Relationship between response to methylphenidate treatment in children with ADHD and psychopathology in their families.

Abstract:

OBJECTIVE:To compare the pattern of familial aggregation of psychopathology in children who are good responders (GR) to methylphenidate (MPH) versus those who are poor responders (PR). METHOD:A total of 118 clinically referred children ages 6 to 12 years, diagnosed with ADHD participated in a double-blind, placebo-controlled, randomized 2-week crossover trial of MPH from 1999 to 2004. A low dose of 0.5 mg/kg of body weight of MPH divided in two equal doses was used. Family history was obtained by interviewing at least one key historian relative of each subject using Family Interview for Genetic Studies. Information was collected on 342 first-degree and 1,151 second-degree relatives of children with attention-deficit/hyperactivity disorder. RESULTS:Forty-four subjects showed mild or no improvement (PR) and 74 showed moderate or very much improvement (GR) on MPH over placebo. First-degree relatives of GR subjects were at significantly higher risk of attention-deficit/hyperactivity disorder than the relatives of PR subjects (p<.05). Second-degree relatives of the GR were at significantly higher risk of antisocial personality disorder compared to the relatives of PR subjects (p<.05). CONCLUSIONS:The significantly higher presence of attention-deficit/hyperactivity disorder in the first-degree relatives and of antisocial personality disorder in the second-degree relatives of GR children suggests that this group may, at least partially, be distinct from the PR group on the basis of genetic determinants.

authors

Grizenko N,Kovacina B,Amor LB,Schwartz G,Ter-Stepanian M,Joober R

doi

10.1097/01.chi.0000184932.64294.d9

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

47-53

issue

1

eissn

0890-8567

issn

1527-5418

pii

S0890-8567(09)62259-0

journal_volume

45

pub_type

杂志文章,随机对照试验
  • Epidemiology of depressive symptoms in the National Longitudinal Study of Adolescent Health.

    abstract:OBJECTIVE:To describe the range of depressive symptoms reported by adolescents in a nationally representative U.S. sample and to examine factors associated with persistent depressive symptoms. METHOD:Secondary analysis was done on National Longitudinal Study of Adolescent Health (AddHealth) data from 13,568 adolescent...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-200202000-00014

    authors: Rushton JL,Forcier M,Schectman RM

    更新日期:2002-02-01 00:00:00

  • Double-blind, placebo-controlled study of single-dose amphetamine formulations in ADHD.

    abstract:OBJECTIVE:To compare the efficacy and time course of single morning doses of Adderall, extended-release, and immediate-release dextroamphetamine sulfate. METHOD:Thirty-five children with attention-deficit/hyperactivity disorder, combined type, were given Adderall, immediate-release dextroamphetamine, dextroamphetamine...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004583-200111000-00006

    authors: James RS,Sharp WS,Bastain TM,Lee PP,Walter JM,Czarnolewski M,Castellanos FX

    更新日期:2001-11-01 00:00:00

  • Psychiatric impairment and childhood victimization experiences in female child molesters.

    abstract:OBJECTIVE:To assess psychiatric impairment and childhood victimization experiences in female child molesters. METHOD:Eleven incarcerated female child molesters were compared to 11 women imprisoned for nonsexual offenses as to their psychiatric diagnoses based on interviews with the Structured Clinical Interview for DS...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199409000-00004

    authors: Green AH,Kaplan MS

    更新日期:1994-09-01 00:00:00

  • Does methylphenidate constrict cognitive functioning?

    abstract::It has been suggested that stimulants enhance attention in children with (attention deficit disorder with hyperactivity) (ADDH) by producing a generalized constriction or "over-focusing." Such a phenomenon might be expected to adversely affect performance on tasks, such as those in the Wallach-Kogan (W-K) battery, whi...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004583-198911000-00014

    authors: Solanto MV,Wender EH

    更新日期:1989-11-01 00:00:00

  • Self-mutilative behavior in adolescents who attempt suicide by overdose.

    abstract:OBJECTIVE:To examine the cognitive/affective and behavioral symptoms of adolescent suicide attempters with self-mutilative behavior (SMB). METHOD:Adolescents evaluated after a suicide attempt that occurred between 1996 and 2000 were divided into two groups: suicide attempters with a history of SMB (n = 52) and suicide...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-200109000-00015

    authors: Guertin T,Lloyd-Richardson E,Spirito A,Donaldson D,Boergers J

    更新日期:2001-09-01 00:00:00

  • Identifying thresholds for classifying childhood psychiatric disorder: issues and prospects.

