Acromegaly secondary to an incidentally discovered growth-hormone-releasing hormone secreting bronchial carcinoid tumour associated to a pituitary incidentaloma.


:In this report we emphasize the opportunity of considering the uncommon causes of chronic GH-excess in the initial diagnostic process, such as GHRH hypersecretion, especially in the presence of ambiguous pituitary neuroimaging. This topic may have an important clinical significance in order to plan the most cost-effective diagnostic procedures and management and to avoid unnecessary pituitary neurosurgery.






Verrua E,Ronchi CL,Ferrante E,Ferrari DI,Bergamaschi S,Ferrero S,Zatelli MC,Branca V,Spada A,Beck-Peccoz P,Lania AG




Has Abstract


2010-09-01 00:00:00












  • Machine learning applications in imaging analysis for patients with pituitary tumors: a review of the current literature and future directions.

    abstract:PURPOSE:To provide an overview of fundamental concepts in machine learning (ML), review the literature on ML applications in imaging analysis of pituitary tumors for the last 10 years, and highlight the future directions on potential applications of ML for pituitary tumor patients. METHOD:We presented an overview of t...


    pub_type: 杂志文章,评审


    authors: Saha A,Tso S,Rabski J,Sadeghian A,Cusimano MD

    更新日期:2020-06-01 00:00:00

  • Clinical features of sellar and suprasellar meningiomas.

    abstract::Meningiomas account for about 1% of sellar masses. Although they can mimic pituitary adenomas, they are more vascularized and invasive. To gain insights that would enhance our ability to establish a pre-surgical diagnosis of meningioma, we performed a retrospective study of these tumors. Query of the surgical patholog...


    pub_type: 杂志文章


    authors: Kwancharoen R,Blitz AM,Tavares F,Caturegli P,Gallia GL,Salvatori R

    更新日期:2014-08-01 00:00:00

  • Acromegaly as a cause of 1,25-dihydroxyvitamin D-dependent hypercalcemia: case reports and review of the literature.

    abstract::Growth hormone excess has been associated with hypercalciuria and nephrolithiasis. Hypercalcemia in acromegaly is rare and usually due to coexistent primary hyperparathyroidism. To report two cases of 1,25-dihydroxyvitamin D (1,25 (OH)(2) D)-dependent hypercalcemia in cromegaly. A 50 year-old female with 2 years histo...


    pub_type: 杂志文章,评审


    authors: Shah R,Licata A,Oyesiku NM,Ioachimescu AG

    更新日期:2012-12-01 00:00:00

  • Ancient views on the hypothalamic-pituitary-thyroid axis: an historical and epistemological perspective.

    abstract::The modern views on the anatomical and physiological interactions between the hypothalamus, pituitary and thyroid gland have emerged only in the last fifty years, although their historical roots may be found in a number of ancient and still not widely known ideas and observations. The regulation of energy body stores ...


    pub_type: 历史文章,杂志文章


    authors: Toni R

    更新日期:2000-10-01 00:00:00

  • The metabolic consequences of thyroxine replacement in adult hypopituitary patients.

    abstract::The metabolic consequences of thyroxine replacement in patients with central hypothyroidism (CH) need to be evaluated. The aim was to examine the outcome of thyroxine replacement in CH. Adult hypopituitary patients (n = 1595) with and without CH from KIMS (Pfizer International Metabolic Database) were studied before a...


    pub_type: 杂志文章


    authors: Filipsson Nyström H,Feldt-Rasmussen U,Kourides I,Popovic V,Koltowska-Häggström M,Jonsson B,Johannsson G

    更新日期:2012-12-01 00:00:00

  • Adamantinomatous craniopharyngiomas express tumor stem cell markers in cells with activated Wnt signaling: further evidence for the existence of a tumor stem cell niche?

    abstract:INTRODUCTION:Early disease onset, clinical manifestation, histomorphology, and increased tendency to relapse distinguish the adamantinomatous craniopharyngioma (adaCP) from the more favorable papillary variant (papCP). A molecular hallmark of adaCP is the activated Wnt signaling pathway indicated by nuclear β-catenin a...


    pub_type: 杂志文章


    authors: Hölsken A,Stache C,Schlaffer SM,Flitsch J,Fahlbusch R,Buchfelder M,Buslei R

    更新日期:2014-12-01 00:00:00

  • Radiotherapy in paediatric Cushing's disease: efficacy and long term follow up of pituitary function.

    abstract::Pituitary radiotherapy (RT) is an effective second-line treatment for paediatric Cushing's disease (CD). We report long-term efficacy and anterior pituitary function in a cohort of paediatric CD patients treated with RT. Between 1988 and 2008, from our cohort of 48 paediatric CD patients, eight paediatric CD patients ...


