Abstract:
:The major transporter of vitamin D metabolites in the circulation is the multifunctional plasma protein Gc, also known as group-specific component, Gc globulin, vitamin D-binding protein, or DBP. There are several phenotypes of Gc, and we examined the influence of Gc phenotype and Gc concentration on vitamin D status. By using isoelectric focusing we identified the Gc phenotype of 595 caucasian recent postmenopausal women enrolled into the Danish Osteoporosis Prevention Study (DOPS). We measured plasma concentration of Gc by immunonephelometry (coefficient of variation [CV] < 5%), 25-hydroxy vitamin D (25OHD) by a competitive protein-binding assay (CV 10%), and 1,25-dihydroxy-vitamin D (1,25(OH)(2)D) by a radioimmunoassay (CV 6--14%), and calculated index as the molar ratio of vitamin concentration divided by Gc concentration. Plasma levels of Gc, 25OHD, 25OHD index, and 1,25(OH)(2)D, but not 1,25(OH)(2)D index, differed significantly between women with different Gc phenotype, being highest in Gc1-1, intermediate in Gc1-2, and lowest in Gc2-2. In multiple regression analysis, Gc concentration was an independent predictor of 1,25(OH)(2)D, whereas Gc phenotype was a significant predictor of 25OHD concentration, even after adjustment for the effects of season, sunbathing habits, skin thickness, use of vitamin supplements, smoking, and body mass index (BMI). Plasma parathyroid hormone (PTH) level did not differ between Gc phenotypes. Despite the fact that more than 60% of the women with Gc phenotype Gc2-2 had plasma 25OHD levels of less than 50 nmol/L none of them had plasma PTH higher than reference limits. Bone mineral content (BMC), Bone mineral density (BMD), and bone markers did not differ between Gc phenotypes. In conclusion, plasma 1,25(OH)(2)D, 25OHD, and 25OHD index are related to Gc phenotype, and we speculate that the thresholds for vitamin D sufficiency differ between Gc phenotypes.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Lauridsen AL,Vestergaard P,Hermann AP,Brot C,Heickendorff L,Mosekilde L,Nexo Edoi
10.1007/s00223-004-0227-5subject
Has Abstractpub_date
2005-07-01 00:00:00pages
15-22issue
1eissn
0171-967Xissn
1432-0827journal_volume
77pub_type
杂志文章abstract::Mice deficient in the chloride channel ClC-7, which is likely involved in acidification of the resorption lacuna, display severe osteopetrosis. To fully characterize the osteopetrotic phenotype, the phenotypes of osteoclasts and osteoblasts were evaluated. ClC-7(-/-) mice and their corresponding wild-type littermates ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-008-9185-7
更新日期:2008-12-01 00:00:00
abstract::Aluminum ions (Al) and chromium (III) ions (Cr), as they exist in aqueous solution at neutral pH, adsorb onto calcium hydroxyapatite crystals (HAP) and severely inhibit their dissolution process, when present in concentrations less than 1 microM. Iron (III) ions (Fe), at concentrations up to 10 microM, have no effect ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555127
更新日期:1987-07-01 00:00:00
abstract::The European Forsteo Observational Study was designed to examine the effectiveness of teriparatide in postmenopausal women with osteoporosis treated for up to 18 months in normal clinical practice in eight European countries. The incidence of clinical vertebral and nonvertebral fragility fractures, back pain, and heal...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-009-9299-6
更新日期:2009-12-01 00:00:00
abstract::To assess whether vertebral fractures are associated with osteopenia in chronic alcoholic patients, a transversal study was carried out in 76 chronic alcoholic males and 62 age-matched healthy males. Lumbar bone mineral density (BMD) by dual photon absorptiometry and spinal chest X-ray films were done in all patients....
