Effects of methylphenidate on reward strength in boys with attention-deficit hyperactivity disorder.

Abstract:

OBJECTIVE:To test the hypothesis that methylphenidate reduces thresholds for reward in children with attention-deficit hyperactivity disorder (ADHD). METHOD:A double-blind crossover design was used in which 16 ADHD boys, aged 8 to 13 years, received methylphenidate on one testing occasion and placebo on another. On each occasion, subjects performed a task that required progressively greater numbers of button presses to earn a fixed monetary payoff. RESULTS:The "breaking point" above which the hyperactive child was unwilling to continue with the task was significantly higher during drug than placebo trials. CONCLUSIONS:The results support an assumption that underlies the reward system dysfunction hypothesis of ADHD, and they suggest that reward mechanisms may underlie the therapeutic effects of stimulants observed across a wide range of tasks and settings.

authors

Wilkison PC,Kircher JC,McMahon WM,Sloane HN

doi

10.1097/00004583-199507000-00013

subject

Has Abstract

pub_date

1995-07-01 00:00:00

pages

897-901

issue

7

eissn

0890-8567

issn

1527-5418

pii

S0890-8567(09)63600-5

journal_volume

34

pub_type

临床试验,杂志文章,随机对照试验
  • Design and rationale of controlled study of long-term methylphenidate and multimodal psychosocial treatment in children with ADHD.

    abstract:OBJECTIVE:To describe the rationale, methodology, and sample characteristics of a dual-site treatment study (New York and Montreal) of children with attention-deficit/hyperactivity disorder (ADHD) conducted between 1990 and 1995. The hypotheses were that (1) methylphenidate combined with comprehensive multimodal psycho...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/01.chi.0000128798.91601.fe

    authors: Klein RG,Abikoff H,Hechtman L,Weiss G

    更新日期:2004-07-01 00:00:00

  • Psychosocial characteristics of physically abused children and adolescents.

    abstract:OBJECTIVE:To examine the association between physical abuse and selected psychosocial measures in a community-based probability sample of children and adolescents. METHOD:A sample of 9- through 17-year-olds (N = 665) and their caretakers in New York State and Puerto Rico were interviewed in the Methods for the Epidemi...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199701000-00026

    authors: Flisher AJ,Kramer RA,Hoven CW,Greenwald S,Alegria M,Bird HR,Canino G,Connell R,Moore RE

    更新日期:1997-01-01 00:00:00

  • Systematic Review and Meta-Analysis: Early Treatment Responses of Selective Serotonin Reuptake Inhibitors and Clomipramine in Pediatric Obsessive-Compulsive Disorder.

    abstract:OBJECTIVE:We conducted a meta-analysis to examine the following: the time course of response to selective serotonin reuptake inhibitors (SSRIs) and clomipramine in pediatric obsessive-compulsive disorder (OCD); whether higher doses of SSRIs are associated with an improved response in pediatric OCD; differences in effic...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.jaac.2016.07.768

    authors: Varigonda AL,Jakubovski E,Bloch MH

    更新日期:2016-10-01 00:00:00

  • Defining treatment response and remission in obsessive-compulsive disorder: a signal detection analysis of the Children's Yale-Brown Obsessive Compulsive Scale.

    abstract:OBJECTIVE:To examine the optimal Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) percent reduction cutoffs for predicting treatment response and clinical remission among children and adolescents with obsessive-compulsive disorder (OCD). METHOD:Youth with OCD (N = 109; range 7 to 19 years) received 14 sessio...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.jaac.2010.04.005

    authors: Storch EA,Lewin AB,De Nadai AS,Murphy TK

    更新日期:2010-07-01 00:00:00

  • The disruptive behavioral disorder in children and adolescents: comorbidity and clinical course.

    abstract::Comorbidity, time to recovery, rate of chronicity, and probability of recurrence following recovery were studied in 51 children diagnosed with attention deficit disorder, conduct disorder, and oppositional defiant disorder. Thirty-three percent of the children had two of the above diagnoses, and one child had all thre...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199203000-00005

    authors: Keller MB,Lavori PW,Beardslee WR,Wunder J,Schwartz CE,Roth J,Biederman J

    更新日期:1992-03-01 00:00:00

  • Comparison of clinical symptoms in autism and Asperger's disorder.

