Vitamin D as a risk factor for patient survival after kidney transplantation: A prospective observational cohort study.

Abstract:

BACKGROUND:Short-term survival after kidney transplantation is excellent, but long-term survival remains low and is equivalent to non-end-stage renal disease patients with many invasive malignancies. The aim of the study was to explore vitamin D status in the early phase after transplantation as a prognostic marker for long-term graft and patient survival. METHODS:All first-time kidney transplant recipients between October 2007 and October 2012 in Norway were included. Vitamin D was measured 10 weeks post-transplant. Information on graft failure and death was obtained from the Norwegian Renal Registry. RESULTS:Seven hundred and sixty-two first-time kidney transplant recipients were included, with a median age of 57 years and a median follow-up of 82 months. In the follow-up period, there were 172 graft failures (23%) and 118 deaths (15%). Eighty-six percent of the transplant recipients with sufficient vitamin D levels were alive with a well-functioning graft after 5 years using Kaplan-Meier survival estimates, compared with 79% and 76% of the patients with vitamin D deficiency and insufficiency, respectively (P = 0.006). CONCLUSION:In a nation-wide cohort of 762 first-time kidney transplant recipients, long-term graft and patient survival were better in recipients with vitamin D sufficiency 10 weeks post-transplant compared with those with vitamin D deficiency and insufficiency.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Thorsen IS,Bleskestad IH,Åsberg A,Hartmann A,Skadberg Ø,Brede C,Ueland T,Pasch A,Reisaeter AV,Gøransson LG

doi

10.1111/ctr.13517

subject

Has Abstract

pub_date

2019-05-01 00:00:00

pages

e13517

issue

5

eissn

0902-0063

issn

1399-0012

journal_volume

33

pub_type

杂志文章
  • De novo donor-specific antibody following BK nephropathy: The incidence and association with antibody-mediated rejection.

    abstract:BACKGROUND AND OBJECTIVES:The risk of de novo donor-specific antibody (dnDSA) development following BK viremia (BKV) or nephropathy (BKN) after kidney transplant remains unclear. We aimed to evaluate the relationships among dnDSA, BKV (BK blood PCR > 15 000 copies), BKN, antibody-mediated rejection (AMR), and allograft...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13194

    authors: Cheungpasitporn W,Kremers WK,Lorenz E,Amer H,Cosio FG,Stegall MD,Gandhi MJ,Schinstock CA

    更新日期:2018-03-01 00:00:00

  • Immunosuppressive standards in simultaneous kidney-pancreas transplantation.

    abstract::Simultaneous pancreas-kidney transplantation is an established procedure for patients with type I diabetes and end-stage renal disease. Continuous advances in the operation techniques with consequent reduction of perioperative morbidity and mortality and the introduction of modern immunosuppressive agents improved not...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-0012.2006.00599.x

    authors: Schmied BM,Müller SA,Mehrabi A,Welsch T,Büchler MW,Zeier M,Schmidt J

    更新日期:2006-01-01 00:00:00

  • Low infectious complications in segmental living related small bowel transplantation in adults.

    abstract::Clinical small bowel transplantation (SBTx) has been associated with a high rate of infectious complications. Laparotomy, preservation injury, abnormal motility, lymphatic disruption, aberrant systemic venous drainage, rejection and antibiotic therapy could all be implicated in the etiology of these complications. In ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2000.140609.x

    authors: Cicalese L,Sileri P,Asolati M,Rastellini C,Abcarian H,Benedetti E

    更新日期:2000-12-01 00:00:00

  • No apparent impact of increased post-operative blood glucose levels on clinical outcome in kidney transplant recipients.

    abstract:BACKGROUND:Our objective is to evaluate whether hyperglycemia in the first 48 h after renal transplantation is independently associated with rejection, post-operative infection and post-transplant diabetes mellitus (PTDM) in a retrospective cohort study. METHODS:Patients who received a renal transplant in our hospital...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2008.00910.x

    authors: van den Berg TJ,Bogers H,Vriesendorp TM,Surachno JS,DeVries JH,ten Berge IJ,Hoekstra JB

