Outcomes after simultaneous kidney-pancreas versus pancreas after kidney transplantation in the current era.

Abstract:

:Simultaneous pancreas and kidney (SPK) and pancreas after kidney (PAK) transplant are both potential options for diabetic ESRD patients. Historically, PAK pancreas graft outcomes were felt to be inferior to SPK pancreas graft outcomes. Little is known about outcomes in the modern era of transplantation. We analyzed our SPK and PAK recipients transplanted between 01/2000 and 12/2016. There were a total of 635 pancreas and kidney transplant recipients during the study period, 611 SPK and 24 PAK. Twelve of the PAK patients received a living donor kidney. There were no significant differences between the two groups in kidney or pancreas graft rejection at 1 year. Similarly, 1-year graft survival for both organs was not different. At last follow-up, uncensored and death-censored graft survival was not statistically different for kidney or pancreas grafts. In addition, in Cox regression analysis SPK and PAK were associated with similar graft survival. Although the majority of pancreas transplants are in the form of SPK, PAK is an acceptable alternative. Simultaneous pancreas and kidney avoids donor risks associated with live donation, so may be preferable in regions with short wait times, but PAK with a living donor kidney may be the best alternative in regions with long SPK wait times.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Parajuli S,Arunachalam A,Swanson KJ,Aziz F,Garg N,Redfield RR,Kaufman D,Djamali A,Odorico J,Mandelbrot DA

doi

10.1111/ctr.13732

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

e13732

issue

12

eissn

0902-0063

issn

1399-0012

journal_volume

33

pub_type

临床试验,杂志文章
  • Effect of melphalan 140 mg/m(2) vs 200 mg/m(2) on toxicities and outcomes in multiple myeloma patients undergoing single autologous stem cell transplantation-a single center experience.

    abstract::Although melphalan at a dose of 140 mg/m(2) (MEL140) is an acceptable conditioning regimen for autologous stem cell transplantation (ASCT) in multiple myeloma (MM) patients, very few studies compared it to the most commonly used dose of 200 mg/m(2) (MEL200). A retrospective review of records of MM patients (2001-2010)...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12762

    authors: Katragadda L,McCullough LM,Dai Y,Hsu J,Byrne M,Hiemenz J,May S,Cogle CR,Norkin M,Brown RA,Wingard JR,Chang M,Moreb JS

    更新日期:2016-08-01 00:00:00

  • Depressive symptoms and mortality in lung transplant.

    abstract:OBJECTIVE:To determine whether depressive symptoms predicted survival before and after lung transplantation. We hypothesized that depressive symptoms might predict survival of wait-listed patients, but would not predict survival post-transplant. METHODS:This was a prospective, longitudinal study. Participants complete...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2010.01236.x

    authors: Evon DM,Burker EJ,Galanko JA,Dedert E,Egan TM

    更新日期:2010-09-01 00:00:00

  • Growth of a nation part I: impact of organ donor obesity on whole-organ pancreas transplantation.

    abstract::Obesity has reached epidemic proportions in the USA. Consequently, there are an increasing number of potential organ donors that are obese, but would otherwise be appropriate donors for pancreas transplantation (PTx). This is a retrospective study of all PTx performed at Indiana University between 2003 and 2009 (n = 3...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2011.01419.x

    authors: Fridell JA,Mangus RS,Taber TE,Goble ML,Milgrom ML,Good J,Vetor R,Powelson JA

    更新日期:2011-05-01 00:00:00

  • Current concepts and systematic review of vascularized composite allotransplantation of the abdominal wall.

    abstract:INTRODUCTION:Abdominal wall vascularized composite allotransplantation (AW-VCA) is a rarely utilized technique for large composite abdominal wall defects. The goal of this article is to systematically review the literature and current concepts of AW-VCA, outline the challenges ahead, and provide an outlook for the futu...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/ctr.12243

    authors: Berli JU,Broyles JM,Lough D,Shridharani SM,Rochlin D,Cooney DS,Lee WP,Brandacher G,Sacks JM

