Abstract:
:Thirty-six of 39 published calculated doubling times (Td's) of uveal melanomas appeared to be longer than 60 days. Metastatic death occurs 35-40 Td's after dissemination. The shortest interval between dissemination and metastatic death in individual patients may, therefore, be calculated as 35 x 60 days = 6 years; the interval may extend to 80 years. This suggests, that local therapy cannot influence the survival data within the first 7 post-therapeutic years, because almost all metastatic deaths within these 7 years are due to pretreatment dissemination. For that reason, the published comparative survival analyses after various therapies have within this period failed to show statistically significant death rates differences. Microscopically viable melanoma tissue has been noted in 215 of 231 histopathologically studied irradiated uveal melanomas. Observed mitotic figures 4-6 years after irradiation indicate retained reproductive integrity. This constitutes a--by enucleation avoidable--incremental risk for post-irradiation exponential growth and dissemination. The risk cannot become statistically manifest before a greater than or equal to 10-year follow-up period. Retained, generally poor, visual acuity in a small percentage of patients cannot balance the incremental risk/benefit ratio of irradiation. A few, at present justifiable, indications for radiotherapy on uveal melanomas are enumerated.
journal_name
Int Ophthalmoljournal_title
International ophthalmologyauthors
Manschot WA,van Strik Rdoi
10.1007/BF00918938subject
Has Abstractpub_date
1992-03-01 00:00:00pages
91-9issue
2eissn
0165-5701issn
1573-2630journal_volume
16pub_type
杂志文章,评审abstract:PURPOSE:To investigate risk factors for choroidal detachment after trabeculectomy. METHODS:We prospectively evaluated 97 patients with open-angle glaucoma who underwent primary trabeculectomy to investigate risk factors for choroidal detachment after trabeculectomy. The primary outcome measure was risk factors for the...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-019-01267-6
更新日期:2020-05-01 00:00:00
abstract::To report a patient with optic disc pit who showed decreased inner diameter of the optic disc pit along with resolution of recurrent macular detachment after pars plana vitrectomy. Pneumatic retinopexy and peripapillary laser photocoagulation was performed in a 28-year-old female with optic disc pit and serous macular...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-012-9656-8
更新日期:2013-04-01 00:00:00
abstract:PURPOSE:To report a comparison analysis of accelerated corneal cross-linking (A-CXL) treatment for progressive keratoconus patients in different pediatric age groups. STUDY DESIGN:Retrospective, cross-sectional. METHODS:Patients with progressive keratoconus aged ≤ 18 were retrospectively reviewed. Forty-one eyes of 4...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01446-w
更新日期:2020-10-01 00:00:00
abstract:PURPOSE:To report a case of toxic optic neuropathy caused by an ocular bee sting. METHODS:Case report and literature review. RESULTS:A 44-year-old female presented with no light perception vision 2 days after a corneal bee sting in her right eye. She was found to have diffuse cornea edema with overlying epithelial de...
