Abstract:
:We have previously identified and mapped porcine expressed sequence tags (ESTs) derived from genes that are preferentially expressed in liver. The aim of the present study was to identify single nucleotide polymorphisms (SNPs) in porcine genes encoding enzymes in hepatic metabolic pathways and use the SNPs for mapping. Furthermore, these genes, which are involved in utilization and partitioning of nutrients, were examined for their effects on carcass and meat quality traits by linkage analyses. In total, 100 ESTs were screened for SNPs by single strand conformation polymorphism analyses across a diverse panel of animals with a 36% success rate. Twelve of 36 polymorphic loci segregated in a three-generation Duroc x Berlin Miniature Pig (F2) resource population, the DUMI resource population, and were genetically mapped. Interval mapping of the corresponding chromosomes was performed to verify mapping of the genes within quantitative trait loci (QTL) regions detected in this resource population. QTL with genome-wide significance were detected in the vicinity of GNMT, ESTL147 and HGD. These loci therefore are positional candidate genes.
journal_name
Anim Genetjournal_title
Animal geneticsauthors
Ponsuksili S,Chomdej S,Murani E,Bläser U,Schreinemachers HJ,Schellander K,Wimmers Kdoi
10.1111/j.1365-2052.2005.01351.xsubject
Has Abstractpub_date
2005-12-01 00:00:00pages
477-83issue
6eissn
0268-9146issn
1365-2052pii
AGE1351journal_volume
36pub_type
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