Noradrenergic mechanisms in ADHD children with and without reading disabilities: a replication and extension.

Abstract:

OBJECTIVE:To examine noradrenergic (NA) function in children with attention-deficit hyperactivity disorder (ADHD) by replicating and expanding upon a previous finding that ADHD children with and without reading disabilities (RD) differ in plasma levels of the NA metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG). METHOD:Plasma levels of MHPG were compared in ADHD children who were subdivided on the basis of the presence or absence of RD. Subsequently, this replication sample was combined with a previously studied sample to further explore the relationship between plasma MHPG levels and measures of cognitive function in children with ADHD. RESULTS:Plasma levels of MHPG were significantly lower in ADHD children without RD, compared with those with RD, replicating a published finding. Analyses in the combined sample indicated that, among children with ADHD, plasma MHPG levels were inversely associated with measures of academic achievement and verbal processing, but not parent or teacher ratings of behavior or continuous performance test measures of attention and impulsivity. CONCLUSIONS:These data indicate that children with ADHD are not homogeneous with regard to NA function and that neurochemical variation is closely associated with differences in clinical characteristics of the children.

authors

Halperin JM,Newcorn JH,Koda VH,Pick L,McKay KE,Knott P

doi

10.1097/00004583-199712000-00017

subject

Has Abstract

pub_date

1997-12-01 00:00:00

pages

1688-97

issue

12

eissn

0890-8567

issn

1527-5418

pii

S0890-8567(09)62710-6

journal_volume

36

pub_type

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