Severe late acute allograft rejection in a child after living-related auxiliary partial orthotopic liver transplantation for ornithine transcarbamylase deficiency.

Abstract:

:Auxiliary liver transplantation (ALT) is known to correct liver-based metabolic disorders. However, it remains unclear whether the presence of a native liver influences the long-term prognosis of ALT for metabolic diseases. We reported on a 4-yr-old girl who had undergone living-related auxiliary partial orthotopic liver transplantation (APOLT) for ornithine transcarbamylase deficiency and experienced severe late acute rejection 18 months after liver transplantation, during weaning of immunosuppressive agents. Results of histological analysis of the graft indicated very severe acute rejection (rejection activity index, 9/9), and computed tomography revealed graft liver atrophy. These observations suggest the possibility that severe rejection might occur in APOLT, especially during weaning of immunosuppression.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Komatsu H,Inui A,Fujisawa T,Sogo T,Miyagawa Y,Inui M,Uemoto S,Inomata Y,Tanaka K

doi

10.1034/j.1399-0012.1999.130404.x

subject

Has Abstract

pub_date

1999-08-01 00:00:00

pages

300-4

issue

4

eissn

0902-0063

issn

1399-0012

journal_volume

13

pub_type

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