Long-term clinicopathological impact of calcineurin inhibitor cessation without specific cytoreductive induction in kidney transplantation.

abstract：INTRODUCTION:Recent immunosuppression with tacrolimus and mycophenolate mofetil has improved the results of renal transplantation. In this study, we analyzed the effect and safety of basiliximab as an induction therapy. MATERIAL AND METHODS:Forty-nine kidney recipients were given tacrolimus, mycophenolate mofetil and ...

journal_title：Clinical transplantation

authors： Miura M,Harada H,Fukuzawa N,Iwami D,Taniguchi A,Seki T,Togashi M,Ogawa Y,Satoh H,Hirano T

更新日期：2005-01-01 00:00:00

abstract：:We examined the UNOS database from 7/15/00-7/17/05 for Regional deceased donor liver utilization. For each region, we performed logistic regression and derived odds ratios (OR) for donor characteristics associated with livers being transplanted outside of the region or not transplanted at all. Regions with smallest an...

journal_title：Clinical transplantation

authors： Hayashi PH,Axelrod DA,Galanko J,Salvalaggio PR,Schnitzler M

更新日期：2011-01-01 00:00:00

abstract：AIMS:To evaluate the effect of donor liver resident mesenchymal cells, M2 macrophages on liver graft outcome after living donor liver transplantation. MATERIALS AND METHODS:Seventy donor biopsies were included in the study. Outcomes at day 3, 7, 30, and 180 postliver transplantation were assessed. Mesenchymal stem cel...

journal_title：Clinical transplantation

authors： Nigam N,Bihari C,Lal D,Rastogi A,Kumar S,Pamecha V,Kaur S,Kumar A,Sarin SK

更新日期：2018-03-01 00:00:00

abstract：:Experimental models suggest that endothelin-1 (ET-1) has a significant role in the pathogenesis of cyclosporin A (CyA)-induced hypertension. However, its serum levels evaluated in different studies, including patients who received solid organ transplants, exhibited controversial results. Our study population consisted...

journal_title：Clinical transplantation

authors： Cauduro RL,Costa C,Lhulier F,Garcia RG,Cabral RD,Gonçalves LF,Manfro RC

更新日期：2005-08-01 00:00:00

abstract：:The study explores the prevalence of unrecognized diabetes mellitus (DM), the incidence and risk factors new onset diabetes mellitus (NODM) and determines whether patient survival differs between patients with transient (NODM that resolves) compared with those with fixed NODM. This is a single center review of solitar...

journal_title：Clinical transplantation

authors： Kiberd M,Panek R,Kiberd BA

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:International data on training, work, and lifestyle of transplant physicians and surgeons are scarce. Such data might help in development of uniform education paths and provide insights for young clinicians interested in this field. This study aimed at the evaluation of these data in all transplant-associate...

journal_title：Clinical transplantation

authors： Hoyer DP,Kaiser GM,Cicinnati V,Radunz S,Braun F,Greif-Higer G,Schulze M,Schmidt HJ,Paul A,Beckebaum S

更新日期：2016-09-01 00:00:00

abstract：:Differentiating acute pyelonephritis (APN) from acute rejection (AR) in renal allograft biopsies can sometimes be difficult because of overlapping clinical and histologic features, lack of positive urine cultures,and variable response to antibiotics. We wanted to study differential gene expression between AR and APN u...

journal_title：Clinical transplantation

authors： Oghumu S,Nori U,Bracewell A,Zhang J,Bott C,Nadasdy GM,Brodsky SV,Pelletier R,Satoskar AR,Nadasdy T,Satoskar AA

更新日期：2016-09-01 00:00:00

abstract：:ABO-incompatible kidney transplantation (ABO-ILKT) has been reported to have a higher rate of early complications and higher medical costs than ABO-compatible kidney transplantation (ABO-CLKT). We aimed to compare the clinical outcomes, complications, and medical costs between ABO-ILKTs and ABO-CLKTs at 2 years post-t...

journal_title：Clinical transplantation

authors： Kakuta Y,Okumi M,Unagami K,Iizuka J,Takagi T,Ishida H,Tanabe K

更新日期：2019-06-01 00:00:00

abstract：INTRODUCTION:A long-term prospective randomized trial evaluating alemtuzumab, a humanized anti-CD52 monoclonal antibody, in a predominantly non-Caucasian population has yet to be reported. METHODS:Ninety deceased donor (DD) first renal transplant recipients were randomized into three different antibody induction group...

journal_title：Clinical transplantation

authors： Ciancio G,Burke GW,Gaynor JJ,Roth D,Kupin W,Rosen A,Cordovilla T,Tueros L,Herrada E,Miller J

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:Chronic allograft nephropathy (CAN), associated with late-allograft dysfunction is caused by alloantigen-dependent and -independent mechanisms, and eventually leads to interstitial fibrosis (ci). Activation of complement cascade is considered to be a poor prognostic marker of graft survival. This study was d...

