Kidney allograft subclinical rejection modulates systemic inflammation measured by C-reactive protein at 1 year after transplantation.

Abstract:

:Kidney allograft inflammation is associated with proinflammatory modifications of peripheral blood mononuclear cells, suggesting that renal inflammation contributes to systemic inflammation. Thus, the aim of this study was to evaluate the relationship between subclinical inflammation in surveillance biopsies performed at 1 year and systemic inflammation assessed by C-reactive protein (CRP) levels at the time of biopsy. We analyzed 544 surveillance biopsies performed at 1 year that were classified as normal (n = 368), borderline (n = 148), or subclinical rejection (SCR) (n = 28). CRP levels were divided into quartiles. Patients in 1st, 2nd, and 3rd quartile were classified as low CRP (n = 408) and patients in the 4th quartile as high CRP (n = 136). Univariate analysis showed that the proportion of patients with SCR was higher in the high CRP group (10.3% vs 3.4%, P = 0.0067). Multivariate analysis showed that independent predictors of high CRP were body mass index (odds ratio [OR] 1.072 and 95% confidence interval [CI] 1.027-1.119), a positive urine culture at the day of the biopsy (OR 2.760 and 95% CI 1.205-6.323), and the presence of SCR at 1-year surveillance biopsy (OR 7.260 and 95% CI 3.530-14.935). In summary, we describe that subclinical acute rejection constitutes an independent predictor of systemic inflammation as measured by CRP.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

García-Carro C,Dörje C,Åsberg A,Midtvedt K,Scott H,Reinholt FP,Holdaas H,Reisaeter AV,Seron D

doi

10.1111/ctr.13196

subject

Has Abstract

pub_date

2018-03-01 00:00:00

pages

e13196

issue

3

eissn

0902-0063

issn

1399-0012

journal_volume

32

pub_type

杂志文章
  • Interaction between panel reactive antibodies, auto- and cold reactive antibodies, and a positive B cell cross-match in renal and cardiac allograft survival.

    abstract::We analyzed the influence on allograft survival of pretransplant panel reactive antibodies (PRA) < 10%, PRA > 10%, autoantibodies, cold antibodies and a positive B cell crossmatch in 807 renal and 237 cardiac transplant recipients. Donors and recipients were predominantly of mixed ancestry (Khoi, San, Xhosa and Caucas...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Creemers P,Brink J,Kahn D

    更新日期:1997-04-01 00:00:00

  • Molecular assessment of antibody-mediated rejection in human pancreas allograft biopsies.

    abstract::Pancreas transplant longevity is limited by immune rejection, which is diagnosed by graft biopsy using the Banff Classification. The histological criteria for antibody-mediated rejection (AMR) are poorly reproducible and inconsistently associated with outcome. We hypothesized that a 34-gene set associated with antibod...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.14065

    authors: Roufosse C,Drachenberg C,Renaudin K,Willicombe M,Toulza F,Dominy K,McLean A,Simmonds N,de Kort H,Cantarovitch D,Scalea J,Mengel M,Adam B

    更新日期:2020-11-01 00:00:00

  • Immunosuppressive standards in simultaneous kidney-pancreas transplantation.

    abstract::Simultaneous pancreas-kidney transplantation is an established procedure for patients with type I diabetes and end-stage renal disease. Continuous advances in the operation techniques with consequent reduction of perioperative morbidity and mortality and the introduction of modern immunosuppressive agents improved not...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-0012.2006.00599.x

    authors: Schmied BM,Müller SA,Mehrabi A,Welsch T,Büchler MW,Zeier M,Schmidt J

    更新日期:2006-01-01 00:00:00

  • Predicting and preventing readmissions in kidney transplant recipients.

    abstract::A lack of research exploring post-transplant process optimization to reduce readmissions and increasing readmission rates at our center from 2009 to 2013 led to this study, aimed at assessing the effect of patient and process factors on 30-d readmission rates after kidney transplantation. This was a retrospective case...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12748

    authors: Covert KL,Fleming JN,Staino C,Casale JP,Boyle KM,Pilch NA,Meadows HB,Mardis CR,McGillicuddy JW,Nadig S,Bratton CF,Chavin KD,Baliga PK,Taber DJ

    更新日期:2016-07-01 00:00:00

  • Limitations of pediatric donor kidneys for transplantation.

    abstract:BACKGROUND:The shortage of grafts for kidney transplantation (Tx) has resulted in an expansion of criteria for pediatric donors. However, the limitations of pediatric donors for kidney Tx are not yet clearly established. We investigated the outcomes of recipients with pediatric kidney grafts from Colorado to elucidate ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Yagisawa T,Kam I,Chan L,Springer JW,Dunn S

