Abstract:
INTRODUCTION:It has been demonstrated that skin tissue cholesterol (SkinTc) is associated with angiographic disease. Now, we further delineate the relative risk of multivessel disease (>50% stenosis in at least two vessels) in the conjoint presence of high SkinTc and high traditional risk burden. METHODS:Patients scheduled for angiography (N = 649) had SkinTc measured immediately prior to the procedure. Patients were classified according to the presence of high (>110) SkinTc and high (>10) Framingham global risk scores. Multivariable logistic regression models were used to estimate relative risk of multivessel disease for patients with isolated high skin tissue cholesterol, isolated high Framingham risk or conjoint high skin tissue cholesterol and high Framingham risk (each compared to neither factor elevated). RESULTS:The mean age was 63 +/- 12 years and 33% (n = 214) were women. Thirty seven percent (n = 237) had angiographically determined multivessel disease. Patients with isolated high SkinTc showed a relative risk of multivessel disease of 1.6 (95% CI = 1.0-2.4), while patients with isolated high Framingham risk had an odds ratio of 1.8 (CI = 1.0-3.4). However, when both scores were elevated, risk of multivessel disease was increased 4.3 times (CI = 2.6-7.2) compared to neither elevated. CONCLUSIONS:We see an independent, additive risk of concurrent multivessel disease when Framingham risk and skin cholesterol are both elevated. Skin tissue cholesterol may have value in further stratifying subjects with Framingham scores >10.
journal_name
Am Heart Jjournal_title
American heart journalauthors
Sprecher DL,Pearce GLdoi
10.1016/j.ahj.2006.04.027subject
Has Abstractpub_date
2006-10-01 00:00:00pages
694-6issue
4eissn
0002-8703issn
1097-6744pii
S0002-8703(06)00412-1journal_volume
152pub_type
杂志文章abstract::A retrospective analysis of our experience with intraprocedural thrombus complicating percutaneous transluminal coronary angioplasty (PTCA) was undertaken. Of 983 PTCA procedures reviewed, 62 (6.3%) were complicated by thrombus. Patients were managed conservatively (group I, n = 18), with redilation (group II, n = 17)...
journal_title:American heart journal
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更新日期:2014-11-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2006-10-01 00:00:00
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更新日期:2009-10-01 00:00:00
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更新日期:1995-01-01 00:00:00
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更新日期:1988-08-01 00:00:00
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pub_type: 杂志文章
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