Early prediction of unexplained syncope by support vector machines.

Abstract:

:The goal of the present study was to develop and evaluate a new method for the prediction of unexplained syncope occurrences. Diagnosis of syncope is currently based on the reproduction of symptoms in combination with hypotension and bradycardia induced by a 45 min 60-70 degrees head-upright tilt test (HUTT). The main drawback of this widely used test concerns its duration that reaches 55 min if the patient does not faint. Our method is a first step in the avoidance of the HUTT. An electrocardiogram and a transthoracic impedance waveform were recorded for 10 min of supine rest of a HUTT in 128 patients with a history of unexplained recurrent syncope. Seven indices were computed on the transthoracic impedance and its first derivative. The prediction quality of every subset of these variables, mixed with age and sex, has been tested by a support vector machine in a retrospective group of 64 patients (100% of sensitivity and 100% of specificity was reached). The best subset obtained has been evaluated prospectively in a group of 64 patients (94% of sensitivity and 79% of specificity was reached). These results compare very favorably with published results for other unexplained syncope detectors.

journal_name

Physiol Meas

authors

Schang D,Feuilloy M,Plantier G,Fortrat JO,Nicolas P

doi

10.1088/0967-3334/28/2/007

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

185-97

issue

2

eissn

0967-3334

issn

1361-6579

pii

S0967-3334(07)23477-X

journal_volume

28

pub_type

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