Abstract:
:A young female patient presented as an acute medical emergency with hypoglycaemia. Investigations revealed panhypopituitarism and an inflammatory pituitary mass. An antibody screen was negative for anti-neutrophil cytoplasmic antibodies with cytoplasmic distribution (cANCA). Pituitary histology showed lymphocytic infiltration and a few Langerhan's cells. The pituitary mass rapidly expanded to involve the optic nerves and led to bilateral blindness. Later, the patient developed diarrhoea, a vasculitis rash, scleritis, and proteinuria. In subsequent investigations cANCA became positive. The patient responded to steroids and cyclophosphamide treatment and remained in partial remission for six months before dying of severe sepsis. This is the first description of Wegener's granulomatosis presenting with acute anterior pituitary failure in the absence of other organ involvement and negative serology.
journal_name
Pituitaryjournal_title
Pituitaryauthors
McIntyre EA,Perros Pdoi
10.1007/s11102-007-0016-zsubject
Has Abstractpub_date
2007-01-01 00:00:00pages
107-11issue
1eissn
1386-341Xissn
1573-7403journal_volume
10pub_type
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