Quantifying agitation in sedated ICU patients using heart rate and blood pressure.

Abstract:

:Agitation is a significant problem in the intensive care unit (ICU), affecting 71% of sedated adult patients during 58% of ICU patient-days (Fraser and Riker 2001 NY Health-Syst. Pharm. 20 17-24). Subjective scale-based assessment methods are currently used to assess the level of patient agitation, but are limited in their accuracy and resolution. This research develops an objective agitation measurement method using heart rate variability (HRV), systolic blood pressure (BP) and blood pressure variability (BPV) data, processed by wavelet transforms and autoregressive signal processing. A fuzzy inference system (FIS) is developed to classify changes in these signals that correlate with observed patient agitation, and combine them into a final agitation level. Proof of concept clinical trials on 13 normal subjects and 5 ICU patients has been performed to verify the validity of this approach in comparison with agitation graded by nursing staff using the Riker sedation-agitation scale (SAS). Results show good correlation with medical staff assessment with no false positive results during calm periods. Clinically, this initial agitation measurement method promises the ability to consistently and objectively quantify patient agitation to enable better management of sedation and agitation through optimized drug delivery leading to reduced length of stay.

journal_name

Physiol Meas

authors

Chase JG,Starfinger C,Lam Z,Agogue F,Shaw GM

doi

10.1088/0967-3334/25/4/020

subject

Has Abstract

pub_date

2004-08-01 00:00:00

pages

1037-51

issue

4

eissn

0967-3334

issn

1361-6579

journal_volume

25

pub_type

临床试验,杂志文章
  • Determination of Cole parameters in multiple frequency bioelectrical impedance analysis using only the measurement of impedances.

    abstract::Conventional bioimpedance spectrometers measure resistance and reactance over a range of frequencies and, by application of a mathematical model for an equivalent circuit (the Cole model), estimate resistance at zero and infinite frequencies. Fitting of the experimental data to the model is accomplished by iterative, ...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/27/9/007

    authors: Ward LC,Essex T,Cornish BH

    更新日期:2006-09-01 00:00:00

  • Predicting clinical ischaemia during awake carotid endarterectomy: use of the SJVO2 probe as a guide to selective shunting.

    abstract::Stroke is a major cause of disability within the western world. About 20% of strokes are a consequence of atheromatous narrowing of the origin of the internal carotid artery. Carotid endarterectomy has been shown to be an effective treatment for those with symptomatic and severe stenosis, provided the risk of death an...

    journal_title:Physiological measurement

    pub_type: 临床试验,杂志文章

    doi:10.1088/0967-3334/24/2/310

    authors: Crossman J,Banister K,Bythell V,Bullock R,Chambers I,Mendelow AD

    更新日期:2003-05-01 00:00:00

  • Effect of body mass index (BMI) on estimation of extracellular volume (ECV) in hemodialysis (HD) patients using segmental and whole body bioimpedance analysis.

    abstract::The aim of the study was to investigate whether body mass index (BMI) influences the estimation of extracellular volume (ECV) in hemodialysis (HD) patients when using segmental bioimpedance analysis (SBIA) compared to wrist-to-ankle bioimpedance analysis (WBIA) during HD with ultrafiltration (UF). Twenty five HD patie...

    journal_title:Physiological measurement

    pub_type: 临床试验,杂志文章

    doi:10.1088/0967-3334/26/2/009

    authors: Carter M,Morris AT,Zhu F,Zaluska W,Levin NW

    更新日期:2005-04-01 00:00:00

  • Effect of organic and inorganic nitrates on cerebrovascular pulsatile power transmission in patients with heart failure and preserved ejection fraction.

    abstract:OBJECTIVE:Increased penetration of pulsatile power to the brain has been implicated in the pathogenesis of age-related cognitive dysfunction and dementia, a common comorbidity in patients with heart failure and preserved ejection fraction (HFpEF). However, there is a lack of knowledge on the effects of organic and inor...

    journal_title:Physiological measurement

    pub_type: 杂志文章,随机对照试验

    doi:10.1088/1361-6579/aab2ef

    authors: Londono-Hoyos F,Zamani P,Beraun M,Vasim I,Segers P,Chirinos JA

    更新日期:2018-04-20 00:00:00

  • Influence of tidal volume and positive end-expiratory pressure on ventilation distribution and oxygenation during one-lung ventilation.

    abstract:OBJECTIVE:The aim of the study was to explore the feasibility of titrating tidal volume (V T) and positive end-expiratory pressure (PEEP) during one-lung ventilation (OLV) based on ventilation distribution and oxygenation. APPROACH:Twenty-four consecutive patients requiring intubation with a double-lumen tube and subs...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/1361-6579/aaaeb2

    authors: Zhao Z,Wang W,Zhang Z,Xu M,Frerichs I,Wu J,Moeller K

    更新日期:2018-03-29 00:00:00

  • Assessment of cerebrospinal fluid outflow conductance using constant-pressure infusion--a method with real time estimation of reliability.

