当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > BAG-1 p29 protein prevents drug-induced cell death in the presence of EGF and enhances resistance to anoikis in SKOV3 human ovarian cancer cells.

BAG-1 p29 protein prevents drug-induced cell death in the presence of EGF and enhances resistance to anoikis in SKOV3 human ovarian cancer cells.

Abstract：

:BAG-1 is a multi-functional protein that exists in three major isoforms, BAG-1 p50, p46, and p36. A fourth isoform of 29 kDa also exists but its function remains mostly unknown. To further understand the role of this smaller isoform in ovarian cancer cells, the SKOV3 cell line was transfected with a doxycycline-inducible human BAG-1 p29 isoform or control plasmid. Ovexpression of BAG-1 p29 promotes protection from apoptosis in the presence of EGF as shown by decreased cell death measured by XTT assay and caspase-3 activity. Unexpectedly, however, BAG-1 p29 does not associate with the EGF receptor. When BAG-1 p29 transfectants were incubated in hydrogel-coated plates, BAG-1 p29-expressing SKOV3 cells were significantly more resistant to anoikis as compared to controls, and this correlated with decreased activation of caspase-3. The results of this study implicate BAG-1 p29 in the regulation of both the EGF signaling cascade and the apoptotic cascade induced by loss of anchorage.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Pagé V,Côté M,Rancourt C,Sullivan M,Piché A

doi

10.1016/j.bbrc.2004.12.193

subject

Has Abstract

pub_date

2005-03-25 00:00:00

pages

874-84

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(04)02921-3

journal_volume

328

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • First structure of the polymyxin resistance proteins.

    abstract：:PmrA/PmrB and PhoP/PhoQ are a pair of two-component systems (TCSs) that allow the Gram-negative bacteria to survive the cationic antimicrobial peptide polymyxin B. The two TCSs are linked by the polymyxin resistance protein, PmrD. The PhoP-activated PmrD protects the phosphorylated response regulator PmrA from dephosp...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.07.144

    authors： Fu W,Yang F,Kang X,Zhang X,Li Y,Xia B,Jin C

    更新日期：2007-10-05 00:00:00

  • Ca(2+) homeostasis and endoplasmic reticulum (ER) stress: An integrated view of calcium signaling.

    abstract：:Cellular Ca(2+) homeostasis is maintained through the integrated and coordinated function of Ca(2+) transport molecules, Ca(2+) buffers and sensors. These molecules are associated with the plasma membrane and different cellular compartments, such as the cytoplasm, nucleus, mitochondria, and cellular reticular network,...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章,评审

    doi：10.1016/j.bbrc.2015.02.004

    authors： Krebs J,Agellon LB,Michalak M

    更新日期：2015-04-24 00:00:00

  • Arabidopsis AAL-toxin-resistant mutant atr1 shows enhanced tolerance to programmed cell death induced by reactive oxygen species.

    abstract：:The fungal AAL-toxin triggers programmed cell death (PCD) through perturbations of sphingolipid metabolism in AAL-toxin-sensitive plants. While Arabidopsis is relatively insensitive to the toxin, the loh2 mutant exhibits increased susceptibility to AAL-toxin due to the knockout of a gene involved in sphingolipid metab...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.08.056

    authors： Gechev TS,Ferwerda MA,Mehterov N,Laloi C,Qureshi MK,Hille J

    更新日期：2008-10-31 00:00:00

  • Mutations of histone demethylase genes encoded by X and Y chromosomes, Kdm5c and Kdm5d, lead to noncompaction cardiomyopathy in mice.

    abstract：:Mammalian X and Y chromosomes evolved from a pair of autosomes. Although most ancestral genes have been lost from the Y chromosome, a small number of ancestral X-Y gene pairs are still present on the sex chromosomes. The KDM5C and KDM5D genes, which encode H3K4 histone demethylases, are a surviving ancestral gene pair...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.02.043

    authors： Kosugi M,Otani M,Kikkawa Y,Itakura Y,Sakai K,Ito T,Toyoda M,Sekita Y,Kimura T

    更新日期：2020-02-17 00:00:00

  • Vascular smooth muscle cells as target for estrogen.

    abstract：:ER mRNA was detected as 6.0 kb band by Northern blot analysis in vascular smooth muscle cells (VSMC) derived from rat aorta. The presence of ER mRNA in VSMC was confirmed by reverse transcriptase-polymerase chain reaction using specific primers for rat ER cDNA. In addition, the immunocytochemistry of ER was performed ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.2106

    authors： Orimo A,Inoue S,Ikegami A,Hosoi T,Akishita M,Ouchi Y,Muramatsu M,Orimo H

    更新日期：1993-09-15 00:00:00

  • Synergistic apoptosis induction in leukemic cells by miR-15a/16-1 and arsenic trioxide.