    abstract:OBJECTIVE:To evaluate empirically the implications of choosing different thresholds to classify conduct disorder and attention-deficit hyperactivity disorder for estimating prevalence, test-retest reliability of measurement, and informant (parent/teacher) agreement and for evaluating comorbidity and associated features...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199611000-00012

    authors: Boyle MH,Offord DR,Racine Y,Szatmari P,Fleming JE,Sanford M

    更新日期:1996-11-01 00:00:00

  • Multidimensional Influences on Autism Symptom Measures: Implications for Use in Etiological Research.

    abstract:OBJECTIVE:Growing awareness that symptoms of autism spectrum disorder (ASD) transcend multiple diagnostic categories, and major advances in the identification of genetic syndromes associated with ASD, have led to widespread use of ASD symptom measures in etiologic studies of neurodevelopmental disorders. Insufficient c...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.jaac.2016.09.490

    authors: Havdahl KA,Hus Bal V,Huerta M,Pickles A,Øyen AS,Stoltenberg C,Lord C,Bishop SL

    更新日期:2016-12-01 00:00:00

  • Perceptions of P.R.N. psychotropic medications by hospitalized child and adolescent recipients.

    abstract:OBJECTIVE:To understand patient perceptions of p.r.n. medication for agitation used in institutional settings. METHOD:A questionnaire was administered to child and adolescent psychiatric inpatients within 12 hours of their receiving p.r.n. medication for agitation and repeated 4 hours later. Research staff completed a...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/01.CHI.0000046817.95464.A6

    authors: Petti TA,Stigler KA,Gardner-Haycox J,Dumlao S

    更新日期:2003-04-01 00:00:00

  • Feasibility of dialectical behavior therapy for suicidal adolescent inpatients.

    abstract:OBJECTIVE:To evaluate the feasibility of dialectical behavior therapy (DBT) implementation in a general child and adolescent psychiatric inpatient unit and to provide preliminary effectiveness data on DBT versus treatment as usual (TAU). METHOD:Sixty-two adolescents with suicide attempts or suicidal ideation were admi...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004583-200403000-00008

    authors: Katz LY,Cox BJ,Gunasekara S,Miller AL

    更新日期:2004-03-01 00:00:00

  • Predictors of treatment efficacy in a clinical trial of three psychosocial treatments for adolescent depression.

    abstract:OBJECTIVE:To assess the predictors of treatment outcome across treatments, as well as those associated with differential treatment response. METHOD:One hundred seven adolescent outpatients, aged 13 to 18 years, with DSM-III-R major depression were randomly assigned to one of three manual-based, brief (12 to 16 session...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004583-199809000-00010

    authors: Brent DA,Kolko DJ,Birmaher B,Baugher M,Bridge J,Roth C,Holder D

    更新日期:1998-09-01 00:00:00

  • Using MRI to examine brain-behavior relationships in males with attention deficit disorder with hyperactivity.

    abstract:OBJECTIVE:The relationship between neuropsychological measures of inhibition and sustained attention and structural brain differences in the regions of the caudate and the frontal region was examined in males with attention deficit disorder with hyperactivity (ADD/H). METHOD:Ten males with ADD/H (aged 8-17) and 11 mal...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-200004000-00017

    authors: Semrud-Clikeman M,Steingard RJ,Filipek P,Biederman J,Bekken K,Renshaw PF

    更新日期:2000-04-01 00:00:00

  • Predicting methylphenidate response in children with ADHD: theoretical, empirical, and conceptual models.

    abstract:OBJECTIVE:To evaluate the theoretical merit and empirical validity of models designed to predict response to methylphenidate (MPH) among children with attention-deficit/hyperactivity disorder (ADHD). METHOD:Seventy-six children with ADHD received each of 4 counterbalanced doses of MPH (5, 10, 15, and 20 mg) in the con...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004583-199904000-00011

    authors: Denney CB,Rapport MD

    更新日期:1999-04-01 00:00:00

  • Adolescent bipolar illness and personality disorder.

    abstract::The relationship between adolescent bipolar illness and personality disorder has not been explored. Studies of adult bipolars suggest a bipolar illness/borderline personality disorder (BPD) association. Twenty euthymic bipolar teens were assessed using the Personality Disorders Examination. Thirty-five percent met DSM...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199005000-00004

    authors: Kutcher SP,Marton P,Korenblum M

    更新日期:1990-05-01 00:00:00

  • Combination lithium and divalproex sodium in pediatric bipolarity.