    abstract::The outflow conductance (C(out)) of the cerebrospinal fluid (CSF) system is a parameter considered to be predictive in selection for hydrocephalus surgery. C(out) can be determined through an infusion test. A new apparatus for performing infusion tests in a standardized and automated way was developed. The objective w...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/26/6/022

    authors: Andersson N,Malm J,Bäcklund T,Eklund A

    更新日期:2005-12-01 00:00:00

  • Aging in autonomic control by multifractal studies of cardiac interbeat intervals in the VLF band.

    abstract::The heart rate responds dynamically to various intrinsic and environmental stimuli. The autonomic nervous system is said to play a major role in this response. Multifractal analysis offers a novel method to assess the response of cardiac interbeat intervals. Twenty-four hour ECG recordings of RR interbeat intervals (o...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/32/10/014

    authors: Makowiec D,Rynkiewicz A,Wdowczyk-Szulc J,Zarczyńska-Buchowiecka M,Gałaska R,Kryszewski S

    更新日期:2011-10-01 00:00:00

  • A measurement of pulmonary blood volume increase during systole in humans.

    abstract::Pulmonary blood volume increase during systole was measured in patients by analysing chest images obtained during ECG gated radionuclide angiography examination. The difference in the total radiation counts between systole and diastole in regions of interest, which included the lungs and the left ventricle, was measur...

    journal_title:Physiological measurement

    pub_type: 临床试验,杂志文章

    doi:10.1088/0967-3334/15/4/010

    authors: Nitzan M,Mahler Y,Schechter D,Yaffe S,Bocher M,Chisin R

    更新日期:1994-11-01 00:00:00

  • Assessment of non-invasive time and frequency atrial fibrillation organization markers with unipolar atrial electrograms.

    abstract::The standard electrocardiogram (ECG) is the most common non-invasive way to study atrial fibrillation (AF). In this respect, previous works have shown that the surface lead V(1) reflects mainly the dominant atrial frequency (DAF) of the right atrium (RA), which has been widely used to study AF. In a similar way, AF or...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/32/1/007

    authors: Alcaraz R,Hornero F,Rieta JJ

    更新日期:2011-01-01 00:00:00

  • Combining and benchmarking methods of foetal ECG extraction without maternal or scalp electrode data.

    abstract::Despite significant advances in adult clinical electrocardiography (ECG) signal processing techniques and the power of digital processors, the analysis of non-invasive foetal ECG (NI-FECG) is still in its infancy. The Physionet/Computing in Cardiology Challenge 2013 addresses some of these limitations by making a set ...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/35/8/1569

    authors: Behar J,Oster J,Clifford GD

    更新日期:2014-08-01 00:00:00

  • A planar elliptical model of cardio-vagal hysteresis.

    abstract::The state-dependent portion of cardio-vagal baroreflex control is called baroreflex hyteresis: we observe hysteresis when RR interval and carotid diameter depend on both the direction and value of arterial pressure. The elasticity of arterial walls, as well as the responsiveness of central command reset controls the r...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/31/6/009

    authors: Ler AS,Cohen MA,Taylor JA

    更新日期:2010-06-01 00:00:00

  • Time-varying analysis of heart rate variability signals with a Kalman smoother algorithm.

    abstract::A time-varying parametric spectrum estimation method for analysing non-stationary heart rate variability signals is presented. As a case study, the dynamics of heart rate variability during an orthostatic test is examined. In this method, the non-stationary signal is first modelled with a time-varying autoregressive m...

    journal_title:Physiological measurement

    pub_type: 临床试验,杂志文章

    doi:10.1088/0967-3334/27/3/002

    authors: Tarvainen MP,Georgiadis SD,Ranta-Aho PO,Karjalainen PA

    更新日期:2006-03-01 00:00:00

  • Treading on the unknown-the feasibility of a novel approach to investigating the motor control of walking.

    abstract:BACKGROUND AND OBJECTIVE:Walking is a complex human behavior, usually performed in a dynamic environment. Gait parameters are thought to reflect this complexity. Re-Step™ is a therapy system in the form of a computerized shoe, originally developed for the training and rehabilitation of individuals with brain damage. Th...

    journal_title:Physiological measurement

    pub_type: 临床试验,杂志文章

    doi:10.1088/1361-6579/aab659

    authors: Koren Y,Raanan Y,Parmet Y,Bar-Haim S

    更新日期:2018-04-26 00:00:00

  • The impact of electrode area, contact impedance and boundary shape on EIT images.