    pub_type: 杂志文章


    authors: Acharya SV,Gopal RA,Goerge J,Menon PS,Bandgar TR,Shah NS

    更新日期:2010-12-01 00:00:00

  • What are critical outcome measures for patients receiving pituitary replacement following brain injury?

    abstract::There are scant prospective studies defining improvements in critical outcome measures with hormone replacement in hypopituitarism secondary to brain injury. We review the tests of cognition and physical function and summarize their use for subjects that are deficient in anterior hormone production during anterior pit...


    pub_type: 杂志文章,评审


    authors: Beca SG,High WM Jr,Masel BE,Mossberg KA,Urban RJ

    更新日期:2012-03-01 00:00:00

  • Inhibition of neuronal nitric oxide synthase activity does not alter vasopressin secretion in septic rats.

    abstract:BACKGROUND/PURPOSE:During the early phase of sepsis, hypotension is accompanied by increase of plasma vasopressin hormone (AVP) levels, which decline during the late phase. This hypotension is due in part to increase of nitric oxide (NO) synthesis by nitric oxide synthase (NOS) enzyme. Neuronal isoform of this enzyme (...


    pub_type: 杂志文章


    authors: Coelho CH,Martins TF,Oliveira-Pelegrin GR,da Rocha MJA

    更新日期:2017-06-01 00:00:00

  • The extended, transnasal, transsphenoidal approach for anterior skull base meningioma: considerations in patient selection.

    abstract:PURPOSE:In this study, we set out to define our institutional criteria for patient eligibility for transsphenoidal resection of parasellar meningiomas, and to report our experience with extended transnasal approaches for these lesions. We aimed to discuss the important considerations of patient selection and risk strat...


    pub_type: 杂志文章


    authors: Castlen JP,Cote DJ,Zaidi HA,Laws ER Jr

    更新日期:2017-10-01 00:00:00

  • Silent somatotroph pituitary adenomas: an update.

    abstract::Silent growth hormone adenomas (SGHA) are a rare entity of non-functioning pituitary neuroendocrine tumors. Diagnosis is invariably made post-operatively of a tumor immunopositive for GH (and Pit-1 in selected cases) but without clinical acromegaly. Mainly young females are affected, and tumors are often uncovered by ...


    pub_type: 杂志文章,评审


    authors: Langlois F,Woltjer R,Cetas JS,Fleseriu M

    更新日期:2018-04-01 00:00:00

  • Prognostic value of nadir GH levels for long-term biochemical remission or recurrence in surgically treated acromegaly.

    abstract:CONTEXT:Outcome of acromegaly surgery is assessed by IGF-1 and glucose-suppressed GH, but whether the latter provides additional clinically relevant information when IGF-1 is normal is unclear. The role of GH suppression testing after surgery requires clarification. METHODS:We studied 97 acromegaly patients with norma...


    pub_type: 杂志文章


    authors: Freda PU,Bruce JN,Reyes-Vidal C,Singh S,DeLeon Y,Jin Z,Khandji AG,Cremers S,Post KD

    更新日期:2020-10-30 00:00:00

  • Glucocorticoid inhibition of growth in rats: partial reversal with the full-length ghrelin analog BIM-28125.

    abstract::Glucocorticoids are important immunosuppressive hormones; these steroids also inhibit somatic growth by decreased growth hormone (GH) secretion and induced protein catabolism. The ability of ghrelin, the endogenous ligand for the GHS-1a receptor, to increase body weight is attributed to a combination of enhanced food ...


    pub_type: 杂志文章


    authors: Tulipano G,Taylor JE,Halem HA,Datta R,Dong JZ,Culler MD,Bianchi I,Cocchi D,Giustina A

    更新日期:2007-01-01 00:00:00

  • Double pituitary lesions in three patients with Cushing's disease.

    abstract::Double pituitary adenomas are rare in surgical specimens and the most common clinical feature in reported patients has been acromegaly. We report 3 cases of double pituitary lesions in patients who presented with Cushing's disease. In a 22-year-old man (case 1) with delayed puberty and low testosterone levels, mild hy...


    pub_type: 杂志文章,评审


    authors: Meij BP,Lopes MB,Vance ML,Thorner MO,Laws ER Jr

    更新日期:2000-11-01 00:00:00

  • Combined treatment of invasive giant prolactinomas.

