Factors associated with skin cancer in lung transplant recipients: A single-center experience.

Abstract:

BACKGROUND:Skin cancer is common after solid organ transplantation, but few have investigated it after lung transplant (LTx). OBJECTIVE:We assessed incidence and predictors of non-melanoma skin cancer (NMSC) post-LTx. METHODS:We studied patients who underwent LTx at our center from 2012 to 2015. RESULTS:Of 287 patients, mean age was 59.6 ± 11 years, 170 (59.2%) were men, and 231 (80.5%) were white. Seventy-six (26.5%) developed NMSC over a median follow-up of 32 months (IQR, 23-45). Of those with NMSC, 37% developed subsequent skin cancer of the same type. Independent predictors of decreased odds of NMSC and squamous cell carcinoma (SCC) were non-white race (P = .002; P = .003) and body mass index >30 kg/m2 compared with underweight patients (P = .001, P = .009). Patients with skin cancer pre-LTx had higher risk of post-LTx skin cancer (P = .02). Voriconazole use ≥100 days was associated with increased risk of SCC (P = .03), but not increased risk of basal cell carcinoma. Out of 76, 4 (5.3%) died from skin cancer. LIMITATIONS:Retrospective, single-center study. CONCLUSION:Squamous cell carcinoma risk post-LTx may increase with prolonged voriconazole use in white patients with pre-LTx history of skin cancer, whereas excess body weight may be protective from NMSC. Regular pre- and post-LTx skin cancer screenings and guidelines are warranted.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Elnahas S,Olson MT,Kang P,Panchanathan R,Masuda T,Walia R,Zeitouni NC,Smith MA,Bremner RM

doi

10.1111/ctr.13718

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

e13718

issue

12

eissn

0902-0063

issn

1399-0012

journal_volume

33

pub_type

临床试验,杂志文章
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    更新日期:2004-12-01 00:00:00

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    doi:10.1111/ctr.13029

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  • Perspectives on donor lung allocation from both sides of the Atlantic: The United States.

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  • Ezetimibe effectively lowers LDL-cholesterol in cardiac allograft recipients on stable statin therapy.

    abstract::We investigated tolerability and efficacy of ezetimibe treatment (10 mg/d) in 25 heart allograft recipients already on stable statin therapy. Total cholesterol (TC), low-density cholesterol (LDL-C), high-density cholesterol (HDL-C), triglycerides (TG), immunosuppressant drug levels, laboratory and clinical parameters ...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1399-0012.2008.00838.x

    authors: Konstandin MH,Blessing E,Doesch A,Ammon K,Koch A,Wabnitz GH,Gleissner CA,Remppis A,Katus HA,Dengler TJ

    更新日期:2008-09-01 00:00:00

  • Comparative evaluation of expanded criteria for patients with hepatocellular carcinoma beyond the Milan criteria undergoing living-related donor liver transplantation.

    abstract:OBJECTIVE:To clarify the predictive impact of expanded criteria for liver transplantation (LT) for patients with hepatocellular carcinoma (HCC) in 54 patients with HCC beyond the Milan criteria (MC) from a series of 109 consecutive living-related donor liver transplantation (LDLT) recipients with HCC. METHODS:Among 54...

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    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2011.01463.x

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  • Feasibility of exercise stress echocardiography for cardiac risk assessment in chronic kidney disease patients prior to renal transplantation.

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    pub_type: 杂志文章

    doi:10.1111/ctr.12796

    authors: Nerlekar N,Mulley W,Rehmani H,Ramkumar S,Cheng K,Vasanthakumar SA,Rashid H,Barton T,Nasis A,Meredith IT,Moir S,Mottram PM

    更新日期:2016-10-01 00:00:00

  • Training, work, and lifestyle of transplant physicians and surgeons in Germany.

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    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12786

    authors: Hoyer DP,Kaiser GM,Cicinnati V,Radunz S,Braun F,Greif-Higer G,Schulze M,Schmidt HJ,Paul A,Beckebaum S

    更新日期:2016-09-01 00:00:00

  • Post-transplant lymphoproliferative disease in lung transplantation: A nested case-control study.

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    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12983

    authors: Leyssens A,Dierickx D,Verbeken EK,Tousseyn T,Verleden SE,Vanaudenaerde BM,Dupont LJ,Yserbyt J,Verleden GM,Van Raemdonck DE,Vos R

    更新日期:2017-07-01 00:00:00

  • Multidetector CT angiography in living donor renal transplantation: accuracy and discrepancies in right venous anatomy.

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    journal_title:Clinical transplantation

    pub_type: 杂志文章

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    更新日期:2011-01-01 00:00:00

  • LabMELD-based organ allocation increases total costs of liver transplantation: a single-center experience.

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    pub_type: 临床试验,杂志文章

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    pub_type: 杂志文章

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    pub_type: 杂志文章

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    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-0012.2008.00892.x

    authors: Bunnapradist S,Ambühl PM

    更新日期:2008-11-01 00:00:00

  • Bone mineral density and osteoporosis in heart transplanted patients: A single-center retrospective study at Skåne University Hospital in Lund 1988-2016.

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    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/ctr.13477

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    更新日期:2019-03-01 00:00:00

  • Renal transplantation outcomes: a comparative analysis between elderly and younger recipients.

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    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2007.00734.x

    authors: Mendonça HM,Dos Reis MA,de Castro de Cintra Sesso R,Câmara NO,Pacheco-Silva A

    更新日期:2007-11-01 00:00:00

  • Indocyanine green elimination but not bilirubin indicates improvement of graft function during MARS therapy.

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    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2007.00706.x

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    更新日期:2007-11-01 00:00:00

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    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13706

    authors: Fabbri KR,Anderson-Haag TL,Spenningsby AM,Israni A,Nygaard RM,Stahler PA

    更新日期:2019-10-01 00:00:00

  • Recurrent allograft HCV presenting as acute cellular rejection: successful management with interferon and ribavirin alone.

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    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2003.00049.x

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    更新日期:2003-06-01 00:00:00

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    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

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    更新日期:1997-08-01 00:00:00

  • Current principles and practice in autologous intraportal islet transplantation: a meta-analysis of the technical considerations.

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    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/ctr.12695

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  • Current concepts and systematic review of vascularized composite allotransplantation of the abdominal wall.

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    pub_type: 杂志文章,评审

    doi:10.1111/ctr.12243

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    pub_type: 杂志文章

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  • The use of flow cytometry for the detection of CMV-specific antigen (pp65) in leukocytes of kidney recipients.

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    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2000.140208.x

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    更新日期:2000-04-01 00:00:00

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    pub_type: 杂志文章,评审

    doi:

    authors: Fecteau AH,Penn I,Hanto DW

    更新日期:1998-08-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2007.00788.x

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    doi:10.1111/ctr.12426

    authors: Jara M,Bednarsch J,Malinowski M,Lüttgert K,Orr J,Puhl G,Seehofer D,Neuhaus P,Stockmann M

    更新日期:2014-12-01 00:00:00

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    authors: Powell JT,Tsapepas DS,Martin ST,Hardy MA,Ratner LE

    更新日期:2013-07-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1111/ctr.12816

    authors: Tooley JE,Bohl DD,Kulkarni S,Rodriguez-Davalos MI,Mangi A,Mulligan DC,Yoo PS

    更新日期:2016-10-01 00:00:00

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    pub_type: 杂志文章

    doi:

    authors: Boros P,Suehiro T,Curtiss S,Sheiner P,Emre S,Guy S,Schwartz ME,Miller CM

    更新日期:1997-12-01 00:00:00