    abstract:OBJECTIVE:Lithium carbonate (Li) or divalproex sodium (DVPX) may be effective for some juveniles with bipolar disorder. Many youths with bipolar disorder do not respond to DVPX or Li monotherapy. An open-label study was conducted to examine the effectiveness of combination DVPX and Li therapy with youths diagnosed with...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1097/01.CHI.0000046893.27264.53

    authors: Findling RL,McNamara NK,Gracious BL,Youngstrom EA,Stansbrey RJ,Reed MD,Demeter CA,Branicky LA,Fisher KE,Calabrese JR

    更新日期:2003-08-01 00:00:00

  • Design and rationale of controlled study of long-term methylphenidate and multimodal psychosocial treatment in children with ADHD.

    abstract:OBJECTIVE:To describe the rationale, methodology, and sample characteristics of a dual-site treatment study (New York and Montreal) of children with attention-deficit/hyperactivity disorder (ADHD) conducted between 1990 and 1995. The hypotheses were that (1) methylphenidate combined with comprehensive multimodal psycho...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/01.chi.0000128798.91601.fe

    authors: Klein RG,Abikoff H,Hechtman L,Weiss G

    更新日期:2004-07-01 00:00:00

  • School-based interventions for anxious children.

    abstract:OBJECTIVE:To compare the effectiveness of three school-based interventions for anxious children: group cognitive-behavioral therapy (CBT) for children, group CBT for children plus parent training group, and no-treatment control. METHOD:Students (7-11 years old) in three elementary schools (N = 453) were screened using...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/01.chi.0000177323.40005.a1

    authors: Bernstein GA,Layne AE,Egan EA,Tennison DM

    更新日期:2005-11-01 00:00:00

  • Cognitive inflexibility and frontal-cortical activation in pediatric obsessive-compulsive disorder.

    abstract:OBJECTIVE:Deficits in cognitive flexibility and response inhibition have been linked to perturbations in cortico-striatal-thalamic circuitry in adult obsessive-compulsive disorder (OCD). Although similar cognitive deficits have been identified in pediatric OCD, few neuroimaging studies have been conducted to examine it...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.jaac.2010.05.006

    authors: Britton JC,Rauch SL,Rosso IM,Killgore WD,Price LM,Ragan J,Chosak A,Hezel DM,Pine DS,Leibenluft E,Pauls DL,Jenike MA,Stewart SE

    更新日期:2010-09-01 00:00:00

  • Are adolescent suicide attempters noncompliant with outpatient care?

    abstract::The outpatient clinic attendance patterns of 115 consecutively referred 10- to 18-year-old suicide attempters and of 110 nonattempters were compared. The two groups did not differ in number of appointments scheduled or missed, but attempters kept significantly fewer appointments than did nonattempters. Seventy-seven p...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199301000-00013

    authors: Trautman PD,Stewart N,Morishima A

    更新日期:1993-01-01 00:00:00

  • Symptom perception in pediatric asthma: relationship to functional morbidity and psychological factors.

    abstract:OBJECTIVE:Perception of changes in respiratory symptoms is a critical element in the self-management of pediatric asthma. The purpose of this study was to quantify perceptual accuracy in childhood asthma, to investigate links between symptom perception and functional morbidity, and to examine relationships between psyc...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199608000-00014

    authors: Fritz GK,McQuaid EL,Spirito A,Klein RB

    更新日期:1996-08-01 00:00:00

  • Characteristics of early rhythmic behaviors in children at risk for developmental disorders.

    abstract:OBJECTIVE:Abnormal stereotyped behaviors are a significant problem for many individuals with mental retardation or mental illness. To increase understanding of the development of abnormal stereotyped behaviors, the authors investigated the early rhythmic behaviors of children at increased risk for developmental delays....

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-200201000-00013

    authors: Kroeker R,Unis AS,Sackett GP

    更新日期:2002-01-01 00:00:00

  • Children's discrimination of expressions of emotions: relationship with indices of social anxiety and shyness.

    abstract:OBJECTIVE:To conduct an exploratory investigation of possible relationships between individual levels of social anxiety and the ability to classify emotional expressions in a group of schoolchildren observing pictures of children of similar age. METHOD:One hundred forty-nine second- and third-grade schoolchildren unde...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004583-200403000-00019

    authors: Battaglia M,Ogliari A,Zanoni A,Villa F,Citterio A,Binaghi F,Fossati A,Maffei C

    更新日期:2004-03-01 00:00:00

  • Cognitive-behavioral family treatment of childhood obsessive-compulsive disorder: a controlled trial.