    abstract：:MicroRNAs (miRNAs) are small noncoding RNAs that regulate target gene expression through translation repression or messenger RNA degradation. MiR-15a and 16-1 form a cluster at the chromosomal region 13q14, which is frequently deleted or down-regulated in chronic lymphocytic leukemia. Arsenic trioxide (As(2)O(3), ATO)...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.10.137

    authors： Gao SM,Chen C,Wu J,Tan Y,Yu K,Xing CY,Ye A,Yin L,Jiang L

    更新日期：2010-12-10 00:00:00

  • 2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain.

    abstract：:The effects of anadamide, 2-arachidonoylglycerol and related compounds on the specific binding of a radiolabeled cannabinoid receptor ligand,[3H]CP55940, to synaptosomal membranes were examined. Anandamide, an endogenous cannabinoid receptor ligand, reduced the specific binding of [3H]CP55940 to synaptosomal membranes...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.2437

    authors： Sugiura T,Kondo S,Sukagawa A,Nakane S,Shinoda A,Itoh K,Yamashita A,Waku K

    更新日期：1995-10-04 00:00:00

  • Ontogeny of the cytosolic receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver, lung, and thymus.

    abstract：:The ontogeny of the cytosolic receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin was studied in Sprague-Dawley rats by quantitation of the receptor in hepatic, lung, and thymic cytosol. Concentrations of hepatic and lung cytosolic receptors increased rapidly after birth and remained at the highest levels from days 2 to ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(84)91084-2

    authors： Gasiewicz TA,Ness WC,Rucci G

    更新日期：1984-01-13 00:00:00

  • The rat H3 receptor: gene organization and multiple isoforms.

    abstract：:Genomic DNA analysis revealed that the coding region of the rat histamine H3 receptor comprises three exons interrupted by two introns of approximately 1 kb each. Several H3 receptor mRNA variants were identified by PCR and cDNA cloning and sequencing. Four variants generated by pseudo-intron retention/deletion at the...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.4073

    authors： Morisset S,Sasse A,Gbahou F,Héron A,Ligneau X,Tardivel-Lacombe J,Schwartz JC,Arrang JM

    更新日期：2001-01-12 00:00:00

  • The pkI gene encoding pyruvate kinase I links to the luxZ gene which enhances bioluminescence of the lux operon from Photobacterium leiognathi.

    abstract：:Partial 3'-end nucleotide sequence of the pkI gene (GenBank accession No. AF019143) from Photobacterium leiognathi ATCC 25521 has been determined, and the encoded pyruvate kinase I is deduced. Pyruvate kinase I is the key enzyme of glycolysis, which converts phosphoenol pyruvate to pyruvate. Alignment and comparison o...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.7461

    authors： Lin JW,Lu HC,Chen HY,Weng SF

    更新日期：1997-10-09 00:00:00

  • Physical interaction between MPP8 and PRC1 complex and its implication for regulation of spermatogenesis.

    abstract：:Epigenetic modifications such as DNA methylation and histone H3 lysine 27 methylation (H3K27me) are repressive marks that silence gene expression. The M phase phosphoprotein (MPP8) associates with proteins involved in both DNA methylation and histone modifications, and therefore, is a potential candidate to mediate cr...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.01.122

    authors： Murata K,Sato S,Haruta M,Goshima T,Chiba Y,Takahashi S,Sharif J,Koseki H,Nakanishi M,Shimada M

    更新日期：2015-03-13 00:00:00

  • Identification and cloning of a second phytase gene (phyB) from Aspergillus niger (ficuum).

    abstract：:An Aspergillus niger (ficuum) genomic DNA lambda EMBL3 library was probed with a 354-bp DNA fragment obtained by polymerase chain reaction of A. niger DNA with oligonucleotides based on partial amino acid sequence of a pH 2.5 optimum acid phosphatase. A clone containing a 1605 bp segment (phyB) encoding the 479 amino ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.2008

    authors： Ehrlich KC,Montalbano BG,Mullaney EJ,Dischinger HC Jr,Ullah AH

    更新日期：1993-08-31 00:00:00

  • Scallop-derived plasmalogens attenuate the activation of PKCδ associated with the brain inflammation.

    abstract：:Activation of protein kinase C delta (PKCδ) has been linked to the neuroinflammation but the relationship with the various neurodegenerative diseases including the Alzheimer's disease (AD) was mostly elusive. In the AD brains, the special phospholipids, ethanolamine plasmalogens (Pls), were found to be reduced and our...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.06.084

    authors： Sejimo S,Hossain MS,Akashi K

    更新日期：2018-09-05 00:00:00

  • 3D model of human arylamine N-acetyltransferase 2: structural basis of the slow acetylator phenotype of the R64Q variant and analysis of the active-site loop.