    更新日期:1998-12-01 00:00:00

  • Presentation and outcomes for organ donation in patients with cerebral gunshot wounds.

    abstract::This study was undertaken to examine the presentation and outcomes relative to solid organ donation in patients with fatal cerebral gunshot wounds at a level I trauma center over a 7-year period. A retrospective chart review of patients with such wounds over the years 1993-99 was completed. Eighty (80) patients were c...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2001.00002.x

    authors: Croezen DH,Van Natta TL

    更新日期:2001-01-01 00:00:00

  • Differential gene expression in non-adherent heart transplant survivors: Implications for regulatory T-cell expression.

    abstract::Survival despite prolonged non-adherence with immunosuppression is rare but has been reported in kidney, lung, and liver transplantation. Its occurrence in heart transplantation is quite rare. Our study was prompted by an index patient who survived despite prolonged medication non-adherence. Prospective consent and bl...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13834

    authors: Baran DA,Rao P,Deo D,Zucker MJ

    更新日期:2020-05-01 00:00:00

  • How does age affect the outcome of kidney transplantation in elderly recipients?

    abstract::The aging of the on-dialysis population raises the issue of whether to propose elderly patients for kidney transplantation and how to manage their immunosuppression. This study aimed to analyze the outcome of kidney transplantation on an Italian series of elderly recipients. We included in this retrospective study all...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13036

    authors: Neri F,Furian L,Cavallin F,Ravaioli M,Silvestre C,Donato P,La Manna G,Pinna AD,Rigotti P

    更新日期:2017-10-01 00:00:00

  • Sequential biological immunosuppression. Induction therapy with rabbit antithymocyte globulin.

    abstract::This paper describes 108 consecutively treated patients receiving 109 cadaveric (CD) and living donor (LD) renal allografts using a protocol of quadruple sequential immunosuppression with a rabbit anti-human thymocyte IgG (Thymoglobuline), azathioprine, tapering corticosteroids, and delayed introduction of cyclosporin...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Guttmann RD,Flemming C

    更新日期:1997-06-01 00:00:00

  • The Transplant Palliative Care Clinic: An early palliative care model for patients in a transplant program.

    abstract::Although patients within a transplant program are awaiting or have received disease modifying or curative treatment, they are also facing advanced illness and the possibility of death. The involvement of specialized palliative care services for these patients may improve symptom management and facilitate advance care ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12838

    authors: Wentlandt K,Dall'Osto A,Freeman N,Le LW,Kaya E,Ross H,Singer LG,Abbey S,Clarke H,Zimmermann C

    更新日期:2016-12-01 00:00:00

  • The curative treatment of familial hypercholesterolemia: Liver transplantation.

    abstract:BACKGROUND:Familial hypercholesterolemia (FH) is an autosomal dominant genetic disorder characterized by premature mortal cardiovascular complications. Liver transplantation (LT) is the only curative treatment option. In this study, the long-term clinical follow-up data of 8 patients who underwent LT with a diagnosis o...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13730

    authors: Gulsoy Kirnap N,Kirnap M,Bascil Tutuncu N,Moray G,Haberal M

    更新日期:2019-12-01 00:00:00

  • Brain natriuretic peptide and right heart dysfunction after heart transplantation.

    abstract::Heart transplantation (HT) should normalize cardiac endocrine function, but brain natriuretic peptide (BNP) levels remain elevated after HT, even in the absence of left ventricular hemodynamic disturbance or allograft rejection. Right ventricle (RV) abnormalities are common in HT recipients (HTx), as a result of engra...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/ctr.12969

    authors: Talha S,Charloux A,Piquard F,Geny B

    更新日期:2017-06-01 00:00:00

  • Outcomes at 7 years post-transplant in black vs nonblack kidney transplant recipients administered belatacept or cyclosporine in BENEFIT and BENEFIT-EXT.

    abstract::Clinical outcomes are generally worse for black vs nonblack renal allograft recipients. In BENEFIT and BENEFIT-EXT, recipients were randomized to belatacept more intense-based, belatacept less intense-based, or cyclosporine-based immunosuppression. At year 7, belatacept was associated with superior graft survival vs c...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/ctr.13225

    authors: Florman S,Vincenti F,Durrbach A,Abouljoud M,Bresnahan B,Garcia VD,Mulloy L,Rice K,Rostaing L,Zayas C,Calderon K,Meier-Kriesche U,Polinsky M,Yang L,Medina Pestana J,Larsen CP

    更新日期:2018-04-01 00:00:00

  • Peritoneal metastasis of intracranial glioblastoma via a ventriculoperitoneal shunt preventing organ retrieval: case report and review of the literature.

