Abstract:
OBJECTIVE:To compare the efficacy and time course of single morning doses of Adderall, extended-release, and immediate-release dextroamphetamine sulfate. METHOD:Thirty-five children with attention-deficit/hyperactivity disorder, combined type, were given Adderall, immediate-release dextroamphetamine, dextroamphetamine Spansules, and placebo in a randomized, double-blind, crossover study. Behavior ratings, locomotor activity measurements, and academic measures were obtained over a period of 8 weeks. RESULTS:All three drugs exhibited robust efficacy versus placebo on nearly all measures. The effects of dextroamphetamine Spansules were less robust in the morning, particularly compared with Adderall, but they lasted 3 to 6 hours longer, depending on the measure. Although parent behavior ratings and locomotor activity showed improvements up to 12 hours after single doses of all three drugs, the number of math problems attempted and completed correctly 4 hours after dosing were only robustly increased by Spansules. CONCLUSIONS:Both immediate-release amphetamines demonstrated earlier onset of effects, but dextroamphetamine Spansules showed more sustained effects that were present on a wider range of measures.
journal_name
J Am Acad Child Adolesc Psychiatryauthors
James RS,Sharp WS,Bastain TM,Lee PP,Walter JM,Czarnolewski M,Castellanos FXdoi
10.1097/00004583-200111000-00006subject
Has Abstractpub_date
2001-11-01 00:00:00pages
1268-76issue
11eissn
0890-8567issn
1527-5418pii
S0890-8567(09)60534-7journal_volume
40pub_type
临床试验,杂志文章,随机对照试验abstract:OBJECTIVE:To determine the prevalence and correlates of psychiatric disorders among preschool children in a primary care pediatric sample. METHOD:In a two-stage design, 3,860 preschool children were screened; 510 received fuller evaluations. RESULTS:For quantitative assessment of disorder (> or = 90th percentile), pr...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199602000-00014
更新日期:1996-02-01 00:00:00
abstract:OBJECTIVE:To describe program outcomes for the Combined Training Program in Child and Adolescent Psychiatry, Pediatrics, and Psychiatry (Triple Board Program). METHOD:All Triple Board Program graduates to date (1991-2003) were asked to participate in a 37-item written survey from February to April 2004. RESULTS:The r...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/01.chi.0000214190.80863.05
更新日期:2006-06-01 00:00:00
abstract:OBJECTIVE:This longitudinal study examined whether responsiveness of the neurotransmitter serotonin (5-HT) in childhood predicts adolescent aggression. METHOD:Boys (N = 33) with disruptive behavior disorders who received assessments of central 5-HT function via the prolactin response to fenfluramine between 1990 and 1...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/01.chi.0000220855.79144.ae
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVE:To determine the impact of a parent education and behavior management intervention (PEBM) on the mental health and adjustment of parents with preschool children with autism. METHOD:A randomized, group-comparison design involving a parent education and counseling intervention to control for nonspecific therap...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/01.chi.0000205701.48324.26
更新日期:2006-05-01 00:00:00
abstract::Variability in the trajectory of clinical symptoms in the early emerging presentation of young children with autism spectrum disorder (ASD) exists within an individual child over time and between different children at any point in time and across time. Georgiades et al.1 recently coined the term "chronogeneity" to ind...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 评论,社论
doi:10.1016/j.jaac.2018.06.021
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:To examine the expression of war-related trauma as manifested by DSM-III-R rates of posttraumatic stress disorder (PTSD) and major depressive disorder in two generations of Cambodian refugees living in the western United States. METHOD:A probability sample of 209 Khmer adolescents and one of their parents we...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004583-199509000-00013
更新日期:1995-09-01 00:00:00
abstract:OBJECTIVE:Suicidal behavior and self-harm are common in adolescents and are associated with elevated psychopathology, risk of suicide, and demand for clinical services. Despite recent advances in the understanding and treatment of self-harm and links between self-harm and suicide and risk of suicide attempt, progress i...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.jaac.2014.10.009
更新日期:2015-02-01 00:00:00