    abstract::The management of invasive giant prolactinomas (IGP) has been an area of some controversy. The relative roles of transsphenoidal surgery, craniotomy, radiation therapy and dopamine agonist based medical therapy are gradually becoming clarified. We report the results of management of 30 patients with IGP. Surgery was t...


    pub_type: 杂志文章


    authors: Yu C,Wu Z,Gong J

    更新日期:2005-01-01 00:00:00

  • Traumatic brain injury induced neuroendocrine changes: acute hormonal changes of anterior pituitary function.

    abstract:PURPOSE:It is estimated that approximately 69 million individuals worldwide will sustain a TBI each year, which accounts for substantial morbidity and mortality in both children and adults. TBI may lead to significant neuroendocrine changes, if the delicate pituitary is ruptured. In this review, we focus on the anterio...


    pub_type: 杂志文章,评审


    authors: Ntali G,Tsagarakis S

    更新日期:2019-06-01 00:00:00

  • Sella turcica: an anatomical, endocrinological, and historical perspective.

    abstract:INTRODUCTION:The sphenoid bone has a superior depression called the sella turcica, Latin for "Turkish saddle," where the pituitary gland is found. The availability of modern radiological imaging techniques has replaced plain radiography of the sella turcica in the investigation of hypothalamo-pituitary abnormalities. H...


    pub_type: 历史文章,杂志文章,评审


    authors: Tekiner H,Acer N,Kelestimur F

    更新日期:2015-08-01 00:00:00

  • Management of cystic prolactinomas: a review.

    abstract:INTRODUCTION:Cystic prolactinoma is a variant of prolactin-secreting pituitary adenoma. The strategies for the management of cystic prolactinoma have not been addressed thoroughly in clinical guidelines. METHODS:A literature search was performed using Pubmed to review the current approaches to the treatment of cystic ...


    pub_type: 杂志文章,评审


    authors: Nakhleh A,Shehadeh N,Hochberg I,Zloczower M,Zolotov S,Taher R,Daoud Naccache D

    更新日期:2018-08-01 00:00:00

  • Geometric survey on magnetic resonance imaging of growth hormone producing pituitary adenoma.

    abstract::Apart from the radiologic features regarding size and invasiveness, we had noticed some differences in morphology among types of pituitary adenomas. We conducted this study to verify the differences in radiologic morphology between growth hormone producing pituitary adenomas (GHoma) and nonfunctioning pituitary adenom...


    pub_type: 杂志文章


    authors: Bakhtiar Y,Hanaya R,Tokimura H,Hirano H,Oyoshi T,Fujio S,Bohara M,Arita K

    更新日期:2014-04-01 00:00:00

  • Chiasmapexy for secondary empty sella syndrome: diagnostic and therapeutic considerations.

    abstract:PURPOSE:Secondary empty sella syndrome (SESS) following pituitary surgery remains a diagnostic and therapeutic challenge. The aim of this study was to specify the diagnostic criteria, surgical indications and results of chiasmapexy in the SESS. METHODS:Three cases from two experienced neurosurgical centers were collec...


    pub_type: 杂志文章,评审


    authors: Graillon T,Passeri T,Boucekine M,Meyer M,Abritti R,Bernat AL,Labidi M,Dufour H,Froelich S

    更新日期:2020-11-02 00:00:00

  • Androgen deficiency: effects on body composition.

    abstract::Published data on the effects of androgen deficiency and testosterone administration on body composition in men and women are reviewed. In experimental paradigms, androgen deprivation decreases lean body mass and increases fat mass in men, and physiologic replacement reverses these abnormalities. The anabolic effects ...


    pub_type: 杂志文章,评审


    authors: Miller KK

    更新日期:2009-01-01 00:00:00

  • "Micromegaly": an update on the prevalence of acromegaly with apparently normal GH secretion in the modern era.

    abstract:PURPOSE:Approximately 25 % of cases of clinically active acromegaly cases treated in our academic center between 1996 and 2000, were diagnosed in patients who had elevated plasma IGF-1 levels, but apparently "normal" 24-h mean plasma GH levels. The current study served to update the data for patients with acromegaly re...


    pub_type: 杂志文章


    authors: Butz LB,Sullivan SE,Chandler WF,Barkan AL

    更新日期:2016-12-01 00:00:00

  • Leptin after IGF-I generation test in a patient with hypopituitarism and myotonic dystrophy disease.

    abstract::A 54-years-old woman diagnosed of myotonic dystrophy (MyD) with past medical history of massive postpartum haemorrhage at age 28 and panhypopituitarism was studied. BMI and body composition were determined and we determined baseline serum IGF-I, IGFBP3, insulin and leptin levels and after the IGF-I generation test per...