    abstract：:The human arylamine N-acetyltransferase NAT2 is responsible for the biotransformation of numerous arylamine drugs and carcinogens. A common polymorphism of the NAT2 gene has been associated with susceptibility to drug toxicity and various malignancies. In this study, we used the crystal structure of the Salmonella typ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2002.6414

    authors： Rodrigues-Lima F,Dupret JM

    更新日期：2002-02-15 00:00:00

  • Titration of variant DNA sequences differing by a single point-mutation by selective dot-blot hybridization with synthetic oligonucleotides.

    abstract：:A dot-blot hybridization procedure with synthetic oligonucleotide probes is reported, which allows the quantitative titration in genomic DNA of variant forms of repeated genes differing by a single nucleotide change. It involves the utilization of a pair of 22-base long oligonucleotides matching the two variant sequen...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)92242-0

    authors： Nicoloso M,Liang HQ,Bachellerie JP

    更新日期：1989-03-31 00:00:00

  • Differential regulation of multiple neuroreceptors in a somatic cell hybrid by inhibitors of glycoprotein processing.

    abstract：:Specific binding of [3H][D-Ala2,D-Leu5]enkephalin, [3H]ethylketocyclazocine, 5-[3H]hydroxytryptamine, and [3H]spiperone was examined in neuroblastoma-brain hybrid cell line NCB-20 following exposure to inhibitors of N-linked protein glycosylation (tunicamycin, TM) and oligosaccharide processing (swainsonine, SW). TM t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(86)90403-1

    authors： McLawhon RW,Berry-Kravis E,Dawson G

    更新日期：1986-02-13 00:00:00

  • Enhancer binding proteins predicted by informational spectrum method.

    abstract：:Enhancer sequences analysed using the informational spectrum method (ISM) show a characteristic frequency at .0488. It has been shown that the characteristic frequency for some DNA binding proteins overlaps the characteristic frequency of their target DNA sequences. We suggest here that two types of proteins, homeopro...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(86)80248-0

    authors： Cosić I,Nesić D,Pavlović M,Williams R

    更新日期：1986-12-15 00:00:00

  • Aging-associated increase of gelsolin for apoptosis resistance.

    abstract：:Gelsolin, a Ca(2+)-dependent actin regulatory protein, was recently suggested to participate in apoptosis regulation. In this study, we found that the level of gelsolin is elevated in senescent human diploid fibroblasts (HDFs) and also in the tissues of old rats, i.e., in the liver, kidney, heart, spleen, stomach, and...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2003.11.061

    authors： Ahn JS,Jang IS,Kim DI,Cho KA,Park YH,Kim K,Kwak CS,Chul Park S

    更新日期：2003-12-26 00:00:00

  • Cadmium binding studies to the earthworm Lumbricus rubellus metallothionein by electrospray mass spectrometry and circular dichroism spectroscopy.

    abstract：:The earthworm Lumbricus rubellus has been found to inhabit cadmium-rich soils and accumulate cadmium within its tissues. Two metallothionein (MT) isoforms (1 and 2) have been identified and cloned from L. rubellus. In this study, we address the metalation status, metal coordination, and structure of recombinant MT-2 f...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.10.023

    authors： Ngu TT,Sturzenbaum SR,Stillman MJ

    更新日期：2006-12-08 00:00:00

  • Antisense suppression of p107 inhibits 3T3-L1 adipocyte differentiation.

    abstract：:The murine 3T3-L1 preadipocyte cell line is well characterized for its capacity to undergo differentiation into adipocytes under appropriate hormonal stimulation. p107, a member of the retinoblastoma tumor suppressor gene family has been shown to be dramatically upregulated during the early requisite clonal expansion ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.4886

    authors： May JS,Prince AM,Lyle RE,McGehee RE Jr

    更新日期：2001-05-18 00:00:00

  • Photofrin as a radiosensitizer in an in vitro cell survival assay.

    abstract：:Chemical modifiers (radiosensitizers) are used in order to increase the efficacy of radiotherapy. The use of Photodynamic Therapy for tumor treatment, especially with Photofrin II, is also known. At present, no chemical modifier has been found to act as a selective radiosensitizer. Experiments using several series of ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2003.09.170

    authors： Kulka U,Schaffer M,Siefert A,Schaffer PM,Olsner A,Kasseb K,Hofstetter A,Dühmke E,Jori G

    更新日期：2003-11-07 00:00:00

  • Odorant binding initially occurring at the central pocket in bovine odorant-binding protein.