    abstract::Electrical impedance tomography (EIT) measures the conductivity distribution within an object based on the current applied and voltage measured at surface electrodes. Thus, EIT images are sensitive to electrode properties (i.e. contact impedance, electrode area and boundary shape under the electrode). While some of th...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/32/7/S02

    authors: Boyle A,Adler A

    更新日期:2011-07-01 00:00:00

  • Are ejection fractions from gated SPECT perfusion studies clinically useful? A comparison with radionuclide ventriculography.

    abstract::Gated SPECT (GSPECT) was evaluated for the measurement of left ventricular ejection fraction (LVEF) by comparing with equilibrium gated radionuclide ventriculography (RNVG). A total of 99 subjects underwent GSPECT and RNVG imaging. All studies were acquired in list mode with GSPECT studies processed to give 16- and 8-...

    journal_title:Physiological measurement

    pub_type: 临床试验,杂志文章

    doi:10.1088/0967-3334/22/2/312

    authors: Wright GA,McDade M,Keeble W,Martin W,Hutton I

    更新日期:2001-05-01 00:00:00

  • Wearable sensors for patient-specific boundary shape estimation to improve the forward model for electrical impedance tomography (EIT) of neonatal lung function.

    abstract::Electrical impedance tomography (EIT) could be significantly advantageous to continuous monitoring of lung development in newborn and, in particular, preterm infants as it is non-invasive and safe to use within the intensive care unit. It has been demonstrated that accurate boundary form of the forward model is import...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/35/6/1149

    authors: Khor JM,Tizzard A,Demosthenous A,Bayford R

    更新日期:2014-06-01 00:00:00

  • Assessment of the dynamic interactions between heart rate and arterial pressure by the cross time-frequency analysis.

    abstract::In this study, a framework for the characterization of the dynamic interactions between RR variability (RRV) and systolic arterial pressure variability (SAPV) is proposed. The methodology accounts for the intrinsic non-stationarity of the cardiovascular system and includes the assessment of both the strength and the p...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/33/3/315

    authors: Orini M,Laguna P,Mainardi LT,Bailón R

    更新日期:2012-03-01 00:00:00

  • Monitoring of body fluid redistribution using segmental bioimpedance during rotation on a short-radius centrifuge.

    abstract:OBJECTIVE:The creation of artificial gravity on board a space station is one of the promising methods for preventing health problems during space missions; a short-radius centrifuge (SRC) is the model of such a method on Earth. Our goal was to evaluate the sensitivity of bioimpedance polysegmental measurements for moni...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/1361-6579/ab840b

    authors: Takhtobina YV,Shchelykalina SP,Smirnov YI,Smirnov AV,Koloteva MI,Vassilieva GY,Nikolaev DV

    更新日期:2020-05-07 00:00:00

  • Independent component analysis of normal and abnormal rhythm in twin pregnancies.

    abstract::We investigated the utility of ICA for evaluation of fetal rhythm in five uncomplicated twin pregnancies and in five twin pregnancies complicated by fetal arrhythmia. Using objective and subjective criteria, we sought to determine how the signal-to-noise ratio, signal fidelity and interference rejection are affected w...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/32/1/004

    authors: Mensah-Brown NA,Lutter WJ,Comani S,Strasburger JF,Wakai RT

    更新日期:2011-01-01 00:00:00

  • A method for modelling and optimizing an electrical impedance tomography system.

    abstract::Electrical impedance tomography (EIT) image reconstruction is an ill-posed problem requiring maximum measurement precision. Recent EIT systems claim 60 to 80 dB precision. Achieving higher values is hard in practice since measurements must be performed at relatively high frequency, on a living subject, while using com...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/27/5/S05

    authors: Hartinger AE,Gagnon H,Guardo R

    更新日期:2006-05-01 00:00:00

  • EITS changes following oleic acid induced lung water.

    abstract::We present the results of using electrical impedance tomographic spectroscopy (EITS) to follow the changes in lung water induced by oleic acid. Measurements were made on three goats before and after the injection of oleic acid. In addition to the EITs measurements, lung water was also measured using a double-indicator...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/17/4a/016

    authors: Brown BH,Flewelling R,Griffiths H,Harris ND,Leathard AD,Lu L,Morice AH,Neufeld GR,Nopp P,Wang W

    更新日期:1996-11-01 00:00:00

  • An automated quasi-continuous capillary refill timing device.

    abstract::Capillary refill time (CRT) is a simple means of cardiovascular assessment which is widely used in clinical care. Currently, CRT is measured through manual assessment of the time taken for skin tone to return to normal colour following blanching of the skin surface. There is evidence to suggest that manually assessed ...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/37/1/83

    authors: Blaxter LL,Morris DE,Crowe JA,Henry C,Hill S,Sharkey D,Vyas H,Hayes-Gill BR