    pub_type: 杂志文章


    authors: Gómez JM,Martínez-Matos JA

    更新日期:1999-01-01 00:00:00

  • Acromegaly in the setting of Tatton-Brown-Rahman Syndrome.

    abstract:PURPOSE:Tatton-Brown-Rahman syndrome (TBRS) is a newly defined genetic entity characterized by overgrowth and intellectual disability, resulting from germline mutations in the gene encoding DNA methyltransferase 3 alpha (DNMT3A). Affected individuals with benign and malignant tumors have been reported; to our knowledge...


    pub_type: 杂志文章


    authors: Hage C,Sabini E,Alsharhan H,Fahrner JA,Beckers A,Daly A,Salvatori R

    更新日期:2020-04-01 00:00:00

  • Moderate dose cranial radiotherapy causes central adrenal insufficiency in long-term survivors of childhood leukaemia.

    abstract::Acute lymphoblastic leukaemia (ALL) is the most common childhood malignancy. The survival rate in the Scandinavian countries is now around 85 %. ALL patients treated with cranial radiotherapy (CRT) are at risk for growth hormone deficiency (GHD), but little is known about other pituitary insufficiencies, e.g. ACTH. Ad...


    pub_type: 杂志文章


    authors: Follin C,Wiebe T,Moëll C,Erfurth EM

    更新日期:2014-02-01 00:00:00

  • Primary central nervous system lymphoma mimicking pituitary apoplexy: case report.

    abstract::Lymphoma involving the pituitary gland is very rare and usually results from metastatic spread of systemic lymphoma. We present a case of primary central nervous system (CNS) large B cell lymphoma that manifested as pituitary apoplexy. A 45-year-old woman presented with headache, and then rapidly developed a third ner...


    pub_type: 杂志文章


    authors: Quintero Wolfe S,Hood B,Barker J,Benveniste RJ

    更新日期:2009-01-01 00:00:00

  • Predictors of endoscopic transsphenoidal surgery outcome in acromegaly: patient and tumor characteristics evaluated by magnetic resonance imaging.

    abstract::The availability of various first-line treatment modalities for acromegaly and evolving surgical techniques emphasize the need for accurately defined predictors of surgical outcome. We retrospectively analysed the outcome of 30 patients with acromegaly after initial endoscopic transsphenoidal surgery in two university...


    pub_type: 杂志文章


    authors: van Bunderen CC,van Varsseveld NC,Baayen JC,van Furth WR,Aliaga ES,Hazewinkel MJ,Majoie CB,Freling NJ,Lips P,Fliers E,Bisschop PH,Drent ML

    更新日期:2013-06-01 00:00:00

  • Importance of cannulated prolactin test in the definition of hyperprolactinaemia.

    abstract:PURPOSE:Recent guidelines suggest that a single prolactin measurement is adequate to confirm hyperprolactinaemia. This may lead to unnecessary investigation of artefactual hyperprolactinaemia. Prolactin measurement drawn from an indwelling cannula after rest removes stress as a confounding variable. The objective was t...


    pub_type: 杂志文章


    authors: Whyte MB,Pramodh S,Srikugan L,Gilbert JA,Miell JP,Sherwood RA,McGregor AM,Aylwin SJ

    更新日期:2015-06-01 00:00:00

  • Outcomes of stereotactic radiosurgery and hypofractionated stereotactic radiotherapy for refractory Cushing's disease.

    abstract:PURPOSE:Hypofractionated stereotactic radiotherapy (HSRT) for refractory Cushing's disease may offer a condensed treatment schedule for patients with large tumors abutting the optic chiasm unsuitable for stereotactic radiosurgery (SRS). To-date only four patients have been treated by HSRT in the published literature. W...


    pub_type: 杂志文章


    authors: Sherry AD,Khattab MH,Xu MC,Kelly P,Anderson JL,Luo G,Utz AL,Chambless LB,Cmelak AJ,Attia A

    更新日期:2019-12-01 00:00:00

  • Decreased insulin requirements after LAR-octreotide but not after lanreotide in an acromegalic patient.

    abstract::A diabetic acromegalic man, not cured after surgery and radiosurgery, received lanreotide i.m. with great clinical and biochemical improvement. He required NPH insulin (76 to 84 units/day) to control his diabetes mellitus. Thirty-six hours after changing to LAR-octreotide (20 mg i.m/month) he presented symptomatic hyp...


    pub_type: 杂志文章


    authors: Webb SM,Ortega E,Rodríguez-Espinosa J,Mato ME,Corcoy R

    更新日期:2001-09-01 00:00:00