Abstract:
:Anemia and other hematological abnormalities are common in patients with Sheehan's syndrome. The response of these abnormalities to replacement of thyroxine and glucocorticoids is not clear. The aim of the present study was to document the profile of hematological abnormalities and response to treatment in patients with Sheehan's syndrome. Forty patients of Sheehan's syndrome and an equal number of age and parity matched healthy controls were studied for prevalence of hematological abnormalities. Hemoglobin concentration, hematocrit, red cell, white cell and platelet count were significantly decreased in patients with Sheehan's syndrome compared to controls. Frequency of anemia, leucopenia, thrombocytopenia and pancytopenia was significantly higher in these patients compared to controls. After achieving euthyroid and eucortisol state, there was a complete recovery of these hematological abnormalities. We conclude that anemia and other cytopenias are common in patients with Sheehan's syndrome and replacement with thyroxine and glucocorticoids results in complete recovery of these abnormalities.
journal_name
Pituitaryjournal_title
Pituitaryauthors
Laway BA,Mir SA,Bashir MI,Bhat JR,Samoon J,Zargar AHdoi
10.1007/s11102-010-0255-2subject
Has Abstractpub_date
2011-03-01 00:00:00pages
39-43issue
1eissn
1386-341Xissn
1573-7403journal_volume
14pub_type
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