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00298430
更新日期:1995-08-01 00:00:00
abstract::Hepatitis C treatment with interferon alpha-2b (IFN-alpha) and ribavirin has been related to decreased bone mineral density. The aim of this study was to investigate the in vitro effects of different concentrations of ribavirin and IFN-alpha on osteoblast-like cells. Human osteoblast-like cells obtained by the outgrow...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-004-0175-0
更新日期:2004-08-01 00:00:00
abstract::The main congenital conditions of hypophosphatemia expressed in adulthood include several forms of hereditary hypophosphatemic rickets and a congenital disorder of vitamin D metabolism characterized by osteomalacia and hypophosphatemia in adult patients. Hypophosphatemia in adults is defined as serum phosphate concent...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/s00223-020-00695-2
更新日期:2021-01-01 00:00:00
abstract::Parathyroid Hormone (PTH) stimulates calcium entry into bone cells in vitro, and this effect has been proposed to mediate the actions of PTH on bone. Using cells harvested from infant rat calvaria by collagenase digestion, we evaluated the sensitivity and specificity of this phenomenon. Calcium uptake was temperature ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02408543
更新日期:1980-01-01 00:00:00
abstract::To experimentally examine the participation of amelogenins in controlled mineral-phase maturation of mammalian enamel, the identification of the individual proteins and their corresponding gene(s) is required. For this purpose, cDNAs were constructed from polyadenylated RNA from 2-day postnatal murine teeth, molecular...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02556627
更新日期:1987-04-01 00:00:00
abstract::Hip fracture may cause and/or complicate institutionalization. We undertook this study to define its overall prevalence among the residents of four nursing homes in Central Italy as well as its latency and impact on mobility when it occurred within institutions. We also performed a case control analysis with the aim o...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002230001212
更新日期:2001-06-01 00:00:00
abstract::The native human parathyroid hormone, hPTH-(1-84), and certain carboxyl truncated analogs such as hPTH-(1-34) and even smaller fragments such as hPTH-(1-31)NH2, [Leu27]cyclo(Glu22-Lys26)hPTH-(1-31)NH2, and hPTH-(1-30)NH2 stimulate femoral trabecular and cortical bone growth in ovariectomized (OVX) rats. Here we show t...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002230010061
更新日期:2000-04-01 00:00:00
abstract::It is our hypothesis that interstitial fluid flow plays a role in the bone remodeling response to mechanical loading. The fluid flow-induced expression of three proteins (collagen, osteopontin, and alkaline phosphatase) involved in bone remodeling was investigated. Rat calvarial osteoblasts subjected to pulsatile flui...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900185
更新日期:1997-01-01 00:00:00
abstract::The aim of this work was to explore the reduction of fluoride concentrations in the skeleton after stopping experimental fluoride administration. Fluoride was administered to the rats at varying doses (0, 50, 100 ppm in drinking water) and for different lengths of time (4, 13, 25 weeks). A series of fluoride concentra...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00318049
更新日期:1995-04-01 00:00:00
abstract::The wedges of the mid-diaphyseal osteotomies carried out to correct the femoral and/or tibial native deformity in type III osteogenesis imperfecta (OI III) were used to study the remodeling patterns and lamellar organization at the level of the major deformity. Histology and scanning electron microscopy (SEM) morpholo...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-013-9771-1
更新日期:2013-11-01 00:00:00
abstract::N-acetyl-beta-D-glucosaminidase (NAG) is a lysosomal enzyme predominantly located in renal proximal tubules. In idiopathic hypoparathyroidism (IHP), 100 Units of human PTH (1-34) increased urinary excretion of NAG from 0.029 +/- 0.027 to 0.173 +/- 0.035 U/lGF (p less than 0.05) in two patients before treatment and fro...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02556010
更新日期:1989-12-01 00:00:00
abstract::The effect of the degree of carboxylation of osteocalcin (OC) on the properties of bone is unclear. The aim of this study was to relate serum concentrations of total OC (tOC) and undercarboxylated OC (ucOC), measured with a two-site immunoassay, to bone mineral density (BMD) at the femoral neck and ultrasonic transmit...