    abstract：:Why bovine odorant-binding protein (OBPb), among OBP family, assumes a dimeric structure has been unclear. Here we clarified, by measuring the fluorescence of intrinsic tryptophan and tyrosine residues of intact OBPb and OBPb whose C-terminal 10 amino acids were deleted, that odorant enters the central pocket formed b...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.06.031

    authors： Ikematsu M,Takaoka D,Yasuda M

    更新日期：2005-08-12 00:00:00

  • A cysteine-free firefly luciferase retains luminescence activity.

    abstract：:A mutant of Photinus pyralis luciferase in which all four native cysteine residues are converted to serines retains about 10% of wild-type activity. This mutant should prove useful as a starting point for the introduction of biophysical probes of conformational changes associated with enzyme function. The activities o...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.1950

    authors： Kumita JR,Jain L,Safroneeva E,Woolley GA

    更新日期：2000-01-07 00:00:00

  • Simultaneous assessment of the effects of exonic mutations on RNA splicing and protein functions.

    abstract：:To simultaneously assess the effects of exonic mutations on RNA splicing and protein functions, we report here an intron-inclusive cDNA (Intinc) expression system. As a test model, twenty-four mutations in exon 9 of the phenylalanine hydroxylase (PAH) gene were examined in an Intinc expression plasmid composed of the ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.06.072

    authors： Ho PY,Huang MZ,Fwu VT,Lin SC,Hsiao KJ,Su TS

    更新日期：2008-09-05 00:00:00

  • Stress-activated protein kinase-dependent induction of c-fos by Cd(2+) is mediated by MKK7.

    abstract：:Exposure of mesangial cells to ionic Cd(2+) induces the proto-oncogene c-fos, while activating both Erk and stress-activated protein kinase (SAPK) MAP kinase pathways. While we have previously used a pharmacological inhibitor of Erk activation to implicate involvement of this pathway in the induction of c-fos by Cd(2+...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.3009

    authors： Ding W,Templeton DM

    更新日期：2000-07-05 00:00:00

  • Expression of Aeromonas caviae ST pyruvate dehydrogenase complex components mediate tellurite resistance in Escherichia coli.

    abstract：:Potassium tellurite (K(2)TeO(3)) is harmful to most organisms and specific mechanisms explaining its toxicity are not well known to date. We previously reported that the lpdA gene product of the tellurite-resistant environmental isolate Aeromonas caviae ST is involved in the reduction of tellurite to elemental telluri...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.01.078

    authors： Castro ME,Molina RC,Díaz WA,Pradenas GA,Vásquez CC

    更新日期：2009-02-27 00:00:00

  • Dopaminergic reduction of intracellular calcium: the role of calcium influx.

    abstract：:The effects of dopamine (DA) on 45Ca2+ ion movement and prolactin release in dispersed female rat anterior pituitary cells were studied to elucidate the mechanism for DA reduction of intracellular calcium levels. In 45Ca2+ prelabeled cells, DA inhibited fractional calcium efflux and prolactin release simultaneously an...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(88)80368-1

    authors： Login IS,Judd AM,MacLeod RM

    更新日期：1988-03-15 00:00:00

  • Dissociation between the inhibitory and stimulatory effects of opioid peptides on cAMP formation in SK-N-SH neuroblastoma cells.

    abstract：:Opioid agonists either potentiate or suppress basal cAMP production in SK-N-SH cells. The inhibitory effect is mediated by PTX-sensitive GTP-binding proteins, while the stimulatory effect involves Ca++ entry and calmodulin activation. Both pathways can be activated simultaneously by opioid agonists. Low (nM) concentra...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.8582

    authors： Sarne Y,Rubovitch V,Fields A,Gafni M

    更新日期：1998-05-08 00:00:00

  • A single replacement of histidine to arginine in EGFR-lytic hybrid peptide demonstrates the improved anticancer activity.

    abstract：:We previously reported that novel targeted "hybrid peptide" in which epidermal growth factor receptor (EGFR) binding peptide was conjugated with lytic-type peptide had selective cytotoxic activity to EGFR expressing cancer cell lines, and in vivo analysis revealed that this EGFR-lytic peptide displayed significant ant...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.03.030

    authors： Tada N,Horibe T,Haramoto M,Ohara K,Kohno M,Kawakami K

    更新日期：2011-04-08 00:00:00

  • Phosphorylation of phosphofructokinase by protein kinase C changes the allosteric properties of the enzyme.

    abstract：:The Ca2+- and phospholipid-dependent protein kinase C from rat brain phosphorylates rabbit muscle phosphofructokinase at the same trypsin-labile site as cyclic AMP-dependent protein kinase. However, protein kinase C also effectively phosphorylates one or more separate sites. Incubation of phosphofructokinase in the pr...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)91975-8

    authors： Hofer HW,Schlatter S,Graefe M

    更新日期：1985-06-28 00:00:00