    abstract:OBJECTIVE:To determine what clinical symptoms clinicians have been using to distinguish between Asperger's disorder (AsD) and autistic disorder (AD). METHOD:Parents of children and adolescents with high-functioning AD (n = 48) and AsD (n = 69) were given a structured interview based on DSM-III-R and ICD-10 diagnostic ...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199611000-00022

    authors: Eisenmajer R,Prior M,Leekam S,Wing L,Gould J,Welham M,Ong B

    更新日期:1996-11-01 00:00:00

  • Is adolescent-onset first-episode psychosis different from adult onset?

    abstract:OBJECTIVE:To examine whether first-episode psychosis patients with onset during adolescence (ages 15-18) differ significantly from those with young-adult onset (ages 19-30). METHOD:Consecutive patients presenting with first-episode psychosis (N = 242) were assessed for demographic and illness characteristics such as d...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/01.chi.0000164591.55942.ea

    authors: Ballageer T,Malla A,Manchanda R,Takhar J,Haricharan R

    更新日期:2005-08-01 00:00:00

  • Longitudinal patterns of cortisol regulation differ in maltreated and nonmaltreated children.

    abstract:OBJECTIVE:Child maltreatment is associated with dysregulation of stress-mediating systems and an increased risk of mental and physical health problems. Specifically, disruptions in hypothalamic-pituitary-adrenal (HPA) axis regulation have been reported in maltreated children. The current study investigates whether incr...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.jaac.2014.08.006

    authors: Doom JR,Cicchetti D,Rogosch FA

    更新日期:2014-11-01 00:00:00

  • Mental health need and access to mental health services by youths involved with child welfare: a national survey.

    abstract:OBJECTIVE:This study assessed the relationship between the need for and use of mental health services among a nationally representative sample of children who were investigated by child welfare agencies after reported maltreatment. METHOD:Data were collected at study entry into the National Survey of Child and Adolesc...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/01.chi.0000127590.95585.65

    authors: Burns BJ,Phillips SD,Wagner HR,Barth RP,Kolko DJ,Campbell Y,Landsverk J

    更新日期:2004-08-01 00:00:00

  • The p Factor Consistently Predicts Long-Term Psychiatric and Functional Outcomes in Anxiety-Disordered Youth.

    abstract:OBJECTIVE:Pediatric anxiety disorders can have a chronic course and are considered gateway disorders to adult psychopathology, but no consistent predictors of long-term outcome have been identified. A single latent symptom dimension that reflects features shared by all mental health disorders, the p factor, is thought ...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.jaac.2020.08.440

    authors: Cervin M,Norris LA,Ginsburg G,Gosch EA,Compton SN,Piacentini J,Albano AM,Sakolsky D,Birmaher B,Keeton C,Storch EA,Kendall PC

    更新日期:2020-09-17 00:00:00

  • Hopelessness in inpatient youths: a closer look at behavior, emotional expression, and social support.

    abstract:OBJECTIVE:To examine the individual and family characteristics of children and adolescents with high levels of hopelessness. METHOD:One hundred inpatient youngsters participated in the study. Several measures, including the Hopelessness Scale for Children, Problem Behavior Scale of the Scales of Independent Behavior, ...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1016/S0890-8567(09)66575-8

    authors: Kashani JH,Suarez L,Allan WD,Reid JC

    更新日期:1997-11-01 00:00:00

  • Editorial: Why Assessing Co-Occurring Eating Disorders and Alcohol Use in Sexual Minority Youth Is Important.

    abstract::The prevalence of psychiatric disorders, such as major depression and anxiety, is higher in sexual minority individuals (eg, those who identify as gay, lesbian, or bisexual or are unsure of their orientation) than heterosexual individuals.1 Eating disorders and alcohol use also are more common in sexual minority group...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 评论,社论

    doi:10.1016/j.jaac.2018.11.006

    authors: Munn-Chernoff MA

    更新日期:2019-02-01 00:00:00

  • Childhood Attention-Deficit/Hyperactivity Disorder and Homelessness: A 33-Year Follow-Up Study.

    abstract:OBJECTIVE:To examine whether childhood attention-deficit/hyperactivity disorder (ADHD) predicts homelessness in adulthood, and whether the persistence of childhood ADHD through adolescence influences the likelihood of homelessness. METHOD:A 33-year prospective, controlled, follow-up was performed of clinic-referred, 6...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.jaac.2016.07.772

    authors: García Murillo L,Ramos-Olazagasti MA,Mannuzza S,Castellanos FX,Klein RG

    更新日期:2016-11-01 00:00:00

  • Predictors of coping with pain in mothers and their children with sickle cell syndrome.