    更新日期:2009-03-01 00:00:00

  • Outcomes at 7 years post-transplant in black vs nonblack kidney transplant recipients administered belatacept or cyclosporine in BENEFIT and BENEFIT-EXT.

    abstract::Clinical outcomes are generally worse for black vs nonblack renal allograft recipients. In BENEFIT and BENEFIT-EXT, recipients were randomized to belatacept more intense-based, belatacept less intense-based, or cyclosporine-based immunosuppression. At year 7, belatacept was associated with superior graft survival vs c...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/ctr.13225

    authors: Florman S,Vincenti F,Durrbach A,Abouljoud M,Bresnahan B,Garcia VD,Mulloy L,Rice K,Rostaing L,Zayas C,Calderon K,Meier-Kriesche U,Polinsky M,Yang L,Medina Pestana J,Larsen CP

    更新日期:2018-04-01 00:00:00

  • Graft volume as the surrogate marker for nephron number affects the outcomes of living-donor kidney transplantation.

    abstract::Post-transplant outcome of kidney allografts depends on various factors, one of which may be the compatibility in volume between graft and recipient. However, previous studies adjusted the graft volume only for recipient's size. As the adjusted graft volume for donor's size would be substituted of nephron number more ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2011.01426.x

    authors: Han SS,Yang SH,Oh YJ,Cho JY,Moon KC,Ha J,Kim YS

    更新日期:2011-05-01 00:00:00

  • The effect of calcineurin inhibitors on endothelial function in renal transplant recipients.

    abstract::Endothelial dysfunction is of vital importance, as it may cause ischemia and dysfunction in various organs. Despite, this problem has been well documented in patients with end-stage renal disease (ESRD), there is not enough data considering this issue following renal transplantation. One of the potential causes of end...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2003.00030.x

    authors: Oflaz H,Turkmen A,Kazancioglu R,Kayacan SM,Bunyak B,Genchallac H,Erol B,Mercanoglu F,Umman S,Sever MS

    更新日期:2003-06-01 00:00:00

  • Reduced nephrotoxicity of cyclosporine A in hypercholesterolemic cadaveric renal transplant patients.

    abstract::In a retrospective analysis of stable cadaveric renal transplant patients we identified 19 patients with high (> 270 mg/dl) and 12 patients with low (< 170 mg/dl) serum cholesterol levels. We found that patients with high cholesterol level had higher serum cyclosporine levels despite similar oral dose of cyclosporine,...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Bastani B,Rittenhouse M,Garvin P

    更新日期:1994-08-01 00:00:00

  • BK polyomavirus in solid organ transplantation-Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.

    abstract::The present AST-IDCOP guidelines update information on BK polyomavirus (BKPyV) infection, replication, and disease, which impact kidney transplantation (KT), but rarely non-kidney solid organ transplantation (SOT). As pretransplant risk factors in KT donors and recipients presently do not translate into clinically val...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13528

    authors: Hirsch HH,Randhawa PS,AST Infectious Diseases Community of Practice.

    更新日期:2019-09-01 00:00:00

  • A call to action: Feasible strategies to reduce the discard of transplantable kidneys in the United States.

    abstract::Changes to the United States kidney allocation system targeted at reducing organ discard have failed to improve organ utilization. High Kidney Donor Profile Index kidneys continue to be discarded at high rates as a result of the regulatory and financial barriers to widespread utilization of these organs. However, ther...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13990

    authors: Stewart ZA,Shah SA,Formica RN,Kandaswamy R,Paramesh AS,Friedman J,Squires R,Cooper M,Axelrod DA

    更新日期:2020-09-01 00:00:00

  • Peripheral endothelial dysfunction in heart transplant recipients: possible role of proinflammatory cytokines.

