantation: the influence of patients' cultural perspectives on compliance with treatment.

    abstract::The potential influence of racially or ethnically diverse cultural perspectives on patient compliance with post-transplant treatments is discussed. Domains of competency regarding culturally sensitive clinical practice are outlined to assist providers in better understanding the perspectives that may influence the vie...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Prieto LR,Miller DS,Gayowski T,Marino IR

    更新日期:1997-12-01 00:00:00

  • Elevated calcium phosphate product after renal transplantation is a risk factor for graft failure.

    abstract:BACKGROUND:Abnormal mineral metabolism is not uncommon after renal transplant (TXP). In dialysis patients, elevated serum phosphorous (P), calcium (Ca), CaP product, and parathyroid hormone (PTH) are associated with increased morbidity and mortality. The effect of these abnormalities on recipient and graft survival aft...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Egbuna OI,Taylor JG,Bushinsky DA,Zand MS

    更新日期:2007-07-01 00:00:00

  • LabMELD-based organ allocation increases total costs of liver transplantation: a single-center experience.

    abstract:INTRODUCTION:In 2006, model for end-stage liver disease (MELD)-based allocation was implemented in the Eurotransplant (ET) region. Sick patients, who in general require more resources, are prioritized. In this analysis, the effect of MELD on costs for liver transplantation (LTx) was assessed. METHODS:Total costs for L...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章


    authors: Bruns H,Hillebrand N,Schneider T,Hinz U,Fischer L,Schmidt J,Goldschmidt AJ,Schemmer P

    更新日期:2011-09-01 00:00:00

  • Outcomes, complications, and economic impact of ABO-incompatible living kidney transplantation: A single-center Japanese cohort study.

    abstract::ABO-incompatible kidney transplantation (ABO-ILKT) has been reported to have a higher rate of early complications and higher medical costs than ABO-compatible kidney transplantation (ABO-CLKT). We aimed to compare the clinical outcomes, complications, and medical costs between ABO-ILKTs and ABO-CLKTs at 2 years post-t...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章


    authors: Kakuta Y,Okumi M,Unagami K,Iizuka J,Takagi T,Ishida H,Tanabe K

    更新日期:2019-06-01 00:00:00

  • Assessment of liver graft function and regeneration by galactosyl-human serum albumin (99mTc-GSA) liver scintigraphy in adult living-donor liver transplantation.

    abstract:BACKGROUND:In adult living-donor liver transplantation (LDLT), the assessment of the graft functional reserve is very important. We evaluated the graft functional reserve by technetium-99m-diethylenetriaminepenta-acetic acid-galactosyl-human serum albumin ((99m)Tc-GSA) liver scintigraphy. PATIENTS AND METHOD:From May ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Iida T,Isaji S,Yagi S,Hori T,Taniguchi K,Ohsawa I,Mizuno S,Usui M,Sakurai H,Yamagiwa K,Yamakado K,Uemoto S

    更新日期:2009-03-01 00:00:00

  • Psychosocial outcome of living donors after living donor liver transplantation: a pilot study.

    abstract::In view of the scarcity of organ resources available for transplantation, living donor liver transplantation (LDLT) is gaining growing importance in the treatment of chronically terminal liver diseases. In the period between December 1999 and October 2000, 47 potential living liver donors were evaluated and 24 right h...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Walter M,Bronner E,Pascher A,Steinmüller T,Neuhaus P,Klapp BF,Danzer G

    更新日期:2002-10-01 00:00:00

  • De novo donor-specific HLA antibodies in heart transplantation: Do transient de novo DSA confer the same risk as persistent de novo DSA?

    abstract:BACKGROUND:It is estimated that 25%-35% of heart transplant recipients develop de novo donor-specific antibodies (dnDSA). One factor that appears to play a role in clinical outcomes is DSA persistence. The objective of this study was to determine the incidence of transient and persistent dnDSA in a Canadian heart trans...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Moayedi Y,Fan CS,Tinckam KJ,Ross HJ,McCaughan JA

    更新日期:2018-11-01 00:00:00

  • Plasma magnesium during human liver transplantation.

    abstract::Patients with severe liver disease and accompanying malnutrition may exhibit electrolyte disturbances including the magnesium balance. In 18 patients plasma magnesium (p-Mg) was determined at the start of the liver transplantation and during the anhepatic and reperfusion phases of the operation. The blood loss was 6.9...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Skak C,Ejlersen E,Mogensen T,Winkel P,Secher NH

    更新日期:1996-04-01 00:00:00

  • Single-dose rATG induction at renal transplantation: superior renal function and glucoregulation with less hypomagnesemia.

    abstract:UNLABELLED: BACKGROUND:Rabbit anti-thymocyte globulin (rATG) induction reduces reperfusion injury and improves renal function in kidney recipients by means of properties unrelated to T-cell lysis. Here, we analyze intensive rATG induction (single dose, rATG(S) , vs. divided dose, rATG(D) ) for improved renal function ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,随机对照试验


    authors: Stevens RB,Lane JT,Boerner BP,Miles CD,Rigley TH,Sandoz JP,Nielsen KJ,Skorupa JY,Skorupa AJ,Kaplan B,Wrenshall LE

    更新日期:2012-01-01 00:00:00

  • Uncontrolled donation after circulatory death improves access to kidney transplantation: A decision analysis.

    abstract:AIM:Uncontrolled donation after cardiac death (uDCD) remains an underutilized source of kidney allografts in the United States. The objective of this study was to estimate the impact of the implementation of a uDCD program on transplantation rates and long-term survival for patients with end-stage renal disease (ESRD) ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Choudhury RA,Prins K,Dor Y,Moore HB,Yaffe H,Nydam TL

    更新日期:2020-07-01 00:00:00

  • Religious beliefs and opinions on clinical xenotransplantation--a survey of university students from Kenya, Sweden and Texas.

    abstract::This study investigated the association between religious beliefs and opinions on xenotransplantation among students from three different countries. A lower proportion of religious students accepted xenotransplantation than did non-religious students. A higher proportion of Protestant students seemed to accept xenotra...

    journal_title:Clinical transplantation

    pub_type: 杂志文章


    authors: Hagelin J,Hau J,Schapiro SJ,Suleman MA,Carlsson HE

    更新日期:2001-12-01 00:00:00