abstract::Specific reading disability is an example of a complex behavioral disorder which is clinically heterogeneous. It is probably also heterogeneous at the levels of etiology and process (pathogenesis), but there may not be a 1:1:1 mapping of etiology to process to clinical outcome. Thus, classification of cases by clinica...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199003000-00008
更新日期:1990-03-01 00:00:00
abstract:OBJECTIVE:To examine differences in behavioral symptoms and cognitive functioning between males and females with autism spectrum disorder (ASD). METHOD:We analyzed data from 2,418 probands with autism (304 females and 2,114 males) included in the Simons Simplex Collection. Sex differences were evaluated across measure...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1016/j.jaac.2013.12.004
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:Child maltreatment is associated with dysregulation of stress-mediating systems and an increased risk of mental and physical health problems. Specifically, disruptions in hypothalamic-pituitary-adrenal (HPA) axis regulation have been reported in maltreated children. The current study investigates whether incr...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1016/j.jaac.2014.08.006
更新日期:2014-11-01 00:00:00
abstract::Functional dysphagia in children has historically been treated using a cognitive behavioral approach. The case of a 7-year-old boy treated using a successful multimodal approach, including behavioral, family, and play therapy with alprazolam augmentation, is reported. The patient showed minimal response to early inter...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199409000-00012
更新日期:1994-09-01 00:00:00
abstract:OBJECTIVES:Little is known about how genes influence the development of symptoms included in the DSM-IV subtypes of attention-deficit/hyperactivity disorder (ADHD) from childhood to adolescence. The aim of this study was to examine genetic influences contributing to the development of hyperactive-impulsive symptoms and...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/01.chi.0000222787.57100.d8
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVE:To derive and test a series of brief diagnosis-specific scales to identify subjects who are at high probability of meeting diagnostic criteria and those who may safely be spared more extensive diagnostic inquiry. METHOD:Secondary data analysis of a large epidemiological data set (n = 1,286) produced a series...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-200104000-00013
更新日期:2001-04-01 00:00:00
abstract::Since 1990, there have been five reported cases of sudden death in children treated with desipramine. This case study describes the sudden deaths of two additional children treated with tricyclic antidepressants, one with desipramine, 3.3 mg/kg per day, the other with imipramine, 6 mg/kg per day and thioridazine, 1 mg...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199703000-00018
更新日期:1997-03-01 00:00:00
abstract:OBJECTIVE:Depression often is comorbid with conduct disorder. The purpose of this study is to assess whether, among youths with conduct disorder, those with depression differ in other ways from those without depression. METHOD:Ninety-nine delinquent boys (aged 13 through 19 years) were evaluated with the Diagnostic In...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199506000-00017
更新日期:1995-06-01 00:00:00
abstract::This Clinical Update reviews the use of telepsychiatry to deliver psychiatric, mental health, and care coordination services to children and adolescents across settings as direct service and in collaboration with primary care providers or other clinicians. The update defines terms and presents the current status of te...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章,实务指引
doi:10.1016/j.jaac.2017.07.008
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:The association between depression and educational attainment in young people is unclear. This systematic review and meta-analysis examines the longitudinal association between depression and subsequent attainment, and its potential effect modifiers and mediators. METHOD:We searched Embase, PsycINFO, PubMed,...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章,评审
doi:10.1016/j.jaac.2020.10.008
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the prevalence, comorbid conditions, and impairments of attention-deficit/hyperactivity disorder (ADHD) among young adolescents in Porto Alegre, Brazil. METHOD:1,013 students aged 12 to 14 years were evaluated at 64 state schools, using a screening instrument based on the 18 DSM-IV ADHD symptoms....