journal_title:Calcified tissue international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002239900432
更新日期:1998-04-01 00:00:00
abstract::The influence of body mass index (BMI) on T scores for total body bone mineral content (TBBMC) and regional bone mineral content (RBMC) was studied in 186 healthy women: 100 postmenopausal, 35 perimenopausal, and 51 premenopausal. The three groups were divided by BMI >25 kg/m2 and BMI <25 kg/m2 and the postmenopausal ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900310
更新日期:1997-08-01 00:00:00
abstract::Teriparatide (TPTD) is the most widely used anabolic agent in the treatment of patients with osteoporosis although its use is restricted in many countries. A recent randomised trial confirmed that TPTD was superior to risedronate at preventing vertebral fractures over a 2-year period. There is limited information on t...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-019-00563-8
更新日期:2019-08-01 00:00:00
abstract::Prostaglandin E2 and leukotriene B4 are metabolites of arachidonic acid with well-characterized effects on osteoblastic cells. Prostaglandin E2 has been shown to be a potent bone-resorbing agent and to stimulate as well as inhibit osteoblastic cell proliferation. Leukotriene B4 has also been demonstrated to stimulate ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00301636
更新日期:1992-04-01 00:00:00
abstract::Doses of 8, 16 (low), 32, 48, 64 (medium), and 150 (high) mg/kg/day of cortisol were administered to groups of 8 growing rats each during 16 days, and their femurs were then submitted to 3-point bending tests at low strain rate. Low doses had no effect. Medium doses, previously shown to improve calcium (Ca) balance an...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00297297
更新日期:1992-01-01 00:00:00
abstract::The purpose of this study was to determine whether total serum calcium, parathyroid gland structure, and/or levels of parathyroid hormone, 1,25 and 24,25 DHCC, are altered in pigs with dental and skeletal fluorosis. Eight experimental animals receiving 2 mg F-/kg b.w. per day from age 8-14 months were compared with ei...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02556714
更新日期:1986-04-01 00:00:00
abstract::We have previously noted that a relatively large load (150 N) is required to induce a strain on the cortex of rat vertebrae similar to that induced on weight-bearing bones by normal mechanical usage. It seems unlikely that the musculature of the tail normally imposes loads of this magnitude, and this suggests that the...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900097
更新日期:1996-08-01 00:00:00
abstract::This study was conducted to determine the effectiveness of three forms of vitamin E supplements following nicotine treatment on bone histomorphometric parameters in an adult male rat model. Rats were divided into seven groups: baseline (B, killed without treatment), control (C, normal saline for 4 months), nicotine (N...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-008-9190-x
更新日期:2009-01-01 00:00:00
abstract::Prior exposure to PTH markedly decreased the responsiveness of isolated, cultured bone cells to the stimulatory effect of the hormone on cyclic AMP formation. This process of desensitization developed within 30 min, persisted during prolonged incubation of the cells in PTH-free medium, and could not be attributed to e...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02408528
更新日期:1980-01-01 00:00:00
abstract::Bone mass increases steadily until age 20-30 years, when peak bone mass (PBM) is acquired. Nutrition plays a critical role in achievement of the optimal genetically programmed PBM, with reduction in the risk of osteoporosis later in life. Intake of nutrients can be estimated through the use of various tools; typically...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-013-9721-y
更新日期:2013-07-01 00:00:00
abstract::Whether the decrease of zinc content in the femoral-metaphyseal tissues of rats with skeletal unloading is involved in the alteration of bone metabolism was investigated. Skeletal unloading was designed using the model of hindlimb suspension in rats. Animals were fed for 4 days with the unloading. The metaphyseal zinc...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00310262
更新日期:1995-09-01 00:00:00
abstract::In several studies on patients with rheumatoid arthritis, an association of bone loss with a persistently high disease activity has been found. The aim of our study was to investigate the relation between disease activity and serum levels of vitamin D metabolites, parathyroid hormone (PTH), and parameters of bone turn...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900416
更新日期:1998-03-01 00:00:00
abstract::The orientation of nanoscale mineral platelets was quantitatively evaluated in relation to the shape of lacunae associated with partially embedded osteocytes (osteoblastic-osteocytes) on the surface of deproteinised trabecular bone of adult sheep. By scanning electron microscopy and image analysis, the mean orientatio...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-015-0072-8
更新日期:2016-02-01 00:00:00
abstract::Vitamin D has long been known to be important for bone health, but there is currently no consensus on the amount of vitamin D needed or how it varies with age, race/ethnicity, body size, absorption efficiency, season, and other factors. This review describes the effects of vitamin D on calcium absorption, parathyroid ...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/s00223-012-9606-5
更新日期:2013-02-01 00:00:00
abstract::The aims of this study were to compare the response to therapy in disease activity in pagetic patients with and without skull involvement and the usefulness of bone markers in the evaluation of these patients. Forty patients with Paget's disease treated with tiludronate and 26 healthy controls were included. Serum tot...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-005-0247-9
更新日期:2006-07-01 00:00:00
abstract::Employing a cytochemical bioassay, we compared parathyroid function in normal and X-linked hypophosphatemic (Hyp) mice. Under basal conditions Hyp mice manifested hypocalcemia and, in accord, had a plasma bioactive parathyroid hormone concentration (3.04 +/- 0.14 pg/ml) significantly greater than that of normals (2.16...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02553712
更新日期:1985-07-01 00:00:00