Adamantinomatous craniopharyngiomas express tumor stem cell markers in cells with activated Wnt signaling: further evidence for the existence of a tumor stem cell niche?

abstract：PURPOSE:Hypofractionated stereotactic radiotherapy (HSRT) for refractory Cushing's disease may offer a condensed treatment schedule for patients with large tumors abutting the optic chiasm unsuitable for stereotactic radiosurgery (SRS). To-date only four patients have been treated by HSRT in the published literature. W...

journal_title：Pituitary

authors： Sherry AD,Khattab MH,Xu MC,Kelly P,Anderson JL,Luo G,Utz AL,Chambless LB,Cmelak AJ,Attia A

更新日期：2019-12-01 00:00:00

abstract：:Lymphoma involving the pituitary gland is very rare and usually results from metastatic spread of systemic lymphoma. We present a case of primary central nervous system (CNS) large B cell lymphoma that manifested as pituitary apoplexy. A 45-year-old woman presented with headache, and then rapidly developed a third ner...

journal_title：Pituitary

authors： Quintero Wolfe S,Hood B,Barker J,Benveniste RJ

更新日期：2009-01-01 00:00:00

abstract：:We aimed to study the occurrence of acute-onset symptoms at initial presentation in a national Danish cohort of patients with childhood- or adult-onset craniopharyngioma, and to investigate potential risk factors for acute presentation. Medical records of 189 consecutive patients (39 children, 150 adults) presenting w...

journal_title：Pituitary

authors： Nielsen EH,Jørgensen JO,Bjerre P,Andersen M,Andersen C,Feldt-Rasmussen U,Poulsgaard L,Kristensen LØ,Astrup J,Jørgensen J,Laurberg P

更新日期：2013-12-01 00:00:00

abstract：:GH and IGF-1 play an important role in the regulation of metabolism and body composition. In patients with uncontrolled acromegaly, cardiovascular morbidity and mortality are increased but are supposed to be normalised after biochemical control is achieved. We aimed at comparing body composition and the cardiovascular...

journal_title：Pituitary

authors： Dimopoulou C,Sievers C,Wittchen HU,Pieper L,Klotsche J,Roemmler J,Schopohl J,Schneider HJ,Stalla GK

更新日期：2010-09-01 00:00:00

abstract：:In this report we emphasize the opportunity of considering the uncommon causes of chronic GH-excess in the initial diagnostic process, such as GHRH hypersecretion, especially in the presence of ambiguous pituitary neuroimaging. This topic may have an important clinical significance in order to plan the most cost-effec...

journal_title：Pituitary

authors： Verrua E,Ronchi CL,Ferrante E,Ferrari DI,Bergamaschi S,Ferrero S,Zatelli MC,Branca V,Spada A,Beck-Peccoz P,Lania AG

更新日期：2010-09-01 00:00:00

abstract：PURPOSE:To evaluate the effects of somatostatin analogs and disease activity status on the upper gastrointestinal system in patients with acromegaly. METHODS:One hundred eighty-one patients with acromegaly were retrospectively assessed. The demographic, biochemical, pathologic, and radiologic data of the patients were...

journal_title：Pituitary

authors： Sahin S,Icli TB,Durcan E,Sulu C,Ozkaya HM,Hatemi AI,Kadioglu P

更新日期：2020-10-19 00:00:00

abstract：INTRODUCTION:Cushing's syndrome is associated with a number of clinical manifestations and co-morbidities which may not resolve even after long-term remission leading to excessive mortality. MATERIALS AND METHODS:This review summarizes the main manifestations of Cushing's syndrome (active or in remission) with particu...

journal_title：Pituitary

authors： Ntali G,Grossman A,Karavitaki N

更新日期：2015-04-01 00:00:00

abstract：:To study the currently available data of recurrence rates of functioning and nonfunctioning pituitary adenomas following surgical cure and to analyze associated predisposing factors, which are not well established. A systematic literature search was conducted using Medline, Embase, Web of Science and the Cochran Libra...

journal_title：Pituitary

authors： Roelfsema F,Biermasz NR,Pereira AM

更新日期：2012-03-01 00:00:00

abstract：:Patients with adult GH deficiency (AGHD) have a high cardiovascular risk and probably an alteration of the oxidative balance, although evidence is lacking. To evaluate the presence of endothelial dysfunction and oxidative stress in patients with AGHD. Biochemical parameters of oxidative stress and endothelial dysfunct...

journal_title：Pituitary

authors： González-Duarte D,Madrazo-Atutxa A,Soto-Moreno A,Leal-Cerro A

更新日期：2012-12-01 00:00:00

abstract：:We report the results of long-term (6-year) treatment of Nelson's syndrome with the long-acting dopamine agonist, cabergoline, in a 55-year-old woman. The disease presented 26 years after bilateral adrenalectomy and radiation treatment for Cushing's disease, followed by glucocorticoid and mineralocorticoid replacement...