journal_title：Clinical transplantation

authors： Ohba K,Miyata Y,Koga S,Nishikido M,Kanetake H,Nazneen A,Razzaque MS,Taguchi T

更新日期：2005-12-01 00:00:00

abstract：:Early steroid discontinuation (ESD) has been associated with a lower incidence of post-transplant diabetes mellitus (PTDM). We retrospectively reviewed the incidence of PTDM in relation to racial groups in kidney transplant recipients treated with ESD. Between January 2002 and September 2003, 125 consecutive primary a...

journal_title：Clinical transplantation

authors： Walczak DA,Calvert D,Jarzembowski TM,Testa G,Sankary HN,Thielke J,Oberholzer J,Benedetti E

更新日期：2005-08-01 00:00:00

abstract：:With increasing shortage of donor organs and changes in organ allocation systems, there is a considerable need for alternative or supportive techniques in the field of liver transplantation. Liver cell transplantation (LCT) is such an innovative technique that is especially promising for use in children, because it is...

journal_title：Clinical transplantation

authors： Meyburg J,Schmidt J,Hoffmann GF

更新日期：2009-12-01 00:00:00

abstract：:Kidney transplant obstruction (KTO) following renal transplantation remains an important reversible cause of allograft dysfunction, requiring prompt diagnosis to prevent long-term graft damage. Although ultrasound can accurately diagnose renal transplant hydronephrosis, it cannot be used to assess its functional signi...

journal_title：Clinical transplantation

authors： Nankivell BJ,Cohn DA,Spicer ST,Evans SG,Chapman JR,Gruenewald SM

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:Skin cancer is common after solid organ transplantation, but few have investigated it after lung transplant (LTx). OBJECTIVE:We assessed incidence and predictors of non-melanoma skin cancer (NMSC) post-LTx. METHODS:We studied patients who underwent LTx at our center from 2012 to 2015. RESULTS:Of 287 patie...

journal_title：Clinical transplantation

authors： Elnahas S,Olson MT,Kang P,Panchanathan R,Masuda T,Walia R,Zeitouni NC,Smith MA,Bremner RM

更新日期：2019-12-01 00:00:00

abstract：:Histoplasma capsulatum is a dimorphic fungus that most often causes asymptomatic infection in the immunocompetent population. In immunocompromised patients, including solid organ transplant (SOT) and hematopoietic cell transplant (HCT) recipients, however, it is likely to cause severe life-threatening infection. Post-...

journal_title：Clinical transplantation

authors： Gajurel K,Dhakal R,Deresinski S

更新日期：2017-10-01 00:00:00

abstract：:The combination of methotrexate and cyclosporine A (MTX-CSA) is the standard regimen for the prevention of graft vs. host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (allo-SCT) from HLA-identical siblings. Mycophenolate mofetil and CSA (MMF-CSA) combination has been successfully used for GV...

journal_title：Clinical transplantation

authors： Ostronoff F,Ostronoff M,Souto-Maior AP,Domingues M,Sucupira A,Manso DA,de Lima AK,Monteiro PG,Florêncio R,Calixto R

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Multidrug-resistant (MDR) gram-negative bacteria are a growing threat to solid organ transplantation (SOT) patients in the intensive care unit (ICU). We aimed to examine the mortality rates of gram-negative MDR bacterial infection in SOT patients compared with patient population undergoing other cardiothorac...

journal_title：Clinical transplantation

authors： Biderman P,Bugaevsky Y,Ben-Zvi H,Bishara J,Goldberg E

更新日期：2015-09-01 00:00:00

abstract：:Idiopathic interstitial pneumonia (IIP) can occur after stem cell transplantation, but the aetiology is unknown. Based on the association between angiitis syndrome and Helicobacter pylori infection, we identified possible risk factors common to these two conditions. Among 83 patients who underwent stem cell transplant...

journal_title：Clinical transplantation

authors： Yamaguchi N,Takatsuka H,Wakae T,Okada M,Fujimori Y,Okamoto T,Kakishita E,Hara H

更新日期：2003-08-01 00:00:00

abstract：:Home-based exercise programs may offer a less costly alternative to providing exercise pre-transplant to a large number of patients. We describe the changes in 6-minute walk distance (6MWD) in lung transplant candidates who participated in a home-based exercise program and their relationship to post-transplant outcome...

journal_title：Clinical transplantation

authors： Massierer D,Bourgeois N,Räkel A,Prévost K,Lands LC,Poirier C,Janaudis-Ferreira T

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:The goal of immunosuppressive therapy in heart transplantation is to maximize safety and efficacy while minimizing morbidity and mortality. We now have numerous drug combinations, but few have been compared with each other. AIM:To compare various immunosuppressive regimens assessing morbidity and mortality ...

journal_title：Clinical transplantation

authors： Aguero J,Almenar L,Martínez-Dolz L,Moro JA,Rueda J,Raso R,Chamorro C,Sanchez JM,Salvador A