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199906000-00019
更新日期:1999-06-01 00:00:00
abstract:OBJECTIVE:To compare subtypes of attention-deficit/hyperactivity disorder (ADHD) (predominantly inattentive and combined types) and a comparison group on an objective measure of activity level (actigraphy). METHOD:Actigraphs were worn by 64 children (49 boys, 15 girls) during a full-day clinical diagnostic assessment;...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-200006000-00014
更新日期:2000-06-01 00:00:00
abstract::One hundred and seventeen biological mothers and 63 biological fathers of depressed and nondepressed, psychiatrically disturbed children and adolescents were interviewed with the Schedule for Affective Disorders and Schizophrenia-Lifetime Version. Diagnostic information was also obtained on 54 biological fathers who w...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-198905000-00008
更新日期:1989-05-01 00:00:00
abstract::In 2009, Dr. Anthony Fauci stated, "The 1918-1919 influenza pandemic was a defining event in the history of public health."1 In 2020, a popular medical website suggested that the 1918 pandemic may offer "lasting lessons for the world in the grip of COVID-19."2 One lesson from the 1918 pandemic relates to residual long...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 评论,信件
doi:10.1016/j.jaac.2020.09.024
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:To conduct a placebo-controlled study of the effectiveness of a universal school-based depression prevention program. METHOD:Three hundred ninety-two students age 13 to 15 from two schools were randomized to intervention (RAP-Kiwi) and placebo programs run by teachers. RAP-Kiwi was an 11-session manual-based...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004583-200405000-00007
更新日期:2004-05-01 00:00:00
abstract:OBJECTIVE:This study investigated the relationship between regional cortical gray matter thinning and symptoms of schizophrenia spectrum personality disorders (PDs) in siblings of patients with childhood-onset schizophrenia (COS). METHOD:A total of 66 siblings of patients with COS were assessed for symptoms of schizop...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1016/j.jaac.2015.11.008
更新日期:2016-02-01 00:00:00
abstract::One of the most discussed recent topics in psychopathology research is the p factor of mental illness. This single dimension is understood to measure "a person's liability to mental disorder, comorbidity among disorders, persistence of disorders over time, and severity of symptoms."1 A recent paper by Constantinou et ...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 评论,信件
doi:10.1016/j.jaac.2019.07.953
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:To assess the course and outcome of anorexia nervosa (AN) and bulimia nervosa (BN) at a median of 90 months of follow-up in a large cohort of women with eating disorders. METHOD:A prospective, naturalistic, longitudinal design was used to map the course of AN and BN in 246 women. Follow-up data are presented...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199907000-00012
更新日期:1999-07-01 00:00:00
abstract::The clinical guidance based on the research article, "Specific Components of Pediatricians' Medication-Related Care Predict Attention-Deficit/Hyperactivity Disorder Improvement," published in the June 2017 issue,1 might be premature. The authors, Epstein et al., suggest that "Physicians do not need to necessarily rely...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 信件
doi:10.1016/j.jaac.2018.02.015
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVE:To examine the efficacy of a modular cognitive-behavioral therapy (CBT) protocol relative to treatment as usual (TAU) among children with high-functioning autism spectrum disorders (ASD) and clinically significant anxiety. METHOD:A total of 45 children (7-11 years of age) with high-functioning ASD and clinic...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jaac.2012.11.007
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:There have been inconsistent findings on the associations between prematurity, poor fetal growth and depression. We examined the associations between gestational age, poor fetal growth and depression in individuals aged 5 to 25 years. METHOD:We identified 37,682 cases based on ICD-9 code 2961 and ICD-10 code...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1016/j.jaac.2020.09.020
更新日期:2020-10-14 00:00:00
abstract:OBJECTIVE:Although generalized anxiety is an important clinical problem among adolescents, there are no interview procedures to provide a global anxiety rating that have demonstrated reliability and validity for this population. The Hamilton Anxiety Rating Scale (HARS) is a general measure of anxiety that was developed...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199403000-00009
更新日期:1994-03-01 00:00:00
abstract::This study showed that children and adolescents with inflammatory bowel disease (IBD) had a more external locus of control than did matched diabetic and healthy children. An external locus of control correlated with severity of physical illness and presence of psychiatric disorders. It also correlated significantly wi...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199111000-00008
更新日期:1991-11-01 00:00:00