Prevention of relapse using DLI can increase survival following HLA-identical transplantation in patients with advanced-stage acute leukemia: a multi-center study.

Abstract:

:A total of 123 consecutive patients with advanced-stage, acute leukemia undergoing HSCT from HLA-identical sibling donors were analyzed. A G-CSF-primed DLI was planned within day 60 post-transplantation before hematologic relapse was diagnosed. Fifty of the 123 individuals received prophylactic DLI, and 73 individuals received no prophylactic treatment. The incidence of grades II-IV acute graft-versus-host disease (GVHD) was 17% for patients receiving DLI and 23% for patients not receiving DLI (p = 0.35). The incidence of chronic GVHD was 38% for patients receiving DLI and 17% for patients not receiving DLI (p = 0.021). The two-yr cumulative incidence of relapse was significantly lower in patients who received prophylactic DLI (46%) compared with patients who did not receive prophylactic DLI (66%) (p = 0.02). The three-yr probability of overall survival was higher in patients who received prophylactic DLI (36%) than in patients who did not receive prophylactic DLI (11%) (p = 0.001). The leukemia-free survival was also higher in patients who received prophylactic DLI (29%) than in patients who did not receive prophylactic DLI (9%) (p = 0.001). Our comparisons suggest that the prophylactic use of DLI can significantly increase survival of patients with advanced-stage, acute leukemia who receive HLA-identical sibling HSCT.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Wang Y,Liu DH,Fan ZP,Sun J,Wu XJ,Ma X,Xu LP,Liu KY,Liu QF,Wu DP,Huang XJ

doi

10.1111/j.1399-0012.2012.01626.x

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

635-43

issue

4

eissn

0902-0063

issn

1399-0012

journal_volume

26

pub_type

杂志文章,多中心研究
  • Long-term outcome in kidney transplant patients with hepatitis C (HCV) infection.

    abstract::To assess the prevalence and long-term impact of HCV on kidney transplant recipients, we assayed 716 pre-transplant sera using a first-generation ELISA. The anti-HCV positive sera were confirmed by a 6-antigen radioimmunoassay (RIA). Patients were followed up for 5 years. Graft survival, function, evidence of chemical...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Orloff SL,Stempel CA,Wright TL,Tomlanovich SJ,Amend WJ,Stock PG,Melzer JS,Vincenti F

    更新日期:1995-04-01 00:00:00

  • Prevalence and immunohistochemical findings of subclinical kidney allograft rejection and its association with graft outcome.

    abstract::Subclinical acute rejection (SAR) occurs in about 30% of stable renal transplant patients and may be a risk factor for a poor allograft outcome. In the present study, the prevalence and clinical features of subclinical rejection, and the expression of immune activation markers in surveillance graft biopsies were asses...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2004.00170.x

    authors: Veronese FV,Noronha IL,Manfro RC,Edelweiss MI,Goldberg J,Gonçalves LF

    更新日期:2004-08-01 00:00:00

  • Low molecular weight heparin dosing and monitoring in solid organ transplant recipients.

    abstract::Anti-Xa monitoring for low molecular weight heparin (LMWH) is currently recommended in obese, renally impaired, and pregnant patients. Substantial evidence indicates that solid organ transplant (SOT) patients are at an increased risk of renal impairment, thus representing a population at risk of LMWH accumulation. The...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12240

    authors: Moten MA,Gaber AO,Putney D,Patel SJ

    更新日期:2013-11-01 00:00:00

  • Efficacy and safety of enteric-coated mycophenolate sodium in renal transplant patients with diabetes mellitus: post hoc analyses from three clinical trials.

    abstract::To examine the efficacy and safety of enteric-coated mycophenolate sodium (EC-MPS, myfortic) in renal transplant patients with diabetes mellitus, six- and 12-month data from three clinical trials with EC-MPS (Studies B301, B302, and myPROMS) were analyzed post hoc. Studies B301 (de novo patients) and B302 (maintenance...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2006.00615.x

    authors: Pietruck F,Budde K,Salvadori M,Sollinger H,Bourbigot B,Gentil MA,Oppenheimer F

    更新日期:2007-01-01 00:00:00

  • The significance of subclinical rejection.

    abstract::Subclinical rejection (SCR) is quite common early following renal transplantation and decreases progressively with time. The immunological profile of the recipient, the immunosuppressive regimen used, and the occurrence of prior episodes of clinical acute rejection (AR) are all risk factors for SCR. SCR, in turn, is a...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-0012.2008.00888.x

    authors: El-Amm JM,Gruber SA

    更新日期:2009-03-01 00:00:00

  • Managing renal transplant ischemia reperfusion injury: novel therapies in the pipeline.