    更新日期:2013-11-01 00:00:00

  • Nitric oxide attenuates ischaemia-reperfusion (I/R) injury in the diabetic liver.

    abstract:BACKGROUND:Liver ischaemia-reperfusion (I/R) occurs during resuscitation from haemorrhagic shock, hepatic transplantation and anatomic resection of the liver. This injury is associated with hepatocellular enzyme release and hepatocyte necrosis. The impact of chronic illnesses such as diabetes mellitus (DM) on hepatic I...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2004.00210

    authors: Rogers H 3rd,Zibari GB,Roberts J,Turnage R,Lefer DJ

    更新日期:2004-01-01 00:00:00

  • The use of flow cytometry for the detection of CMV-specific antigen (pp65) in leukocytes of kidney recipients.

    abstract::Flow cytometric assay (FCA) was used to detect a cytomegalovirus (CMV) specific antigen (pp65) in CMV-infected fibroblast cells and in leukocytes of kidney recipients. FCA distinguished clearly between the infected and non-infected fibroblast cells. Regarding transplant patients, the FCA was positive when the number o...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2000.140208.x

    authors: Essa S,Pacsa AS,Al-Attiyah R,El-Shazly A,Raghupathy R,Said T

    更新日期:2000-04-01 00:00:00

  • Comparison of histopathological characteristics of allograft biopsy between responder and non-responder to antiproteinuric effect of angiotensin-converting enzyme inhibitor (ACEI).

    abstract::Angiotensin-converting enzyme inhibitor (ACEI) has become recognized as agents that have renoprotective effects in the treatment of progressive renal diseases including post-transplant kidneys. Previously we demonstrated the safety and effectiveness of ACEI treatment on the hypertensive proteinuric post-transplant pat...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2004.00244.x

    authors: Namba Y,Moriyama T,Kyo M,Oka K,Kokado Y,Shi Y,Imamura R,Ichimaru N,Okuyama A,Takahara S

    更新日期:2004-01-01 00:00:00

  • Heart transplantation in the early phase of the COVID-19 pandemic: A single-center case series.

    abstract::The infectious disease coronavirus disease 2019 (COVID-19) was declared a pandemic by the World Health Organization in March 2020. The impact of COVID-19 on solid organ transplantations, including heart transplantation, is currently unclear. Many transplant programs have been forced to swiftly re-evaluate and adapt th...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.14042

    authors: Hsu JJ,Al-Saffar F,Ardehali R,Baas AS,Carlson M,Cruz D,Deng M,Fan A,Fraschilla S,Gaynor P,Kamath M,Kubak BM,Schaenman J,Stimpson E,Vucicevic D,Ardehali A,Nsair A

    更新日期:2020-09-01 00:00:00

  • Conversion to sirolimus-based maintenance immunosuppression using daclizumab bridge therapy in renal transplant recipients.

    abstract:INTRODUCTION:Conversion from calcineurin inhibitor (CI)-based maintenance immunosuppression to sirolimus (SRL)-based immunosuppression may be beneficial in selected renal transplant recipients. The purpose of this study was to evaluate the safety and efficacy of a daclizumab (DAC) bridge protocol in patients converted ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2004.00220.x

    authors: Sundberg AK,Rohr MS,Hartmann EL,Adams PL,Stratta RJ

    更新日期:2004-01-01 00:00:00

  • Clinical analysis of living donor liver transplantation in patients with portal vein thrombosis.

    abstract::The aim of this study was to improve outcomes in living donor liver transplantation (LDLT) patients with portal vein thrombosis (PVT). Of 246 adult patients who underwent LDLT with a right lobe graft between January 2000 and May 2007, PVT was diagnosed in 50 patients (20.3%), who were further subdivided into partial (...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2010.01217.x

    authors: Kim SJ,Kim DG,Park JH,Moon IS,Lee MD,Kim JI,Yoon YC,Yoo YK

    更新日期:2011-01-01 00:00:00

  • Human parvovirus B19 infection in organ transplant recipients.