    更新日期:2016-01-01 00:00:00

  • Detection of animal tissue thickness using simple vertical electric sounding (VES).

    abstract::Tetrapolar linear arrays are commonly used in geophysics to explore the vertical distribution of resistivity values in a geological section of a specific point on the earth. This technique, known as vertical electric sounding (VES), uses different electrode configurations. For our experiments, we utilized its more pop...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/18/1/007

    authors: Gonzalez CA,offniga O,Padilla LE

    更新日期:1997-02-01 00:00:00

  • Impedance analyser module for EIT and spectroscopy using undersampling.

    abstract::In this paper we present the concept, the design and the test procedure for a DSP-based high-precision and high-performance wide-band (up to 10 MHz) bioimpedance analyser module for application in EIT or bioimpedance spectroscopy. The module implements a digital concept with appropriate signal conditioning hardware fo...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/22/1/303

    authors: Dudykevych T,Gersing E,Thiel F,Hellige G

    更新日期:2001-02-01 00:00:00

  • Imputation of partial pressures of arterial oxygen using oximetry and its impact on sepsis diagnosis.

    abstract:OBJECTIVE:The ratio of the partial pressure of arterial oxygen to fraction of inspired oxygen is a key component of the sequential organ failure assessment score that operationally defines sepsis. But, it is calculated infrequently due to the need for the acquisition of an arterial blood gas. So, we sought to find an o...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/1361-6579/ab5154

    authors: Gadrey SM,Lau CE,Clay R,Rhodes GT,Lake DE,Moore CC,Voss JD,Moorman JR

    更新日期:2019-12-03 00:00:00

  • Photoplethysmography detection of lower limb peripheral arterial occlusive disease: a comparison of pulse timing, amplitude and shape characteristics.

    abstract::The assessment and diagnosis of lower limb peripheral arterial occlusive disease (PAOD) is important since it can lead progressively to disabling claudication, ischaemic rest pain and gangrene. Historically, the first assessment has been palpation of the peripheral pulse since it can become damped, delayed and diminis...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/26/5/018

    authors: Allen J,Oates CP,Lees TA,Murray A

    更新日期:2005-10-01 00:00:00

  • Arterial blood pressure measurement and pulse wave analysis--their role in enhancing cardiovascular assessment.

    abstract::The most common method of clinical measurement of arterial blood pressure is by means of the cuff sphygmomanometer. This instrument has provided fundamental quantitative information on arterial pressure in individual subjects and in populations and facilitated estimation of cardiovascular risk related to levels of blo...

    journal_title:Physiological measurement

    pub_type: 历史文章,杂志文章,评审

    doi:10.1088/0967-3334/31/1/R01

    authors: Avolio AP,Butlin M,Walsh A

    更新日期:2010-01-01 00:00:00

  • Machine learning for nocturnal mass diagnosis of atrial fibrillation in a population at risk of sleep-disordered breathing.

    abstract:OBJECTIVE:In this research, we introduce a new methodology for atrial fibrillation (AF) diagnosis during sleep in a large population sample at risk of sleep-disordered breathing. APPROACH:The approach leverages digital biomarkers and recent advances in machine learning (ML) for mass AF diagnosis from overnight-hours o...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/1361-6579/abb8bf

    authors: Chocron A,Efraim R,Mandel F,Rueschman M,Palmius N,Penzel T,Elbaz M,Behar JA

    更新日期:2020-11-06 00:00:00

  • Adaptive techniques in electrical impedance tomography reconstruction.

    abstract::We present an adaptive algorithm for solving the inverse problem in electrical impedance tomography. To strike a balance between the accuracy of the reconstructed images and the computational efficiency of the forward and inverse solvers, we propose to combine an adaptive mesh refinement technique with the adaptive Ka...

    journal_title:Physiological measurement

    pub_type: 杂志文章

    doi:10.1088/0967-3334/35/6/1111

    authors: Li T,Isaacson D,Newell JC,Saulnier GJ

    更新日期:2014-06-01 00:00:00

  • Video and audio processing in paediatrics: a review.

    abstract:OBJECTIVE:Video and sound acquisition and processing technologies have seen great improvements in recent decades, with many applications in the biomedical area. The aim of this paper is to review the overall state of the art of advances within these topics in paediatrics and to evaluate their potential application for ...

    journal_title:Physiological measurement

    pub_type: 杂志文章,评审

    doi:10.1088/1361-6579/ab0096

    authors: Cabon S,Porée F,Simon A,Rosec O,Pladys P,Carrault G

    更新日期:2019-02-26 00:00:00