    abstract::Ischemia reperfusion injury (IRI) is an early, non-specific inflammatory response that follows perfusion of warm blood into a cold asanguinous organ following transplantation. The occurrence of IRI may have a pivotal impact on acute and long-term renal allograft function. Initially, IRI contributes to delayed graft fu...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/ctr.12121

    authors: Powell JT,Tsapepas DS,Martin ST,Hardy MA,Ratner LE

    更新日期:2013-07-01 00:00:00

  • Epidemiology, risk factors, and impact of bacterial infections on outcomes for pancreatic grafts.

    abstract::We aimed to determine the epidemiology, risk factors, and impact of bacterial infection on pancreatic function after pancreas transplantation. Data for pancreas transplant recipients were retrospectively reviewed between 2000 and 2014 for at least 1 year. We collected and analyzed post-transplant data for bacterial in...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13333

    authors: Bodro M,Ferrer J,Ricart MJ,Sanclemente G,Linares L,Cervera C,Cofan F,Ventura-Aguiar P,Lopez-Boado MÁ,Marco F,Fuster J,García-Valdecasas JC,Moreno A

    更新日期:2018-08-01 00:00:00

  • Implementation of a mobile team to provide normothermic regional perfusion in controlled donation after circulatory death: Pilot study and first results.

    abstract::Normothermic regional perfusion (NRP) in controlled donation after circulatory death is becoming a popular method due to the favorable results of the grafts procured under this technique. This procedure requires experience, and, sometimes, the availability of extracorporeal membrane oxygenation (ECMO) machines to impl...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13899

    authors: Pérez Redondo M,Alcántara Carmona S,Fernández Simón I,Villanueva Fernández H,Ortega López A,Pardo Rey C,Duerto Álvarez J,Lipperheide Vallhonrat I,González Romero M,Ballesteros Ortega D,Del Río Gallegos F,Rubio Muñoz JJ

    更新日期:2020-08-01 00:00:00

  • Diagnosis of hepatic allograft rejection: role of liver biopsy.

    abstract::The role of the liver biopsy for establishing a diagnosis of liver allograft rejection was investigated by examining under code 151 liver biopsies from 32 recipients and correlating the results with the clinical diagnosis determined by chart review. One-hundred-and-four biopsies were obtained to evaluate the cause of...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Aran PP,Bissel MG,Whitington PF,Bostwick DG,Adamac T,Baker AL

    更新日期:1993-10-01 00:00:00

  • Living donor evaluation and exclusion: the Stanford experience.

    abstract:BACKGROUND:The proportion of prospective living donors disqualified for medical reasons is unknown. The objective of this study is to delineate and quantify specific reasons for exclusion of prospective living donors from kidney donation. METHODS:All adult prospective kidney donors who contacted our transplant program...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1399-0012.2010.01336.x

    authors: Lapasia JB,Kong SY,Busque S,Scandling JD,Chertow GM,Tan JC

    更新日期:2011-09-01 00:00:00

  • A new approach for increasing the organ supply.

    abstract::The donation of organs and tissues for the benefit of another person is an altruistic act and one that is a guaranteed option for the next-of-kin through various national Required Request legislations. At the Washington Hospital Center we have developed an approach that permits organ recovery from non-heart beating do...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Kowalski AE,Light JA,Ritchie WO,Sasaki TM,Callender CO,Gage F

    更新日期:1996-12-01 00:00:00

  • Attitudes of commercial renal transplant recipients toward renal transplantation in India.

    abstract::Renal transplantation offers patients with end-stage renal disease the best opportunity for rehabilitation and long-term survival. However, there is a critical shortage of transplantable kidneys worldwide. This plays well into the hands of transplanters and entrepreneurs involved in commercial renal transplantation, p...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Qunibi W,Abulrub D,Shaheen F,el-Din AB,Alfurayh O,Almeshari K

    更新日期:1995-08-01 00:00:00

  • Randomized trial of early corticosteroid reduction vs. regular-dose corticosteroid maintenance in combination with tacrolimus and mycophenolate mofetil in living donor kidney transplant recipients: the Brazilian CORRETA trial.

    abstract::This multicenter, randomized trial aimed to compare the safety and efficacy of an early reduction in corticosteroid dose vs. long-term maintenance in Brazilian patients on an immunosuppressive regimen based on tacrolimus and mycophenolate mofetil (MMF). In the control arm, prednisone was progressively reduced from day...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1399-0012.2009.01185.x

    authors: Garcia VD,Carvalho DB,Gonçalves RT,Cavalcanti RL,Campos HH,Abbud-Filho M,Lobao-Neto AA

    更新日期:2010-07-01 00:00:00

  • Mast cell phenotypes in the allograft after lung transplantation.

