Abstract：
:We observed chronological changes of platelet endothelial cell adhesion molecule-1 (PECAM-1), final mediator of neutrophil transendothelial migration, immunoreactivity, and protein level in the gerbil hippocampus proper after 5 min of transient ischemia. One day after ischemic insult, PECAM-1 immunoreactivity and protein level increased slightly in the hippocampus proper. Thereafter, PECAM-1 immunoreactivity and protein level increased significantly in the hippocampus proper by 4 days after ischemic insult. Especially, PECAM-1 in the hippocampal CA1 region was higher than that in the CA2/3 region. Five days after ischemic insult, PECAM-1 immunoreactivity decreased compared to the 4 days post-ischemic group. However, the RNA levels of PECAM-1 in the hippocampus proper were significantly decreased in the 4 days post-ischemic groups compared to that in the sham-operated group. This result suggests that the increase of PECAM-1 and decrease of PECAM-1 RNA in the CA1 region 4 days after ischemia may be associated with transmigration of neurotrophil.
journal_name
Brain Resjournal_title
Brain researchauthors
Hwang IK,Kim DW,Yoo KY,Jung BK,Song JH,Jung JY,Choi SY,Kang TC,Lee JY,Kwon YG,Won MHdoi
10.1016/j.brainres.2005.04.049subject
Has Abstractpub_date
2005-06-28 00:00:00pages
251-7issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(05)00634-7journal_volume
1048pub_type
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