Abstract：
BACKGROUND:Psoriasis is a chronic inflammatory skin disease in which several Th1 cytokines such as interleukin-1 beta (IL-beta) have been shown to play a pivotal role. Psychological stress has also been implicated in triggering or exacerbating the disease. METHODS:Salivary IL-1beta and cortisol levels of 25 patients with psoriasis were compared with those of 50 age- and sex-matched healthy controls under basal conditions and after a standardized stressful procedure including mental arithmetics and the Stroop Color-Word Naming Test. RESULTS:At baseline, mean IL-1beta levels were higher in patients with psoriasis than controls (p <0.001), whereas mean cortisol levels did not differ significantly between groups. Although IL-1beta levels increased after stress among controls, they did not increase among patients with psoriasis, with a significant group-by-time interaction (p <0.01). After stress, cortisol levels were significantly increased in both groups as compared with baseline (p < or =0.001), without any group-by-time interaction. Perceived stress was similar among psoriatic patients and controls. There was no significant correlation between changes in IL-1beta and changes in cortisol. CONCLUSIONS:The higher basal IL-1beta levels among psoriatic patients suggest that its production is increased. Changes in proinflammatory cytokine activity in psoriatic skin may play an important role in propagating inflammation. The blunted response of IL-1beta to stress observed in psoriatic patients may reflect a "ceiling effect", or be ascribed to a defective response of the immune system to adrenergic stimuli.
journal_name
Arch Med Resjournal_title
Archives of medical researchauthors
Mastrolonardo M,Alicino D,Zefferino R,Pasquini P,Picardi Adoi
10.1016/j.arcmed.2006.09.009subject
Has Abstractpub_date
2007-02-01 00:00:00pages
206-11issue
2eissn
0188-4409issn
1873-5487pii
S0188-4409(06)00337-7journal_volume
38pub_type
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journal_title：Archives of medical research
pub_type： 杂志文章,评审
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journal_title：Archives of medical research
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更新日期：2007-01-01 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：1994-07-01 00:00:00
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更新日期：1997-10-01 00:00:00
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journal_title：Archives of medical research
pub_type： 临床试验,杂志文章
doi：
更新日期：1996-07-01 00:00:00
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doi：
更新日期：1998-10-01 00:00:00
abstract：BACKGROUND:The present study was designed to examine whether resveratrol, a potent antioxidant, protects against renal ischemia-reperfusion (I/R) injury. METHODS:Wistar albino rats were unilaterally nephrectomized and subjected to 45 min of renal pedicle occlusion followed by 6 h of reperfusion. Resveratrol (RVT, 30 m...
journal_title：Archives of medical research
pub_type： 杂志文章
doi：10.1016/j.arcmed.2006.04.003
更新日期：2006-10-01 00:00:00
