Twelve cases of pituitary metastasis: a case series and review of the literature.

abstract：PURPOSE:Approximately 25 % of cases of clinically active acromegaly cases treated in our academic center between 1996 and 2000, were diagnosed in patients who had elevated plasma IGF-1 levels, but apparently "normal" 24-h mean plasma GH levels. The current study served to update the data for patients with acromegaly re...

journal_title：Pituitary

authors： Butz LB,Sullivan SE,Chandler WF,Barkan AL

更新日期：2016-12-01 00:00:00

abstract：PURPOSE:Survivin is an apoptosis inhibitor, expressed in almost all types of human malignancies, but rarely in differentiated normal tissues. Recently, survivin gene splice variants with different anti-apoptotic activities have been reported. The current study was undertaken to examine the expression of survivin and it...

journal_title：Pituitary

authors： Waligórska-Stachura J,Andrusiewicz M,Sawicka-Gutaj N,Kubiczak M,Jankowska A,Liebert W,Czarnywojtek A,Waśko R,Blanco-Gangoo AR,Ruchała M

更新日期：2015-06-01 00:00:00

abstract：:Isolated familial somatotropinomas (IFS) rarely occurs in the absence of multiple endocrine neoplasia type I (MEN1) or the Carney complex. In the present study we report two Italian siblings affected by GH-secreting adenomas. There was no history of parental consanguinity. The sister presented at 18 years of age with ...

journal_title：Pituitary

authors： De Menis E,Prezant TR

更新日期：2002-01-01 00:00:00

abstract：:In this report, an extremely rare case of pediatric thyrotropin-secreting pituitary macroadenoma (TSHoma) is described. An 8-year-old boy, complaining of unsteady gait, was suspected of endocrinopathy because of emaciation and muscle weakness of the legs. Endocrinological work-up established a diagnosis of hyperthyroi...

journal_title：Pituitary

authors： Nakayama Y,Jinguji S,Kumakura S,Nagasaki K,Natsumeda M,Yoneoka Y,Saito T,Fujii Y

更新日期：2012-03-01 00:00:00

abstract：:Dopamine agonists have been shown to reduce growth hormone secretion in some patients with acromegaly, but their effect on adenoma size has not been well appreciated. We describe a 69 year-old woman with acromegaly caused by a somatotroph macroadenoma who received primary treatment with the dopamine agonist cabergolin...

journal_title：Pituitary

authors： Rickels MR,Snyder PJ

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:Granular cell tumors of the neurohypophysis are rare, solitary lesions, mostly presenting in the adult age. They rarely grow to a sufficient size to cause mass effect related symptoms and they may be found in most cases incidentally at autopsy. Because of their rarity as of now they have been described only as ...

journal_title：Pituitary

authors： Gagliardi F,Spina A,Barzaghi LR,Bailo M,Losa M,Terreni MR,Mortini P

更新日期：2016-06-01 00:00:00

abstract：PURPOSE:To evaluate the effects of somatostatin analogs and disease activity status on the upper gastrointestinal system in patients with acromegaly. METHODS:One hundred eighty-one patients with acromegaly were retrospectively assessed. The demographic, biochemical, pathologic, and radiologic data of the patients were...

journal_title：Pituitary

authors： Sahin S,Icli TB,Durcan E,Sulu C,Ozkaya HM,Hatemi AI,Kadioglu P

更新日期：2020-10-19 00:00:00

abstract：:Oral estrogens reduce GH-induced IGF-1 production and preliminary studies have shown that adjuvant estroprogestin (EP) therapy with octreotide LAR may control disease activity in some female patients who are partially responsive to octreotide LAR. Our aim was to verify if EP alone or in combination with octreotide LAR...

journal_title：Pituitary

authors： Vallette S,Serri O

更新日期：2010-12-01 00:00:00

abstract：:MAP-2, a well characterized member of the microtubule associated protein (MAP) family, binds to and stabilizes microtubules and is involved in cell proliferation as well as neuronal differentiation. The aim of the present work was to study MAP-2 expression in human adenohypophyses and pituitary adenomas. To our knowle...

journal_title：Pituitary

authors： Rotondo F,Oniya K,Kovacs K,Bell CD,Scheithauer BW

更新日期：2005-01-01 00:00:00

abstract：:We evaluated the efficacy of Gamma knife stereotactic radiosurgery (GKSR) as an adjunctive management modality for patients with drug resistant or intolerant cavernous sinus invasive prolactinomas. Twenty-two patients with cavernous sinus invasive prolactinoma underwent GKSR between 1994 and 2009. Thirteen patients we...

journal_title：Pituitary

authors： Liu X,Kano H,Kondziolka D,Park KJ,Iyer A,Shin S,Niranjan A,Flickinger JC,Lunsford LD

