The effect of somatostatin analogs and acromegaly on the upper gastrointestinal system.

abstract：PURPOSE:To report the results of a consecutive series of patients who underwent an endoscopic endonasal approach (EEA) for resection of a pituitary adenoma and compare them to previous series of microscopic and endoscopic approaches. METHODS:A retrospective review of clinical and radiographic outcomes of a consecutive...

journal_title：Pituitary

authors： Paluzzi A,Fernandez-Miranda JC,Tonya Stefko S,Challinor S,Snyderman CH,Gardner PA

更新日期：2014-08-01 00:00:00

abstract：PURPOSE:Secondary empty sella syndrome (SESS) following pituitary surgery remains a diagnostic and therapeutic challenge. The aim of this study was to specify the diagnostic criteria, surgical indications and results of chiasmapexy in the SESS. METHODS:Three cases from two experienced neurosurgical centers were collec...

journal_title：Pituitary

authors： Graillon T,Passeri T,Boucekine M,Meyer M,Abritti R,Bernat AL,Labidi M,Dufour H,Froelich S

更新日期：2020-11-02 00:00:00

abstract：PURPOSE:DAX-1 (NR0B1) is an orphan nuclear receptor, which plays a critical role in development and regulation of the adrenal gland and hypothalamo-pituitary-gonadal axis. Mutations in NR0B1 lead to adrenal hypoplasia congenita (AHC), hypogonadotropic hypogonadism (HH) and azoospermia in men. Presentation is typically ...

journal_title：Pituitary

authors： Kyriakakis N,Shonibare T,Kyaw-Tun J,Lynch J,Lagos CF,Achermann JC,Murray RD

更新日期：2017-10-01 00:00:00

abstract：INTRODUCTION:Autoimmune lymphocytic hypophysitis associates predominantly with other autoimmune endocrinopathies and is most commonly treated with glucocorticoids and/or decompressive pituitary surgery. Here we report a new association and treatment modality for lymphocytic hypophysitis. METHODS:A 52-year-old woman pr...

journal_title：Pituitary

authors： Xu C,Ricciuti A,Caturegli P,Keene CD,Kargi AY

更新日期：2015-08-01 00:00:00

abstract：:MAP-2, a well characterized member of the microtubule associated protein (MAP) family, binds to and stabilizes microtubules and is involved in cell proliferation as well as neuronal differentiation. The aim of the present work was to study MAP-2 expression in human adenohypophyses and pituitary adenomas. To our knowle...

journal_title：Pituitary

authors： Rotondo F,Oniya K,Kovacs K,Bell CD,Scheithauer BW

更新日期：2005-01-01 00:00:00

abstract：:A young female patient presented as an acute medical emergency with hypoglycaemia. Investigations revealed panhypopituitarism and an inflammatory pituitary mass. An antibody screen was negative for anti-neutrophil cytoplasmic antibodies with cytoplasmic distribution (cANCA). Pituitary histology showed lymphocytic infi...

journal_title：Pituitary

authors： McIntyre EA,Perros P

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:Hypophysitis develops in up to 19% of melanoma patients treated with ipilimumab, a cytotoxic T-lymphocyte antigen-4 antibody. Early detection may avert life-threatening hypopituitarism. We aimed to assess the incidence of ipilimumab-induced hypophysitis (IH) at a quaternary melanoma referral centre, and to dete...

journal_title：Pituitary

authors： De Sousa SMC,Sheriff N,Tran CH,Menzies AM,Tsang VHM,Long GV,Tonks KTT

更新日期：2018-06-01 00:00:00

abstract：INTRODUCTION:Early disease onset, clinical manifestation, histomorphology, and increased tendency to relapse distinguish the adamantinomatous craniopharyngioma (adaCP) from the more favorable papillary variant (papCP). A molecular hallmark of adaCP is the activated Wnt signaling pathway indicated by nuclear β-catenin a...

journal_title：Pituitary

authors： Hölsken A,Stache C,Schlaffer SM,Flitsch J,Fahlbusch R,Buchfelder M,Buslei R

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:Doses of growth hormone in adults with growth hormone deficiency are now lower than previously. However, it is not clear they are as effective as higher doses. The objective of this meta-analysis was to assess efficacy of low to moderate dose (LD) GH replacement on standard endpoints of GH compared to higher do...

journal_title：Pituitary

authors： Newman CB,Carmichael JD,Kleinberg DL

更新日期：2015-06-01 00:00:00

abstract：:Non-functioning pituitary neuroendocrine tumors do not cause endocrine symptoms related to hypersecretion of adenohypophyseal hormones and are clinically characterized by symptoms due to growing sellar tumor mass. Histopathological classification of this tumor group has always been challenging due to their heterogenei...