    abstract:OBJECTIVE:To evaluate the relative efficacy of (1) individual cognitive-behavioral family-based therapy (CBFT); (2) group CBFT; and (3) a waitlist control group in the treatment of childhood obsessive-compulsive disorder (OCD). METHOD:This study, conducted at a university clinic in Brisbane, Australia, involved 77 chi...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004583-200401000-00014

    authors: Barrett P,Healy-Farrell L,March JS

    更新日期:2004-01-01 00:00:00

  • Mechanisms of Change in the Prevention of Depression: An Indicated School-Based Prevention Trial at the Transition to High School.

    abstract:OBJECTIVE:Depression represents a major public health concern, and prevalence increases significantly during adolescence. The high school transition may exacerbate the risk of depression for youth with pre-existing vulnerability. The High School Transition Program (HSTP) is a brief, skills-based intervention that has d...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.jaac.2019.05.031

    authors: Blossom JB,Adrian MC,Stoep AV,McCauley E

    更新日期:2020-04-01 00:00:00

  • Variability in time reproduction: difference in ADHD combined and inattentive subtypes.

    abstract:OBJECTIVE:To examine the relationship between time reproduction, performance variability, and sustained attention deficits in children with attention-deficit/hyperactivity disorder (ADHD) combined (ADHD-C) and inattentive (ADHD-I) subtypes, relative to matched controls. METHOD:Participants (age range 7.1-14.1 years) p...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-200502000-00009

    authors: Mullins C,Bellgrove MA,Gill M,Robertson IH

    更新日期:2005-02-01 00:00:00

  • Effects of methylphenidate on reward strength in boys with attention-deficit hyperactivity disorder.

    abstract:OBJECTIVE:To test the hypothesis that methylphenidate reduces thresholds for reward in children with attention-deficit hyperactivity disorder (ADHD). METHOD:A double-blind crossover design was used in which 16 ADHD boys, aged 8 to 13 years, received methylphenidate on one testing occasion and placebo on another. On ea...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004583-199507000-00013

    authors: Wilkison PC,Kircher JC,McMahon WM,Sloane HN

    更新日期:1995-07-01 00:00:00

  • Sleep patterns in preschool-age children with autism, developmental delay, and typical development.

    abstract:OBJECTIVE:A prominent noncore symptom of autistic disorder is disturbed sleep, but relatively few studies have investigated this symptom. METHOD:A multimethod approach assessed the quantity and quality of sleep in 194 children (68 with autism [AUT], 57 with developmental delay without autism [DD], 69 with typical deve...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/CHI.ObO13e3181799f7c

    authors: Goodlin-Jones BL,Tang K,Liu J,Anders TF

    更新日期:2008-08-01 00:00:00

  • A comparison of American and English hospital discharge rates for pediatric bipolar disorder, 2000 to 2010.

    abstract:OBJECTIVE:Controversy exists over the diagnosis and prevalence of pediatric bipolar disorder (PBD). Although several small surveys suggest that the rate of the PBD diagnosis in clinical settings is higher in the United States than in other countries, no comprehensive cross-national comparisons of clinical practice have...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.jaac.2014.02.008

    authors: James A,Hoang U,Seagroatt V,Clacey J,Goldacre M,Leibenluft E

    更新日期:2014-06-01 00:00:00

  • Being bullied during childhood and the prospective pathways to self-harm in late adolescence.

    abstract:OBJECTIVE:To assess whether being bullied between 7 and 10 years of age is directly associated with self-harm in late adolescence when controlling for previous exposure to an adverse family environment (domestic violence, maladaptive parenting); concurrent internalizing and externalizing behavior; and subsequent psycho...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.jaac.2013.03.012

    authors: Lereya ST,Winsper C,Heron J,Lewis G,Gunnell D,Fisher HL,Wolke D

    更新日期:2013-06-01 00:00:00

  • Noradrenergic mechanisms in ADHD children with and without reading disabilities: a replication and extension.

    abstract:OBJECTIVE:To examine noradrenergic (NA) function in children with attention-deficit hyperactivity disorder (ADHD) by replicating and expanding upon a previous finding that ADHD children with and without reading disabilities (RD) differ in plasma levels of the NA metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG). METHO...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199712000-00017

    authors: Halperin JM,Newcorn JH,Koda VH,Pick L,McKay KE,Knott P

    更新日期:1997-12-01 00:00:00

  • Psychiatric comorbidity and the 16-month trajectory of substance-abusing and substance-dependent juvenile offenders.

    abstract:OBJECTIVES:To examine the concurrent correlates of internalizing and externalizing disorders among substance-abusing and substance-dependent juvenile offenders and to determine the association between psychiatric comorbidity and psychosocial functioning of the youths 16 months later. METHOD:Participants were 118 juven...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199909000-00015

    authors: Randall J,Henggeler SW,Pickrel SG,Brondino MJ

    更新日期:1999-09-01 00:00:00