Abstract:
:A micro-epidemic of hantavirus infections occurred in Lower Bavaria, South-East Germany, starting in April 2004. While only three cases were registered from 2001 to 2003, a dramatically increased number of clinically apparent human hantavirus infections (n=38) was observed in 2004, plus seven additional cases by June 2005. To determine the reservoir responsible for the infections, a total of 43 rodents were trapped in Lower Bavaria. Serological and genetic investigations revealed that Puumala virus (PUUV) is dominant in the local population of bank voles. Partial PUUV S segment nucleotide sequences originating from bank voles at four different trapping sites in Lower Bavaria showed a low divergence (up to 3.1%). This is contrasted by a nucleotide sequence divergence of 14-16% to PUUV strains detected in Belgium, France, Slovakia or North-Western Germany. PUUV sequences from bank voles in Lower Bavaria represent a new PUUV subtype which seems to be responsible for the observed increase of human hantavirus infections in 2004-2005.
journal_name
Epidemiol Infectjournal_title
Epidemiology and infectionauthors
Essbauer S,Schmidt J,Conraths FJ,Friedrich R,Koch J,Hautmann W,Pfeffer M,Wölfel R,Finke J,Dobler G,Ulrich Rdoi
10.1017/S0950268806006170subject
Has Abstractpub_date
2006-12-01 00:00:00pages
1333-44issue
6eissn
0950-2688issn
1469-4409pii
S0950268806006170journal_volume
134pub_type
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