更新日期：2008-01-01 00:00:00

abstract：:Patients with severe liver disease and accompanying malnutrition may exhibit electrolyte disturbances including the magnesium balance. In 18 patients plasma magnesium (p-Mg) was determined at the start of the liver transplantation and during the anhepatic and reperfusion phases of the operation. The blood loss was 6.9...

journal_title：Clinical transplantation

authors： Skak C,Ejlersen E,Mogensen T,Winkel P,Secher NH

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:One severe side effect of calcineurin inhibitors (CNIs: such as cyclosporine [CsA] and tacrolimus [FK506]) is neurotoxicity. CNIs are substrates for CYP3A5 and P-glycoprotein (P-gp), encoded by ABCB1 gene. In the present study, we hypothesized that genetic variability in CYP3A5 and ABCB1 genes may be associa...

journal_title：Clinical transplantation

authors： Yanagimachi M,Naruto T,Tanoshima R,Kato H,Yokosuka T,Kajiwara R,Fujii H,Tanaka F,Goto H,Yagihashi T,Kosaki K,Yokota S

更新日期：2010-11-01 00:00:00

abstract：:Sarcopenia frequently occurs in cirrhotic patients who are waiting for liver transplantation (LT). This disease is associated with increased morbidity and mortality rates during the LT period. Recently, the careful assessment of nutritional status for end-stage liver disease patients has received a great deal of atten...

journal_title：Clinical transplantation

authors： Nam NH,Kaido T,Uemoto S

更新日期：2019-12-01 00:00:00

abstract：:Atherosclerosis is a chronic inflammatory process affecting mainly elastic and muscular arteries. Although small arteries and arterioles are usually spared, atherosclerosis can occur in these small vasculatures for a very short period. Here we report a case of atherosclerosis-like lesions that occurred in a transplant...

journal_title：Clinical transplantation

authors： Shimoyamada H,Fan J,Watanabe T,Nagata M

更新日期：2002-01-01 00:00:00

abstract：INTRODUCTION:Health-related quality of life (HRQOL) is severely impaired in advanced liver disease. The purpose of this study was to evaluate the impact of actual liver function and disease-specific factors on HRQOL of patients evaluated for liver transplantation. PATIENTS AND METHODS:Disease-specific QOL was analyzed...

journal_title：Clinical transplantation

authors： Jara M,Bednarsch J,Malinowski M,Lüttgert K,Orr J,Puhl G,Seehofer D,Neuhaus P,Stockmann M

更新日期：2014-12-01 00:00:00

abstract：:Renal transplantation remains the definitive treatment for end-stage renal disease (ESRD). The shorter renal vein in right donor nephrectomies is associated with higher incidence of technical failure. We present here our experience with autologous internal jugular vein (IJV) conduits to facilitate living-donor transpl...

journal_title：Clinical transplantation

authors： Lu T,Yi SG,Bismuth J,Knight RJ,Gaber AO,Bechara CF

更新日期：2018-08-01 00:00:00

abstract：:The presence of Epstein-Barr virus (EBV), human papilloma virus (HPV), and cytomegalovirus (CMV) was studied in 20 patients who developed malignancies after heart transplantation in the Helsinki University Central Hospital. The tumors were analyzed for the presence of HPV by polymerase chain reaction and for EBV by in...

journal_title：Clinical transplantation

authors： Mattila PS,Aalto SM,Heikkilä L,Mattila S,Nieminen M,Auvinen E,Hedman K,Tarkkanen J

更新日期：2001-10-01 00:00:00

abstract：:Management of transplant patients receiving cyclosporine therapy is complicated by interpatient and intrapatient variability in pharmacokinetic parameters caused by the drug's unpredictable bioavailability. Cyclosporine, a highly lipophilic cyclic polypeptide, has recently been reformulated using a microemulsion deliv...

journal_title：Clinical transplantation

authors： Ritschel WA

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:The burden of mast cell (MC) infiltration and their phenotypes, MC-tryptase (MCT ) and MC-tryptase/chymase (MCTC ), after lung transplantation (LT) has not been evaluated in human studies. METHODS:We reviewed 20 transbronchial lung biopsy (TBLB) specimen from patients with early normal allograft (<6 months ...

journal_title：Clinical transplantation

authors： Banga A,Han Y,Wang X,Hsieh FH

更新日期：2016-07-01 00:00:00

abstract：:This study evaluated the efficacy of primary endovascular stenting in cases of transplant renal artery stenosis (TRAS) from cadaver and non-heart-beating donor kidneys. Patients with TRAS (n = 13) from a single-centre transplant population (n = 476) were treated by primary percutaneous angioplasty and endovascular ste...

journal_title：Clinical transplantation

authors： Ridgway D,White SA,Nixon M,Carr S,Blanchard K,Nicholson ML

更新日期：2006-05-01 00:00:00