journal_title：Pituitary

authors： Shraga-Slutzky I,Shimon I,Weinshtein R

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:There has been growing interest on medical therapy for the management of Cushing's disease (CD), particularly in cases of persistent or recurrent hypercortisolism. Ketoconazole, an inhibitor of adrenal steroidogenesis, is the most widely used drug, whereas cabergoline and pasireotide are the most promising...

journal_title：Pituitary

authors： Vilar L,Naves LA,Machado MC,Bronstein MD

更新日期：2015-04-01 00:00:00

abstract：:160 clinically non-secreting pituitary adenomas were examined in regard to their expression of the markers PCNA, bcl2, Ki 67 in the mib-1 modification and p53 which are still under investigation for their relevance to cell proliferation. The series contained 60 null cell adenomas, 60 oncocytomas and 40 gonadotroph ade...

journal_title：Pituitary

authors： Schreiber S,Saeger W,Lüdecke DK

更新日期：1999-05-01 00:00:00

abstract：OBJECTIVE:Lymphocytic hypophysitis (LH) is a rare chronic inflammatory disorder characterized by lymphocytic infiltration of the pituitary gland commonly affecting women during pregnancy or post-partum period. The pathogenesis remains uncertain, however an autoimmune process is frequently implicated. There is limited d...

journal_title：Pituitary

authors： Lim S,Elston MS,Swarbrick MJ,Conaglen JV

更新日期：2009-01-01 00:00:00

abstract：:Adequate ADH secretion, adrenal and thyroid functions are vital during the acute and post-acute phases of TBI. Deficiencies of these functions as a result of TBI are increasingly recognized. During the acute phase of TBI the incidence of severe DI is 2.9%; the incidence of less severe forms of DI is 21.6-26%. The deve...

journal_title：Pituitary

authors： Tsagarakis S,Tzanela M,Dimopoulou I

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to define safety and efficacy of medical therapy in the treatment of nonfunctioning pituitary tumours. DESIGN:We studied thirteen patients with a clinically nonfunctioning pituitary macroadenoma for response to cabergoline treatment for 1 year. Twelve/13 patients were already op...

journal_title：Pituitary

authors： Lohmann T,Trantakis C,Biesold M,Prothmann S,Guenzel S,Schober R,Paschke R

更新日期：2001-08-01 00:00:00

abstract：:Leptin is a key mediator in the maintenance of neuroendocrine homeostasis. The aim of this study was to determine the changes in serum leptin, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), nitric oxide (NO) levels in patients with hyperprolactinemia. The study consists of 16 consecutive patients with ...

journal_title：Pituitary

authors： Balci H,Akgun-Dar K,Gazioglu N,Kapucu A,Bolayirli M,Oz B

更新日期：2009-01-01 00:00:00

abstract：:We report a case of hepatolithiasis (intrahepatic stone) complicated by gram-negative sepsis in a 37 year old male with acromegaly being treated with octreotide. As a child, he had suffered a traumatic injury to his liver requiring the surgical repair of a laceration. This is the first reported case of hepatolithiasis...

journal_title：Pituitary

authors： Sheehan MT,Nippoldt TB

更新日期：2000-12-01 00:00:00

abstract：:In western countries, the process of "ageing of the population" is increasingly forcing clinical medicine to find answers for pathologies affecting the elder segments of our community. In this respect, pituitary adenomas often raise difficult questions on surgical indications, since little is known about postoperative...

journal_title：Pituitary

authors： Locatelli M,Bertani G,Carrabba G,Rampini P,Zavanone M,Caroli M,Sala E,Ferrante E,Gaini SM,Spada A,Mantovani G,Lania A

更新日期：2013-06-01 00:00:00

abstract：PURPOSE:Thyrotropin-secreting pituitary adenoma is a rare disorder and was recently classified as an aggressive tumor in the World Health Organization guidelines. The number of available studies on cosecreting thyrotropin/growth hormone pituitary adenoma is especially limited. METHODS:A single-center retrospective ana...

journal_title：Pituitary

authors： Li X,Lynch L,Xing H,Wang Z,Zhu J,Deng K,Wang R,Yao Y,Lian X

更新日期：2020-10-01 00:00:00

abstract：:Hyperprolactinemia has been associated with impaired metabolism, including insulin resistance. However, the metabolic effects of elevated prolactin (PRL) levels are not completely clarified. The aim of this study was to obtain more insights of metabolic consequences in hyperprolactinemia patients. Fourteen consecutive...

