Abstract:
PURPOSE:Secondary empty sella syndrome (SESS) following pituitary surgery remains a diagnostic and therapeutic challenge. The aim of this study was to specify the diagnostic criteria, surgical indications and results of chiasmapexy in the SESS. METHODS:Three cases from two experienced neurosurgical centers were collected and the available literature was reviewed. RESULTS:The 3 patients were operated for a giant non-functioning pituitary adenoma, a cystic macroprolactinoma, and an arachnoid cyst respectively. Postoperative visual outcome was initially improved, and then worsened progressively. At the time of SESS diagnosis, visual field defect was severe in all cases with optic nerve (ON) atrophy in 2 cases. Patients were operated via an endoscopic endonasal extradural approach. One patient was re-operated because of early fat reabsorption. Visual outcome improved in 1 case and stabilized in 2 cases. Statistical analyses performed on 24 cases from the literature review highlighted that patient age and severity of the preoperative visual defect were respectively significant and nearly significant prognostic factors for visual outcome, unlike the surgical technique. CONCLUSION:T2-weighted or CISS/FIESTA sequence MRI is mandatory to visualize adhesions, ON kinking and neurovascular conflict. TS approach is the most commonly used approach. The literature review could not conclude on the need for an intra or extradural approach suggesting case by case adapted strategy. Intrasellar packing with non-absorbable material such as bone should be considered. Severity of the visual loss clearly decreases the visual outcome suggesting early chiasmapexy. In case of severe and long standing symptoms before surgery, benefits and surgical risks should be carefully balanced.
journal_name
Pituitaryjournal_title
Pituitaryauthors
Graillon T,Passeri T,Boucekine M,Meyer M,Abritti R,Bernat AL,Labidi M,Dufour H,Froelich Sdoi
10.1007/s11102-020-01104-5subject
Has Abstractpub_date
2020-11-02 00:00:00eissn
1386-341Xissn
1573-7403pii
10.1007/s11102-020-01104-5pub_type
杂志文章,评审相关文献
Pituitary文献大全abstract::The molecular pathogenesis of prolactinomas has resisted elucidation; with the exception of a RAS mutation in a single aggressive prolactinoma, no mutational changes have been identified. In prolactinomas, a further obstacle has been the paucity of surgical specimens suitable for molecular analysis since prolactionoma...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-007-0082-2
更新日期:2008-01-01 00:00:00
abstract::Leptin is a key mediator in the maintenance of neuroendocrine homeostasis. The aim of this study was to determine the changes in serum leptin, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), nitric oxide (NO) levels in patients with hyperprolactinemia. The study consists of 16 consecutive patients with ...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-008-0140-4
更新日期:2009-01-01 00:00:00
abstract::We report on a 74-year-old male patient who presented with progressive neuroophthalmologic symptoms soon after the administration of a long-acting gonadotropin-releasing hormone agonist for treatment of a prostate cancer. Imaging revealed a destructively growing and extensively calcified sellar mass inconsistent with ...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-009-0199-6
更新日期:2011-12-01 00:00:00
abstract::The diagnoses of acromegaly and dwarfism require biochemical confirmation of abnormal GH and IGF-1 concentrations. The same parameters are used for therapeutic decisions, i.e. initiation or termination of particular treatments. Therefore, reliable and epidemiologically and statistically proven criteria of normalcy for...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-007-0029-7
更新日期:2007-01-01 00:00:00
abstract::We report the results of long-term (6-year) treatment of Nelson's syndrome with the long-acting dopamine agonist, cabergoline, in a 55-year-old woman. The disease presented 26 years after bilateral adrenalectomy and radiation treatment for Cushing's disease, followed by glucocorticoid and mineralocorticoid replacement...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-006-9290-4
更新日期:2006-01-01 00:00:00