    abstract::We report a 61-yr-old kidney transplant recipient with human Parvovirus B19 (HPV B19) infection presenting as a severe pancytopenia 1 month after transplantation. Bone marrow aspiration revealed severe erythroid hypoplasia with giant and dystrophic proerythroblasts. Bone marrow cells were positive for HPV B19 DNA dete...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1034/j.1399-0012.1999.t01-1-130103.x

    authors: Marchand S,Tchernia G,Hiesse C,Tertian G,Cartron J,Kriaa F,Boubenider S,Goupy C,Lecointe D,Charpentier B

    更新日期:1999-02-01 00:00:00

  • Blood glutathione as a marker of cardiac allograft vasculopathy in heart transplant recipients.

    abstract:BACKGROUND:Cardiac allograft vasculopathy (CAV) limits survival after heart transplantation (HTx). Between immunologic and non-immunologic factors, reactive oxygen species generation has been proposed as pathogenetic mechanism. This study was aimed at evaluating redox status in HTx recipients and verifying whether it c...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2005.00352.x

    authors: De Chiara B,Bigi R,Campolo J,Parolini M,Turazza F,Masciocco G,Frigerio M,Fiorentini C,Parodi O

    更新日期:2005-06-01 00:00:00

  • Prevalence and immunohistochemical findings of subclinical kidney allograft rejection and its association with graft outcome.

    abstract::Subclinical acute rejection (SAR) occurs in about 30% of stable renal transplant patients and may be a risk factor for a poor allograft outcome. In the present study, the prevalence and clinical features of subclinical rejection, and the expression of immune activation markers in surveillance graft biopsies were asses...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2004.00170.x

    authors: Veronese FV,Noronha IL,Manfro RC,Edelweiss MI,Goldberg J,Gonçalves LF

    更新日期:2004-08-01 00:00:00

  • After discontinuation of calcineurin inhibitors, tapering of mycophenolate mofetil further impairs donor-directed cytotoxicity.

    abstract:BACKGROUND:Recently, we described a significant decrease in donor-specific cytotoxic T-lymphocyte precursor frequency (CTLpf) after discontinuation of calcineurin inhibitors (CNI), while the proliferative capacity in mixed lymphocyte culture (MLC), and the number of interferon-gamma (IFN-gamma) producing cells (pc) in ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2007.00754.x

    authors: van Besouw NM,van de Wetering J,van der Mast BJ,de Kuiper R,Baan CC,Weimar W

    更新日期:2008-03-01 00:00:00

  • Measurement of liver volumes by portal vein flow by Doppler ultrasound in living donor liver transplantation.

    abstract:BACKGROUND:The accurate estimation of liver volume and right/left ratio in donor candidates is critical, but there is no method using portal vein (PV) flow. METHODS:Of 125 donor candidates, right/left liver volume ratio was estimated using ultrasound (US)-PV area ratio and Doppler US-PV flow ratio, and the results wer...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13050

    authors: Choi SH,Kwon JH,Kim KW,Jang HY,Kim JH,Kwon HJ,Lee J,Song GW,Lee SG

    更新日期:2017-09-01 00:00:00

  • Short- and midterm results for internal jugular vein extension for short right renal vein kidney transplant.

    abstract::Renal transplantation remains the definitive treatment for end-stage renal disease (ESRD). The shorter renal vein in right donor nephrectomies is associated with higher incidence of technical failure. We present here our experience with autologous internal jugular vein (IJV) conduits to facilitate living-donor transpl...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/ctr.13312

    authors: Lu T,Yi SG,Bismuth J,Knight RJ,Gaber AO,Bechara CF

    更新日期:2018-08-01 00:00:00

  • Prolonged cardiac allograft ischemic time--no impact on long-term survival but at what cost?

    abstract:INTRODUCTION:The aim of this paper was to review the outcomes of cardiac transplantation with regards to short- and long-term survival, focusing particularly on patients who receive organs with long ischemic times and the resource utilization necessary to support such patients through their postoperative period. METHO...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2007.00644.x

    authors: Marasco SF,Esmore DS,Richardson M,Bailey M,Negri J,Rowland M,Kaye D,Bergin PJ

    更新日期:2007-05-01 00:00:00

  • Itraconazole for the treatment of pulmonary aspergillosis in heart transplant recipients.

    abstract::The objective of this study was to evaluate the effects of itraconazole as a first choice drug in the treatment of pulmonary aspergillosis in heart transplant recipients. Heart transplant recipients suffering from invasive pulmonary aspergillosis were included in this study. Group 1 included 4 patients treated with i....

