Genome-wide expression dynamics during mouse embryonic development reveal similarities to Drosophila development.

abstract：:Tbx18 has been shown to be essential for ureteral development. However, it remains unclear whether it plays a direct role in kidney development. Here we addressed this by focusing on examining the pattern and contribution of Tbx18+ cells in the kidney and its role in kidney vascular development. Expression studies and...

journal_title：Developmental biology

authors： Xu J,Nie X,Cai X,Cai CL,Xu PX

更新日期：2014-07-01 00:00:00

abstract：:Voltage-gated Na(+) and K(+) channels are localized to distinct subcellular domains in mammalian myelinated nerve fibers. Specifically, Na(+) channels are clustered in high densities at nodes of Ranvier, while K(+) channels are found in juxtaparanodal zones just beyond regions of axoglial contact where sequential laye...

journal_title：Developmental biology

authors： Rasband MN,Trimmer JS

更新日期：2001-08-01 00:00:00

abstract：:The Id1 and Id3 genes play major roles during cardiac development, despite their expression being confined to non-myocardial layers (endocardium-endothelium-epicardium). We previously described that Id1Id3 double knockout (dKO) mouse embryos die at mid-gestation from multiple cardiac defects, but early lethality precl...

journal_title：Developmental biology

authors： Zhao Q,Beck AJ,Vitale JM,Schneider JS,Gao S,Chang C,Elson G,Leibovich SJ,Park JY,Tian B,Nam HS,Fraidenraich D

更新日期：2011-01-01 00:00:00

abstract：:The origin and development of mouse kidney vasculature were examined in chorioallantoic grafts of early kidney rudiments and of experimentally induced explants of separated metanephric mesenchymes. Whole kidney rudiments developed into advanced stages, expressed the segment-specific antigenic markers of tubules and th...

journal_title：Developmental biology

authors： Sariola H,Ekblom P,Lehtonen E,Saxén L

更新日期：1983-04-01 00:00:00

abstract：:Smad4 is defined as the common-mediator Smad (co-Smad) required for transducing signals for all TGF-beta superfamily members. This paper describes two Smad4s in Xenopus: XSmad4alpha, which is probably the Xenopus orthologue of human Smad4, and a distinct family member, XSmad4beta, which differs primarily at the extrem...

journal_title：Developmental biology

authors： Howell M,Itoh F,Pierreux CE,Valgeirsdottir S,Itoh S,ten Dijke P,Hill CS

更新日期：1999-10-15 00:00:00

abstract：:Tabby is a mouse mutant characterized by deficient development of the ectodermal organs: teeth, hair, and a subset of glands. Ectodysplasin, the protein encoded by the Tabby gene, was recently identified as a novel TNF-like transmembrane protein but little is known about its function. We have examined the Tabby tooth ...

journal_title：Developmental biology

authors： Pispa J,Jung HS,Jernvall J,Kettunen P,Mustonen T,Tabata MJ,Kere J,Thesleff I

更新日期：1999-12-15 00:00:00

abstract：:The commitment and differentiation of the alveolar type I (AT1) cell lineage is a critical step for the formation of distal lung saccules, which are the primitive alveolar units required for postnatal respiration. How AT1 cells arise from the distal lung epithelial progenitor cells prior to birth and whether this proc...

journal_title：Developmental biology

authors： Wang X,Wang Y,Snitow ME,Stewart KM,Li S,Lu M,Morrisey EE

更新日期：2016-06-15 00:00:00

abstract：:As the germ band shortens in Drosophila melanogaster embryos, cell shape changes cause segments to narrow anteroposteriorly and to lengthen dorsoventrally. One of the genes required for this retraction process is the hindsight (hnt) gene. hnt encodes a nuclear Zinc-finger protein that is expressed in the extraembryoni...

journal_title：Developmental biology

authors： Lamka ML,Lipshitz HD

更新日期：1999-10-01 00:00:00

abstract：:Transcription factors (TFs) can regulate different sets of genes to determine specific cell types by means of combinatorial codes. We previously identified closely-spaced TF binding motifs located 8.2-8.5 kb 5' to the ATG of the murine Pou4f3 gene, a gene required for late hair cell (HC) differentiation and survival. ...

journal_title：Developmental biology

authors： Masuda M,Pak K,Chavez E,Ryan AF

更新日期：2012-12-01 00:00:00

abstract：:Eggs and embryos of the sea urchin Lytechinus pictus were labeled with [35S]methionine. Aqueous extracts of protein were prepared and analyzed by a high resolution two-dimensional polyacrylamide gel electrophoresis system described recently by O'Farrell utilizing isoelectric focusing and sodium dodecyl sulfate electro...