journal_title:International ophthalmology
pub_type: 杂志文章,评审
doi:10.1007/s10792-018-0978-z
更新日期:2019-07-01 00:00:00
abstract:PURPOSE:To evaluate the learning curve of non-penetrating glaucoma surgery (NPGS). METHODS:The study included 32 eyes of 27 patients' (20 male and 7 female) with medically uncontrolled glaucoma. Non-penetrating glaucoma surgeries performed by trainees under control of an experienced surgeon between 2005 and 2007 at ou...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-017-0691-3
更新日期:2018-10-01 00:00:00
abstract:PURPOSE:To evaluate the effect of metronidazole ophthalmic solutions on corneal neovascularization (CNV) in a rat model. METHODS:A chemical burn was created in the right central cornea of 40 rats. Animals were randomized and distributed into four study groups (n = 10 rats per group) designated Met_0.1%, Met_0.5%, sham...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-018-0922-2
更新日期:2019-05-01 00:00:00
abstract:PURPOSE:Proliferative vitreoretinopathy (PVR) is characterized by the formation of cellular membranes on the detached retina and also in the vitreous. Glial cells can be found in epiretinal and subretinal membranes from eyes with PVR, proliferative diabetic retinopathy (PDR), idiopathic macular pucker, uveitis and othe...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1023/a:1022509614815
更新日期:2001-01-01 00:00:00
abstract:PURPOSE:Pseudoexfoliation syndrome (PEX) is a late onset disorder of extracellular matrix turnover, associated systemically with cardiovascular and cerebrovascular disease. To evaluate the suggested association of polymorphisms of homocysteine metabolism genes MTHFR (rs1801131, rs1801133) and MTHFD1 (rs8006686) with PE...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-017-0498-2
更新日期:2018-04-01 00:00:00
abstract::Ectopic cilia are the most rare of cilial anomalies. We report a 27-year-old man who presents with tarsal conjunctival symptomatic ectopic cilia. On slit-lamp examination eversion of the lower eyelid demonstrated that several black-white cilia were protruding from the conjunctiva. ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-008-9228-0
更新日期:2009-08-01 00:00:00
abstract:PURPOSE:This study evaluates the outcomes of ruthenium-106 (Ru-106) plaque brachytherapy for vasoproliferative tumors (VPTs) of the ocular fundus in a single referral ocular oncology center. METHODS:The clinical charts of all patients diagnosed with VPT who underwent plaque radiotherapy from 2002 to 2017 were reviewed...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01386-5
更新日期:2020-08-01 00:00:00
abstract::Retinal arteriovenous malformations are rare and most are reported to be asymptomatic. We report an 11-year-old boy who attended for blunt trauma to his eye. The first ophthalmologic examination was performed in Nikookari Hospital Eye Emergency Room. Visual acuity was 20/20 and relative afferent pupillary defect was n...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-012-9636-z
更新日期:2013-02-01 00:00:00
abstract::A 22-year-old male presented to us with complaints of sudden painful loss of vision in left eye 10 days ago along with inward deviation of the left eye. Best-corrected visual acuity (BCVA) in right eye was 20/20 and 20/50 in left eye. Left eye showed limitation of abduction, a relative afferent pupillary defect, norma...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-018-0910-6
更新日期:2019-05-01 00:00:00
abstract:PURPOSE:Corneal melting with perforation is a severe ophthalmic complication of autoimmune disorders such as rheumatoid arthritis. It requires urgent medical management in order to maintain the integrity of the globe and preserve vision. Treating this complication by penetrating keratoplasty is problematic due to the h...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-017-0545-z
更新日期:2018-06-01 00:00:00
abstract::The Acuityscope projects an image of a three bar resolution test target onto the patient's retina, where it is viewed and read by an observer. The test target consists of a series of three bar targets varying in size on a logarithmic scale. Individual targets are identified in the projected image by Bailey-Lovie log v...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00224470
更新日期:1991-03-01 00:00:00
abstract::We investigated in normal persons of different ages ranging from 4 months to 85 years the frequency of different ferning types as well as the results of the Schirmer I test, break-up time and tear protein profile. With increasing age, ferning types of higher degree were significantly more frequent. Furthermore, a corr...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00137950
更新日期:1991-11-01 00:00:00
abstract::The purpose of this study was to evaluate the impact of intravitreal bevacizumab injections on the management and outcome of patients affected by retinal vein occlusions, their effectiveness on morphological and functional parameters, the modalities of long-term management and the need for additional laser treatment d...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-014-0002-1
更新日期:2014-12-01 00:00:00
abstract:PURPOSE:To assess ophthalmic manifestations in patients with stroke and emphasize the importance of a formal screening for visual problems in stroke patients in hospital and rehabilitation settings. METHODS:This was a cross-sectional study of 50 newly diagnosed patients with stroke with Glasgow Coma Scale (GCS) > 8 ex...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-019-01131-7
更新日期:2019-12-01 00:00:00