    abstract:OBJECTIVE:This study examined predictors of strategies used to cope with pain in children with sickle cell disease and their mothers. METHOD:Disease severity, socioeconomic status, child adjustment and adaptive behavior, maternal psychopathology, and family functioning were examined in 55 mother-child dyads to determi...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199411000-00005

    authors: Sharpe JN,Brown RT,Thompson NJ,Eckman J

    更新日期:1994-11-01 00:00:00

  • Maternal characteristics and perceptions of pervasive and situational hyperactives and normal controls.

    abstract::Thirty 6- to 9-year-old boys were rated by their mothers and teachers as being pervasively hyperactive, situationally hyperactive, or not hyperactive at home or school. Maternal characteristics and perceptions of their children's behavior problems were collected. Children's global and molecular social skills were also...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199007000-00008

    authors: Beck SJ,Young GH,Tarnowski KJ

    更新日期:1990-07-01 00:00:00

  • Being bullied during childhood and the prospective pathways to self-harm in late adolescence.

    abstract:OBJECTIVE:To assess whether being bullied between 7 and 10 years of age is directly associated with self-harm in late adolescence when controlling for previous exposure to an adverse family environment (domestic violence, maladaptive parenting); concurrent internalizing and externalizing behavior; and subsequent psycho...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.jaac.2013.03.012

    authors: Lereya ST,Winsper C,Heron J,Lewis G,Gunnell D,Fisher HL,Wolke D

    更新日期:2013-06-01 00:00:00

  • Increased Functional Connectivity Between Ventral Attention and Default Mode Networks in Adolescents With Bulimia Nervosa.

    abstract:OBJECTIVE:Bulimia nervosa (BN) is characterized by excessive attention to self and specifically to body shape and weight, but the ventral attention (VAN) and default mode (DMN) networks that support attentional and self-referential processes are understudied in BN. This study assessed whether altered functional connect...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.jaac.2018.09.433

    authors: Domakonda MJ,He X,Lee S,Cyr M,Marsh R

    更新日期:2019-02-01 00:00:00

  • Personality predictors of outcome for adolescents hospitalized for suicidal ideation.

    abstract:OBJECTIVE:Recent cross-sectional studies of adolescents have noted an association between the personality traits of perfectionism and self-criticism and suicidal ideation. The present study was undertaken to examine the relationship between personality dimensions and the outcome of treatment of adolescents hospitalized...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/01.CHI.0000046847.56865.B0

    authors: Enns MW,Cox BJ,Inayatulla M

    更新日期:2003-06-01 00:00:00

  • Effects of desipramine on autonomic control of the heart.

    abstract:OBJECTIVE:To assess the effects of desipramine (DMI) on autonomic control of the heart. METHODS:Blood pressure, RR interval (the time between successive heart beats), and RR interval variability, a noninvasive measure of autonomic control of the heart, were assessed in 13 subjects younger than 30 years old. RESULTS:D...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199402000-00006

    authors: Walsh BT,Giardina EG,Sloan RP,Greenhill L,Goldfein J

    更新日期:1994-02-01 00:00:00

  • Tricyclic antidepressants and cardiac autonomic control in children and adolescents.

    abstract:OBJECTIVE:To elucidate the effects of tricyclic antidepressants on sympathetic and vagal modulation of heart rate variability. METHOD:Seventy-five children and adolescents (mean age 10.5 years, SD 2.0) from therapeutic and regular schools underwent challenges of paced breathing and orthostatic postural change, while h...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199801000-00017

    authors: Mezzacappa E,Steingard R,Kindlon D,Saul JP,Earls F

    更新日期:1998-01-01 00:00:00

  • Salivary cortisol, personality, and aggressive behavior in adolescent boys: a 5-year longitudinal study.

    abstract:OBJECTIVE:The present investigation tested the hypothesis that low resting salivary cortisol concentration in preadolescent boys would be associated with aggressive behavior later in adolescence. Second, it tested whether personality traits would mediate this relation. METHOD:Resting salivary cortisol concentrations f...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/01.CHI.0000070246.24125.6D

    authors: Shoal GD,Giancola PR,Kirillova GP

    更新日期:2003-09-01 00:00:00

  • General medical problems among the offspring of depressed parents: a 10-year follow-up.

    abstract:OBJECTIVE:To examine the association between both parental and offspring depression and the general medical problems of a sample of offspring at high and low risk for depression. METHOD:Offspring (n = 222) from families with either depressed or nondepressed parents were followed up for a period of 10 years. Data colle...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199806000-00010

    authors: Kramer RA,Warner V,Olfson M,Ebanks CM,Chaput F,Weissman MM

    更新日期:1998-06-01 00:00:00

  • Inpatient psychiatric treatment of children and adolescents: a review of outcome studies.

