Abstract：
:Mast cells produce symptoms by local and remote effects of mediator release and by their presence in increased numbers in normal tissue and bone marrow, where they damage and impair normal organ function. Moreover, mast cells are long-lived and heterogeneous in their response to secretagogues and to inhibitors of mediator release. Clinicians sorting out the diagnosis of SM on the basis of presenting signs and symptoms continue to have their diagnostic skills challenged because of the rarity of this disorder, the fact that many symptoms of SM are present in more common disorders, and the multiple guises that SM may assume at the time of presentation.
journal_name
Immunol Allergy Clin North Amjournal_title
Immunology and allergy clinics of North Americaauthors
Butterfield JHdoi
10.1016/j.iac.2006.05.006subject
Has Abstractpub_date
2006-08-01 00:00:00pages
487-513issue
3eissn
0889-8561issn
1557-8607pii
S0889-8561(06)00053-1journal_volume
26pub_type
杂志文章,评审abstract：:Heterogeneous presentations of disease pose particular diagnostic and management challenges to the clinician. Progestogen hypersensitivity (PH) classically consists of hypersensitivity symptoms to endogenous progesterone during the luteal phase of the menstrual cycle. However, with the rise of assisted fertility and t...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
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更新日期：2017-11-01 00:00:00
abstract：:Chronic rhinosinusitis (CRS) has a substantial impact on patients' quality of life (QOL). Among the many metrics available for measuring treatment success in CRS, patient-reported outcome measures that quantify changes in QOL are the most widely used methods. In addition, objective data from imaging, endoscopy, and ol...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
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journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
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更新日期：2003-11-01 00:00:00
abstract：:This article focuses on issues of safety and monitoring when immunosuppressive pharmacologic therapies are prescribed for the treatment of connective tissue disease (CTD)-associated interstitial pneumonias, vasculitides, and bronchiolitis. Prospective, randomized placebo-controlled clinical trials have yet to be perfo...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
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journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2018.12.004
更新日期：2019-05-01 00:00:00
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journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2008.09.005
更新日期：2009-02-01 00:00:00
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journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2015.01.005
更新日期：2015-05-01 00:00:00
abstract：:Measurement of urinary leukotriene E(4) (uLTE(4)) is a sensitive and noninvasive method of assaying total body cysteinyl leukotriene production and changes in cysteinyl leukotriene production. Recent studies have reported on novel uLTE(4) receptor interactions, and new applications for uLTE(4), as a biomarker of envir...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2012.06.012
更新日期：2012-08-01 00:00:00
abstract：:Acute eosinophilic pneumonia, chronic eosinophilia, Churg-Strauss syndrome, and the hypereosinophilic syndrome are pulmonary eosinophilic syndromes characterized by an increased number of eosinophils in peripheral blood, in lung tissue, in sputum, in bronchoalveolar lavage fluid, or in all of these. These pulmonary eo...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2007.07.005
更新日期：2007-08-01 00:00:00
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journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章
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更新日期：2010-08-01 00:00:00
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journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2006.09.001
更新日期：2006-11-01 00:00:00
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journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2008.06.003
更新日期：2008-11-01 00:00:00
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journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2018.08.004
更新日期：2019-02-01 00:00:00
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journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2014.02.004
更新日期：2014-05-01 00:00:00
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journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2010.09.004
更新日期：2011-02-01 00:00:00
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journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2012.04.007
更新日期：2012-05-01 00:00:00
abstract：:Mastocytosis is a World Health Organization-defined clonal mast cell disorder characterized by significant clinicopathologic heterogeneity. Despite this diversity, a mutation of the KIT gene, most commonly D816V, is found in almost all cases and believed a driver lesion. Peripheral blood allele-specific oligonucleotid...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2018.04.005
更新日期：2018-08-01 00:00:00
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journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2007.03.007
更新日期：2007-05-01 00:00:00
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journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章
doi：10.1016/j.iac.2011.02.011
更新日期：2011-05-01 00:00:00
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journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2015.07.005
更新日期：2015-11-01 00:00:00
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journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2015.05.006
更新日期：2015-08-01 00:00:00
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journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s0889-8561(02)00084-x
更新日期：2003-05-01 00:00:00
abstract：:Atopic dermatitis (AD) is a heterogeneous disease and many attempts have been made to define subsets of patients based on clinical characteristics. However, the current characterization of patients with AD might not adequately reflect the pathophysiologic diversity within patients with AD. This article reviews current...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
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更新日期：2017-02-01 00:00:00
abstract：:Asthma is characterized by persistent airway inflammation, which is associated with airway hyperresponsiveness and variable airflow obstruction, which accounts for the majority of symptoms experienced by asthmatic patients. Allergen sensitization and inhalation causes airway inflammation, and is likely important in th...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2005.05.005
更新日期：2005-08-01 00:00:00
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journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章
doi：10.1016/j.iac.2005.09.003
更新日期：2005-11-01 00:00:00
abstract：:The incidence of immune-mediated anaphylaxis during anesthesia ranges from 1 in 10,000 to 1 in 20,000. Neuromuscular blocking agents represent the most frequently involved substances, followed by latex and antibiotics, but every drug or substance used may be involved. Diagnosis relies on tryptase measurements at the t...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章
doi：10.1016/j.iac.2009.04.004
更新日期：2009-08-01 00:00:00
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journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s0889-8561(03)00029-8
更新日期：2003-08-01 00:00:00
abstract：:Mastocytosis is characterized by accumulation of pathologic mast cells in tissues. Most patients with mastocytosis experience mast cell activation symptoms in response to various triggers. The diagnosis of mastocytosis should be made from objective pathologic findings. Modern diagnostic criteria and classification of ...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2014.02.003
更新日期：2014-05-01 00:00:00
abstract：:Aspirin-exacerbated respiratory disease is a significant endotype of both asthma and chronic rhinosinusitis with nasal polyps. The disease demonstrates what seems to be a unified inflammatory mechanism culminating in highly eosinophilic nasal polyp disease and asthma. The rate of polyp recurrence and morbidity from as...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.iac.2016.06.002
更新日期：2016-11-01 00:00:00
abstract：:The study of aging, susceptibility to tumors, and immunity is at an initial stage, and numerous excellent questions challenge immunologists and tumor biologists. Because unpredicted factors contribute to tumor susceptbility in the human population, the authors feel that the development of an animal model is essential ...
journal_title：Immunology and allergy clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s0889-8561(02)00085-1
更新日期：2003-02-01 00:00:00