abstract::The purpose of this study was to investigate the reproducibility of choroidal thickness measurements in normal subjects on 3 spectral domain optical coherence tomography instruments, namely: Zeiss Cirrus HD-OCT (Carl Zeiss Meditec Inc., Dublin, CA), Heidelberg Spectralis (Heidelberg Engineering, Heidelberg, Germany), ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-016-0306-4
更新日期:2017-06-01 00:00:00
abstract:PURPOSE:We report a case of atypical, extratarsal chalazion referred with a history of a chronic inflammatory mass found on the edge of the lower eyelid. METHODS:A 3-year-old female developed a small mass on the medial side of the right lower lid in 4-month duration. She was seen by her ophthalmologist and the diagnos...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-016-0409-y
更新日期:2017-12-01 00:00:00
abstract:PURPOSE:To investigate the natural course, visual outcome, and risk factors for visual loss after nonarteritic anterior ischemic optic neuropathy (NAION) attack in Chinese patients from a tertiary medical center in Southern Taiwan. METHODS:This is a longitudinal observational study that included sixty NAION patients, ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01448-8
更新日期:2020-10-01 00:00:00
abstract::Sarcoidosis is a multisystem disease characterized by enhanced immune responses at sites of involvement. To elucidate the immunopathogenesis of ophthalmic lesions, cell infiltrates in biopsies from conjunctiva and other tissues involved (lungs, lymph nodes, skin) were studied in 26 patients with active sarcoidosis in ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00131162
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:To determine the inflammatory course and level of visual rehabilitation after cataract extraction and posterior chamber lens implantation in patients with Fuchs' heterochromic iridocyclitis complicated by cataract. METHODS:In a clinical trial, 32 eyes (visual acuity of 20/160 or worse) of 30 patients underw...
journal_title:International ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1023/a:1026490902566
更新日期:1997-01-01 00:00:00
abstract::The purpose of this article is to report an unusual bilateral inferior subluxation of the lens in a patient with Marfan's syndrome. A 14-year-old boy presented with gradual painless diminution of vision in both eyes. His family history showed that his maternal uncle also had similar complaints. Systemic examination of...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-013-9750-6
更新日期:2014-02-01 00:00:00
abstract:PURPOSE:To assess the outcomes and analyze complication rates following primary iris claw IOL retrofixation with intravitreal triamcinolone acetonide. METHODS:This is a retrospective interventional case series. Patients with poor capsular support-diagnosed preoperatively or owing to intraoperative complications-were t...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-017-0467-9
更新日期:2018-02-01 00:00:00
abstract:PURPOSE:To investigate the overexpression of genes in sebaceous gland carcinoma (SGC) of the eyelid compared to sebaceous adenoma of the eyelid in order to elucidate the molecular mechanism underlying pathogenesis. METHODS:We performed histopathological examination of eyelid tissues surgically removed from four patien...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-019-01185-7
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Only a few studies have investigated structural and functional changes in monocular blind individuals. Our aim in this study was to segmentally investigate the cerebellar structures of subjects with late-onset monocular blindness (LMB) using a Voxel-based volumetric analysis system. METHODS:The segmental vo...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01629-5
更新日期:2020-11-12 00:00:00
abstract::The clinical and histopathological findings are described in a case of cerebral and ocular abnormalities associated with (congenital) muscular dystrophy. Histopathological examination of the eyes revealed a fetal configuration of the anterior chamber angle, elongated ciliary processes, cataract, persistence of primary...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF01007744
更新日期:1993-08-01 00:00:00
abstract:PURPOSE:To compare the efficacy and safety of two intravitreal anti-vascular endothelial growth factor (anti-VEGF) agents, ranibizumab and aflibercept, for the treatment of vascularized pigment epithelium detachment (vPED) due to age-related macular degeneration (AMD) in a follow-up time of 12 months. METHODS:Particip...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-018-0833-2
更新日期:2019-02-01 00:00:00
abstract::The aim of this study is to report the clinical outcome of a diabetic patient with optic nerve head neovascularization treated with an intravitreal injection of triamcinolone acetonide. A 52-year-old patient presented with clinically significant diffuse macular edema and optic nerve head neovascularization due to prol...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1023/b:inte.0000031740.85124.78
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:Autoenucleation is a severe, rare form of self-mutilation. The majority of cases have been reported in the 15- to 60-year age group, usually in psychiatric patients with a history of depression or schizophrenia, sometimes caused by drug abuse. CASE REPORT:We report a case of left-sided autoenucleation in an...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-008-9222-6
更新日期:2009-08-01 00:00:00