Pain on injection of lipid-free propofol and propofol emulsion containing medium-chain triglyceride: a comparative study.

Abstract:

UNLABELLED:Pain on injection of propofol continues to be a problem for anesthesiologists. A lipid-free formulation of propofol and a propofol emulsion containing medium-chain triglyceride have become available in the Indian market. We performed this study to assess the pain on injection of propofol emulsion containing medium-chain triglyceride as the lipid carrier and lipid-free propofol formulation. One-hundred-thirty adult patients were randomly assigned to one of two groups: Group I received propofol emulsion containing medium-chain triglyceride and Group II received lipid-free propofol. One fourth of the total calculated induction dose was injected over 5 s in the largest vein on the dorsum of a hand. Pain was assessed using verbal response and behavioral signs. Both formulations caused pain on injection. However, the lipid-free propofol solution produced frequent (89%) and severe pain on injection compared with the emulsion containing medium-chain triglyceride (40%). IMPLICATIONS:Pain on injection of two formulations of propofol was compared. A lipid-free formulation produced more pain on injection as compared with the emulsion containing medium-chain triglyceride.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Dubey PK,Kumar A

doi

10.1213/01.ane.0000166951.72702.05

subject

Has Abstract

pub_date

2005-10-01 00:00:00

pages

1060-2, table of contents

issue

4

eissn

0003-2999

issn

1526-7598

pii

101/4/1060

journal_volume

101

pub_type

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