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Nanas JN,Saroglou G,Anastasiou-Nana MI,Kostis EB,Petrochilou-Paschou VP,Kontoyannis DA,Stamatelopoulos SF,Moulopoulos SD

    更新日期:1998-02-01 00:00:00

  • Immunoreactive trypsinogen levels in pediatric patients with intestinal failure awaiting intestinal transplantation.

    abstract::The aim of this study was to evaluate pancreatic function in total parenteral nutrition (TPN)-dependent children with permanent intestinal failure by measuring immunoreactive trypsinogen (IRT) levels. Between 1992 and 1996, 105 pediatric patients with permanent intestinal failure were referred to the Children's Hospit...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.1999.130505.x

    authors: Rovera GM,Sigurdsson L,Reyes J,Bouch LD,Naylor EW,Kocoshis SA

    更新日期:1999-10-01 00:00:00

  • MR cholangiography in orthotopic liver transplantation: sensitivity and specificity in detecting biliary complications.

    abstract:BACKGROUND:To assess the diagnostic value of magnetic resonance cholangiography (MRC) when evaluating biliary complications in a large series of liver transplants. METHODS:One hundred and twenty-nine patients prospectively underwent magnetic resonance (MR) imaging and MR cholangiography at 1.5-T device after orthotopi...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2009.01190.x

    authors: Boraschi P,Donati F,Gigoni R,Volpi A,Salemi S,Filipponi F,Falaschi F

    更新日期:2010-07-01 00:00:00

  • Molecular assessment of antibody-mediated rejection in human pancreas allograft biopsies.

    abstract::Pancreas transplant longevity is limited by immune rejection, which is diagnosed by graft biopsy using the Banff Classification. The histological criteria for antibody-mediated rejection (AMR) are poorly reproducible and inconsistently associated with outcome. We hypothesized that a 34-gene set associated with antibod...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.14065

    authors: Roufosse C,Drachenberg C,Renaudin K,Willicombe M,Toulza F,Dominy K,McLean A,Simmonds N,de Kort H,Cantarovitch D,Scalea J,Mengel M,Adam B

    更新日期:2020-11-01 00:00:00

  • Managing renal transplant ischemia reperfusion injury: novel therapies in the pipeline.

    abstract::Ischemia reperfusion injury (IRI) is an early, non-specific inflammatory response that follows perfusion of warm blood into a cold asanguinous organ following transplantation. The occurrence of IRI may have a pivotal impact on acute and long-term renal allograft function. Initially, IRI contributes to delayed graft fu...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/ctr.12121

    authors: Powell JT,Tsapepas DS,Martin ST,Hardy MA,Ratner LE

    更新日期:2013-07-01 00:00:00

  • Orthotopic liver transplantation for adult-onset type II citrullinaemia.

    abstract::Citrullinaemia is a rare autosomal recessive disorder due to a deficiency of argininosuccinate synthetase (ASS). While the clinical course of the adult onset form (Type II) is unpredictable, many patients undergo sudden deterioration with progressive cerebral oedema. Two patients with Type II citrullinaemia were refer...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Kawamoto S,Strong RW,Kerlin P,Lynch SV,Steadman C,Kobayashi K,Nakagawa S,Matsunami H,Akatsu T,Saheki T

    更新日期:1997-10-01 00:00:00

  • Use of enteric-coated mycophenolate sodium in liver transplant patients with intestinal intolerance caused by mycophenolate mofetil.