    abstract::Endothelium-dependent vasodilation in the peripheral circulation may be impaired in heart transplant recipients (HTx rec). Conflicting results have been obtained and the mechanisms involved have not been examined. In the present study, we examined whether long-time survivors of heart transplantation (Tx) show signs of...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2000.140307.x

    authors: Holm T,Aukrust P,Andreassen AK,Ueland T,Brosstad F,Frøland SS,Simonsen S,Gullestad L

    更新日期:2000-06-01 00:00:00

  • Impact of dose reductions on efficacy outcome in heart transplant patients receiving enteric-coated mycophenolate sodium or mycophenolate mofetil at 12 months post-transplantation.

    abstract::Mycophenolic acid (MPA) dose reduction is associated with increased risk of rejection and graft loss in renal transplantation. This analysis investigated the impact of MPA dose changes with enteric-coated mycophenolate sodium (EC-MPS) or mycophenolate mofetil (MMF) in de novo heart transplant recipients. In a 12-month...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1399-0012.2008.00887.x

    authors: Segovia J,Gerosa G,Almenar L,Livi U,Viganò M,Arizón JM,Yonan N,Di Salvo TG,Renlund DG,Kobashigawa JA,ERL 2401 Study Group.

    更新日期:2008-11-01 00:00:00

  • The use of flow cytometry for the detection of CMV-specific antigen (pp65) in leukocytes of kidney recipients.

    abstract::Flow cytometric assay (FCA) was used to detect a cytomegalovirus (CMV) specific antigen (pp65) in CMV-infected fibroblast cells and in leukocytes of kidney recipients. FCA distinguished clearly between the infected and non-infected fibroblast cells. Regarding transplant patients, the FCA was positive when the number o...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2000.140208.x

    authors: Essa S,Pacsa AS,Al-Attiyah R,El-Shazly A,Raghupathy R,Said T

    更新日期:2000-04-01 00:00:00

  • Differential gene expression in non-adherent heart transplant survivors: Implications for regulatory T-cell expression.

    abstract::Survival despite prolonged non-adherence with immunosuppression is rare but has been reported in kidney, lung, and liver transplantation. Its occurrence in heart transplantation is quite rare. Our study was prompted by an index patient who survived despite prolonged medication non-adherence. Prospective consent and bl...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13834

    authors: Baran DA,Rao P,Deo D,Zucker MJ

    更新日期:2020-05-01 00:00:00

  • Calciphylaxis in end-stage liver and renal disease patients before and after transplant.

    abstract::Calciphylaxis is a rare vascular disorder characterized by calcification of arterioles which causes tissue inflammation and necrosis. It is associated with the metabolic disturbances seen in end-stage renal disease (ESRD) and has also been described in patients with cirrhosis with preserved kidney function. Characteri...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/ctr.13272

    authors: Couri T,Stier M,Mikolajczyk A,Aronsohn A

    更新日期:2018-06-01 00:00:00

  • Current principles and practice in autologous intraportal islet transplantation: a meta-analysis of the technical considerations.

    abstract:OBJECTIVES:Autologous islet transplantation (IAT) following pancreatectomy is now a recognized, albeit highly specialized procedure carried out in a small number of centers worldwide. Current clinical principles and best practice with emphasis on examining the technical aspects of surgery in centers with significant IA...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/ctr.12695

    authors: Kumar R,Chung WY,Dennison AR,Garcea G

    更新日期:2016-04-01 00:00:00

  • High-dose busulfan and the risk of pulmonary mortality after autologous stem cell transplant.

    abstract::The non-relapse mortality of autologous stem cell transplant is low enough that the procedure has been extended to older patients with non-Hodgkin's lymphoma. We treated 537 non-Hodgkin's lymphoma patients with high-dose chemotherapy consisting of busulfan, cyclophosphamide, and etoposide followed by autologous stem c...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2006.00581.x

    authors: Kalaycio M,Pohlman B,Kuczkowski E,Rybicki L,Andresen S,Sobecks R,Bolwell B

