A novel guanylyl cyclase receptor, BdmGC-1, is highly expressed during the development of the oriental fruit fly Bactrocera dorsalis (Hendel).

Abstract:

:A novel receptor guanylyl cyclase (GC) has been identified from the oriental fruit fly Bactrocera dorsalis (Hendel) and has been designated BdmGC-1. Protein domain analysis revealed that BdmGC-1 possesses a characteristic domain organization similar to all known receptor GCs but with a unique carboxyl-terminal extension. When overexpressed in 293T cells, BdmGC-1 manifests as a cell-surface glycoprotein with a marked cGMP-generating activity but is unresponsive to all ligands known to activate mammalian receptor GCs. BdmGC-1 mRNAs were highly expressed during development but had low or no expression in adult tissues. On the basis of its unique sequence and distinct developmental expression pattern, BdmGC-1 represents a novel receptor GC that may play a critical role during the development of B. dorsalis.

journal_name

Insect Mol Biol

journal_title

Insect molecular biology

authors

Chang JC,Yang RB,Chen YH,Lu KH

doi

10.1111/j.1365-2583.2006.00609.x

subject

Has Abstract

pub_date

2006-02-01 00:00:00

pages

69-77

issue

1

eissn

0962-1075

issn

1365-2583

pii

IMB609

journal_volume

15

pub_type

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