    abstract:BACKGROUND:Post-transplant gastrointestinal (GI) side effects can impair a patient's quality of life (QoL). This study investigates the improvement in GI side effects and related QoL changes in recipients of liver transplantation (OLT) after converting patients from mycophenolate mofetil (MMF) to enteric-coated mycophe...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1399-0012.2009.01019.x

    authors: Doria C,Ramirez CB,Frank AM,Vaccino S,Fraser N,Marino IR

    更新日期:2009-11-01 00:00:00

  • Psychosocial barriers associated with organ donation in Mexico.

    abstract:INTRODUCTION:There is a severe shortage of organs for transplantation worldwide, and Mexico has one of the lowest organ donation rates. In this study, we explored the psychosocial barriers that prevent posthumous organ donation by Mexicans. METHOD:We asked 218 adults who were not willing to be donors to complete the s...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13112

    authors: Marván ML,Álvarez Del Río A,Jasso K,Santillán-Doherty P

    更新日期:2017-11-01 00:00:00

  • Two-stage liver transplantation: an effective procedure in urgent conditions.

    abstract::Temporary portocaval shunt and total hepatectomy is a technique used in the presence of toxic liver syndrome because of fulminant hepatic failure, hepatic trauma, primary non-function (PNF), and eclampsia. We performed this technique on four patients. An indication for anhepatic state was severe hemodynamic instabilit...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2009.01118.x

    authors: Montalti R,Busani S,Masetti M,Girardis M,Di Benedetto F,Begliomini B,Rompianesi G,Rinaldi L,Ballarin R,Pasetto A,Gerunda GE

    更新日期:2010-01-01 00:00:00

  • Role of 99mTc-labeled DISIDA scan in the assessment of marginal liver grafts after orthotopic transplantation.

    abstract::Accurate prognostic indicators are lacking for livers with early marginal graft function, making the decision to re-transplant a difficult one. Therefore, we studied 99mTc-labeled DISIDA scanning as a predictor of recovery of marginal grafts. Records of 28 liver transplant recipients with prolonged periods of marginal...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Karademir S,Csete ME,Jurim O,Finstad T,Hawkins R,Bussuttil RW,Shaked A

    更新日期:1994-02-01 00:00:00

  • How does age affect the outcome of kidney transplantation in elderly recipients?

    abstract::The aging of the on-dialysis population raises the issue of whether to propose elderly patients for kidney transplantation and how to manage their immunosuppression. This study aimed to analyze the outcome of kidney transplantation on an Italian series of elderly recipients. We included in this retrospective study all...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13036

    authors: Neri F,Furian L,Cavallin F,Ravaioli M,Silvestre C,Donato P,La Manna G,Pinna AD,Rigotti P

    更新日期:2017-10-01 00:00:00

  • Elderly donor liver grafts are not associated with a higher incidence of biliary complications after liver transplantation: results of a national multicenter study.

    abstract:BACKGROUND:Liver transplantation with livers grafts from elderly donors has been associated with a higher risk of biliary complications. The aim of this study was to examine whether our national protocol could contribute to a lower incidence of biliary complications. METHODS:All adult recipients in the Netherlands tra...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,多中心研究

    doi:10.1111/ctr.12569

    authors: Westerkamp AC,Korkmaz KS,Bottema JT,Ringers J,Polak WG,van den Berg A,van Hoek B,Metselaar HJ,Porte RJ

    更新日期:2015-07-01 00:00:00

  • Global experience and perspective on anonymous nondirected live donation in living donor liver transplantation.

    abstract::Anonymous nondirected living liver donation (ANLLD), sometimes referred to as "altruistic" donation, occurs when a biologically unrelated person comes forward to donate a portion of his/her liver to a transplant candidate who is unknown to the donor. Here, we explore the current status of ANLLD with special considerat...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13836

    authors: Raza MH,Aziz H,Kaur N,Lo M,Sher L,Genyk Y,Emamaullee J

    更新日期:2020-04-01 00:00:00