journal_title：Pituitary

authors： Berinder K,Nyström T,Höybye C,Hall K,Hulting AL

更新日期：2011-09-01 00:00:00

abstract：:The availability of various first-line treatment modalities for acromegaly and evolving surgical techniques emphasize the need for accurately defined predictors of surgical outcome. We retrospectively analysed the outcome of 30 patients with acromegaly after initial endoscopic transsphenoidal surgery in two university...

journal_title：Pituitary

authors： van Bunderen CC,van Varsseveld NC,Baayen JC,van Furth WR,Aliaga ES,Hazewinkel MJ,Majoie CB,Freling NJ,Lips P,Fliers E,Bisschop PH,Drent ML

更新日期：2013-06-01 00:00:00

abstract：:Meningiomas account for about 1% of sellar masses. Although they can mimic pituitary adenomas, they are more vascularized and invasive. To gain insights that would enhance our ability to establish a pre-surgical diagnosis of meningioma, we performed a retrospective study of these tumors. Query of the surgical patholog...

journal_title：Pituitary

authors： Kwancharoen R,Blitz AM,Tavares F,Caturegli P,Gallia GL,Salvatori R

更新日期：2014-08-01 00:00:00

abstract：:Twenty years after the first description of combined hypopituitarism (CPHD) caused by PROP1 mutations, the phenotype of affected subjects is still challenging for clinicians. These patients suffer from pituitary hormone deficits ranging from IGHD to panhypopituitarism. ACTH deficiency usually develops later in life. P...

journal_title：Pituitary

authors： Doknic M,Gasic V,Stojanovic M,Pavlovic S,Marinkovic S,Miljic D,Pekic S,Manojlovic-Gacic E,Damjanovic D,Soldatovic I,Petakov M

更新日期：2020-08-01 00:00:00

abstract：PURPOSE:To determine the particle size, concentration, airborne duration and spread during endoscopic endonasal pituitary surgery in actual patients in a theatre setting. METHODS:This observational study recruited a convenience sample of three patients. Procedures were performed in a positive pressure operating room. ...

journal_title：Pituitary

authors： Dhillon RS,Nguyen LV,Rowin WA,Humphries RS,Kevin K,Ward JD,Yule A,Phan TD,Zhao YC,Wynne D,McNeill PM,Hutchins N,Scott DA

更新日期：2021-01-19 00:00:00

abstract：:Anemia and other hematological abnormalities are common in patients with Sheehan's syndrome. The response of these abnormalities to replacement of thyroxine and glucocorticoids is not clear. The aim of the present study was to document the profile of hematological abnormalities and response to treatment in patients wi...

journal_title：Pituitary

authors： Laway BA,Mir SA,Bashir MI,Bhat JR,Samoon J,Zargar AH

更新日期：2011-03-01 00:00:00

abstract：PURPOSE:Doses of growth hormone in adults with growth hormone deficiency are now lower than previously. However, it is not clear they are as effective as higher doses. The objective of this meta-analysis was to assess efficacy of low to moderate dose (LD) GH replacement on standard endpoints of GH compared to higher do...

journal_title：Pituitary

authors： Newman CB,Carmichael JD,Kleinberg DL

更新日期：2015-06-01 00:00:00

abstract：:Most patients with acromegaly have some degree of insulin resistance. The principal mediator of insulin resistance in acromegaly is hypersecretion of growth hormone. Growth hormone acts at several levels to block insulin actions including inhibiting phosphorylation of the insulin receptor and one of its principal sign...

journal_title：Pituitary

authors： Clemmons DR

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:Approximately 25 % of cases of clinically active acromegaly cases treated in our academic center between 1996 and 2000, were diagnosed in patients who had elevated plasma IGF-1 levels, but apparently "normal" 24-h mean plasma GH levels. The current study served to update the data for patients with acromegaly re...

journal_title：Pituitary

authors： Butz LB,Sullivan SE,Chandler WF,Barkan AL

更新日期：2016-12-01 00:00:00

abstract：:Acromegaly is caused by a somatotropinoma in the vast majority of the cases. These are monoclonal tumors that can occur sporadically or rarely in a familial setting. In the last few years, novel familial syndromes have been described and recent studies explored the landscape of somatic mutations in sporadic somatotrop...

journal_title：Pituitary

authors： Gadelha MR,Kasuki L,Korbonits M

更新日期：2017-02-01 00:00:00

abstract：:Ideal surgical treatment of craniopharyngiomas remains a major challenge for neurosurgeons. Craniopharyngiomas grow in the deep-seated hypothalamic area that is paramount for vegetative, emotional and endocrine function, and for maintaining worthwhile life. The benign histological nature of craniopharyngiomas belies t...

journal_title：Pituitary

authors： Honegger J,Tatagiba M

更新日期：2008-01-01 00:00:00