journal_title：Pituitary

authors： Manojlovic-Gacic E,Engström BE,Casar-Borota O

更新日期：2018-04-01 00:00:00

abstract：:Oral estrogens reduce GH-induced IGF-1 production and preliminary studies have shown that adjuvant estroprogestin (EP) therapy with octreotide LAR may control disease activity in some female patients who are partially responsive to octreotide LAR. Our aim was to verify if EP alone or in combination with octreotide LAR...

journal_title：Pituitary

authors： Vallette S,Serri O

更新日期：2010-12-01 00:00:00

abstract：:The molecular pathogenesis of prolactinomas has resisted elucidation; with the exception of a RAS mutation in a single aggressive prolactinoma, no mutational changes have been identified. In prolactinomas, a further obstacle has been the paucity of surgical specimens suitable for molecular analysis since prolactionoma...

journal_title：Pituitary

authors： Evans CO,Moreno CS,Zhan X,McCabe MT,Vertino PM,Desiderio DM,Oyesiku NM

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Cystic prolactinoma is a variant of prolactin-secreting pituitary adenoma. The strategies for the management of cystic prolactinoma have not been addressed thoroughly in clinical guidelines. METHODS:A literature search was performed using Pubmed to review the current approaches to the treatment of cystic ...

journal_title：Pituitary

authors： Nakhleh A,Shehadeh N,Hochberg I,Zloczower M,Zolotov S,Taher R,Daoud Naccache D

更新日期：2018-08-01 00:00:00

abstract：:Lymphoma involving the pituitary gland is very rare and usually results from metastatic spread of systemic lymphoma. We present a case of primary central nervous system (CNS) large B cell lymphoma that manifested as pituitary apoplexy. A 45-year-old woman presented with headache, and then rapidly developed a third ner...

journal_title：Pituitary

authors： Quintero Wolfe S,Hood B,Barker J,Benveniste RJ

更新日期：2009-01-01 00:00:00

abstract：:Published data on the effects of androgen deficiency and testosterone administration on body composition in men and women are reviewed. In experimental paradigms, androgen deprivation decreases lean body mass and increases fat mass in men, and physiologic replacement reverses these abnormalities. The anabolic effects ...

journal_title：Pituitary

authors： Miller KK

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:Survivin is an apoptosis inhibitor, expressed in almost all types of human malignancies, but rarely in differentiated normal tissues. Recently, survivin gene splice variants with different anti-apoptotic activities have been reported. The current study was undertaken to examine the expression of survivin and it...

journal_title：Pituitary

authors： Waligórska-Stachura J,Andrusiewicz M,Sawicka-Gutaj N,Kubiczak M,Jankowska A,Liebert W,Czarnywojtek A,Waśko R,Blanco-Gangoo AR,Ruchała M

更新日期：2015-06-01 00:00:00

abstract：:Most patients with acromegaly have some degree of insulin resistance. The principal mediator of insulin resistance in acromegaly is hypersecretion of growth hormone. Growth hormone acts at several levels to block insulin actions including inhibiting phosphorylation of the insulin receptor and one of its principal sign...

journal_title：Pituitary

authors： Clemmons DR

更新日期：2002-01-01 00:00:00

abstract：:Meningiomas account for about 1% of sellar masses. Although they can mimic pituitary adenomas, they are more vascularized and invasive. To gain insights that would enhance our ability to establish a pre-surgical diagnosis of meningioma, we performed a retrospective study of these tumors. Query of the surgical patholog...

journal_title：Pituitary

authors： Kwancharoen R,Blitz AM,Tavares F,Caturegli P,Gallia GL,Salvatori R

更新日期：2014-08-01 00:00:00

abstract：:Dopamine agonists have been shown to reduce growth hormone secretion in some patients with acromegaly, but their effect on adenoma size has not been well appreciated. We describe a 69 year-old woman with acromegaly caused by a somatotroph macroadenoma who received primary treatment with the dopamine agonist cabergolin...

journal_title：Pituitary

authors： Rickels MR,Snyder PJ

更新日期：2004-01-01 00:00:00

abstract：:Anemia and other hematological abnormalities are common in patients with Sheehan's syndrome. The response of these abnormalities to replacement of thyroxine and glucocorticoids is not clear. The aim of the present study was to document the profile of hematological abnormalities and response to treatment in patients wi...

journal_title：Pituitary

authors： Laway BA,Mir SA,Bashir MI,Bhat JR,Samoon J,Zargar AH

更新日期：2011-03-01 00:00:00

abstract：:Silent growth hormone adenomas (SGHA) are a rare entity of non-functioning pituitary neuroendocrine tumors. Diagnosis is invariably made post-operatively of a tumor immunopositive for GH (and Pit-1 in selected cases) but without clinical acromegaly. Mainly young females are affected, and tumors are often uncovered by ...