journal_title：Developmental biology

authors： Brandhorst BP

更新日期：1976-09-01 00:00:00

abstract：:Two 80- to 100-kb chromosomal replicons containing clustered chorion genes amplify in the ovarian follicle cells during the final 22 hr of Drosophila oogenesis. We have studied the relationship between amplification and transcription within one of these domains, located at 7E10-7F3,4 on the X chromosome. A tandem clus...

journal_title：Developmental biology

authors： Parks S,Wakimoto B,Spradling A

更新日期：1986-09-01 00:00:00

abstract：:Although local epithelial-mesenchymal tissue interactions which are presumably mediated by extracellular matrix molecules are important regulators of tooth morphogenesis and differentiation, our studies have indicated that these developmental processes also depend on circulating molecules. The iron-carrying serum prot...

journal_title：Developmental biology

authors： Partanen AM,Ekblom P,Thesleff I

更新日期：1985-09-01 00:00:00

abstract：:Stimulation of epithelial cell cycling by the neuropeptide head activator was analyzed in Hydra magnipapillata and compared with the action of head activator on bud formation and tentacle formation during head regeneration. The results obtained indicate that head activator treatment stimulates epithelial cell division...

journal_title：Developmental biology

authors： Hobmayer B,Holstein TW,David CN

更新日期：1997-03-01 00:00:00

abstract：:Choriogenesis (eggshell formation) within the silkmoth Antheraea polyphemus proceeds in parallel for the two major subpopulations of follicle cells, diverging only during the very late period when aeropyle crown surface structures form in one region but not in the other. Correlated with their appearance is the synthes...

journal_title：Developmental biology

authors： Regier JC,Cole C,Leclerc RF

更新日期：1993-11-01 00:00:00

abstract：:Leaf primordia, first visible as small bumps, are produced in a cyclical pattern at the edges of the shoot apex, a smooth region at the top of the stem. Their formation is a biomechanical process. This review first considers hypothetical construction mechanisms and then summarizes research that provides information ab...

journal_title：Developmental biology

authors： Selker JM,Steucek GL,Green PB

更新日期：1992-09-01 00:00:00

abstract：:The development of neural crest-derived melanocytes, as well as haematopoietic and germ cells, is affected by mutations of the Kit and Mgf genes, which lead to dominant spotting (W) or steel (Sl) phenotypes. Mgf codes for the ligand of the receptor tyrosine kinase encoded by the Kit locus. KitW-v, a point mutation exe...

journal_title：Developmental biology

authors： Mackenzie MA,Jordan SA,Budd PS,Jackson IJ

更新日期：1997-12-01 00:00:00

abstract：:The corepressor SMRT acts on a range of transcription factors, including the retinoid and thyroid hormone nuclear receptors. The carboxy-terminal region of SMRT contains CoRNR box motifs that mediate these interactions. We have shown, in Xenopus, that SMRT can exist as isoforms containing either two or three CoRNR box...

journal_title：Developmental biology

authors： Malartre M,Short S,Sharpe C

更新日期：2006-04-15 00:00:00

abstract：:c-fms and c-kit are structurally related tyrosine kinase receptors for colony-stimulating factor-1 (CSF-1) and for steel factor (SF), respectively. The level of c-fms mRNA, like c-kit mRNA, increases during the maturation of oocytes and is an abundant maternal message found in the unfertilized oocyte. Following fertil...

journal_title：Developmental biology

authors： Arceci RJ,Pampfer S,Pollard JW

更新日期：1992-05-01 00:00:00

abstract：:The Drosophila segment polarity gene known as shaggy or zeste white 3 encodes a ubiquitously expressed serine-threonine protein kinase which is critical for a number of important developmental processes. In the developing wing blade, clones of cells lacking the normal shaggy-zeste white 3 product form dense tufts of m...

journal_title：Developmental biology

authors： Blair SS

更新日期：1994-03-01 00:00:00

abstract：:The distribution of the catalytic and regulatory subunits of the cAMP-dependent protein kinase between cytoplasm and nucleus was determined during the development of Dictyostelium discoideum. In vegetative amoebae approximately 2% of the subunits were in the nucleus. During development there was an approximately 5-fol...