abstract:PURPOSE:To evaluate the effects of somatostatin analogs and disease activity status on the upper gastrointestinal system in patients with acromegaly. METHODS:One hundred eighty-one patients with acromegaly were retrospectively assessed. The demographic, biochemical, pathologic, and radiologic data of the patients were...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-020-01095-3
更新日期:2020-10-19 00:00:00
abstract::Patients with adult GH deficiency (AGHD) have a high cardiovascular risk and probably an alteration of the oxidative balance, although evidence is lacking. To evaluate the presence of endothelial dysfunction and oxidative stress in patients with AGHD. Biochemical parameters of oxidative stress and endothelial dysfunct...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-011-0374-4
更新日期:2012-12-01 00:00:00
abstract:PURPOSE:Endogenous Cushing's syndrome (CS) is a rare disease that results from exposure to high levels of cortisol; Cushing's disease (CD) is the most frequent form of CS. Patients with CS suffer from a variety of comorbidities that increase the risk of mortality. Surgical resection of the disease-causing lesion is gen...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-016-0742-1
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:Tatton-Brown-Rahman syndrome (TBRS) is a newly defined genetic entity characterized by overgrowth and intellectual disability, resulting from germline mutations in the gene encoding DNA methyltransferase 3 alpha (DNMT3A). Affected individuals with benign and malignant tumors have been reported; to our knowledge...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-019-01019-w
更新日期:2020-04-01 00:00:00
abstract:INTRODUCTION:Temozolomide (TMZ) is an oral alkylating agent that has been used over the past 8 years to treat aggressive pituitary tumors resistant to conventional therapy. To date, only 25 patients treated with TMZ for ACTH producing pituitary tumors (14 adenomas and 11 carcinomas) have been reported. MATERIALS AND M...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-015-0694-x
更新日期:2016-04-01 00:00:00
abstract::Although leptin was originally viewed as an antiobesity hormone, it is now evident that it may have more pleiotropic actions. Experiments in rodents have shown that leptin activates the sympathetic nervous system, is involved in regulation of blood pressure, hematopoiesis, immune function, angiogenesis and brain, bone...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1023/a:1012938308654
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Autoimmune hypophysitis (AH) is a rare autoimmune inflammatory disorder of pituitary gland. OBJECTIVE:To analyse clinical, hormonal, radiological features and management outcomes of AH. DESIGN:Retrospective analysis of patients with primary hypophysitis (where secondary causes of hypophysitis were ruled ou...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-013-0550-9
更新日期:2015-02-01 00:00:00
abstract::The management of invasive giant prolactinomas (IGP) has been an area of some controversy. The relative roles of transsphenoidal surgery, craniotomy, radiation therapy and dopamine agonist based medical therapy are gradually becoming clarified. We report the results of management of 30 patients with IGP. Surgery was t...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-005-5087-0
更新日期:2005-01-01 00:00:00
abstract::A young female patient presented as an acute medical emergency with hypoglycaemia. Investigations revealed panhypopituitarism and an inflammatory pituitary mass. An antibody screen was negative for anti-neutrophil cytoplasmic antibodies with cytoplasmic distribution (cANCA). Pituitary histology showed lymphocytic infi...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-007-0016-z
更新日期:2007-01-01 00:00:00
abstract::Cushing's disease, i.e., pituitary ACTH-secreting adenoma causing excess glucocorticoid secretion, is a rare disease with significant mortality and morbidity. Timely diagnosis and appropriate treatment can alter the course of the disease and are therefore mandatory. First step of the diagnostic work-up is the endogeno...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-006-0407-6
更新日期:2006-01-01 00:00:00
abstract::Hyperprolactinemia has been associated with impaired metabolism, including insulin resistance. However, the metabolic effects of elevated prolactin (PRL) levels are not completely clarified. The aim of this study was to obtain more insights of metabolic consequences in hyperprolactinemia patients. Fourteen consecutive...