更新日期：2013-03-01 00:00:00

abstract：:Growth hormone excess has been associated with hypercalciuria and nephrolithiasis. Hypercalcemia in acromegaly is rare and usually due to coexistent primary hyperparathyroidism. To report two cases of 1,25-dihydroxyvitamin D (1,25 (OH)(2) D)-dependent hypercalcemia in cromegaly. A 50 year-old female with 2 years histo...

journal_title：Pituitary

authors： Shah R,Licata A,Oyesiku NM,Ioachimescu AG

更新日期：2012-12-01 00:00:00

abstract：PURPOSE:Patients treated for pituitary adenomas generally report a reduced quality of life (QoL). At present, the patient's perspective of QoL has not been fully addressed and this, and further insight in potential determinants of QoL in pituitary diseases is required to design strategies to improve QoL. We aimed to de...

journal_title：Pituitary

authors： Andela CD,Niemeijer ND,Scharloo M,Tiemensma J,Kanagasabapathy S,Pereira AM,Kamminga NG,Kaptein AA,Biermasz NR

更新日期：2015-02-01 00:00:00

abstract：INTRODUCTION:Early disease onset, clinical manifestation, histomorphology, and increased tendency to relapse distinguish the adamantinomatous craniopharyngioma (adaCP) from the more favorable papillary variant (papCP). A molecular hallmark of adaCP is the activated Wnt signaling pathway indicated by nuclear β-catenin a...

journal_title：Pituitary

authors： Hölsken A,Stache C,Schlaffer SM,Flitsch J,Fahlbusch R,Buchfelder M,Buslei R

更新日期：2014-12-01 00:00:00

abstract：:Aggressive pituitary adenomas are notoriously difficult to manage due to their size, invasiveness, speed of growth and high frequency of recurrence. Except for prolactinomas, surgery (usually transsphenoidal but sometimes transcranial) is the first-line option, but re-growth of aggressive tumors is almost inevitable a...

journal_title：Pituitary

authors： Buchfelder M

更新日期：2009-01-01 00:00:00

abstract：:Although leptin was originally viewed as an antiobesity hormone, it is now evident that it may have more pleiotropic actions. Experiments in rodents have shown that leptin activates the sympathetic nervous system, is involved in regulation of blood pressure, hematopoiesis, immune function, angiogenesis and brain, bone...

journal_title：Pituitary

authors： Popovic V,Damjanovic S,Dieguez C,Casanueva FF

更新日期：2001-01-01 00:00:00

abstract：:In order to explore the presence of, and the potential role of, secretagogin in human pituitary adenomas, an analytical strategy that integrated comparative proteomics and comparative transcriptomics was used to detect the protein and the mRNA expression, respectively, of secretagogin in human non-functional pituitary...

journal_title：Pituitary

authors： Zhan X,Evans CO,Oyesiku NM,Desiderio DM

更新日期：2003-01-01 00:00:00

abstract：:The role of pituitary radiotherapy (RT) in the management of clinically non-functioning pituitary tumors (NFTs) remains controversial. Observational studies suggest that RT is effective in preventing the regrowth of NFT remnants following initial surgical debulking. However, not all tumor remnants will regrow in the a...

journal_title：Pituitary

authors： Gittoes NJ

更新日期：2003-09-01 00:00:00

abstract：:A diabetic acromegalic man, not cured after surgery and radiosurgery, received lanreotide i.m. with great clinical and biochemical improvement. He required NPH insulin (76 to 84 units/day) to control his diabetes mellitus. Thirty-six hours after changing to LAR-octreotide (20 mg i.m/month) he presented symptomatic hyp...

journal_title：Pituitary

authors： Webb SM,Ortega E,Rodríguez-Espinosa J,Mato ME,Corcoy R

更新日期：2001-09-01 00:00:00

abstract：:The purpose of this study is to verify whether acute pre-treatment with alprazolam (ALP), a benzodiazepine that inhibits HPA secretion in normal subjects, could better characterize patients with subclinical Cushing's syndrome (SCS) than the 1-mg dexamethasone test (DST). In 22 patients with SCS, 10 with overt Cushing'...

journal_title：Pituitary

authors： Giordano R,Berardelli R,Karamouzis I,D'Angelo V,Picu A,Zichi C,Fussotto B,Manzo M,Mengozzi G,Ghigo E,Arvat E

更新日期：2013-09-01 00:00:00

abstract：:Apart from the radiologic features regarding size and invasiveness, we had noticed some differences in morphology among types of pituitary adenomas. We conducted this study to verify the differences in radiologic morphology between growth hormone producing pituitary adenomas (GHoma) and nonfunctioning pituitary adenom...

journal_title：Pituitary

authors： Bakhtiar Y,Hanaya R,Tokimura H,Hirano H,Oyoshi T,Fujio S,Bohara M,Arita K