journal_title：Pituitary

authors： Langlois F,Woltjer R,Cetas JS,Fleseriu M

更新日期：2018-04-01 00:00:00

abstract：:The purpose of this study is to verify whether acute pre-treatment with alprazolam (ALP), a benzodiazepine that inhibits HPA secretion in normal subjects, could better characterize patients with subclinical Cushing's syndrome (SCS) than the 1-mg dexamethasone test (DST). In 22 patients with SCS, 10 with overt Cushing'...

journal_title：Pituitary

authors： Giordano R,Berardelli R,Karamouzis I,D'Angelo V,Picu A,Zichi C,Fussotto B,Manzo M,Mengozzi G,Ghigo E,Arvat E

更新日期：2013-09-01 00:00:00

abstract：:The metabolic consequences of thyroxine replacement in patients with central hypothyroidism (CH) need to be evaluated. The aim was to examine the outcome of thyroxine replacement in CH. Adult hypopituitary patients (n = 1595) with and without CH from KIMS (Pfizer International Metabolic Database) were studied before a...

journal_title：Pituitary

authors： Filipsson Nyström H,Feldt-Rasmussen U,Kourides I,Popovic V,Koltowska-Häggström M,Jonsson B,Johannsson G

更新日期：2012-12-01 00:00:00

abstract：:Acromegaly is caused by a somatotropinoma in the vast majority of the cases. These are monoclonal tumors that can occur sporadically or rarely in a familial setting. In the last few years, novel familial syndromes have been described and recent studies explored the landscape of somatic mutations in sporadic somatotrop...

journal_title：Pituitary

authors： Gadelha MR,Kasuki L,Korbonits M

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Xanthogranulomas are inflammatory masses most commonly found at peripheral sites such as the skin. Sellar and parasellar xanthogranulomas are rare and present a diagnostic challenge as they are difficult to differentiate from other sellar lesions such as craniopharyngiomas and Rathke's cleft cysts pre-operat...

journal_title：Pituitary

authors： Ved R,Logier N,Leach P,Davies JS,Hayhurst C

更新日期：2018-06-01 00:00:00

abstract：:We report on a 74-year-old male patient who presented with progressive neuroophthalmologic symptoms soon after the administration of a long-acting gonadotropin-releasing hormone agonist for treatment of a prostate cancer. Imaging revealed a destructively growing and extensively calcified sellar mass inconsistent with ...

journal_title：Pituitary

authors： Sahli R,Christ E,Kuhlen D,Giger O,Vajtai I

更新日期：2011-12-01 00:00:00

abstract：:We report a 59-year-old acromegalic woman, who presented with generalized bone pain, weakness, fatigue and foamy urine, who was found to have multiple myeloma (MM); and a 60-year-old acromegalic woman with dizziness, vomiting and abdominal pain, high blood pressure and splenomegaly that was posteriorly diagnosed as ha...

journal_title：Pituitary

authors： Barbosa FR,Vieira Neto L,Lima GA,Wildemberg LE,Portugal R,Gadelha MR

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Suprasellar pituitary adenomas (SPAs) are a special type of pituitary adenoma. Although dozens of SPA cases have been reported, the exact definition and the characteristics of SPA have not been exhaustively discussed before. METHODS:In a retrospective electronic medical records review, 13 patients with SPA ...

journal_title：Pituitary

authors： Zhu J,Wang Z,Zhang Y,Liu J,Li X,Deng K,Lu L,Yao Y

更新日期：2020-08-01 00:00:00

abstract：PURPOSE:Patients treated for pituitary adenomas generally report a reduced quality of life (QoL). At present, the patient's perspective of QoL has not been fully addressed and this, and further insight in potential determinants of QoL in pituitary diseases is required to design strategies to improve QoL. We aimed to de...

journal_title：Pituitary

authors： Andela CD,Niemeijer ND,Scharloo M,Tiemensma J,Kanagasabapathy S,Pereira AM,Kamminga NG,Kaptein AA,Biermasz NR

更新日期：2015-02-01 00:00:00

abstract：:In western countries, the process of "ageing of the population" is increasingly forcing clinical medicine to find answers for pathologies affecting the elder segments of our community. In this respect, pituitary adenomas often raise difficult questions on surgical indications, since little is known about postoperative...

journal_title：Pituitary

authors： Locatelli M,Bertani G,Carrabba G,Rampini P,Zavanone M,Caroli M,Sala E,Ferrante E,Gaini SM,Spada A,Mantovani G,Lania A

更新日期：2013-06-01 00:00:00