    abstract:BACKGROUND:The burden of mast cell (MC) infiltration and their phenotypes, MC-tryptase (MCT ) and MC-tryptase/chymase (MCTC ), after lung transplantation (LT) has not been evaluated in human studies. METHODS:We reviewed 20 transbronchial lung biopsy (TBLB) specimen from patients with early normal allograft (<6 months ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12758

    authors: Banga A,Han Y,Wang X,Hsieh FH

    更新日期:2016-07-01 00:00:00

  • Tuberculosis in southern Chinese renal-transplant recipients.

    abstract:OBJECTIVES:To analyze the characteristics of tuberculosis (TB) in Southern Chinese renal transplant recipients, and summarize the corresponding experiences in diagnosis and management. METHOD:Retrospectively study 41 documented post-transplant TB cases out of the 2333 patients who received kidney transplantation in th...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2008.00878.x

    authors: Chen SY,Wang CX,Chen LZ,Fei JG,Deng SX,Qiu J,Li J,Chen GO,Fu HM,Xie CM

    更新日期:2008-11-01 00:00:00

  • Anti-IL-2R blockers comparing with polyclonal antibodies: Higher risk of rejection without negative mid-term outcomes after ABO-incompatible kidney transplantation.

    abstract::There is no recommendation regarding the type of induction therapy to use in ABO-incompatible (ABOi) kidney transplantation. The aim of this retrospective study was to compare the outcome of ABOi living donor kidney transplant (LDKT) recipients who received either polyclonal antibodies or anti-interleukin-2 receptor (...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13681

    authors: Del Bello A,Divard G,Belliere J,Congy-Jolivet N,Lanfranco L,Ricard R,Delas A,Colombat M,Esposito L,Hebral AL,Cointault O,Lefaucheur C,Loupy A,Kamar N

    更新日期:2019-10-01 00:00:00

  • Bone fractures and lumbar mineral density after renal transplantation. A long-term cross-sectional study.

    abstract:BACKGROUND:The purpose of this work was to investigate the association of vertebral and peripheral fractures 10 yr after grafting with bone metabolic markers and body mass density (BMD). PATIENTS AND METHODS:One hundred thirty-eight recipients with stable graft function were included in a cross-sectional study. Graft ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12666

    authors: Jiménez S,Marcén R,Vaamonde C,Caballero C,Fernández-Rodríguez A,Villafruela JJ,Galeano C,Teruel JL,Quereda C

    更新日期:2016-02-01 00:00:00

  • Suggested guidelines for the use of tacrolimus in pancreas/kidney transplantation.

    abstract::As experience with tacrolimus (FK506, Prograf) accumulates and reduced rejection rates are increasingly demonstrated, some transplant centers are adopting tacrolimus-based primary immunosuppressive regimens for their patients undergoing pancreas/kidney transplantation. The guidelines provided in this article based on ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Gruessner RW,Bartlett ST,Burke GW,Stock PG

    更新日期:1998-06-01 00:00:00

  • Mycobacterium tuberculosis after solid organ transplantation: A review of more than 2000 cases.

    abstract:BACKGROUND:Mycobacterium tuberculosis (TB) is a common pathogen worldwide, and it may cause significant infection after solid organ transplantation (SOT). We reviewed all reported TB cases to provide an update on its epidemiology, clinical presentation, management, and outcome after SOT. METHODS:MEDLINE, EMBASE, and O...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/ctr.13259

    authors: Abad CLR,Razonable RR

    更新日期:2018-06-01 00:00:00

  • Urinary microbiome associated with chronic allograft dysfunction in kidney transplant recipients.

    abstract:BACKGROUND:We performed a study to identify differences in the urinary microbiome associated with chronic allograft dysfunction (CAD) and compared the urinary microbiome of male and female transplant recipients with CAD. METHODS:This case-control study enrolled 67 patients within the Deterioration of Kidney Allograft ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13436

    authors: Wu JF,Muthusamy A,Al-Ghalith GA,Knights D,Guo B,Wu B,Remmel RP,Schladt DP,Alegre ML,Oetting WS,Jacobson PA,Israni AK

    更新日期:2018-12-01 00:00:00

  • Regional differences in deceased donor liver transplantation and their implications for organ utilization and allocation.

    abstract::We examined the UNOS database from 7/15/00-7/17/05 for Regional deceased donor liver utilization. For each region, we performed logistic regression and derived odds ratios (OR) for donor characteristics associated with livers being transplanted outside of the region or not transplanted at all. Regions with smallest an...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2010.01214.x

    authors: Hayashi PH,Axelrod DA,Galanko J,Salvalaggio PR,Schnitzler M

    更新日期:2011-01-01 00:00:00

  • Functional assessment of immune markers of graft rejection: a comprehensive study in live-related donor renal transplantation.