更新日期：2014-04-01 00:00:00

abstract：:We report the results of long-term (6-year) treatment of Nelson's syndrome with the long-acting dopamine agonist, cabergoline, in a 55-year-old woman. The disease presented 26 years after bilateral adrenalectomy and radiation treatment for Cushing's disease, followed by glucocorticoid and mineralocorticoid replacement...

journal_title：Pituitary

authors： Shraga-Slutzky I,Shimon I,Weinshtein R

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:Tatton-Brown-Rahman syndrome (TBRS) is a newly defined genetic entity characterized by overgrowth and intellectual disability, resulting from germline mutations in the gene encoding DNA methyltransferase 3 alpha (DNMT3A). Affected individuals with benign and malignant tumors have been reported; to our knowledge...

journal_title：Pituitary

authors： Hage C,Sabini E,Alsharhan H,Fahrner JA,Beckers A,Daly A,Salvatori R

更新日期：2020-04-01 00:00:00

abstract：:The metabolic consequences of thyroxine replacement in patients with central hypothyroidism (CH) need to be evaluated. The aim was to examine the outcome of thyroxine replacement in CH. Adult hypopituitary patients (n = 1595) with and without CH from KIMS (Pfizer International Metabolic Database) were studied before a...

journal_title：Pituitary

authors： Filipsson Nyström H,Feldt-Rasmussen U,Kourides I,Popovic V,Koltowska-Häggström M,Jonsson B,Johannsson G

更新日期：2012-12-01 00:00:00

abstract：:Traumatic brain injury (TBI) is an important public health problem with an increasing incidence in the last years. Relatively few cases are fatal; most individuals will survive and, in the long-term, the sequalae of TBI will include neuroendocrine dysfunctions with a much higher frequency than previously suspected. Pa...

journal_title：Pituitary

authors： Caputo M,Mele C,Prodam F,Marzullo P,Aimaretti G

更新日期：2019-06-01 00:00:00

abstract：:Adipsic diabetes insipidus (ADI) is a rare condition in which thirst, an essential clinical feature for the prevention of hypernatraemic dehydration, is absent. We report the first case of adipsic diabetes insipidus to occur following surgery for a pituitary macroprolactinoma, with loss of both osmoregulated and baror...

journal_title：Pituitary

authors： Sherlock M,Agha A,Crowley R,Smith D,Thompson CJ

更新日期：2006-01-01 00:00:00

abstract：:Craniopharyngiomas (CP) are partly cystic embryogenic malformations of the sellar and parasellar region. With an overall incidence of 0.5-2.0 new cases/million population/year, approximately 30-50 % of all cases represent childhood CP. Typical manifestations at diagnosis are headache, visual impairment, polyuria/polyd...

journal_title：Pituitary

authors： Müller HL

更新日期：2013-03-01 00:00:00

abstract：:Cushing's disease, i.e., pituitary ACTH-secreting adenoma causing excess glucocorticoid secretion, is a rare disease with significant mortality and morbidity. Timely diagnosis and appropriate treatment can alter the course of the disease and are therefore mandatory. First step of the diagnostic work-up is the endogeno...

journal_title：Pituitary

authors： De Martin M,Pecori Giraldi F,Cavagnini F

更新日期：2006-01-01 00:00:00

abstract：:Published data on the effects of androgen deficiency and testosterone administration on body composition in men and women are reviewed. In experimental paradigms, androgen deprivation decreases lean body mass and increases fat mass in men, and physiologic replacement reverses these abnormalities. The anabolic effects ...

journal_title：Pituitary

authors： Miller KK

更新日期：2009-01-01 00:00:00

abstract：:Surgical cure cannot be achieved in most patients with invasive non-functioning pituitary macroadenoma (NFPA). Short-term residual tumor treatment with somatostatin analogs has produced disappointing results. This prospective case-control study assessed the efficacy of chronic treatment with long acting octreotide (oc...

journal_title：Pituitary

authors： Fusco A,Giampietro A,Bianchi A,Cimino V,Lugli F,Piacentini S,Lorusso M,Tofani A,Perotti G,Lauriola L,Anile C,Maira G,Pontecorvi A,De Marinis L

更新日期：2012-12-01 00:00:00

abstract：:We report the case of a B-cell type pituitary lymphoma in a 65 year-old male immunocompetent patient who presented with hypogonadotropic hypogonadism and central hypothyroidism and subsequently developed pulmonary lymphoma. Only three cases of pituitary lymphoma have been previously reported, one in a patient with acq...

journal_title：Pituitary

authors： Mathiasen RA,Jarrahy R,Cha ST,Kovacs K,Herman VS,Ginsberg E,Shahinian HK

更新日期：2000-05-01 00:00:00