Abstract:
:The combination of the unique pathologic features of usual interstitial pneumonia (UIP) on biopsy, the progressive clinical course, and resistance to anti-inflammatory therapy constitutes the cardinal manifestations of what is termed idiopathic pulmonary fibrosis (IFP)/usual interstitial pneumonia, and it has led to recent suggestions that new therapies should be directed at regulating fibroblast functions rather than targeting the inflammatory response. The observation that "early" UIP looks like "late" UIP but there is less of it has been largely responsible for re-evaluation of the paradigm that IPF is the result of uncontrolled lung inflammation. This article highlights aspects of current thoughts on pathogenesis of IFP and expands on recent reviews.
journal_name
Clin Chest Medjournal_title
Clinics in chest medicineauthors
Noble PW,Homer RJdoi
10.1016/j.ccm.2004.04.003subject
Has Abstractpub_date
2004-12-01 00:00:00pages
749-58, viiissue
4eissn
0272-5231issn
1557-8216pii
S0272-5231(04)00047-4journal_volume
25pub_type
杂志文章,评审abstract::As recently as the 1992 Report of the American Thoracic Society Workshop on Lung Transplantation, no QOL facts were given and no knowledge gaps related to QOL outcomes were cited. Even at the present time, the information in that area is based on a relatively small set of preliminary reports. Current information indic...
journal_title:Clinics in chest medicine
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abstract::The specialty has the knowledge and technology to change the outcome of lung cancer. Lung cancer, diagnosed in early stages, is as curable as all other cancers. Sputum cytology is the initial step in diagnosing roentgenographically occult lung cancer. Sputum cytology is complementary to CT scanning. Sputum cytology id...
journal_title:Clinics in chest medicine
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journal_title:Clinics in chest medicine
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journal_title:Clinics in chest medicine
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journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
doi:
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abstract::The clinical applications of bronchoalveolar lavage are assessed in regard to its current place as an aid for the practicing physician in the management of individual patients. ...
journal_title:Clinics in chest medicine
pub_type: 杂志文章
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journal_title:Clinics in chest medicine
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journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
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journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
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更新日期:1990-03-01 00:00:00
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journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
doi:10.1016/j.ccm.2008.03.005
更新日期:2008-09-01 00:00:00
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journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
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journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
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journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
doi:
更新日期:1985-03-01 00:00:00
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journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
doi:10.1016/s0272-5231(05)70076-9
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journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
doi:
更新日期:1990-06-01 00:00:00
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journal_title:Clinics in chest medicine
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journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
doi:10.1016/s0272-5231(05)70145-3
更新日期:1999-06-01 00:00:00
abstract::The pathogenic importance of cytomegalovirus (CMV) infection in AIDS-associated pneumonitis is controversial. Uncertainty regarding the significance of CMV isolation from pulmonary secretions of AIDS patients results in part from the difficulty in distinguishing CMV infection from CMV disease and from the high frequen...
journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
doi:
更新日期:1988-09-01 00:00:00
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journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
doi:
更新日期:1989-03-01 00:00:00
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journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
doi:
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abstract::Recent progress in medical therapies has diminished the role of transplantation in the management of PPH during the past decade. Drug therapy is not effective in some patients, responses to therapy are not sustained over time in others, and drug side effects eventually limit the benefits of treatment in a few more. Lu...
journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
doi:10.1016/s0272-5231(05)70293-8
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abstract::This article reviews several important noninfectious pulmonary complications that threaten survival, pulmonary function, and quality of life after lung transplantation. Topics reviewed include primary graft dysfunction (PGD), native lung hyperinflation, anastomotic complications, phrenic nerve injury, pleural complica...
journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
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journal_title:Clinics in chest medicine
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journal_title:Clinics in chest medicine
pub_type: 杂志文章,评审
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journal_title:Clinics in chest medicine
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journal_title:Clinics in chest medicine
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journal_title:Clinics in chest medicine
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journal_title:Clinics in chest medicine
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abstract::Respiratory viruses are common in solid organ and hematopoietic stem cell transplant recipients and a recognized cause of significant morbidity and mortality. Epidemiology, risk factors, and attributable mortality in both populations are reviewed. In addition, virus-specific prevention and treatment options, including...
journal_title:Clinics in chest medicine
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journal_title:Clinics in chest medicine
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