    abstract::A better understanding of the immunobiological processes and predictors of graft rejection holds promise for the development of potential therapeutic strategies and also individualization of immunosuppression. The objective of this study is to analyze the clinical relevance of immune parameters such as antidonor antih...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2005.00445.x

    authors: Panigrahi A,Deka R,Bhowmik D,Dash SC,Tiwari SC,Guleria S,Mehta SN,Mehra NK

    更新日期:2006-01-01 00:00:00

  • Improvement of gastrointestinal symptoms after conversion from mycophenolate mofetil to enteric-coated mycophenolate sodium in liver transplant patients.

    abstract::As many as 50% of liver transplant patients suffer gastrointestinal (GI) disturbances post-transplant. Conversion from mycophenolate mofetil (MMF) to mycophenolate sodium (EC-MPS) alleviates GI symptom burden in renal transplant recipients. We employed a validated patient and physician-reported assessment to evaluate ...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1399-0012.2011.01444.x

    authors: Toledo AH,Hendrix L,Buchholz V,Fisher E,Newton K,Smith C,Gerber DA

    更新日期:2012-01-01 00:00:00

  • Renal allograft loss due to proximal extension of ileofemoral deep venous thrombosis.

    abstract::Renal allograft recipients with thrombophilic (hypercoagulable) states are at higher risk for early allograft loss. Presumably, the combination of endothelial injury at surgery and thrombophilia predisposes to arterial or venous thrombosis. Of 270 consecutive renal transplants at our center one allograft failed second...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2002.02006.x

    authors: Ramirez PJ,Gohh RY,Kestin A,Monaco AP,Morrissey PE

    更新日期:2002-08-01 00:00:00

  • Mycobacterium tuberculosis infections in solid organ transplantation: Guidelines from the infectious diseases community of practice of the American Society of Transplantation.

    abstract::These updated guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation review the diagnosis, prevention, and management of tuberculosis in the pre- and post-transplant period. The challenges of screening for both latent and active TB in the setting of transplantation are...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13513

    authors: Subramanian AK,Theodoropoulos NM,Infectious Diseases Community of Practice of the American Society of Transplantation.

    更新日期:2019-09-01 00:00:00

  • Impact of venous drainage on regeneration of the anterior segment of right living-related liver grafts.

    abstract::The effect of additional venous reconstruction on morphologic and functional regeneration of the anterior segment of right-lobe liver grafts was compared among three groups according to graft type: right liver graft without the middle hepatic vein (MHV) or MHV tributaries (n=7), with MHV tributaries (n=25) and with th...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2006.00515.x

    authors: Mizuno S,Iida T,Yagi S,Usui M,Sakurai H,Isaji S,Uemoto S

    更新日期:2006-07-01 00:00:00

  • Post-transplant C-reactive protein monitoring can predict chronic allograft nephropathy.

    abstract::Chronic allograft nephropathy (CAN) is a major problem after renal transplantation and chronic inflammation can be one of its promoters. C-reactive protein (CRP) is an important marker of inflammation and atherosclerosis. We retrospectively analyzed the predictive role of serum CRP levels on the development of CAN and...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2004.00286.x

    authors: Sezer S,Akcay A,Ozdemir FN,Kulah E,Arat Z,Haberal M

    更新日期:2004-12-01 00:00:00

  • Conundrums with FlowPRA beads.

    abstract::In 1969, a study by Patel and Terasaki persuaded the renal transplant community that a pre-transplant cross-match should always be performed between donor and recipient to detect HLA antibodies and prevent hyperacute allograft rejection. Although the role of the cross-match among nonsensitized patients is controversia...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.16.s7.3.x

    authors: Gebel HM,Harris SB,Zibari G,Bray RA

    更新日期:2002-01-01 00:00:00

  • Short- and midterm results for internal jugular vein extension for short right renal vein kidney transplant.

    abstract::Renal transplantation remains the definitive treatment for end-stage renal disease (ESRD). The shorter renal vein in right donor nephrectomies is associated with higher incidence of technical failure. We present here our experience with autologous internal jugular vein (IJV) conduits to facilitate living-donor transpl...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/ctr.13312

    authors: Lu T,Yi SG,Bismuth J,Knight RJ,Gaber AO,Bechara CF

    更新日期:2018-08-01 00:00:00

  • Engraftment of heavily transfused patients with severe aplastic anemia with a fludarabine-based regimen.

    abstract::We have developed a practical conditioning regimen without anti-thymocyte globulin (ATG), irradiation, or other myeloablative alkylating agent for low-income countries in which patients with severe aplastic anemia (SAA), who usually have heavily transfused and a prolonged disease history. The application of ATG, Busul...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/ctr.12061

    authors: Wang SB,Li L,Pan XH,Hu DM,Peng LH,Liu L,Xie ZJ,Yin B,Sun XJ,Yu J,Liang Y

    更新日期:2013-03-01 00:00:00