journal_title：Developmental biology

authors： Woffendin C,Chambers TC,Schaller KL,Leichtling BH,Rickenberg HV

更新日期：1986-05-01 00:00:00

abstract：:Monoclonal antibodies highly selective for developmentally regulated antigens present in the cornea (Zak and Linsenmayer, Dev. Biol. 99, 373-381, 1983) have been used to immunohistochemically evaluate differentiation in intact chick corneas cultured on the chorioallantoic membrane (CAM) of host embryos. One antibody i...

journal_title：Developmental biology

authors： Zak NB,Linsenmayer TF

更新日期：1985-04-01 00:00:00

abstract：:Hand proteins are evolutionally conserved basic helix-loop-helix (bHLH) transcription factors implicated in development of neural crest-derived tissues, heart and limb. Hand1 is expressed in the distal (ventral) zone of the branchial arches, whereas the Hand2 expression domain extends ventrolaterally to occupy two-thi...

journal_title：Developmental biology

authors： Barbosa AC,Funato N,Chapman S,McKee MD,Richardson JA,Olson EN,Yanagisawa H

更新日期：2007-10-01 00:00:00

abstract：:We report the embryonic phenotype of muscleblind (mbl), a recently described Drosophila gene involved in terminal differentiation of adult ommatidia. mbl is a nuclear protein expressed late in the embryo in pharyngeal, visceral, and somatic muscles, the ventral nerve cord, and the larval photoreceptor system. All thre...

journal_title：Developmental biology

authors： Artero R,Prokop A,Paricio N,Begemann G,Pueyo I,Mlodzik M,Perez-Alonso M,Baylies MK

更新日期：1998-03-15 00:00:00

abstract：:Thrombospondin type 1 repeat (TSR) superfamily members regulate diverse biological activities ranging from cell motility to inhibition of angiogenesis. In this study, we verified that mouse protein O-fucosyltransferase-2 (POFUT2) specifically adds O-fucose to TSRs. Using two Pofut2 gene-trap lines, we demonstrated tha...

journal_title：Developmental biology

authors： Du J,Takeuchi H,Leonhard-Melief C,Shroyer KR,Dlugosz M,Haltiwanger RS,Holdener BC

更新日期：2010-10-01 00:00:00

abstract：:Regulation of gene expression during early embryonic development in the rabbit was investigated by quantitative assay of firefly luciferase activity obtained by microinjection of three plasmid constructs using the regulatory region of polyomavirus promoter (PrPyV) with two different enhancer sequences (wild type or mu...

journal_title：Developmental biology

authors： Christians E,Rao VH,Renard JP

更新日期：1994-07-01 00:00:00

abstract：:The interstitial cells of hydra form a multipotent stem cell system, producing terminally differentiated nerve cells and nematocytes during asexual growth. Under well-fed conditions the interstitial cell population doubles in size every 4 days. We have investigated the possible role of nerve cells in regulating this b...

journal_title：Developmental biology

authors： Heimfeld S,Bode HR

更新日期：1985-08-01 00:00:00

abstract：:Experiments in which the developing gut of avian embryos was back-transplanted to permit the bowel to interact with the developing neural tube were undertaken. Segments of intestine from 4-day quail embryos were implanted between the somites and neural tubes of chick embryos of 7 to 24 somites. The spinal cord respond...

journal_title：Developmental biology

authors： Rothman TP,Gershon MD,Fontaine-Pérus JC,Chanconie M,Le Douarin NM

更新日期：1987-12-01 00:00:00

abstract：:The polypeptide sequence predicted from the Pem oncofetal gene cDNA contains a homeodomain most closely related to the paired class. Pem, paired class member orthodenticle, and the bicoid maternal gene product homeodomains all have lysine residues at a recognition helix position implicated in DNA-binding specificity. ...

journal_title：Developmental biology

authors： Rayle RE

更新日期：1991-07-01 00:00:00

abstract：:There has been a resurgence of interest in comparative embryology. It is now important to be able to compare gene expression in different species at similar developmental stages. One phenomenon which may make it difficult to compare embryos in this way is heterochrony--a change in developmental timing during evolution...

journal_title：Developmental biology

authors： Richardson MK

更新日期：1995-12-01 00:00:00

abstract：:The ability of adult vertebrates to repair tissue damage is widespread and impressive; however, the ability to regenerate structurally complex organs such as the limb is limited largely to the salamanders. The fact that most of the tissues of the limb can regenerate has led investigators to question and identify the b...

journal_title：Developmental biology

authors： Satoh A,Bryant SV,Gardiner DM

更新日期：2012-06-15 00:00:00