journal_title:Pituitary
pub_type: 临床试验,杂志文章
doi:10.1007/s11102-010-0277-9
更新日期:2011-09-01 00:00:00
abstract::Most patients with acromegaly have some degree of insulin resistance. The principal mediator of insulin resistance in acromegaly is hypersecretion of growth hormone. Growth hormone acts at several levels to block insulin actions including inhibiting phosphorylation of the insulin receptor and one of its principal sign...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1023/a:1023321421760
更新日期:2002-01-01 00:00:00
abstract:PURPOSE:Thyrotropin-secreting pituitary adenoma is a rare disorder and was recently classified as an aggressive tumor in the World Health Organization guidelines. The number of available studies on cosecreting thyrotropin/growth hormone pituitary adenoma is especially limited. METHODS:A single-center retrospective ana...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-020-01064-w
更新日期:2020-10-01 00:00:00
abstract::Craniopharyngiomas (CP) are partly cystic embryogenic malformations of the sellar and parasellar region. With an overall incidence of 0.5-2.0 new cases/million population/year, approximately 30-50 % of all cases represent childhood CP. Typical manifestations at diagnosis are headache, visual impairment, polyuria/polyd...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-012-0401-0
更新日期:2013-03-01 00:00:00
abstract:PURPOSE:Patients treated for pituitary adenomas generally report a reduced quality of life (QoL). At present, the patient's perspective of QoL has not been fully addressed and this, and further insight in potential determinants of QoL in pituitary diseases is required to design strategies to improve QoL. We aimed to de...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-014-0561-1
更新日期:2015-02-01 00:00:00
abstract:PURPOSE:To report the results of a consecutive series of patients who underwent an endoscopic endonasal approach (EEA) for resection of a pituitary adenoma and compare them to previous series of microscopic and endoscopic approaches. METHODS:A retrospective review of clinical and radiographic outcomes of a consecutive...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-013-0502-4
更新日期:2014-08-01 00:00:00
abstract::Glucocorticoids are important immunosuppressive hormones; these steroids also inhibit somatic growth by decreased growth hormone (GH) secretion and induced protein catabolism. The ability of ghrelin, the endogenous ligand for the GHS-1a receptor, to increase body weight is attributed to a combination of enhanced food ...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-007-0054-6
更新日期:2007-01-01 00:00:00
abstract::Double pituitary adenomas are rare in surgical specimens and the most common clinical feature in reported patients has been acromegaly. We report 3 cases of double pituitary lesions in patients who presented with Cushing's disease. In a 22-year-old man (case 1) with delayed puberty and low testosterone levels, mild hy...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1023/a:1011499609096
更新日期:2000-11-01 00:00:00
abstract:PURPOSE:To determine the particle size, concentration, airborne duration and spread during endoscopic endonasal pituitary surgery in actual patients in a theatre setting. METHODS:This observational study recruited a convenience sample of three patients. Procedures were performed in a positive pressure operating room. ...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-021-01125-8
更新日期:2021-01-19 00:00:00
abstract:PURPOSE:Ectopic pituitary adenomas (EPA) are rare tumors thought to arise from embryological remnants along the route of normal pituitary migration. Clinically, these tumors vary in hormonal activity and can exert mass effect based on location and size. METHODS:We performed a single-center retrospective analysis of pa...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-019-00954-y
更新日期:2019-08-01 00:00:00
abstract::Inferior petrosal sinus sampling (IPSS) of ACTH with CRH stimulation helps distinguish pituitary ACTH-dependent Cushing's syndrome from the ectopic ACTH syndrome (EAS). The usefulness of the paradoxical response of other pituitary hormones including prolactin to CRH remains controversial. Data from 33 IPSS procedures ...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-009-0200-4
更新日期:2010-06-01 00:00:00
abstract::Lactotroph adenomas, also called prolactinomas and prolactin-secreting adenomas, constitute nearly 80% of functioning pituitary tumors and about 30-50% of all adenomas in the clinical practice. Lactotroph adenomas occur in the general population at a prevalence of 45/100,000, are more common in women, but also involve...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-019-00997-1
更新日期:2020-02-01 00:00:00
abstract::Medications commonly cause hyperprolactinemia and their use must be differentiated from pathologic causes. The most common medications to cause hyperprolactinemia are the antipsychotic agents, although some of the newer atypical antipsychotics do not do so. Other medications causing hyperprolactinemia include antidepr...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-008-0106-6
更新日期:2008-01-01 00:00:00
abstract::Cushing's Syndrome (CS) is associated with an increased mortality, where hypercoagulability seems to have a crucial role in both arterial and venous thrombosis. Parameters of in vitro thrombin generation (TG) such as lag time, peak thrombin and endogenous thrombin potential (ETP), that describe the time until thrombin...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-013-0467-3
更新日期:2014-02-01 00:00:00
abstract::Wegener's granulomatosis (WG) is an anti-neutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis of small and medium-sized vessels. Pituitary involvement in WG is rare with only 22 previous case reports in the English medical literature between 1966 and 2006. Herein we report another patient with WG-rela...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-007-0021-2
更新日期:2008-01-01 00:00:00