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First structure of the polymyxin resistance proteins.

Abstract：

:PmrA/PmrB and PhoP/PhoQ are a pair of two-component systems (TCSs) that allow the Gram-negative bacteria to survive the cationic antimicrobial peptide polymyxin B. The two TCSs are linked by the polymyxin resistance protein, PmrD. The PhoP-activated PmrD protects the phosphorylated response regulator PmrA from dephosphorylation, and promotes the transcription of PmrA-activated genes responsible for polymyxin resistance. PmrD is the first protein identified to mediate the connectivity between two TCSs by protecting the phosphorylated response regulator of the downstream TCS. PmrD shows no homology to proteins with known structures. We present here the solution structure of PmrD from Escherichia coli, the first three-dimensional structure of the PmrD family. Our study provides the structural basis of the novel interacting mechanism of bacterial two-component signal-transduction systems.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Fu W,Yang F,Kang X,Zhang X,Li Y,Xia B,Jin C

doi

10.1016/j.bbrc.2007.07.144

subject

Has Abstract

pub_date

2007-10-05 00:00:00

pages

1033-7

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(07)01637-3

journal_volume

361

pub_type

杂志文章

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