    abstract::All outcome studies of child and adolescent residential treatment and inpatient psychiatric hospitalization reported in the literature from 1975 to the present were examined. A set of statistical procedures was developed to integrate the findings of the 34 studies, which provided a weighted predictive value for 10 var...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章,评审

    doi:10.1097/00004583-199011000-00001

    authors: Pfeiffer SI,Strzelecki SC

    更新日期:1990-11-01 00:00:00

  • Randomized trial of the Availability, Responsiveness and Continuity (ARC) organizational intervention for improving youth outcomes in community mental health programs.

    abstract:OBJECTIVES:The primary objective of the study was to assess whether the Availability, Responsiveness and Continuity (ARC) organizational intervention improved youth outcomes in community based mental health programs. The second objective was to assess whether programs with more improved organizational social contexts f...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.jaac.2013.02.005

    authors: Glisson C,Hemmelgarn A,Green P,Williams NJ

    更新日期:2013-05-01 00:00:00

  • Isolation and restraint in juvenile correctional facilities.

    abstract::Although mental health and correctional programs for juveniles house similar populations, their approaches to behavioral management can be quite different. This difference is evident in the use of isolation and restraint. Both of these interventions are effective behavioral management tools but are subject to abuse if...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章,评审

    doi:10.1097/00004583-199003000-00014

    authors: Mitchell J,Varley C

    更新日期:1990-03-01 00:00:00

  • Systematic Review and Meta-analysis: The Association Between Child and Adolescent Depression and Later Educational Attainment.

    abstract:OBJECTIVE:The association between depression and educational attainment in young people is unclear. This systematic review and meta-analysis examines the longitudinal association between depression and subsequent attainment, and its potential effect modifiers and mediators. METHOD:We searched Embase, PsycINFO, PubMed,...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/j.jaac.2020.10.008

    authors: Wickersham A,Sugg HVR,Epstein S,Stewart R,Ford T,Downs J

    更新日期:2021-01-01 00:00:00

  • Approaches to enhancing the early detection of autism spectrum disorders: a systematic review of the literature.

    abstract:BACKGROUND:A reliable diagnosis of autism can be made as early as 24 months, yet in many children diagnoses are made much later. A delay in diagnosis translates into a missed opportunity to provide early intervention services and to improve outcomes. The aim of the current study was to review the literature on early de...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/j.jaac.2013.11.002

    authors: Daniels AM,Halladay AK,Shih A,Elder LM,Dawson G

    更新日期:2014-02-01 00:00:00

  • Safe Thinking and Affect Regulation (STAR): human immunodeficiency virus prevention in alternative/therapeutic schools.

    abstract:OBJECTIVE:To evaluate the effectiveness of Safe Thinking and Affect Regulation (STAR), a 14-session HIV-prevention program for adolescents at alternative/therapeutic schools. Because these youth frequently have difficulties with emotions and cognitions, it was designed to improve sexuality-specific affect management an...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jaac.2011.06.018

    authors: Brown LK,Nugent NR,Houck CD,Lescano CM,Whiteley LB,Barker D,Viau L,Zlotnick C

    更新日期:2011-10-01 00:00:00

  • Expressed emotion moderates the effects of family-focused treatment for bipolar adolescents.

    abstract:OBJECTIVE:Family interventions have been found to be effective in pediatric bipolar disorder (BD). This study examined the moderating effects of parental expressed emotion (EE) on the 2-year symptomatic outcomes of adolescent BD patients assigned to family-focused therapy for adolescents (FFT-A) or a brief psychoeducat...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/CHI.0b013e3181a0ab9d

    authors: Miklowitz DJ,Axelson DA,George EL,Taylor DO,Schneck CD,Sullivan AE,Dickinson LM,Birmaher B

    更新日期:2009-06-01 00:00:00

  • Editorial: Bullying and Suicide Risk: Restructuring Prevention, Identification, and Treatment to Address a Global Mental Health Crisis.

    abstract::Bullying is a global phenomenon with significant mental health consequences. Although bullying prevention programs have garnered attention over the last several years, the results of these programs have been mixed, at best. As Koyanagi et al.1 highlight in this issue of the Journal, the consequences of bullying can be...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 评论,社论

    doi:10.1016/j.jaac.2019.04.007

    authors: Karnik NS,Winiarski DA

    更新日期:2019-09-01 00:00:00