    更新日期:2006-11-01 00:00:00

  • Preservation of the donor pancreas for whole pancreas and islet transplantation.

    abstract::Whole pancreas and islet cell transplantation are both reliant upon the procurement and preservation of a high quality donor pancreas for a successful outcome. In the climate of a reducing donor pool it is imperative that donor optimization, meticulous surgical retrieval and evidence based methods of preservation are ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-0012.2009.01151.x

    authors: Ridgway D,Manas D,Shaw J,White S

    更新日期:2010-01-01 00:00:00

  • Short-term outcomes of en bloc combined heart and liver transplantation in the failing Fontan.

    abstract::Patients with failing Fontan physiology and liver cirrhosis are being considered for combined heart and liver transplantation. We performed a retrospective review of our experience with en bloc combined heart and liver transplantation in Fontan patients > 10 years old from 2006 to 18 per Institutional Review Board app...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/ctr.13540

    authors: Vaikunth SS,Concepcion W,Daugherty T,Fowler M,Lutchman G,Maeda K,Rosenthal DN,Teuteberg J,Woo YJ,Lui GK

    更新日期:2019-06-01 00:00:00

  • De novo donor-specific HLA antibodies in heart transplantation: Do transient de novo DSA confer the same risk as persistent de novo DSA?

    abstract:BACKGROUND:It is estimated that 25%-35% of heart transplant recipients develop de novo donor-specific antibodies (dnDSA). One factor that appears to play a role in clinical outcomes is DSA persistence. The objective of this study was to determine the incidence of transient and persistent dnDSA in a Canadian heart trans...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13416

    authors: Moayedi Y,Fan CS,Tinckam KJ,Ross HJ,McCaughan JA

    更新日期:2018-11-01 00:00:00

  • Steroid-sparing maintenance immunosuppression is safe and effective after simultaneous liver-kidney transplantation.

    abstract::Optimization of maintenance immunosuppression (mIS) regimens in the transplant recipient requires a balance between sufficient potency to prevent rejection and avoidance of excessive immunosuppression to prevent toxicities and complications. The optimal regimen after simultaneous liver-kidney (SLK) transplantation rem...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.14036

    authors: Weeks SR,Luo X,Toman L,Gurakar AO,Naqvi FF,Alqahtani SA,Philosophe B,Cameron AM,Desai NM,Ottmann SE,Segev DL,Garonzik-Wang J

    更新日期:2020-10-01 00:00:00

  • Effect of storage temperature on early graft function following liver transplantation.

    abstract::The effect of storage temperature on early graft function following liver transplantation was investigated by analyzing the results following transplantation during three periods in which different techniques for graft storage were used. The techniques involved ice-packing (period 1), storage in a standard operating ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Morino M,Adam R,Diamond T,Castaing D,Reynes M,Bismuth H

    更新日期:1992-04-01 00:00:00

  • Incidence and risk factors for new-onset diabetes in living-donor liver transplant recipients.

    abstract::With the increased number of long-term survivors after liver transplantation, new-onset diabetes after transplantation (NODAT) is becoming more significant in patient follow-up. However, the incidence of new-onset diabetes after living-donor liver transplantation (LDLT) has not been well elucidated. The aim of this st...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/ctr.12103

    authors: Honda M,Asonuma K,Hayashida S,Suda H,Ohya Y,Lee KJ,Yamamoto H,Takeichi T,Inomata Y

    更新日期:2013-05-01 00:00:00

  • Overview of reduced-size liver transplantation.

    abstract::Organ donor availability is the major limiting factor in pediatric liver transplantation, and many children succumb from their liver disease before a suitable donor can be found. In an attempt to overcome this shortage, reduced-size liver transplantation, split liver transplantation, and living-donor liver transplanta...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:

    authors: Emond JC,Whitington PF,Broelsch CE

    更新日期:1991-04-01 00:00:00

  • Rejection after conversion to a proliferation signal inhibitor in chronic heart transplantation.