    abstract::The case of patient with glioblastoma metastatic to the peritoneal cavity 9 months after ventriculoperitoneal shunt surgery precluding cadaver organ procurement is presented. Even though central nervous tumors rarely metastasize spontaneously, the literature indicates that systemic metastases are related to previous s...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:

    authors: Fecteau AH,Penn I,Hanto DW

    更新日期:1998-08-01 00:00:00

  • Importance of bone marrow cell dose in bone marrow transplantation.

    abstract::The importance of the size of the infused marrow cell dose (MCD) was investigated in 274 patients undergoing allogeneic BMT between 1975 and 1990. Among those, 65 had acute myelogenous leukemia (AML), 79 acute lymphoblastic leukemia (ALL), 58 chronic myelogenous leukemia (CML) and 25 severe aplastic anemia (SAA). MC...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Paulin T

    更新日期:1992-02-01 00:00:00

  • Prevention of de novo hepatitis B infection after liver transplantation with allografts from hepatitis B core antibody positive donors.

    abstract::The frequent scarcity of organ donors has made it necessary to consider transplantation of organs that may have the potential to transmit hepatitis B virus (HBV) to the recipient. Previous reports have documented the probability of infection of particular recipient populations with transplanted livers from hepatitis B...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Dodson SF

    更新日期:2000-01-01 00:00:00

  • First human double hand transplantation: efficacy of a conventional immunosuppressive protocol.

    abstract::Based on the results achieved in single human hand transplantations, we decided to perform the first double hand transplantation with a conventional immunosuppressive protocol in a patient with a high potential for functional recovery. Two years after transplantation the efficacy and the safety of this immunosuppressi...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2003.00005.x

    authors: Petruzzo P,Revillard JP,Kanitakis J,Lanzetta M,Hakim NS,Lefrançois N,Owen E,Dubernard JM

    更新日期:2003-10-01 00:00:00

  • Current concepts and systematic review of vascularized composite allotransplantation of the abdominal wall.

    abstract:INTRODUCTION:Abdominal wall vascularized composite allotransplantation (AW-VCA) is a rarely utilized technique for large composite abdominal wall defects. The goal of this article is to systematically review the literature and current concepts of AW-VCA, outline the challenges ahead, and provide an outlook for the futu...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/ctr.12243

    authors: Berli JU,Broyles JM,Lough D,Shridharani SM,Rochlin D,Cooney DS,Lee WP,Brandacher G,Sacks JM

    更新日期:2013-11-01 00:00:00

  • Marijuana use should not preclude consideration for kidney transplantation.

    abstract::Transplant eligibility for tobacco and/or marijuana using candidates varies among transplant centers. This study compared the impact of marijuana use and tobacco use on kidney transplant recipient outcomes. Kidney transplant recipients at a single center from 2001 to 2015 were reviewed for outcomes of all-cause graft ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13706

    authors: Fabbri KR,Anderson-Haag TL,Spenningsby AM,Israni A,Nygaard RM,Stahler PA

    更新日期:2019-10-01 00:00:00

  • Comparison of nutritional status in hemodialysis patients with and without failed renal allografts.

    abstract:BACKGROUND:The survival of patients returning to hemodialysis (HD) following kidney transplant failure is unfavorable. However, the factors responsible for this poor outcome are largely unknown; chronic inflammation due to failed allograft and malnutrition may contribute to morbidity and mortality. We aimed to compare ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2009.01097.x

    authors: Yelken BM,Gorgulu N,Caliskan Y,Yazici H,Turkmen A,Yildiz A,Sever MS

    更新日期:2010-07-01 00:00:00

  • Clinical analysis of living donor liver transplantation in patients with portal vein thrombosis.

    abstract::The aim of this study was to improve outcomes in living donor liver transplantation (LDLT) patients with portal vein thrombosis (PVT). Of 246 adult patients who underwent LDLT with a right lobe graft between January 2000 and May 2007, PVT was diagnosed in 50 patients (20.3%), who were further subdivided into partial (...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2010.01217.x

    authors: Kim SJ,Kim DG,Park JH,Moon IS,Lee MD,Kim JI,Yoon YC,Yoo YK

    更新日期:2011-01-01 00:00:00

  • Complications related to totally implantable venous access devices in children and adults following lung transplantation.

    abstract:INTRODUCTION:Totally implantable venous access devices (TIVADs) are the preferred devices for patients with advanced lung disease who require long-term venous access. The primary purpose of this study was to describe the natural history of TIVADs left in place at the time of transplant. METHODS:This multicenter retros...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,多中心研究

    doi:10.1111/ctr.13465

    authors: Cho JK,Acord M,Goldfarb SB,Reddy SN,Goldberg HJ,Courtwright AM

    更新日期:2019-02-01 00:00:00

  • Psychosocial outcome of living donors after living donor liver transplantation: a pilot study.