    abstract::We sought to determine the incidence, risk factors, and consequences of acute rejection (AR) after conversion from a calcineurin inhibitor (CNI) to a proliferation signal inhibitor (PSI) in maintenance heart transplantation. Relevant clinical data were retrospectively obtained for 284 long-term heart transplant recipi...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,多中心研究

    doi:10.1111/ctr.12241

    authors: González-Vílchez F,Vázquez de Prada JA,Paniagua MJ,Almenar L,Mirabet S,Gómez-Bueno M,Díaz-Molina B,Arizón JM,Delgado J,Pérez-Villa F,Crespo-Leiro MG,Martínez-Dolz L,Roig E,Segovia J,Lambert JL,Lopez-Granados A,Escribano P

    更新日期:2013-11-01 00:00:00

  • Cost-benefit analysis of a clinical pharmacist-managed medication assistance program in a renal transplant clinic.

    abstract:UNLABELLED:Medicare pays for 80% of the cost of immunosuppressant agents needed within the first 3 years of solid organ transplantation; however, many patients cannot afford the remaining 20%. Furthermore, many patients who are beyond 3 years post-transplantation and have prescription coverage cannot afford the co-paym...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2000.140405.x

    authors: Chisholm MA,Vollenweider LJ,Mulloy LL,Wynn JJ,Wade WE,DiPiro JT

    更新日期:2000-08-01 00:00:00

  • Reduced dose Thymoglobulin, tacrolimus, and mofetil mycophenolate results in excellent solitary pancreas transplantation outcomes.

    abstract:BACKGROUND:Graft survival following solitary pancreas transplantation has traditionally lagged behind that of simultaneous pancreas-kidney transplants. Thymoglobulin (TMG), a polyclonal rabbit-derived antilymphocyte antibody was originally introduced as treatment for acute rejection of renal allografts. However, data r...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2002.02031.x

    authors: Tan M,Cantarovich M,Mangel R,Paraskevas S,Fortier M,Metrakos P

    更新日期:2002-12-01 00:00:00

  • Liver transplantation in patients aged 65 and over: a case-control study.

    abstract:INTRODUCTION:The average age of patients undergoing liver transplantation (LT) is consistently increasing. The aim of this case-control study is to evaluate survival and outcome of patients ≥65 yr compared to younger patients undergoing LT. MATERIALS AND METHODS:From 10/00 to 4/08 we performed 330 primary LT, 31 (9.4%...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2010.01230.x

    authors: Montalti R,Rompianesi G,Di Benedetto F,Ballarin R,Gerring RC,Busani S,De Pietri L,De Ruvo N,Iemmolo RM,Guerrini GP,Smerieri N,Gerunda GE

    更新日期:2010-09-01 00:00:00

  • Ethnicity, medical insurance, and living kidney donation.

    abstract:BACKGROUND:Relationships between race/ethnicity, recipient medical insurance, and living donor kidney transplantation (LKT) are incompletely described. METHODS:Associations between medical insurance and LKT were assessed in 447 recipients at a southeastern US transplant center. Primary and secondary payers were includ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12168

    authors: Reeves-Daniel AM,Farney AC,Fletcher AJ,Assimos D,Westcott C,Rogers J,Stratta RJ,Rocco MV,Freedman BI

    更新日期:2013-07-01 00:00:00

  • Physical examination of the potential tissue donor, what do European tissue banks do?

    abstract::According to the EU Directive 2006/17/EC, European tissue banks are required to perform a physical examination on every potential tissue donor. The directive itself, however, does not specify the content of this examination. The aim of this study was to investigate the current practice of physical examination in Europ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2009.01089.x

    authors: Van Geyt C,Van Wijk M,Bokhorst A,Beele H

    更新日期:2010-03-01 00:00:00