    abstract::In view of the scarcity of organ resources available for transplantation, living donor liver transplantation (LDLT) is gaining growing importance in the treatment of chronically terminal liver diseases. In the period between December 1999 and October 2000, 47 potential living liver donors were evaluated and 24 right h...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2002.02002.x

    authors: Walter M,Bronner E,Pascher A,Steinmüller T,Neuhaus P,Klapp BF,Danzer G

    更新日期:2002-10-01 00:00:00

  • The impact of diabetes mellitus and glycemic control on clinical outcomes following liver transplant for hepatitis C.

    abstract::Hepatitis C is the leading indication for liver transplantation in the USA and recurrence is universal. The impact of preexisting diabetes, new-onset diabetes after transplant (NODAT), and glycemic control on fibrosis progression has not been studied. This retrospective longitudinal cohort study included adult liver r...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12391

    authors: Morbitzer KA,Taber DJ,Pilch NA,Meadows HB,Fleming JN,Bratton CF,McGillicuddy JW,Baliga PK,Chavin KD

    更新日期:2014-08-01 00:00:00

  • Concerns regarding the financial aspects of kidney transplantation: perspectives of pre-transplant patients and their family members.

    abstract:BACKGROUND:African American and non-African American pre-transplant patients' and their families' concerns about the financial costs of kidney transplantation have not been well studied. METHODS:We conducted structured group interviews among pre-transplant patients (seven African American, five non-African American) a...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12428

    authors: Ganji S,Ephraim PL,Ameling JM,Purnell TS,Lewis-Boyer LL,Boulware LE

    更新日期:2014-10-01 00:00:00

  • A peculiar vacuolization in the kidney transplant of a child treated with tacrolimus.

    abstract::Tacrolimus (TAC) is a useful immunosuppressive agent in the prevention of rejection. However, the blood level between its therapeutic and toxic levels is narrow such that its nephrotoxicity is a problem. Moreover, its bioavailability and pharmacokinetics are highly variable. We experienced a case of acute nephrotoxici...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2000.0140s3030.x

    authors: Watanabe S,Yamaguchi Y,Hattori M,Chikamoto H,Matsumoto N,Suzuki T,Oonishi M,Horita S,Tokumoto T,Tanabe K,Shiraga H,Toma H,Ito K

    更新日期:2000-01-01 00:00:00

  • Outcome of kidney transplant in primary, repeat, and kidney-after-nonrenal solid-organ transplantation: 15-year analysis of recent UNOS database.

    abstract::The number of nonrenal solid-organ transplants increased substantially in the last few decades. Many of these patients develop renal failure and receive kidney transplantation. The aim of this study was to evaluate patient and kidney allograft survival in primary, repeat, and kidney-after-nonrenal organ transplantatio...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13108

    authors: El-Husseini A,Aghil A,Ramirez J,Sawaya B,Rajagopalan N,Baz M,Mei X,Davenport DL,Gedaly R

    更新日期:2017-11-01 00:00:00

  • Outcomes of antiviral treatment in hepatitis C virus liver transplant patients off immunosuppression in the direct acting antivirals era: A case series.

    abstract:BACKGROUND:Clearance of hepatitis C virus (HCV) under antiviral therapy, including direct-acting antivirals (DAAs), has been associated with higher risk of rejection. Whether patients who are not on immunosuppression (IS) during DAA therapy are at higher risk of rejection is unknown. METHODS:Four transplant recipients...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13303

    authors: Campos-Varela I,Agudelo EZ,Terrault NA

    更新日期:2018-07-01 00:00:00

  • After discontinuation of calcineurin inhibitors, tapering of mycophenolate mofetil further impairs donor-directed cytotoxicity.

    abstract:BACKGROUND:Recently, we described a significant decrease in donor-specific cytotoxic T-lymphocyte precursor frequency (CTLpf) after discontinuation of calcineurin inhibitors (CNI), while the proliferative capacity in mixed lymphocyte culture (MLC), and the number of interferon-gamma (IFN-gamma) producing cells (pc) in ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2007.00754.x

    authors: van Besouw NM,van de Wetering J,van der Mast BJ,de Kuiper R,Baan CC,Weimar W

    更新日期:2008-03-01 00:00:00

  • Short- and midterm results for internal jugular vein extension for short right renal vein kidney transplant.

    abstract::Renal transplantation remains the definitive treatment for end-stage renal disease (ESRD). The shorter renal vein in right donor nephrectomies is associated with higher incidence of technical failure. We present here our experience with autologous internal jugular vein (IJV) conduits to facilitate living-donor transpl...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/ctr.13312

    authors: Lu T,Yi SG,Bismuth J,Knight RJ,Gaber AO,Bechara CF

    更新日期:2018-08-01 00:00:00